Georg Brabant

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas
    N Burrows
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
    Endocr Relat Cancer 17:61-72. 2010
  2. doi request reprint Hypothyroidism following childhood cancer therapy-an under diagnosed complication
    Georg Brabant
    Department of Endocrinology, the Christie NHS Foundation Trust, Manchester, United Kingdom
    Int J Cancer 130:1145-50. 2012
  3. ncbi request reprint Is there a need to redefine the upper normal limit of TSH?
    G Brabant
    Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule, Hannover, Germany
    Eur J Endocrinol 154:633-7. 2006
  4. doi request reprint [New normal ranges for TSH: when to treat?]
    G Brabant
    Department of Endocrinology, Christie s Hospital, Manchester, UK
    Dtsch Med Wochenschr 134:2510-3. 2009
  5. ncbi request reprint Thyrotropin suppressive therapy in thyroid carcinoma: what are the targets?
    G Brabant
    Department of Endocrinology, Christie Hospital, Wilmslow Road, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 93:1167-9. 2008
  6. ncbi request reprint Normal levels of serum IGF-I: determinants and validity of current reference ranges
    G Brabant
    Department of Endocrinology, Christie Hospital, Wilmslow Rd, Manchester M20 4BX, UK
    Pituitary 10:129-33. 2007
  7. ncbi request reprint GH releasing peptide 2 test: the holy grail of testing GH deficiency?
    Georg Brabant
    Department of Endocrinology, Christie Hospital, University of Manchester, Manchester M20 4BX, UK
    Eur J Endocrinol 157:29-30. 2007
  8. doi request reprint Etiology, baseline characteristics, and biochemical diagnosis of GH deficiency in the adult: are there regional variations?
    G Brabant
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Eur J Endocrinol 161:S25-31. 2009
  9. doi request reprint Visualizing hormone actions in the brain
    Georg Brabant
    Department of Endocrinology, The Christie, Manchester Academic Health Science Centre, Wilmslow Road, Manchester M20 4BX, UK
    Trends Endocrinol Metab 22:153-63. 2011
  10. ncbi request reprint Clinical implications of residual growth hormone (GH) response to provocative testing in adults with severe GH deficiency
    Georg Brabant
    Department of Endocrinology, Christie Hospital, Wilmslow Road, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 92:2604-9. 2007

Detail Information

Publications69

  1. pmc Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas
    N Burrows
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
    Endocr Relat Cancer 17:61-72. 2010
    ..Given the strong association of HIF-1 alpha with an aggressive disease phenotype and therapeutic resistance, this pathway may be an attractive target for improved therapy in thyroid carcinomas...
  2. doi request reprint Hypothyroidism following childhood cancer therapy-an under diagnosed complication
    Georg Brabant
    Department of Endocrinology, the Christie NHS Foundation Trust, Manchester, United Kingdom
    Int J Cancer 130:1145-50. 2012
    ....
  3. ncbi request reprint Is there a need to redefine the upper normal limit of TSH?
    G Brabant
    Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule, Hannover, Germany
    Eur J Endocrinol 154:633-7. 2006
    ..4-4.0 mU/l. Classifying subjects with a TSH value between 2 and 4 mU/l as abnormal, as well as intervening with thyroxine treatment in such subjects, is probably doing more harm than good...
  4. doi request reprint [New normal ranges for TSH: when to treat?]
    G Brabant
    Department of Endocrinology, Christie s Hospital, Manchester, UK
    Dtsch Med Wochenschr 134:2510-3. 2009
    ..In contrast, subtle alterations of TSH in the context of subclinical hyperthyroidism are associated with a significantly higher risk particularly of atrial fibrillation...
  5. ncbi request reprint Thyrotropin suppressive therapy in thyroid carcinoma: what are the targets?
    G Brabant
    Department of Endocrinology, Christie Hospital, Wilmslow Road, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 93:1167-9. 2008
  6. ncbi request reprint Normal levels of serum IGF-I: determinants and validity of current reference ranges
    G Brabant
    Department of Endocrinology, Christie Hospital, Wilmslow Rd, Manchester M20 4BX, UK
    Pituitary 10:129-33. 2007
    ..Even though reference ranges have been developed in large cohorts of healthy subjects, the dependency of these data on a given assay technology argues for assay specific normative data for IGF-I...
