R J Beynon

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint The dynamics of the proteome: strategies for measuring protein turnover on a proteome-wide scale
    Robert J Beynon
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    Brief Funct Genomic Proteomic 3:382-90. 2005
  2. pmc Enabling proteomics: the need for an extendable 'workbench' for user-configurable solutions
    Robert J Beynon
    Department of Veterinary Preclinical Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    Comp Funct Genomics 5:52-5. 2004
  3. pmc Asymmetric proteome equalization of the skeletal muscle proteome using a combinatorial hexapeptide library
    Jenny Rivers
    Protein Function Group, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 6:e28902. 2011
  4. pmc A proteomics study of the response of North Ronaldsay sheep to copper challenge
    Deborah M Simpson
    Department of Veterinary Preclinical Sciences, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    BMC Vet Res 2:36. 2006
  5. pmc Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
    Sarah A Roberts
    Mammalian Behaviour and Evolution Group, University of Liverpool, Neston CH64 7TE, UK
    BMC Biol 8:75. 2010
  6. ncbi request reprint Metabolic labeling of proteins for proteomics
    Robert J Beynon
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, United Kingdom
    Mol Cell Proteomics 4:857-72. 2005
  7. ncbi request reprint A simple tool for drawing proteolytic peptide maps
    Robert J Beynon
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool Crown Street, Liverpool L69 7ZJ, UK
    Bioinformatics 21:674-5. 2005
  8. ncbi request reprint Urinary proteins and the modulation of chemical scents in mice and rats
    Robert J Beynon
    Faculty of Veterinary Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZJ, UK
    Peptides 25:1553-63. 2004
  9. ncbi request reprint Sequential exoproteolysis as a structural probe: a cautionary note
    Robert J Beynon
    Protein Function Group, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    J Mass Spectrom 39:188-92. 2004
  10. ncbi request reprint Multiplexed absolute quantification in proteomics using artificial QCAT proteins of concatenated signature peptides
    Robert J Beynon
    Department of Veterinary Preclinical Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    Nat Methods 2:587-9. 2005

Collaborators

Detail Information

Publications63

  1. ncbi request reprint The dynamics of the proteome: strategies for measuring protein turnover on a proteome-wide scale
    Robert J Beynon
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    Brief Funct Genomic Proteomic 3:382-90. 2005
    ..If we are to understand the changes in the proteome, we will need to define such processes. In this brief review, strategies for the determination of intracellular protein dynamics on a proteome-wide scale are discussed...
  2. pmc Enabling proteomics: the need for an extendable 'workbench' for user-configurable solutions
    Robert J Beynon
    Department of Veterinary Preclinical Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    Comp Funct Genomics 5:52-5. 2004
    ..I will outline a specification of a flexible proteomics tool that could address many current bottlenecks and deficiencies...
  3. pmc Asymmetric proteome equalization of the skeletal muscle proteome using a combinatorial hexapeptide library
    Jenny Rivers
    Protein Function Group, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 6:e28902. 2011
    ..However, the asymmetry in equalization is manifest at either low and high ionic strength values but manipulation of the solvent conditions may extend the capacity of the method...
  4. pmc A proteomics study of the response of North Ronaldsay sheep to copper challenge
    Deborah M Simpson
    Department of Veterinary Preclinical Sciences, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    BMC Vet Res 2:36. 2006
    ..Such data gives us a proteome-centered perspective of the pathogenesis of copper-induced oxidative stress in this breed...
  5. pmc Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
    Sarah A Roberts
    Mammalian Behaviour and Evolution Group, University of Liverpool, Neston CH64 7TE, UK
    BMC Biol 8:75. 2010
    ....
  6. ncbi request reprint Metabolic labeling of proteins for proteomics
    Robert J Beynon
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, United Kingdom
    Mol Cell Proteomics 4:857-72. 2005
    ..Confounding issues include the metabolic lability of the amino acid precursor, incomplete labeling, and the role of protein turnover in labeling kinetics. All of these are controllable, provided that appropriate precautions are adopted...
