Mark E Bastin

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Quantifying the effects of normal ageing on white matter structure using unsupervised tract shape modelling
    Mark E Bastin
    Medical and Radiological Sciences Medical Physics, University of Edinburgh, and Western General Hospital, Edinburgh, UK
    Neuroimage 51:1-10. 2010
  2. doi request reprint Tract shape modelling provides evidence of topological change in corpus callosum genu during normal ageing
    Mark E Bastin
    Medical and Radiological Sciences Medical Physics, University of Edinburgh, UK
    Neuroimage 43:20-8. 2008
  3. ncbi request reprint Diffusion tensor and magnetization transfer MRI measurements of periventricular white matter hyperintensities in old age
    Mark E Bastin
    Medical and Radiological Sciences Medical Physics, School of Clinical Sciences and Community Health, University of Edinburgh, United Kingdom
    Neurobiol Aging 30:125-36. 2009
  4. doi request reprint ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936
    Donald M Lyall
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Behav Genet 43:13-23. 2013
  5. doi request reprint Neuroprotective lifestyles and the aging brain: activity, atrophy, and white matter integrity
    Alan J Gow
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Neurology 79:1802-8. 2012
  6. doi request reprint Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke
    Vera Cvoro
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK
    Stroke 40:767-72. 2009
  7. pmc Estimated maximal and current brain volume predict cognitive ability in old age
    Natalie A Royle
    Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Scottish Imaging Network, a Platform for Scientific Excellence SINAPSE Collaboration, Edinburgh, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Electronic address
    Neurobiol Aging 34:2726-33. 2013
  8. doi request reprint Brain iron deposits are associated with general cognitive ability and cognitive aging
    Lars Penke
    Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom
    Neurobiol Aging 33:510-517.e2. 2012
  9. doi request reprint A general factor of brain white matter integrity predicts information processing speed in healthy older people
    Lars Penke
    Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom
    J Neurosci 30:7569-74. 2010
  10. pmc Brain white matter damage in aging and cognitive ability in youth and older age
    Maria Del C Valdés Hernández
    Brain Research Imaging Centre, Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK
    Neurobiol Aging 34:2740-7. 2013

Detail Information

Publications82

  1. pmc Quantifying the effects of normal ageing on white matter structure using unsupervised tract shape modelling
    Mark E Bastin
    Medical and Radiological Sciences Medical Physics, University of Edinburgh, and Western General Hospital, Edinburgh, UK
    Neuroimage 51:1-10. 2010
    ..These data therefore suggest that brain atrophy and white matter lesions play a significant role in driving regional patterns of age-related changes in white matter tract shape and integrity...
  2. doi request reprint Tract shape modelling provides evidence of topological change in corpus callosum genu during normal ageing
    Mark E Bastin
    Medical and Radiological Sciences Medical Physics, University of Edinburgh, UK
    Neuroimage 43:20-8. 2008
    ..These data show that it is possible automatically to segment comparable tracts in the brains of older subjects using single seed point tractography, if the seed point is carefully chosen...
  3. ncbi request reprint Diffusion tensor and magnetization transfer MRI measurements of periventricular white matter hyperintensities in old age
    Mark E Bastin
    Medical and Radiological Sciences Medical Physics, School of Clinical Sciences and Community Health, University of Edinburgh, United Kingdom
    Neurobiol Aging 30:125-36. 2009
    ..However, within PVWMH, MTR correlates strongly with water diffusion parameters probably because of the pathologically associated neuronal loss, demyelination and gliosis...
  4. doi request reprint ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936
    Donald M Lyall
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Behav Genet 43:13-23. 2013
    ..Previous findings may therefore have been subject to type 1 error. Further study into links between ADRB2, cognitive function and brain white matter integrity is required...
  5. doi request reprint Neuroprotective lifestyles and the aging brain: activity, atrophy, and white matter integrity
    Alan J Gow
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Neurology 79:1802-8. 2012
    ..Whether activity might protect the integrity of the brain's white matter, or reduce atrophy and white matter lesion (WML) load, was examined in the Lothian Birth Cohort 1936 (n = 691), a longitudinal study of aging...
