Anthony J Brookes

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. pmc Locus Reference Genomic sequences: an improved basis for describing human DNA variants
    Raymond Dalgleish
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Genome Med 2:24. 2010
  2. ncbi request reprint Genetic association analysis: lessons from the study of Alzheimers disease
    Anthony J Brookes
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Mutat Res 573:152-9. 2005
  3. pmc Automated design of paralogue ratio test assays for the accurate and rapid typing of copy number variation
    Colin D Veal
    Department of Genetics, University of Leicester, Leicester, UK
    Bioinformatics 29:1997-2003. 2013
  4. pmc HGV2009 meeting: bigger and better studies provide more answers and more questions
    Katherine Reekie
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    Hum Mutat 31:886-8. 2010
  5. pmc HGVbaseG2P: a central genetic association database
    Gudmundur A Thorisson
    Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK
    Nucleic Acids Res 37:D797-802. 2009
  6. doi request reprint Genotype-phenotype databases: challenges and solutions for the post-genomic era
    Gudmundur A Thorisson
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Nat Rev Genet 10:9-18. 2009
  7. pmc GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies
    Tim Beck
    Department of Genetics, University of Leicester, Leicester, UK
    Eur J Hum Genet 22:949-52. 2014
  8. doi request reprint Defensins and the dynamic genome: what we can learn from structural variation at human chromosome band 8p23.1
    Edward J Hollox
    Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
    Genome Res 18:1686-97. 2008
  9. doi request reprint An informatics project and online "Knowledge Centre" supporting modern genotype-to-phenotype research
    Adam J Webb
    Department of Genetics, University of Leicester, University Road, Leicester, United Kingdom
    Hum Mutat 32:543-50. 2011
  10. doi request reprint Cafe Variome: general-purpose software for making genotype-phenotype data discoverable in restricted or open access contexts
    Owen Lancaster
    Department of Genetics, University of Leicester, Leicester, UK
    Hum Mutat 36:957-64. 2015

Detail Information

Publications60

  1. pmc Locus Reference Genomic sequences: an improved basis for describing human DNA variants
    Raymond Dalgleish
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Genome Med 2:24. 2010
    ..Further information can be found on the LRG web site: http://www.lrg-sequence.org...
  2. ncbi request reprint Genetic association analysis: lessons from the study of Alzheimers disease
    Anthony J Brookes
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Mutat Res 573:152-9. 2005
    ....
  3. pmc Automated design of paralogue ratio test assays for the accurate and rapid typing of copy number variation
    Colin D Veal
    Department of Genetics, University of Leicester, Leicester, UK
    Bioinformatics 29:1997-2003. 2013
    ..PRT has been successfully applied to several studies analyzing common CNV. However, its use has not been widespread because of difficulties in assay design...
  4. pmc HGV2009 meeting: bigger and better studies provide more answers and more questions
    Katherine Reekie
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    Hum Mutat 31:886-8. 2010
    ..Key themes included Genome-Wide Association Studies (GWAS), progress beyond GWAS, sequencing developments, and bioinformatics approaches to large-scale datasets...
  5. pmc HGVbaseG2P: a central genetic association database
    Gudmundur A Thorisson
    Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK
    Nucleic Acids Res 37:D797-802. 2009
    ..We present a range of user-friendly but powerful website tools for searching, browsing and visualizing G2P study findings. HGVbaseG2P is available at http://www.hgvbaseg2p.org...
  6. doi request reprint Genotype-phenotype databases: challenges and solutions for the post-genomic era
    Gudmundur A Thorisson
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Nat Rev Genet 10:9-18. 2009
    ..Along with emerging technologies that enhance connectivity and data retrieval, these advances should help to create a powerful knowledge environment for genotype-phenotype information...
  7. pmc GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies
    Tim Beck
    Department of Genetics, University of Leicester, Leicester, UK
    Eur J Hum Genet 22:949-52. 2014
    ..As a result, the resource now provides over 67 million P-values for over 1600 studies, making it the world's largest openly accessible online collection of summary-level GWAS association information. ..
  8. doi request reprint Defensins and the dynamic genome: what we can learn from structural variation at human chromosome band 8p23.1
    Edward J Hollox
    Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
    Genome Res 18:1686-97. 2008
    ..Finally, we discuss the bioinformatics challenges raised, discuss the evolution of the region, and suggest some future priorities for structural variation research...