  7. ncbi request reprint A simple tool for drawing proteolytic peptide maps
    Robert J Beynon
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool Crown Street, Liverpool L69 7ZJ, UK
    Bioinformatics 21:674-5. 2005
    ..The program creates an output file as scalable vector graphics that can then be viewed in a web browser or imported into a graphics-editing program...
  8. ncbi request reprint Urinary proteins and the modulation of chemical scents in mice and rats
    Robert J Beynon
    Faculty of Veterinary Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZJ, UK
    Peptides 25:1553-63. 2004
    ....
  9. ncbi request reprint Sequential exoproteolysis as a structural probe: a cautionary note
    Robert J Beynon
    Protein Function Group, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    J Mass Spectrom 39:188-92. 2004
    ....
  10. ncbi request reprint Multiplexed absolute quantification in proteomics using artificial QCAT proteins of concatenated signature peptides
    Robert J Beynon
    Department of Veterinary Preclinical Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    Nat Methods 2:587-9. 2005
    ....
  11. ncbi request reprint Multiple roles of major urinary proteins in the house mouse, Mus domesticus
    R J Beynon
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX, UK
    Biochem Soc Trans 31:142-6. 2003
    ..This multiplicity of function, from a generic ligand-binding property to an extremely specific individuality, sets the MUPs apart from other lipocalin family proteins that are involved in chemical signalling...
  12. ncbi request reprint Polymorphism in major urinary proteins: molecular heterogeneity in a wild mouse population
    Robert J Beynon
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, United Kingdom
    J Chem Ecol 28:1429-46. 2002
    ..The restriction of the polymorphic variation to one segment of the polypeptide may be of functional significance, either in the modulation of ligand release or in communication of individuality signals within urinary scent marks...
  13. pmc Effect of polymorphisms on ligand binding by mouse major urinary proteins
    A Darwish Marie
    Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool, L69 3BX, United Kingdom
    Protein Sci 10:411-7. 2001
    ..This work raises the possibility that the calyx-binding site can show specificity for different ligands, the implications of which on pheromone binding and chemical communication are discussed...
  14. ncbi request reprint Individual recognition in mice mediated by major urinary proteins
    J L Hurst
    Department of Veterinary Clinical Science and Animal Husbandry, University of Liverpool, Leahurst, Neston CH64 7TE, UK
    Nature 414:631-4. 2001
    ..Here we show in wild house mice (Mus domesticus) that urinary MUPs play an important role in the individual recognition mechanism...
  15. ncbi request reprint The subunit structure and dynamics of the 20S proteasome in chicken skeletal muscle
    Julia R Hayter
    Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool L69 7ZJ, United Kingdom
    Mol Cell Proteomics 4:1370-81. 2005
    ..The ability to measure turnover rates of proteins on a proteome-wide scale in protein assemblies and in a complex organism provides a new dimension to the understanding of the dynamic proteome...
  16. ncbi request reprint Proteome dynamics in complex organisms: using stable isotopes to monitor individual protein turnover rates
    Mary K Doherty
    Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool, UK
    Proteomics 5:522-33. 2005
    ..For the first time, it is feasible to contemplate the analysis of turnover of individual proteins in intact animals...
  17. doi request reprint Cross species proteomics
    J C Wright
    Department Veterinary Preclinical Sciences, University of Liverpool, Crown Street, Liverpool, UK
    Methods Mol Biol 604:123-35. 2010
    ..This is followed by recommendations of best practice and suggestions to researchers facing this challenge as well as a final section predicting developments, which may help improve cross species proteomics in the future...
  18. doi request reprint The scent of senescence: sexual signalling and female preference in house mice
    M Garratt
    Mammalian Behaviour and Evolution Group, Institute of Integrative Biology, University of Liverpool, Neston, UK
    J Evol Biol 24:2398-409. 2011
    ..These results reveal that investment in olfactory signalling is reduced during senescence and suggest that senesced males and their scent may be less attractive to females...
