Delphine Boche

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Atypical inflammation in the central nervous system in prion disease
    V Hugh Perry
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Curr Opin Neurol 15:349-54. 2002
  2. ncbi request reprint Immunotherapy for Alzheimer's disease and other dementias
    Delphine Boche
    Division of Clinical Neurosciences, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, SO166YD, UK
    Clin Neuropharmacol 29:22-7. 2006
  3. doi request reprint Review: activation patterns of microglia and their identification in the human brain
    D Boche
    Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
    Neuropathol Appl Neurobiol 39:3-18. 2013
  4. doi request reprint Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease
    Delphine Boche
    Southampton General Hospital, University of Southampton, UK
    Acta Neuropathol 120:13-20. 2010
  5. doi request reprint The role of the immune system in clearance of Abeta from the brain
    Delphine Boche
    Division of Clinical Neurosciences, University of Southampton, Southampton, UK
    Brain Pathol 18:267-78. 2008
  6. ncbi request reprint TGFbeta1 regulates the inflammatory response during chronic neurodegeneration
    Delphine Boche
    CNS Inflammation Group, Southampton Neurosciences Group, School of Biological Sciences, University of Southampton, Southampton, SO16 7PX Hampshire, UK
    Neurobiol Dis 22:638-50. 2006
  7. ncbi request reprint Immunotherapy for Alzheimer's disease and other dementias
    Delphine Boche
    Division of Clinical Neurosciences, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Curr Opin Neurol 18:720-5. 2005
  8. doi request reprint Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis
    Delphine Boche
    Division of Clinical Neurosciences, School of Medicine, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Acta Neuropathol 120:369-84. 2010
  9. ncbi request reprint Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo
    Delphine Boche
    CNS Inflammation Group, Southampton Neuroscience Group, School of Biological Sciences, University of Southampton, Southampton, Hampshire, UK
    J Cereb Blood Flow Metab 23:1174-82. 2003
  10. doi request reprint Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain
    D Boche
    Division of Clinical Neurosciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Brain 131:3299-310. 2008