  7. ncbi request reprint GH releasing peptide 2 test: the holy grail of testing GH deficiency?
    Georg Brabant
    Department of Endocrinology, Christie Hospital, University of Manchester, Manchester M20 4BX, UK
    Eur J Endocrinol 157:29-30. 2007
  8. doi request reprint Etiology, baseline characteristics, and biochemical diagnosis of GH deficiency in the adult: are there regional variations?
    G Brabant
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Eur J Endocrinol 161:S25-31. 2009
    ..These data suggest that a complex relation between biochemical and clinical signs of GHD exists, and that the spectrum of adult GHD syndrome is influenced by regional diagnostic and clinical particularities...
  9. doi request reprint Visualizing hormone actions in the brain
    Georg Brabant
    Department of Endocrinology, The Christie, Manchester Academic Health Science Centre, Wilmslow Road, Manchester M20 4BX, UK
    Trends Endocrinol Metab 22:153-63. 2011
    ..In summarizing the major current studies we discuss the potential of these techniques for an emerging new field in endocrinology...
  10. ncbi request reprint Clinical implications of residual growth hormone (GH) response to provocative testing in adults with severe GH deficiency
    Georg Brabant
    Department of Endocrinology, Christie Hospital, Wilmslow Road, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 92:2604-9. 2007
    ..It is unknown whether the amount of residual GH reserve under the cutoff value has any physiological implication...
  11. doi request reprint Similar clinical features among patients with severe adult growth hormone deficiency diagnosed with insulin tolerance test or arginine or glucagon stimulation tests
    Andrew Toogood
    Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
    Endocr Pract 18:325-34. 2012
    ....
  12. doi request reprint Diet-induced obesity, exogenous leptin-, and MADB106 tumor cell challenge affect tissue leukocyte distribution and serum levels of cytokines in F344 rats
    Patrick Behrendt
    Institute for Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Endocrine 38:104-12. 2010
    ..In conclusion, our data reveal a distinct distribution pattern of monocytes and NK cells in dio rats as compared to normal weight littermates and an additional modulatory effect of a leptin- and MADB106 tumor cell challenge...
  13. ncbi request reprint Hepatic leptin signaling in obesity
    Georg Brabant
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    FASEB J 19:1048-50. 2005
    ..Thus, the liver seems to play a major role in the modulation of the leptin signal and insulin resistance in obesity...
  14. doi request reprint Altered phenotype of NK cells from obese rats can be normalized by transfer into lean animals
    Anne Lautenbach
    Institute for Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Obesity (Silver Spring) 17:1848-55. 2009
    ..obese (ob-->ob) animals. These results show for the first time that the altered phenotype of NK cells from obese rats can be normalized by generation of a physiological (metabolic) environment of lean rats...
  15. doi request reprint GDC-0941 inhibits metastatic characteristics of thyroid carcinomas by targeting both the phosphoinositide-3 kinase (PI3K) and hypoxia-inducible factor-1α (HIF-1α) pathways
    Natalie Burrows
    Hypoxia and Therapeutics Group, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    J Clin Endocrinol Metab 96:E1934-43. 2011
    ..Phosphoinositide 3-kinase (PI3K) regulates the transcription factor hypoxia-inducible factor-1 (HIF-1) in thyroid carcinoma cells. Both pathways are associated with aggressive phenotype in thyroid carcinomas...
  16. doi request reprint GH/IGF-I regulation in obesity--mechanisms and practical consequences in children and adults
    Ilonka Kreitschmann-Andermahr
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Horm Res Paediatr 73:153-60. 2010
    ..We further discuss the basis of current testing for GH deficiency in obesity and the validity of the various provocative tests in overweight subjects...