  19. pmc The ownership signature in mouse scent marks is involatile
    C M Nevison
    Animal Behaviour Group, Faculty of Veterinary Science, University of Liverpool, Leahurst, Neston CH64 7TE, UK
    Proc Biol Sci 270:1957-63. 2003
    ..Individual signatures in scent marks thus appear to be carried by non-volatile proteins or by non-volatile protein-ligand complexes, rather than by volatiles emanating from the scent...
  20. ncbi request reprint Avian proteomics: advances, challenges and new technologies
    M K Doherty
    Protein Function Group, Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool, UK
    Cytogenet Genome Res 117:358-69. 2007
    ..This review discusses the current developments in this relatively new field, new technologies and how they may be applied to biological questions, and the challenges faced by researchers in this ever-expanding and exciting field...
  21. pmc MHC odours are not required or sufficient for recognition of individual scent owners
    Jane L Hurst
    Animal Behavior Group, Faculty of Veterinary Science, University of Liverpool, Neston, UK
    Proc Biol Sci 272:715-24. 2005
    ....
  22. ncbi request reprint Scent wars: the chemobiology of competitive signalling in mice
    Jane L Hurst
    Faculty of Veterinary Science, University of Liverpool, Leahurst, Neston CH64 7TE
    Bioessays 26:1288-98. 2004
    ....
  23. ncbi request reprint Protein turnover on the scale of the proteome
    Mary K Doherty
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, L69 7ZJ, UK
    Expert Rev Proteomics 3:97-110. 2006
    ..These methods are driven by stable isotope metabolic labeling of cells in culture or in intact animals. This review considers the merits and difficulties of different methods that allow access to proteome dynamics...
  24. doi request reprint Turnover of the human proteome: determination of protein intracellular stability by dynamic SILAC
    Mary K Doherty
    School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    J Proteome Res 8:104-12. 2009
    ..Moreover, measurement of the turnover rate of individual components of supramolecular complexes provides a unique insight in processes of protein complex assembly and turnover...
  25. ncbi request reprint The proteome of chicken skeletal muscle: changes in soluble protein expression during growth in a layer strain
    Mary K Doherty
    Protein Function Group, Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool L69 7ZJ, UK
    Proteomics 4:2082-93. 2004
    ..For many of these proteins, growth over 27 days elicited dramatic changes in relative expression levels. Chicken skeletal muscle offers an excellent system for developmental proteomics...
  26. pmc Making progress in genetic kin recognition among vertebrates
    Jane L Hurst
    Mammalian Behaviour and Evolution Group, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston CH647TE, UK
    J Biol 9:13. 2010
    ..Theoretical and experimental studies reveal challenges ahead in achieving a true systems-level understanding of this process and its outcomes...
  27. ncbi request reprint The genetic basis of individual-recognition signals in the mouse
    Sarah A Cheetham
    Mammalian Behaviour and Evolution Group, Department of Veterinary Preclinical Science, University of Liverpool, Leahurst, Neston CH64 7TE, United Kingdom
    Curr Biol 17:1771-7. 2007
    ..Specific signals for genetic identity recognition in other species now need to be investigated...
  28. ncbi request reprint Protein turnover in chicken skeletal muscle: understanding protein dynamics on a proteome-wide scale
    M K Doherty
    Veterinary Preclinical Science, University of Liverpool, Crown Street, Liverpool, L69 7ZJ, UK
    Br Poult Sci 45:S27-8. 2004
  29. pmc The genetic basis of inbreeding avoidance in house mice
    Amy L Sherborne
    Population and Evolutionary Biology Group, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, United Kingdom
    Curr Biol 17:2061-6. 2007
    ..Recognition of close kin as unsuitable mates might be more variable across species than a generic vertebrate-wide ability to avoid inbreeding based on MHC...