  6. doi request reprint Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke
    Vera Cvoro
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK
    Stroke 40:767-72. 2009
    ..We used spectroscopic imaging to measure N-acetyl aspartate (NAA, a marker of normal neurons) and lactate (a marker of ischemia) to compare with diffusion and perfusion values in the diffusion lesion in acute ischemic stroke...
  7. pmc Estimated maximal and current brain volume predict cognitive ability in old age
    Natalie A Royle
    Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Scottish Imaging Network, a Platform for Scientific Excellence SINAPSE Collaboration, Edinburgh, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Electronic address
    Neurobiol Aging 34:2726-33. 2013
    ..As 1 of the largest studies of associations between brain volume and cognitive ability with normal aging, this work contributes to the wider understanding of how some early-life factors influence cognitive aging. ..
  8. doi request reprint Brain iron deposits are associated with general cognitive ability and cognitive aging
    Lars Penke
    Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom
    Neurobiol Aging 33:510-517.e2. 2012
    ..The pattern of results suggests that iron deposits are not only a biomarker of general cognitive ability in old age and age-related cognitive decline, but that they are also related to the lifelong-stable trait of intelligence...
  9. doi request reprint A general factor of brain white matter integrity predicts information processing speed in healthy older people
    Lars Penke
    Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom
    J Neurosci 30:7569-74. 2010
    ..Further studies should investigate whether these findings relate more to the role of tract integrity and information processing speed in nonpathological cognitive aging or in lifelong-stable processes...
  10. pmc Brain white matter damage in aging and cognitive ability in youth and older age
    Maria Del C Valdés Hernández
    Brain Research Imaging Centre, Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK
    Neurobiol Aging 34:2740-7. 2013
    ..Early-life IQ also influenced WMH in later life. Determining how lower IQ in youth leads to increasing brain damage with aging is important for future successful cognitive aging. ..
  11. pmc APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds
    Donald M Lyall
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
    Int J Stroke 10:1297-300. 2015
    ..Two markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease...
  12. pmc Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936
    Donald M Lyall
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK Department of Psychology, University of Edinburgh, Edinburgh, UK Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine, Western General Hospital, Edinburgh, UK MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Neurobiol Aging 35:1513.e25-33. 2014
    ....
  13. pmc Associations between level and change in physical function and brain volumes
    Benjamin S Aribisala
    Brain Research Imaging Centre, Division of Neuroimaging Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom SINAPSE Scottish Imaging Network, A Platform for Scientific Excellence collaboration, Edinburgh, United Kingdom Department of Computer Science, Faculty of Science, Lagos State University, Lagos, Nigeria
    PLoS ONE 8:e80386. 2013
    ..We examined associations between brain structure and physical function (contemporaneous and change over the previous three years) in community-dwelling older adults...
  14. doi request reprint Brain aging, cognition in youth and old age and vascular disease in the Lothian Birth Cohort 1936: rationale, design and methodology of the imaging protocol
    Joanna M Wardlaw
    Brain Research Imaging Centre, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Int J Stroke 6:547-59. 2011
    ..However, the changes in brain structure that accompany normal aging, and the role they play in cognitive decline, remain to be fully elucidated...
  15. doi request reprint Early brain temperature elevation and anaerobic metabolism in human acute ischaemic stroke
    Bartosz Karaszewski
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh, EH4 2XU, UK
    Brain 132:955-64. 2009
    ..Further studies are required to determine why early brain temperature elevation is highest in potential penumbral tissue...
  16. doi request reprint Brain atrophy associations with white matter lesions in the ageing brain: the Lothian Birth Cohort 1936
    Benjamin S Aribisala
    Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK
    Eur Radiol 23:1084-92. 2013
    ..We investigated whether and to what degree they are related in deep and superficial structures using both volumetric and visual ratings...