  17. ncbi request reprint The androgen receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Berlin, Germany
    Eur J Endocrinol 155:127-30. 2006
    ..A polymorphic CAG repeat sequence within the AR gene was reported to modulate its transactivation activity. Therefore, we investigated a putative interaction between testosterone and the CAG repeat length polymorphism with respect to IR...
  18. doi request reprint Comparison of serum cortisol measurement by immunoassay and liquid chromatography-tandem mass spectrometry in patients receiving the 11β-hydroxylase inhibitor metyrapone
    Phillip J Monaghan
    Biochemistry Department, the Christie NHS Foundation Trust, Withington, Manchester M20 4BX, UK
    Ann Clin Biochem 48:441-6. 2011
    ..To investigate the effect of the 11β-hydroxylase inhibitor metyrapone on serum cortisol assay, a comparison of measurement by immunoassay versus liquid chromatography-tandem mass spectrometry (LC-MS/MS) was conducted...
  19. doi request reprint Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions
    Nadine Frerker
    Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Clin Chem Lab Med 47:275-87. 2009
    ....
  20. ncbi request reprint Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study
    Georg Brabant
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule, Hannover, Germany
    Horm Res 60:53-60. 2003
    ..The objective of the present study was to develop cross-sectional reference values for S-IGF-I measured by an automated chemiluminescence immunoassay (Nichols Advantage)...
  21. ncbi request reprint Increased resistin blood levels are not associated with insulin resistance in patients with renal disease
    Jan T Kielstein
    Department of Internal Medicine, Division of Nephrology, Medical School Hannover, Hannover, Germany
    Am J Kidney Dis 42:62-6. 2003
    ..Resistin is a newly discovered insulin inhibitor secreted by adipocytes. We explored the potential role of resistin in the pathophysiological process of insulin resistance encountered in patients with renal disease...
  22. doi request reprint Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy
    Sina Nettekoven
    Nutrition Physiology and Human Nutrition Unit, Institute of Food Science, Leibniz University of Hannover, Wunstorfer Str 14, 30453, Hannover, Germany
    Eur J Pediatr 167:1369-77. 2008
    ..The routine monitoring of serum 25-OHD and vitamin D supplementation on an individual basis should be considered...
  23. ncbi request reprint Palmitate-induced Ca2+-signaling in pancreatic beta-cells
    Oleg Remizov
    Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Mol Cell Endocrinol 212:1-9. 2003
    ..Therefore mitochondrial signals other than ATP appear to be generated from palmitate metabolism that underly the palmitate-induced Ca2+-signals in pancreatic beta-cells...
  24. doi request reprint Subcellular distribution of the sodium iodide symporter in benign and malignant thyroid tissues
    Inga Kollecker
    Department of Pathology, Medical School of Hannover, Hannover, Germany
    Thyroid 22:529-35. 2012
    ....
  25. ncbi request reprint [Thyroid gland malfunction]
    G Brabant
    Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    MMW Fortschr Med 146:30-2, 34. 2004
    ..As in the case of hypothyroidism treated with L-thyroxine, the primary target parameter is titration of TSH into the normal range...
  26. doi request reprint Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas
    Natalie Burrows
    Hypoxia and Therapeutics Group, Manchester Pharmacy School, University of Manchester, Stopford Building, Manchester, UK
    Oncotarget . 2016
    ..Interestingly, some loss of ATM and DNA-PKcs was observed. These data provide new insight into the mechanisms of hypoxia-associated radioresistance in thyro{id-carcinoma...
  27. doi request reprint Inhibiting the phosphatidylinositide 3-kinase pathway blocks radiation-induced metastasis associated with Rho-GTPase and Hypoxia-inducible factor-1 activity
    Natalie Burrows
    Hypoxia and Therapeutics Group, Manchester Pharmacy School, University of Manchester, UK
    Radiother Oncol 108:548-53. 2013
    ..We evaluated radiation-induced effects on metastasis in thyroid carcinoma cells and tumours, mechanistically focusing on phosphatidylinositide 3-kinase (PI3K) and associated pathways...