  30. ncbi request reprint Proteome analysis of intact proteins in complex mixtures
    Julia R Hayter
    Department of Veterinary Preclinical Sciences, University of Liverpool, Crown Street Liverpool L69 7ZJ, United Kingdom
    Mol Cell Proteomics 2:85-95. 2003
    ..The ability to resolve such a complex mixture of proteins with a routine instrument is of considerable value in analyses of protein expression and in the confirmation of post-translational changes in mature proteins...
  31. ncbi request reprint Positional proteomics: selective recovery and analysis of N-terminal proteolytic peptides
    Lucy McDonald
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    Nat Methods 2:955-7. 2005
    ..The method is tolerant of several fragmentation methods, and the databases that must be searched are substantially less complex...
  32. ncbi request reprint Application of gas chromatography-mass spectrometry with selected ion monitoring to the urinanalysis of 4-pyridoxic acid
    D M Leyland
    Department of Biochemistry, University of Liverpool, UK
    J Chromatogr 581:179-85. 1992
    ....
  33. ncbi request reprint The greater susceptibility of North Ronaldsay sheep compared with Cambridge sheep to copper-induced oxidative stress, mitochondrial damage and hepatic stellate cell activation
    S Haywood
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX, UK
    J Comp Pathol 133:114-27. 2005
    ..Likewise the upregulation of cathepsin-D indicated increased lysosomal activity and HSC activation. The findings may be relevant to copper toxicosis in human infants...
  34. doi request reprint Acetone precipitation of proteins and the modification of peptides
    Deborah M Simpson
    Protein and Functional Genomics Group, University of Liverpool, Crown Street, Liverpool L69 7ZJ, United Kingdom
    J Proteome Res 9:444-50. 2010
    ..A significant number of peptides (about 5% of a typical proteome) meet the requirements for this reaction and could, therefore, change the outcome of studies...
  35. ncbi request reprint Dynamics of protein turnover, a missing dimension in proteomics
    Julie M Pratt
    Department of Veterinary Preclinical Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZJ, United Kingom
    Mol Cell Proteomics 1:579-91. 2002
    ....
  36. pmc Stable isotope labelling in vivo as an aid to protein identification in peptide mass fingerprinting
    Julie M Pratt
    Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool, UK
    Proteomics 2:157-63. 2002
    ..The method is tolerant to the extent of labelling, and as such, may be applicable to a range of single cell systems...
  37. ncbi request reprint Global cooling: cold acclimation and the expression of soluble proteins in carp skeletal muscle
    Lynn McLean
    Proteomics and Functional Genomics Research Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, UK
    Proteomics 7:2667-81. 2007
    ..Genes encoding CK isoforms were downregulated and the genes encoding key proteins of the ubiquitin-proteasome pathway were upregulated. These findings are consistent with a specific cold-induced enhancement of proteolysis of CK...
  38. ncbi request reprint Absolute multiplexed quantitative analysis of protein expression during muscle development using QconCAT
    Jenny Rivers
    Proteomics and Functional Genomics Group, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, United Kingdom
    Mol Cell Proteomics 6:1416-27. 2007
    ..QconCATs offer a new and efficient approach to precise and simultaneous absolute quantification of multiple proteins, subproteomes, or even entire proteomes...
  39. ncbi request reprint Multiplexed absolute quantification for proteomics using concatenated signature peptides encoded by QconCAT genes
    Julie M Pratt
    Department of Veterinary Preclinical Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZJ, UK
    Nat Protoc 1:1029-43. 2006
    ..The total time required to complete this protocol (from the receipt of the QconCAT expression plasmid to the absolute quantification of the set of proteins encoded by the QconCAT protein in an analyte sample) is approximately 29 d...
  40. doi request reprint Quantitative analysis of HGF and EGF-dependent phosphotyrosine signaling networks
    Dean E Hammond
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool, L69 3BX, United Kingdom
    J Proteome Res 9:2734-42. 2010
    ..Using available protein-interaction data the identified proteins have been assembled into a highly connected network that can be visualized using the Cytoscape tool...
