Alexander W Bruce
Affiliation: University of Cambridge
- Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence levelAlexander W Bruce
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
Genome Res 19:994-1005. 2009..These relationships have never been reported in mammalian systems for any transcription factor...
- Complex exon-intron marking by histone modifications is not determined solely by nucleosome distributionPawandeep Dhami
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
PLoS ONE 5:e12339. 2010..We believe that these histone modification patterns provide links between chromatin accessibility, Pol II movement and co-transcriptional splicing...
- Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locusPawandeep Dhami
The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
PLoS ONE 5:e9059. 2010..Our analysis opens up several areas for further investigation and adds new layers of complexity to our understanding of the regulation of SCL expression...
- The landscape of histone modifications across 1% of the human genome in five human cell linesChristoph M Koch
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SA, United Kingdom
Genome Res 17:691-707. 2007..These results provide an overview of the functional relationship among histone modifications and gene expression in human cells...
- Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sitesGeorge A Follows
Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 2XY, United Kingdom
Genome Res 16:1310-9. 2006..ADHM provides a powerful approach to identifying DNaseI hypersensitive sites across large genomic regions...