  28. doi request reprint Measurement of salivary cortisol with liquid chromatography-tandem mass spectrometry in patients undergoing dynamic endocrine testing
    Ilias Perogamvros
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Clin Endocrinol (Oxf) 72:17-21. 2010
    ..We aimed to evaluate the potential of SalC measured by LC-MS/MS in patients undergoing assessment of the HPA axis...
  29. ncbi request reprint Circulating concentrations of growth-differentiation factor 15 in apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new immunoradiometric sandwich assay
    Tibor Kempf
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Clin Chem 53:284-91. 2007
    ..There has been increasing interest in using circulating GDF15 as a biomarker in patients, for example those with cardiovascular disease...
  30. ncbi request reprint Circulating ghrelin levels in patients with polycystic ovary syndrome
    Christof Schofl
    Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, D 30623 Hannover, Germany
    J Clin Endocrinol Metab 87:4607-10. 2002
    ..This suggests that ghrelin could be linked to insulin resistance in PCOS women. However, whether low ghrelin in PCOS is a cause or the consequence of insulin resistance awaits further investigations...
  31. ncbi request reprint Simultaneous medullary and papillary microcarcinoma of thyroid in a patient with secondary hyperparathyroidism
    Matthias Behrand
    Department of Visceral and Transplantion Surgery, Medizinische Hochschule, Hannover, Germany
    Endocr Pathol 13:65-73. 2002
    ..Therefore, a common oncogenic stimulus may have been involved. In the final analysis, the reason for both malignancies could not be clearly established...
  32. pmc Hypoxia-inducible factor in thyroid carcinoma
    Natalie Burrows
    Hypoxia and Therapeutics Group, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    J Thyroid Res 2011:762905. 2011
    ....
  33. pmc Wnt signaling in estrogen-induced lactotroph proliferation
    Adam Giles
    Endocrinology and Diabetes Group, Faculty of Medical and Human Sciences, AV Hill Building, Oxford Road, University of Manchester, Manchester M13 9PT, UK
    J Cell Sci 124:540-7. 2011
    ..In summary, Wnt4 is expressed in the adult pituitary gland, and its expression is increased by estrogen exposure, suggesting that its involvement in adult tissue plasticity is likely to involve β-catenin-independent signaling pathways...
  34. pmc Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV-1-infected patients with lipodystrophy
    Georg M N Behrens
    Department of Clinical Immunology, Hannover Medical School, Hannover, Germany
    J Clin Invest 110:1319-27. 2002
    ..To our knowledge, this is the first report providing in vivo evidence that, in lipodystrophic HIV patients, impaired glucose transport and phosphorylation cause reduced insulin-mediated glucose uptake...
  35. ncbi request reprint Changes in cerebral endothelial barrier antigen, without alteration of permeability for intravenously injected leptin in diet-induced obesity in rats
    Heike Nave
    Department of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Exp Toxicol Pathol 55:45-9. 2003
    ..Further functional and morphological studies are necessary to evaluate the specific role of other organs and distinct forms of leptin (free and protein-bound) in the pathogenesis of diet-induced obesity...
  36. ncbi request reprint Serum levels of human growth hormone during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction
    Armin J Becker
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 59:609-14. 2002
    ..It has recently been demonstrated that GH serum levels in the systemic and cavernous blood of healthy men increases during developing penile erection...
  37. ncbi request reprint Low serum levels of testosterone in men with minimal traumatic hip fractures
    E Leifke
    Devision of Gastroenterology, Hepatology and Endocrinology, MHH, Hannover, Germany
    Exp Clin Endocrinol Diabetes 113:208-13. 2005
    ..In view of the scarce and inconsistent data published on this issue (1 longitudinal and 6 cross-sectional studies) the present study supports the patho-physiological relevance of low serum testosterone for the occurrence of MTHF in men...
  38. ncbi request reprint Elevated bound leptin correlates with energy expenditure in cirrhotics
    J Ockenga
    Department of Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany
    Gastroenterology 119:1656-62. 2000
    ..Our aim was to characterize leptin components and their relationships to body composition, resting energy expenditure (REE), and substrate use in patients with posthepatic liver cirrhosis...