  41. ncbi request reprint Copper-associated liver disease: a proteomics study of copper challenge in a sheep model
    Deborah M Simpson
    Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool, UK
    Proteomics 4:524-36. 2004
    ..This was followed by evidence of an impaired ability of the liver to compensate as copper loading increased, accompanied by oxidative stress-induced injury...
  42. pmc Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation
    N Arecco
    Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Sci Rep 6:24708. 2016
    ....
  43. ncbi request reprint The nature of the subcutaneous gel in chick hatchlings: a proteomics approach
    L McLean
    Protein Function Group, Faculty of Veterinary Sciences, University of Liverpool, UK
    Br Poult Sci 45:S37. 2004
  44. doi request reprint Limited variation in the major urinary proteins of laboratory mice
    Sarah A Cheetham
    Mammalian Behaviour and Evolution Group, Department of Veterinary Preclinical Science, University of Liverpool, Leahurst Campus, Neston, CH64 7TE, UK
    Physiol Behav 96:253-61. 2009
    ..The lack of normal variation in MUP patterns within and between strains has important implications for the use of laboratory mice in behavioural or neurophysiological research investigating social recognition or mate choice...
  45. ncbi request reprint Strategies for measuring dynamics: the temporal component of proteomics
    Robert J Beynon
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, England, United Kingdom
    Methods Biochem Anal 49:15-25. 2006
  46. pmc Exploiting proteomic data for genome annotation and gene model validation in Aspergillus niger
    James C Wright
    Dept Veterinary Preclinical Sciences, University of Liverpool, Liverpool, UK
    BMC Genomics 10:61. 2009
    ....
  47. doi request reprint The direct assessment of genetic heterozygosity through scent in the mouse
    Michael D Thom
    Mammalian Behaviour and Evolution Group, Department of Veterinary Preclinical Science, University of Liverpool, Leahurst, Neston CH64 7TE, United Kingdom
    Curr Biol 18:619-23. 2008
    ..This is the first evidence that animals may use signals of genetic heterozygosity that have no direct association with individual vigour...
  48. doi request reprint Observation of heterogeneous gene products by FT-ICR MS
    Duncan H L Robertson
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, UK
    J Am Soc Mass Spectrom 19:103-10. 2008
    ..This approach provides a facile method for the assessment of protein homogeneity and for the detection of structural variants, without recourse to proteolytic digestion and analysis of the resulting products...
  49. doi request reprint Asparagine deamidation and the role of higher order protein structure
    Jenny Rivers
    Proteomics and Functional Genomics Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, United Kingdom
    J Proteome Res 7:921-7. 2008
    ..This work has significant consequences for identification of proteins using peptide mass fingerprinting...
  50. ncbi request reprint Positional proteomics: preparation of amino-terminal peptides as a strategy for proteome simplification and characterization
    Lucy McDonald
    Proteomics and Functional Genomics Group, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    Nat Protoc 1:1790-8. 2006
    ..The N-terminal peptides can then be analyzed by mass spectrometry. This low cost, rapid method is readily adopted using off the shelf reagents...
  51. pmc Structural and functional differences in isoforms of mouse major urinary proteins: a male-specific protein that preferentially binds a male pheromone
    Stuart D Armstrong
    Protein Function Group, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    Biochem J 391:343-50. 2005
    ..This atypical MUP is also present in a random sample of wild-caught male mice, confirming that this protein is not specific to the inbred mouse strain but is present in natural populations also...
  52. ncbi request reprint Avoidance of proteolysis in extracts
    Robert J Beynon
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, UK
    Methods Mol Biol 244:75-84. 2004
  53. doi request reprint Comparative proteomics reveals evidence for evolutionary diversification of rodent seminal fluid and its functional significance in sperm competition
    Steven A Ramm
    Mammalian Behaviour and Evolution Group, Department of Veterinary Preclinical Science, University of Liverpool, Leahurst Campus, Neston, Cheshire, United Kingdom
    Mol Biol Evol 26:189-98. 2009
    ....
