Alexander W Bruce

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level
    Alexander W Bruce
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
    Genome Res 19:994-1005. 2009
  2. pmc Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution
    Pawandeep Dhami
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS ONE 5:e12339. 2010
  3. pmc Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus
    Pawandeep Dhami
    The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    PLoS ONE 5:e9059. 2010
  4. pmc The landscape of histone modifications across 1% of the human genome in five human cell lines
    Christoph M Koch
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SA, United Kingdom
    Genome Res 17:691-707. 2007
  5. pmc Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites
    George A Follows
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 2XY, United Kingdom
    Genome Res 16:1310-9. 2006

Collaborators

Detail Information

Publications5

  1. pmc Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level
    Alexander W Bruce
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
    Genome Res 19:994-1005. 2009
    ..These relationships have never been reported in mammalian systems for any transcription factor...
  2. pmc Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution
    Pawandeep Dhami
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS ONE 5:e12339. 2010
    ..We believe that these histone modification patterns provide links between chromatin accessibility, Pol II movement and co-transcriptional splicing...
  3. pmc Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus
    Pawandeep Dhami
    The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    PLoS ONE 5:e9059. 2010
    ..Our analysis opens up several areas for further investigation and adds new layers of complexity to our understanding of the regulation of SCL expression...
  4. pmc The landscape of histone modifications across 1% of the human genome in five human cell lines
    Christoph M Koch
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SA, United Kingdom
    Genome Res 17:691-707. 2007
    ..These results provide an overview of the functional relationship among histone modifications and gene expression in human cells...
  5. pmc Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites
    George A Follows
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 2XY, United Kingdom
    Genome Res 16:1310-9. 2006
    ..ADHM provides a powerful approach to identifying DNaseI hypersensitive sites across large genomic regions...