  39. doi request reprint Long-term safety of growth hormone replacement after CNS irradiation
    S MacKenzie
    Department of Endocrinology, The Christie, Manchester Academic Health Science Centre, Wilmslow Road, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 96:2756-61. 2011
    ..It is unclear whether replacement therapy with GH (GHRT) further increases this risk...
  40. doi request reprint Effects of normalization of plasma testosterone levels in hypogonadal men on plasma levels and urinary excretion of asymmetric dimethylarginine (ADMA)
    E Leifke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Horm Metab Res 40:56-9. 2008
    ..While this effect of normalization of plasma T may impress as favorable, most available studies on effects of T administration to hypogonadal men have not shown beneficial effects on functions of the vascular wall...
  41. ncbi request reprint Sex steroids and body composition in men with cystic fibrosis
    E Leifke
    Abteilung Gastroenterologie, Hepatologie and Endokrinologie, Medizinischen Hochschule Hannover, Carl Neuberg Str 1, 30165 Hanover, Germany
    Eur J Endocrinol 148:551-7. 2003
    ..Delayed sexual maturation and low body weight is common in cystic fibrosis (CF). Concomitant data on sex hormones and concomitant body composition are lacking in men with CF...
  42. ncbi request reprint Serum leptin levels following hypothalamic surgery
    G Brabant
    Abt. Klinische Endokrinologie, Medizinische Hochschule, Hannover, Germany
    Horm Metab Res 28:728-31. 1996
    ..The rapid increase in serum leptin levels observed in some Ctx subjects suggests that early postoperative measurement of serum leptin levels may help to identify patients at risk of weight gain following hypothalamic destruction...
  43. ncbi request reprint Sympathoadrenal counterregulation in patients with hypothalamic craniopharyngioma
    Christof Schofl
    Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    J Clin Endocrinol Metab 87:624-9. 2002
    ..However, a common hypothalamic center controlling both counterregulatory catecholamine and glucagon release is unlikely, and sympathoadrenal activation is not required for hypoglycemia-induced glucagon secretion in humans...
  44. ncbi request reprint Insulin-dependent modulation of plasma ghrelin and leptin concentrations is less pronounced in type 2 diabetic patients
    Christian Anderwald
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna Medical School, Vienna, Austria
    Diabetes 52:1792-8. 2003
    ..These findings indicate an indirect effect of insulin via ghrelin on the suppression of hunger sensation and appetite...
  45. ncbi request reprint Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation
    Henrik Fagman
    Institute of Anatomy and Cell Biology, Goteborg University, Box 420, SE 40530 Goteborg, Sweden
    Oncogene 22:6013-22. 2003
    ..Residual function(s) of N-terminal APC fragments in tumor cells carrying APC mutations might be beneficial to tumor growth and survival...
  46. ncbi request reprint Ghrelin concentrations in morbidly obese patients after adjustable gastric banding
    Ursula Hanusch-Enserer
    N Engl J Med 348:2159-60. 2003
  47. ncbi request reprint Wnt/beta-catenin signaling mediates antineoplastic effects of imatinib mesylate (gleevec) in anaplastic thyroid cancer
    Annavarapu Srinivas Rao
    Department of Gastroenterology, Hepatology, and Endocrinology, D 30625 Hannover, Germany
    J Clin Endocrinol Metab 91:159-68. 2006
    ..However, it is unclear whether the selective tyrosine kinase (TK) inhibitor, imatinib mesylate, is linked to the Wnt/beta-catenin cascade and is able to modulate the pathway...
  48. ncbi request reprint Insulin-like growth factor-I: marker for diagnosis of acromegaly and monitoring the efficacy of treatment
    Georg Brabant
    Department of Clinical Endocrinology, Hannover Medical School, Germany
    Eur J Endocrinol 148:S15-20. 2003
    ..Thus, serum IGF-I is an important marker of disease activity and a sensitive, practical, and reliable measure of integrated GH concentrations in patients with acromegaly...