  9. doi request reprint An informatics project and online "Knowledge Centre" supporting modern genotype-to-phenotype research
    Adam J Webb
    Department of Genetics, University of Leicester, University Road, Leicester, United Kingdom
    Hum Mutat 32:543-50. 2011
    ....
  10. doi request reprint Cafe Variome: general-purpose software for making genotype-phenotype data discoverable in restricted or open access contexts
    Owen Lancaster
    Department of Genetics, University of Leicester, Leicester, UK
    Hum Mutat 36:957-64. 2015
    ..Current uses include rare disease data discovery, patient matchmaking, and a Beacon Web service. ..
  11. pmc Semantically enabling a genome-wide association study database
    Tim Beck
    Department of Genetics, University of Leicester, University Road, Leicester, UK
    J Biomed Semantics 3:9. 2012
    ..abstract:..
  12. pmc A 129-kb deletion on chromosome 12 confers substantial protection against rheumatoid arthritis, implicating the gene SLC2A3
    Colin D Veal
    Department of Genetics, University of Leicester, Leicester, UK
    Hum Mutat 35:248-56. 2014
    ....
  13. doi request reprint The phenotype and genotype experiment object model (PaGE-OM): a robust data structure for information related to DNA variation
    Anthony J Brookes
    University of Leicester, Department of Genetics, Leicester, UK
    Hum Mutat 30:968-77. 2009
    ..It will help to improve information management, assist data integration, and simplify the task of informatics resource design and construction for genotype and phenotype data projects...
  14. pmc A mechanistic basis for amplification differences between samples and between genome regions
    Colin D Veal
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    BMC Genomics 13:455. 2012
    ..The most affected genome regions tend to correlate with high C + G content, however this relationship is complex and does not explain why the direction and magnitude of effects varies considerably between samples...
  15. pmc Genomic variation in a global village: report of the 10th annual Human Genome Variation Meeting 2008
    Anthony J Brookes
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    Hum Mutat 30:1134-8. 2009
    ..The HGV meetings foster collaboration, and fruits of the interactions from 2008 are anticipated for the 11th annual meeting in September 2009...
  16. ncbi request reprint MegaPlex PCR: a strategy for multiplex amplification
    Linda Strömqvist Meuzelaar
    Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK
    Nat Methods 4:835-7. 2007
    ..We demonstrate this method by co-amplifying and genotyping 75 unselected human single-nucleotide polymorphism (SNP) loci...
  17. doi request reprint Solving bottlenecks in data sharing in the life sciences
    Raymond Dalgleish
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    Hum Mutat 33:1494-6. 2012
    ..Several key challenges were identified and solutions to each of these were proposed...
  18. doi request reprint Knowledge engineering for health: a new discipline required to bridge the "ICT gap" between research and healthcare
    Tim Beck
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    Hum Mutat 33:797-802. 2012
    ....
  19. pmc DNA diagnostics by surface-bound melt-curve reactions
    Linda Strömqvist Meuzelaar
    Department of Genetics, University of Leicester, University Rd, Leicester, LE1 7RH, UK
    J Mol Diagn 9:30-41. 2007
    ..In conclusion, DASH performs accurately and robustly when applied to DNA diagnostic challenges, including mutation scoring and mutation scanning...
  20. ncbi request reprint Towards compendia of negative genetic association studies: an example for Alzheimer disease
    Mia E L Blomqvist
    Center for Genomics and Bioinformatics, Karolinska Institute, Berzeliusvag 35, 171 77 Stockholm, Sweden
    Hum Genet 119:29-37. 2006
    ..By reporting these data we hope to encourage the publication of gene compendia to guide further studies and aid future meta-analyses aimed at resolving the involvement of genes in complex human traits...
  21. ncbi request reprint Linkage disequilibrium patterns vary substantially among populations
    Sarah L Sawyer
    Center for Genomics and Bioinformatics, Karolinska Institute, Berzelius vag 35, Stockholm 17177, Sweden
    Eur J Hum Genet 13:677-86. 2005
    ....
  22. ncbi request reprint Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease
    Lars Feuk
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Am J Med Genet B Neuropsychiatr Genet 136:69-71. 2005
    ..This study of multiple new markers in the region will facilitate further association studies in this important AD region...