Detail Information

Publications23

  1. ncbi request reprint Atypical inflammation in the central nervous system in prion disease
    V Hugh Perry
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Curr Opin Neurol 15:349-54. 2002
    ..There is also now evidence to suggest that a peripheral infection, and its consequent systemic cytokine expression, may drive central nervous system cytokine expression and perhaps exacerbate disease...
  2. ncbi request reprint Immunotherapy for Alzheimer's disease and other dementias
    Delphine Boche
    Division of Clinical Neurosciences, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, SO166YD, UK
    Clin Neuropharmacol 29:22-7. 2006
    ..The aim of this article is to review the role of immunotherapy in the removal of proteins which accumulate abnormally in neurodegenerative disorders associated with dementia, in particular amyloid-beta accumulation in Alzheimer's disease...
  3. doi request reprint Review: activation patterns of microglia and their identification in the human brain
    D Boche
    Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
    Neuropathol Appl Neurobiol 39:3-18. 2013
    ....
  4. doi request reprint Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease
    Delphine Boche
    Southampton General Hospital, University of Southampton, UK
    Acta Neuropathol 120:13-20. 2010
    ..However, the continuing progression of cognitive decline in AD patients after Abeta immunisation may be explained by its lack of apparent effect on tangles...
  5. doi request reprint The role of the immune system in clearance of Abeta from the brain
    Delphine Boche
    Division of Clinical Neurosciences, University of Southampton, Southampton, UK
    Brain Pathol 18:267-78. 2008
    ..In animal models, immunotherapy at an early age can protect against Abeta accumulation and it will be interesting to see if this can usefully be applied to humans to prevent AD...
  6. ncbi request reprint TGFbeta1 regulates the inflammatory response during chronic neurodegeneration
    Delphine Boche
    CNS Inflammation Group, Southampton Neurosciences Group, School of Biological Sciences, University of Southampton, Southampton, SO16 7PX Hampshire, UK
    Neurobiol Dis 22:638-50. 2006
    ..These data suggest that TGFbeta1 plays a critical role in the downregulation of microglial responses minimizing brain inflammation and thus avoiding exacerbation of brain damage...
  7. ncbi request reprint Immunotherapy for Alzheimer's disease and other dementias
    Delphine Boche
    Division of Clinical Neurosciences, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Curr Opin Neurol 18:720-5. 2005
    ..The aim of this article is to review the role of immunotherapy in the removal of proteins which accumulate abnormally in neurodegenerative disorders associated with dementia, in particular amyloid-beta accumulation in Alzheimer's disease...
  8. doi request reprint Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis
    Delphine Boche
    Division of Clinical Neurosciences, School of Medicine, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Acta Neuropathol 120:369-84. 2010
    ..The information obtained will be important in helping to understand the pathogenesis not only of AD but also of other neurodegenerative disorders associated with protein aggregation...
  9. ncbi request reprint Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo
    Delphine Boche
    CNS Inflammation Group, Southampton Neuroscience Group, School of Biological Sciences, University of Southampton, Southampton, Hampshire, UK
    J Cereb Blood Flow Metab 23:1174-82. 2003
    ..We have demonstrated in vivo that the cerebral tolerance phenomenon induced by LPS pretreatment is mediated by TGF-beta 1 cytokine...
  10. doi request reprint Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain
    D Boche
    Division of Clinical Neurosciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Brain 131:3299-310. 2008
    ..The extent to which these vascular alterations following Abeta immunization in Alzheimer's disease are reflected in changes in cognitive function remains to be determined...
  11. doi request reprint Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization
    Elina Zotova
    Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Mailpoint 806, Southampton General Hospital, Southampton SO16 6YD, UK
    Brain 136:2677-96. 2013
    ..The results suggest that, in the long term, amyloid-β immunotherapy results in downregulation of microglial activation and potentially reduces the inflammation-mediated component of the neurodegeneration of Alzheimer's disease. ..
  12. ncbi request reprint Abeta species removal after abeta42 immunization
    James A R Nicoll
    Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK
    J Neuropathol Exp Neurol 65:1040-8. 2006
    ..Abeta immunotherapy can clear all Abeta species from the cortex. However, if it is to be used for treatment of established Alzheimer disease, then the residual tau pathology and cerebral amyloid angiopathy require further study...
  13. pmc Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease
    Colm Cunningham
    CNS Inflammation Group, School of Biological Sciences, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom
    J Virol 79:5174-84. 2005
    ..We also propose that serum cytokine and APP measurements are not useful during preclinical disease. Possible consequences of the clear chronic elevation of APPs in the CNS are discussed...
  14. doi request reprint Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
    Clive Holmes
    Division of Clinical Neurosciences, University of Southampton, Southampton, UK Moorgreen Hospital, Hampshire Partnership Trust, Southampton, UK
    Lancet 372:216-23. 2008
    ..Our aim was to assess the relation between Abeta(42) immune response, degree of plaque removal, and long-term clinical outcomes...
  15. doi request reprint Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy
    Roy O Weller
    Clinical Neurosciences, University of Southampton School of Medicine, LD74, South Laboratory and Pathology Block, Southampton General Hospital, Southampton SO166YD, UK
    Acta Neuropathol 118:87-102. 2009
    ..Drainage of Abeta along perivascular pathways in ageing artery walls may need to be improved to maximise the potential for improvement of cognitive function with immunotherapy...
  16. doi request reprint Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β
    Jay Amin
    Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK
    Neuropathol Appl Neurobiol 41:445-57. 2015
    ..Using a post-mortem cohort of immunized AD cases, we investigated the effect of Aβ immunization on GSK-3β expression and pPKR...
  17. doi request reprint Aβ immunotherapy for Alzheimer's disease: effects on apoE and cerebral vasculopathy
    Kenji Sakai
    Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
    Acta Neuropathol 128:777-89. 2014
    ..ARIA occurring in some current trials of Aβ immunotherapy may reflect an extreme form of these vascular changes. ..
  18. doi request reprint Metaflammasome components in the human brain: a role in dementia with alzheimer's pathology?
    Mariko Taga
    Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, UK
    Brain Pathol . 2016
    ..Expression of the proteins was not related to APOE genotype. These findings highlight a role for these proteins in AD pathophysiology but not necessarily as a complex. This article is protected by copyright. All rights reserved...
  19. doi request reprint Heme-Hemopexin Scavenging Is Active in the Brain and Associates With Outcome After Subarachnoid Hemorrhage
    Patrick Garland
    From the Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom P G, J D, J A R N, D B, D O B, I G Neurosurgery, Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom A J D, D O B, I G R and D, Bio Products Laboratory Limited, Hertfordshire, United Kingdom A I O and the Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom J G
    Stroke 47:872-6. 2016
    ..Free heme is bound by hemopexin and rapidly scavenged by CD91. We hypothesized that heme scavenging in the brain would be associated with outcome after hemorrhage...
  20. ncbi request reprint Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Glia 49:375-84. 2005
    ....
  21. pmc Microglia regulate hippocampal neurogenesis during chronic neurodegeneration
    Chiara De Lucia
    Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom
    Brain Behav Immun 55:179-90. 2016
    ....
  22. doi request reprint What do we know about the inflammasome in humans?
    Jay Amin
    Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK
    Brain Pathol . 2016
    ..Modulation of the inflammasome has been proposed as a novel treatment for several of these diseases and there are currently clinical trials ongoing to test this theory. This article is protected by copyright. All rights reserved...
  23. pmc Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy
    Elina Zotova
    Division of Clinical Neurosciences, School of Medicine, University of Southampton, Mailpoint 806, Level D, South Pathology Block, Southampton General Hospital, Southampton, SO16 6YD, UK
    Alzheimers Res Ther 2:1. 2010
    ....