  49. ncbi request reprint Ghrelin in chronic liver disease
    Frank Tacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Hepatol 38:447-54. 2003
    ..We investigated the role of ghrelin and insulin-like growth factor-1 (IGF-1), the mediator of the GH axis, in patients with chronic liver diseases (CLD)...
  50. ncbi request reprint Increased intramyocellular lipid concentration identifies impaired glucose metabolism in women with previous gestational diabetes
    Alexandra Kautzky-Willer
    Department of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Austria
    Diabetes 52:244-51. 2003
    ..IMCL could serve as an additional parameter of increased diabetes risk because it identifies insulin-resistant pGDM and those who were diagnosed earlier and/or required insulin during pregnancy...
  51. ncbi request reprint Radiation-induced thyroid carcinogenesis as a function of time and dietary iodine supply: an in vivo model of tumorigenesis in the rat
    Carsten Boltze
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Endocrinology 143:2584-92. 2002
    ..This model may help to define genetic alterations long before histological changes are detectable...
  52. ncbi request reprint Associations between body mass, leptin, IGF-I and circulating adrenal androgens in children with obesity and premature adrenarche
    Dagmar l'Allemand
    Children s Hospital, Charite Campus Virchow, Humboldt University, Berlin, Germany
    Eur J Endocrinol 146:537-43. 2002
    ..To explain why adrenal androgens rise with increasing adiposity during childhood, the role of body mass index (BMI), leptin and IGF-I was studied. We also tested whether these parameters contribute to inducing premature adrenarche (PA)...
  53. ncbi request reprint The thyroid axis in ageing
    Holger Leitol
    Department of Clinical Endocrinology, Center for Internal Medicine and Dermatology, Medizinische Hochschule Hannover, Germany
    Novartis Found Symp 242:193-201; discussion 201-4. 2002
    ..The following article attempts to delineate some aspects of the interplay of the regulation of thyroid function and the ageing process...
  54. ncbi request reprint Differential effects of GH replacement on the components of the leptin system in GH-deficient individuals
    Harpal S Randeva
    Sir Quinton Hazel Molecular Medicine Research Center, Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL
    J Clin Endocrinol Metab 87:798-804. 2002
    ..However, the observed changes in free leptin and bound leptin and, more importantly, the rise in soluble leptin receptor, are not explained entirely by modifications in body composition and may be a direct result of GH/IGF-I...
  55. ncbi request reprint Circulating leptin and thyroid dysfunction
    Tina Zimmermann-Belsing
    Department of Endocrinology, University Hospital, Rigshospitalet, Copenhagen, Denmark
    Eur J Endocrinol 149:257-71. 2003
    ..In this review, we have focused on leptin in relation to thyroid pathophysiology...
  56. ncbi request reprint Serum pattern of circulating free leptin, bound leptin, and soluble leptin receptor in the physiological menstrual cycle
    Franz Geisthövel
    Center for Gynecological Endocrinology and Reproductive Medicine, Freiburg im Breisgau, Germany
    Fertil Steril 81:398-402. 2004
    ..To investigate the serum pattern of free leptin, bound leptin, and soluble leptin receptor throughout the physiological menstrual cycle...
  57. ncbi request reprint Leptin and insulin response to long-term total parenteral nutrition depends on body fat mass
    Kinan Rifai
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Clin Nutr 25:773-9. 2006
    ..However, the artificial situation of long-term total parenteral nutrition (TPN) and its effects on serum leptin and insulin is not fully understood...
  58. ncbi request reprint Plasma ghrelin in obesity before and after weight loss after laparoscopical adjustable gastric banding
    Ursula Hanusch-Enserer
    Department of Internal Medicine, Wilhelminspital, A 1160 Vienna, Austria
    J Clin Endocrinol Metab 89:3352-8. 2004
    ..In conclusion, prolonged weight loss results in a rise of fasting ghrelin concentrations that correlates with fasting insulin concentrations but not improvement of insulin sensitivity...
  59. ncbi request reprint Predictors of abnormal glucose metabolism in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Germany
    Eur J Endocrinol 154:295-301. 2006
    ..This procedure is time-consuming and inconvenient, limiting its general use. Therefore, an easy method is wanted to separate PCOS women with normal from those with potentially abnormal glucose metabolism...