  54. pmc Biomarkers for ragwort poisoning in horses: identification of protein targets
    Rowan E Moore
    Proteomics and Functional Genomics Research Group, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool, L69 7ZJ, UK
    BMC Vet Res 4:30. 2008
    ..In this study a non-invasive in vitro model system has been developed to investigate whether pyrrole toxins induce specific modifications of equine blood proteins that are detectable by proteomic methods...
  55. ncbi request reprint A proteome analysis of the subcutaneous gel in avian hatchlings
    Lynn McLean
    Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool L69 7ZJ, United Kingdom
    Mol Cell Proteomics 3:250-6. 2004
    ....
  56. ncbi request reprint Characterization of cauxin in the urine of domestic and big cats
    Lynn McLean
    Proteomics and Functional Genomics Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, UK
    J Chem Ecol 33:1997-2009. 2007
    ..The levels of cauxin in the urine of all big cats were substantially lower than that in the urine of intact male domestic cats...
  57. ncbi request reprint Characterization and comparison of major urinary proteins from the house mouse, Mus musculus domesticus, and the aboriginal mouse, Mus macedonicus
    Duncan H L Robertson
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, P O Box 147, Liverpool, L69 3BX, UK
    J Chem Ecol 33:613-30. 2007
    ..In addition, the differences in protein structure allow speculation into molecular mechanisms of MUP function...
  58. pmc Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice
    Jonathan M Mudge
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SA, UK
    Genome Biol 9:R91. 2008
    ..Whilst important information about MUP functionality has been gained in recent years, the gene cluster is poorly studied in terms of structure, genic polymorphism and evolution...
  59. ncbi request reprint Hardware acceleration of processing of mass spectrometric data for proteomics
    Istvan Bogdan
    Department of Automatic Control and Systems Engineering, The University of Sheffield, Mappin Street, Sheffield S1 3JD, UK
    Bioinformatics 23:724-31. 2007
    ....
  60. pmc Anabolic effects of a non-myotoxic dose of the beta2-adrenergic receptor agonist clenbuterol on rat plantaris muscle
    Jatin G Burniston
    Muscle Physiology and Proteomics Laboratory, Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool L3 2ET, UK
    Muscle Nerve 35:217-23. 2007
    ..The clenbuterol-induced increase in muscle growth was concomitant with qualitative changes in the muscle's proteome that need to be considered when proposing therapeutic uses for this agent...
  61. pmc High-performance hardware implementation of a parallel database search engine for real-time peptide mass fingerprinting
    István A Bogdán
    Department of Automatic Control and Systems Engineering, The University of Sheffield, Mappin Street, Sheffield S1 3JD, UK
    Bioinformatics 24:1498-502. 2008
    ..The database search processor and the mass spectra processor, running on a reconfigurable computing platform, provide a complete real-time PMF protein identification solution...
  62. doi request reprint Protein quantification by selective isolation and fragmentation of isotopic pairs using FT-ICR MS
    Hannah Johnson
    Michael Barber Centre for Mass Spectrometry, School of Chemistry and Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom
    J Am Soc Mass Spectrom 19:973-7. 2008
    ..The utility of this approach has been demonstrated in the absolute quantification of components of an unfractionated chicken muscle protein mixture...
  63. doi request reprint QCAL--a novel standard for assessing instrument conditions for proteome analysis
    Claire E Eyers
    Michael Barber Centre for Mass Spectrometry, Manchester Interdisciplinary Biocentre, School of Chemistry, University of Manchester, Manchester, United Kingdom
    J Am Soc Mass Spectrom 19:1275-80. 2008
    ..This protein, a concatenation of tryptic peptides that is expressed in E. coli, provides a stoichiometrically controlled mixture of peptides that are amenable to analysis by all commonly used instrumentation platforms for proteomics...