  23. ncbi request reprint Scoring insertion-deletion polymorphisms by dynamic allele-specific hybridization
    Sarah L Sawyer
    Karolinska Institute, Stockholm, Sweden
    Biotechniques 35:292-6, 298. 2003
    ..While no disease association was found, the data quality confirmed that DASH is a robust and useful procedure for genotyping indels of the size range typically found in the human genome...
  24. ncbi request reprint Genetic variation in a haplotype block spanning IDE influences Alzheimer disease
    Jonathan A Prince
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Hum Mutat 22:363-71. 2003
    ..These results provide substantial evidence that genetic variation within or extremely close to IDE impacts both disease risk and traits related to the severity of AD...
  25. ncbi request reprint Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism
    Hagit Katzov
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Hum Mutat 23:358-67. 2004
    ..Results indicate that variants of ABCA1 may affect the risk of AD, providing further support for a genetic link between AD and cholesterol metabolism...
  26. ncbi request reprint Further evidence for role of a promoter variant in the TNFRSF6 gene in Alzheimer disease
    Lars Feuk
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Hum Mutat 21:53-60. 2003
    ..The haplotype analysis did not give further significant findings. These results together with previous data suggest that a promoter marker in TNFRSF6 plays a moderate but demonstrable role in AD etiology...
  27. ncbi request reprint A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
    Ludmila Prokunina
    Institute of Genetics and Pathology, Section for Medical Genetics, Rudbeck Laboratories, University of Uppsala, Dag Hammarsjölds väg 20, 751 85, Uppsala, Sweden
    Nat Genet 32:666-9. 2002
    ....
  28. pmc SNPs meet CNVs in genome-wide association studies: HGV2007 meeting report
    Xavier Estivill
    Genes and Disease Program, Center for Genomic Regulation CRG UPF, Barcelona, Spain
    PLoS Genet 4:e1000068. 2008
  29. ncbi request reprint Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease
    Mia E L Blomqvist
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Neurogenetics 5:115-9. 2004
    ..Results were consistent between AD and PD, suggesting the presence of equivalent detrimental and protective alleles. These data highlight a genomic region in the proximity of IDE that may contribute to AD and PD in a similar manner...
  30. ncbi request reprint Genetic variation in CTNNA3 encoding alpha-3 catenin and Alzheimer's disease
    Mia E L Blomqvist
    Center for Genomics and Bioinformatics, Karolinska Institute, Berzeliusvag 35, S 171 77 Stockholm, Sweden
    Neurosci Lett 358:220-2. 2004
    ..More detailed studies of regional linkage disequilibrium structure around CTNNA3 will likely be required to determine whether sequence variation in this region impacts AD...
  31. ncbi request reprint Association of ADRB1 and UCP3 gene polymorphisms with insulin sensitivity but not obesity
    Salim Mottagui-Tabar
    Department of Molecular Medicine, National Public Health Institute, University of Helsinki, Biomedicum, Helsinki, Finland
    Horm Res 69:31-6. 2008
    ..Obesity is strongly hunted by insulin resistance and susceptibility genes for the two conditions could be separate or common. Variations within the UCPs and ADRBs genes may give important clues to their involvement in disease...
  32. ncbi request reprint Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease
    Annica Johansson
    Department of Clinical Neuroscience, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Hum Genet 114:581-7. 2004
    ..Our results provide an important independent replication of previous findings, supporting the existence of CYP46A1 sequence variants that contribute to variability in beta-amyloid metabolism...
  33. pmc Integrative annotation of 21,037 human genes validated by full-length cDNA clones
    Tadashi Imanishi
    Integrated Database Group, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan
    PLoS Biol 2:e162. 2004
    ..The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology...
  34. ncbi request reprint Common variants of ACE contribute to variable age-at-onset of Alzheimer's disease
    Patrick G Kehoe
    Department of Care of the Elderly, The John James Building, Frenchay Hospital, University of Bristol, UK
    Hum Genet 114:478-83. 2004
    ..These results provide an important complement to existing AD risk data, confirming that ACE harbors sequence variants that contribute to aspects of AD pathology...
  35. ncbi request reprint Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians
    Harvest F Gu
    Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Diabetes 53:S31-5. 2004
    ..The present study provides additional evidence that SNPs in the proximal promoter region of the APM1 gene contribute to the development of type 2 diabetes...
  36. ncbi request reprint 4th International Meeting on Single Nucleotide Polymorphism and Complex Genome Analysis. Various uses for DNA variations
    Anthony J Brookes
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Eur J Hum Genet 10:153-5. 2002
    ..Consequently, many diverse and ambitious projects are underway, from which the data itself will eventually show what is and is not possible...