  60. ncbi request reprint Influence of GH substitution therapy in deficient adults on the recurrence rate of hormonally inactive pituitary adenomas: a case control study
    Michael Buchfelder
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Eur J Endocrinol 157:149-56. 2007
    ..Since GH substitution is considered to promote tumour regrowth, adequate treatment is performed with some reservation. Therefore, we aimed to elucidate the effect of GH replacement therapy on tumour recurrence following surgery...
  61. ncbi request reprint Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study
    Henry Volzke
    Institute of Community Medicine, University of Greifswald, D 17487 Greifswald, Germany
    J Clin Endocrinol Metab 92:4039-45. 2007
    ..The aims of the present study were: 1) to investigate possible associations between serum IGF-I levels and thyroid disorders and 2) to analyze the role of serum IGF binding protein (IGFBP)-3 and TSH levels for these associations...
  62. ncbi request reprint Letter Re: Id1 gene expression in hyperplastic and neoplastic thyroid tissues
    Annavarapu Srinivas Rao
    J Clin Endocrinol Metab 90:5906. 2005
  63. ncbi request reprint Applicability of recently established reference values for serum insulin-like growth factor 1: A comparison of two assays--an (automated) chemiluminescence immunoassay and an enzyme-linked immunosorbent assay
    Diana Ivan
    Division of Endocrinology and Diabetology, Philipps University Hospital, Marburg, Germany
    Clin Lab 51:381-7. 2005
    ..971, p<0.0001). In conclusion, the reference values established for the chemiluminescence assay are applicable also for the enzyme-linked immunosorbent assay...
  64. pmc Central insulin action regulates peripheral glucose and fat metabolism in mice
    Linda Koch
    Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, and Center of Molecular Medicine Cologne, Cologne, Germany
    J Clin Invest 118:2132-47. 2008
    ..These studies demonstrate that central insulin action plays an important role in regulating WAT mass and glucose metabolism via hepatic Stat3 activation...
  65. ncbi request reprint High adiponectin in chronic liver disease and cholestasis suggests biliary route of adiponectin excretion in vivo
    Frank Tacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Hepatol 42:666-73. 2005
    ..Models of fatty liver diseases and fibrosis suggest a hepatoprotective effect of adiponectin, an adipocyte-derived hormone with antidiabetic, antiobesity, antiatherogenic and anti-inflammatory effects...
  66. ncbi request reprint Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome
    Joachim Spranger
    Department of Clinical Nutrition, German Institute of Human Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Clin Endocrinol (Oxf) 61:738-46. 2004
    ..The aim of the study was to elucidate determinants of circulating adiponectin levels and to investigate the potential role of adiponectin in insulin resistance in PCOS women...
  67. ncbi request reprint Cognitive changes in short-term hypothyroidism assessed with event-related brain potentials
    Thomas F Münte
    Department of Neuropsychology, Otto von Guericke Universitat Magdeburg, Universitatsplatz 2, Gebäude 24, 39016 Magdeburg, Germany
    Psychoneuroendocrinology 29:1109-18. 2004
    ..These data show that hypothyroidism during (131)Iodine-therapy is associated with clinically relevant cognitive dysfunctions, especially with effortful attention demanding tasks...
  68. ncbi request reprint The polycystic ovary syndrome per se is not associated with increased chronic inflammation
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition, 14558 Potsdam Rehbruecke, Germany
    Eur J Endocrinol 150:525-32. 2004
    ....
  69. ncbi request reprint Germline NF1 mutational spectra and loss-of-heterozygosity analyses in patients with pheochromocytoma and neurofibromatosis type 1
    Birke Bausch
    Department of Neurology, University Medical Center Freiburg, Germany
    J Clin Endocrinol Metab 92:2784-92. 2007
    ..Because of the low prevalence of pheochromocytoma in NF1, we ascertained subjects by pheochromocytoma that also had NF1 in the hope of describing the germline NF1 mutational spectra of NF1-related pheochromocytoma...