J Birks

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Donepezil for mild cognitive impairment
    J Birks
    University of Oxford, Department of Clinical Geratology, Radcliffe Infirmary, Woodstock Road, Oxford, UK OX2 6HE
    Cochrane Database Syst Rev . 2006
  2. ncbi request reprint Ginkgo biloba for cognitive impairment and dementia
    J Birks
    University of Oxford, Nuffield Department of Clinical Medicine, CDCIG Room 5802, John Radcliffe Hospital, Oxford, UK, OX3 9DU
    Cochrane Database Syst Rev . 2007
  3. ncbi request reprint Donepezil for dementia due to Alzheimer's disease
    J Birks
    University of Oxford, Department of Clinical Geratology, Radcliffe Infirmary, Woodstock Road, Oxford, UK, OX2 6HE
    Cochrane Database Syst Rev . 2006
  4. ncbi request reprint Cholinesterase inhibitors for Alzheimer's disease
    J Birks
    University of Oxford, Department of Clinical Geratology, Radcliffe Infirmary, Woodstock Road, Oxford, UK, OX2 6HE
    Cochrane Database Syst Rev . 2006
  5. ncbi request reprint Investigational treatment for vascular cognitive impairment
    Jacqueline Birks
    University of Oxford, Cochrane Dementia and Cognitive Improvement Group, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Expert Opin Investig Drugs 16:647-58. 2007
  6. ncbi request reprint Vitamin B12 and folate deficiency in later life
    Robert Clarke
    Clinical Trial Service Unit Division of Clinical Geratology University Department of Pharmacology, University of Oxford, Oxford, UK
    Age Ageing 33:34-41. 2004
  7. ncbi request reprint Screening for vitamin B-12 and folate deficiency in older persons
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 77:1241-7. 2003
  8. ncbi request reprint Low vitamin B-12 status and risk of cognitive decline in older adults
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 86:1384-91. 2007
  9. ncbi request reprint Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Clin Chem 53:963-70. 2007
  10. ncbi request reprint Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study
    Harold Hin
    Hightown Surgery, Hightown Gardens, Banbury, UK
    Age Ageing 35:416-22. 2006

Detail Information

Publications15

  1. ncbi request reprint Donepezil for mild cognitive impairment
    J Birks
    University of Oxford, Department of Clinical Geratology, Radcliffe Infirmary, Woodstock Road, Oxford, UK OX2 6HE
    Cochrane Database Syst Rev . 2006
    ..Donepezil (Aricept, E2020), a cholinesterase inhibitor, has been shown to benefit all severities of AD including mild and it would be reasonable to investigate its efficacy for those with MCI...
  2. ncbi request reprint Ginkgo biloba for cognitive impairment and dementia
    J Birks
    University of Oxford, Nuffield Department of Clinical Medicine, CDCIG Room 5802, John Radcliffe Hospital, Oxford, UK, OX3 9DU
    Cochrane Database Syst Rev . 2007
    ....
  3. ncbi request reprint Donepezil for dementia due to Alzheimer's disease
    J Birks
    University of Oxford, Department of Clinical Geratology, Radcliffe Infirmary, Woodstock Road, Oxford, UK, OX2 6HE
    Cochrane Database Syst Rev . 2006
    ..One of the aims of therapy is to inhibit the breakdown of a chemical neurotransmitter, acetylcholine, by blocking the relevant enzyme. This can be done by a group of chemicals known as cholinesterase inhibitors...
  4. ncbi request reprint Cholinesterase inhibitors for Alzheimer's disease
    J Birks
    University of Oxford, Department of Clinical Geratology, Radcliffe Infirmary, Woodstock Road, Oxford, UK, OX2 6HE
    Cochrane Database Syst Rev . 2006
    ..Despite the evidence from the clinical studies and the intervening clinical experience the debate on whether ChEIs are effective continues...
  5. ncbi request reprint Investigational treatment for vascular cognitive impairment
    Jacqueline Birks
    University of Oxford, Cochrane Dementia and Cognitive Improvement Group, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Expert Opin Investig Drugs 16:647-58. 2007
    ..For the purposes of this review, the authors focus on interventions that have been evaluated by randomised controlled trials...
  6. ncbi request reprint Vitamin B12 and folate deficiency in later life
    Robert Clarke
    Clinical Trial Service Unit Division of Clinical Geratology University Department of Pharmacology, University of Oxford, Oxford, UK
    Age Ageing 33:34-41. 2004
    ..to examine the prevalence of vitamin B12 deficiency and folate deficiency in later life in representative samples of the elderly population in the United Kingdom...
  7. ncbi request reprint Screening for vitamin B-12 and folate deficiency in older persons
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 77:1241-7. 2003
    ..Folate deficiency also results in elevated tHcy. Measurement of these metabolites can be used to screen for functional vitamin B-12 or folate deficiency...
  8. ncbi request reprint Low vitamin B-12 status and risk of cognitive decline in older adults
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 86:1384-91. 2007
    ..Elevated total homocysteine (tHcy) concentrations have been associated with cognitive impairment, but it is unclear whether low vitamin B-12 or folate status is responsible for cognitive decline...
  9. ncbi request reprint Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Clin Chem 53:963-70. 2007
    ..Concentrations of this active component, carried on holotranscobalamin (holoTC), may be of greater relevance than total vitamin B(12)...
  10. ncbi request reprint Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study
    Harold Hin
    Hightown Surgery, Hightown Gardens, Banbury, UK
    Age Ageing 35:416-22. 2006
    ..low vitamin B12 concentrations are common in older people, but the clinical relevance of biochemical evidence of vitamin B12 deficiency in the absence of anaemia is uncertain...
  11. ncbi request reprint For debate: is the evidence for the efficacy of cholinesterase inhibitors in the symptomatic treatment of Alzheimer's disease convincing or not?
    David Ames
    Department of Psychiatry, University of Melbourne, Australia
    Int Psychogeriatr 20:259-92. 2008
  12. ncbi request reprint Does donepezil improve well-being for dementia due to Alzheimer's disease?
    Jacqueline Birks
    Cochrane Neurological Network
    Neuroepidemiology 24:168-9. 2005
  13. ncbi request reprint Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta-analysis of individual patient data from randomised controlled trials
    Anne Whitehead
    The University of Reading, Medical and Pharmaceutical Statistics Research Unit, Reading, UK
    Int J Geriatr Psychiatry 19:624-33. 2004
    ..The objective was to evaluate the efficacy and tolerability of donepezil (5 and 10 mg/day) compared with placebo in alleviating manifestations of mild to moderate Alzheimer's disease (AD)...
  14. ncbi request reprint Evidence-based pharmacotherapy of Alzheimer's disease
    John Grimley Evans
    Cochrane Dementia and Cognitive Improvement Group, University of Oxford, UK
    Int J Neuropsychopharmacol 7:351-69. 2004
    ..Memantine has been licensed in Europe for treatment of patients with moderately severe to severe Alzheimer's disease...
  15. ncbi request reprint Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population
    Angela M Devlin
    Department of Internal Medicine, University of California, Davis, Davis, CA, USA
    Am J Clin Nutr 83:708-13. 2006
    ..Homocysteine concentrations are influenced by vitamin status and genetics, especially several polymorphisms in folate-metabolizing genes...