  37. ncbi request reprint Negligible validation rate for public domain stop-codon SNPs
    Sarah L Sawyer
    Hum Mutat 22:252-4. 2003
  38. pmc DASH-2: flexible, low-cost, and high-throughput SNP genotyping by dynamic allele-specific hybridization on membrane arrays
    Magnus Jobs
    Center for Genomics and Bioinformatics, Karolinska Institute, Berzelius vag 35, S 171 77 Stockholm, Sweden
    Genome Res 13:916-24. 2003
    ..8-100%, and assay costs are 0.05 USD or less per genotype assignment. DASH-2 thus provides a powerful new alternative for genotyping practice, which can be used without the need for expensive robotics support...
  39. ncbi request reprint Haplotypes extending across ACE are associated with Alzheimer's disease
    Patrick G Kehoe
    Department of Care of the Elderly, University of Bristol, The John James Building, Frenchay Hospital, Bristol, UK
    Hum Mol Genet 12:859-67. 2003
    ..Results support a model whereby decreased ACE activity may influence AD susceptibility by a mechanism involving beta-amyloid metabolism...
  40. ncbi request reprint Evaluation of multiple presenilin 2 SNPs for association with early-onset sporadic Alzheimer disease
    W Mathias Howell
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Am J Med Genet 111:157-63. 2002
    ..From this study we find no evidence to suggest that variations in the PSEN2 gene pose as major risk factors for sporadic EOAD...
  41. ncbi request reprint An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk
    Judith A Schwartzbaum
    Division of Epidemiology, School of Public Health, Ohio State University, Starling Loving Hall, 320 West Tenth Avenue, Columbus, OH 43210, USA
    Cancer Epidemiol Biomarkers Prev 16:2448-54. 2007
    ..Nonetheless, the association between the T-G IL-4Ralpha haplotype and glioblastoma risk may indicate a role of immune factors in glioblastoma development...
  42. ncbi request reprint Complex SNP-related sequence variation in segmental genome duplications
    David Fredman
    Center for Genomics and Bioinformatics, Karolinska Institute, Berzelius vag 35, S 171 77 Stockholm, Sweden
    Nat Genet 36:861-6. 2004
    ..Given that duplicons comprise at least 5% of the genome and many are yet to be annotated in the genome draft, effective strategies to identify multisite variation must be established and deployed...
  43. pmc Lower rate of genomic variation identified in the trans-membrane domain of monoamine sub-class of Human G-Protein Coupled Receptors: the Human GPCR-DB Database
    Claes Wahlestedt
    Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius vag 35, 17177 Stockholm, Sweden
    BMC Genomics 5:91. 2004
    ..GPCR receptors of physiological and clinical importance were prioritized for statistical analysis. Natural variation and rare mutation information were merged and presented online in the Human GPCR-DB database http://cyrix.cgb.ki.se...
  44. ncbi request reprint Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain
    Mia E L Blomqvist
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Neurobiol Aging 26:795-802. 2005
    ..Results indicate that alleles of IDE contribute to variability in A beta deposition in the AD brain and suggest that this relationship may have relevance for the degree of cognitive dysfunction in AD patients...
  45. ncbi request reprint MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
    Maria Swanberg
    Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden
    Nat Genet 37:486-94. 2005
    ..We conclude that polymorphisms in Mhc2ta and MHC2TA result in differential MHC molecule expression and are associated with susceptibility to common complex diseases with inflammatory components...
  46. ncbi request reprint Genotyping by dynamic heating of monolayered beads on a microheated surface
    Aman Russom
    Department of Signals, Sensors and Systems, Microsystem Technology, Royal Institute of Technology, Stockholm, Sweden
    Electrophoresis 25:3712-9. 2004
    ..Our bead-based DASH approach has enabled a dramatic volume reduction and is a step towards developing a cost-effective high-throughput DASH method on arrays of single beads...
  47. ncbi request reprint Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, and Medical Biosciences, Pathology, University of Umea, Umea, Sweden
    Clin Cancer Res 10:7150-6. 2004
    ..To additionally evaluate the possible role of RNASEL in susceptibility to prostate cancer risk, we performed a comprehensive genetic analysis of sequence variants in RNASEL in the Swedish population...
  48. ncbi request reprint DNA, diseases and databases: disastrously deficient
    George P Patrinos
    Erasmus University Medical Center, Faculty of Medicine and Health Sciences, MGC Department of Cell Biology and Genetics, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Trends Genet 21:333-8. 2005
    ..g. technological hurdles, publication requirements, the short-sighted and popularist research system). A lack of targeted funding is arguably the most fundamental problem, but one that can be solved...
  49. pmc Polymorphisms associated with asthma are inversely related to glioblastoma multiforme
    Judith Schwartzbaum
    Division of Epidemiology and Biometrics, School of Public Health, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 65:6459-65. 2005
    ..However, our findings are also consistent with associations between IL-4RA, IL-13, and GBM that are independent of their role in allergic conditions...
  50. ncbi request reprint Haplotype block structures show significant variation among populations
    Nianjun Liu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Genet Epidemiol 27:385-400. 2004
    ....
  51. ncbi request reprint Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels
    Harvest F Gu
    Department of Molecular Medicine, Rolf Luft Center for Diabetes Research, Karolinska Hospital, Stockholm, Sweden
    Diabetes 53:2137-42. 2004
    ....
  52. ncbi request reprint Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes
    Chandra A Reynolds
    Department of Psychology, University of California Riverside, 92521, USA
    Behav Genet 36:185-94. 2006
    ..There were no significant findings for LRP. Dominance, often untested in previous studies, was important in the current study's findings...
  53. ncbi request reprint Nonsynonymous SNPs: validation characteristics, derived allele frequency patterns, and suggestive evidence for natural selection
    David Fredman
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Hum Mutat 27:173-86. 2006
    ..Four particularly striking clusters of these markers were apparent, and three of these coincide with genes/regions from among only several dozen such domains previously suggested by others to carry signatures of selection...
  54. ncbi request reprint Seventh international meeting on single nucleotide polymorphism and complex genome analysis: 'ever bigger scans and an increasingly variable genome'
    Dominique Rocha
    Genus Cambridge Research Laboratory, University of Cambridge, Department of Pathology, Genus plc, Tennis Court Road, CB2 1QP, Cambridge, UK
    Hum Genet 119:451-6. 2006
    ..Overall, there have been a number of recent advances in genomics that promise to accelerate the pace of dissecting the genetic basis of many complex diseases in humans-and perhaps in other species...
  55. ncbi request reprint Rapid melting curve analysis on monolayered beads for high-throughput genotyping of single-nucleotide polymorphisms
    Aman Russom
    Department of Signals, Sensors and Systems, Microsystem Technology, Royal Institute of Technology, 100 44 Stockholm, Sweden
    Anal Chem 78:2220-5. 2006
    ..In addition, an array version of the chip was implemented enabling the preparation of an array of bead arrays for high-throughput and rapid SNP genotyping...
  56. ncbi request reprint A quality assessment survey of SNP genotyping laboratories
    Paivi Lahermo
    Finnish Genome Center, University of Helsinki, Helsinki, Finland
    Hum Mutat 27:711-4. 2006
    ..Lessons from the survey are that special attention should be given to the quality of the DNA samples prior to genotyping, and that a conservative approach for calling the genotypes should be used to achieve a high accuracy...
  57. ncbi request reprint Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk: strong confirmation of functional promoter SNP
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, University of Umea, 901 87, Umea, Sweden
    Hum Genet 118:339-47. 2005
    ..Due to the difficulties in replication of genetic association studies, this finding is unusual and novel...
  58. ncbi request reprint Human Genome Variation 2006: emerging views on structural variation and large-scale SNP analysis
    Goncalo Abecasis
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Nat Genet 39:153-5. 2007
    ..The meeting highlighted recent advances in characterization of genetic variation, including genome-wide association studies and structural variation...
  59. ncbi request reprint Association of arthritis with a gene complex encoding C-type lectin-like receptors
    Johnny C Lorentzen
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, S 17176 Stockholm, Sweden
    Arthritis Rheum 56:2620-32. 2007
    ..To identify susceptibility genes in a rat model of rheumatoid arthritis (RA) and to determine whether the corresponding human genes are associated with RA...
  60. ncbi request reprint Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene
    Nilufer Ertekin-Taner
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Hum Mol Genet 14:447-60. 2005
    ..PLAU_1 is a plausible pathogenic mutation that could act by increasing Abeta42, but additional biological experiments are required to show this definitively...