  17. pmc Assessing the performance of atlas-based prefrontal brain parcellation in an aging cohort
    Benjamin S Aribisala
    Brain Research Imaging Centre, Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Comput Assist Tomogr 37:257-64. 2013
    ..We assessed atlas-based parcellation of the prefrontal lobe in an aging population using visual assessment and volumetric and spatial concordance...
  18. ncbi request reprint A probabilistic model-based approach to consistent white matter tract segmentation
    Jonathan D Clayden
    Neuroinformatics Doctoral Training Centre, School of Informatics, University of Edinburgh, Edinburgh EHI 2QL, UK
    IEEE Trans Med Imaging 26:1555-61. 2007
    ..We demonstrate that this method is able to significantly improve segmentation consistency without directly constraining the tractography algorithm...
  19. ncbi request reprint Effects of random subject rotation on optimised diffusion gradient sampling schemes in diffusion tensor MRI
    Susana Muñoz Maniega
    Clinical Neurosciences, Western General Hospital, University of Edinburgh, EH4 2XU Edinburgh, UK
    Magn Reson Imaging 26:451-60. 2008
    ..These data indicate that for large subject rotations the B-matrix should be recalculated to provide accurate diffusion anisotropy information...
  20. pmc Erratum to: Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse
    Christopher M Henstridge
    Centre for Cognitive and Neural Systems, University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, UK
    Acta Neuropathol Commun 3:83. 2015
    ..The original version of this article [1] unfortunately contained several mistakes. The presentation of Table 2 and 3 was incorrect, in the HTML and PDF versions of this article. The corrected Tables 2 and 3 are given below...
  21. pmc Brain volumetric changes and cognitive ageing during the eighth decade of life
    Stuart J Ritchie
    Department of Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom
    Hum Brain Mapp 36:4910-25. 2015
    ..114 to 0.334). These results build a comprehensive picture of macrostructural brain volume changes and declines in important cognitive faculties during the eighth decade of life...
  22. pmc White matter hyperintensities and normal-appearing white matter integrity in the aging brain
    Susana Muñoz Maniega
    Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK Scottish Imaging Network A Platform for Scientific Excellence SINAPSE Collaboration, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology CCACE, University of Edinburgh, Edinburgh, UK
    Neurobiol Aging 36:909-18. 2015
    ....
  23. doi request reprint Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images
    Maria Del C Valdés Hernández
    Brain Research Imaging Centre, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh, United Kingdom Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom SINAPSE Scottish Imaging Network, A Platform for Scientific Excellence collaboration, Scotland, United Kingdom
    J Magn Reson Imaging 40:324-33. 2014
    ..This study aims to explore the differentiation and association between calcified regions and noncalcified iron deposits on clinical brain MRI in elderly, otherwise healthy subjects...
  24. doi request reprint Quantitative tractography and tract shape modeling in amyotrophic lateral sclerosis
    Mark E Bastin
    Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom Brain Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
    J Magn Reson Imaging 38:1140-5. 2013
    ....
  25. pmc Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities
    Benjamin S Aribisala
    From Brain Research Imaging Centre B S A, S W, Z M, M C V H, N A R, S M M, M E B, J M W, Centre for Cognitive Ageing and Cognitive Epidemiology B S A, M C V H, N A R, S M M, A J G, M E B, J S, I J D, J M W, Department of Psychology J C, I J D, and Geriatric Medicine Unit J S, University of Edinburgh, Edinburgh, United Kingdom Scottish Imaging Network A Platform for Scientific Excellence SINAPSE, Edinburgh, United Kingdom B S A, M C V H, N A R, S M M, M E B, J M W Department of Computer Science, Lagos State University, Nigeria B S A and Department of Psychology, Heriot Watt University, Brazil
    Stroke 45:605-7. 2014
    ..Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634)...
  26. pmc Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936
    David Alexander Dickie
    Brain Research Imaging Centre, The University of Edinburgh, Edinburgh, UK Neuroimaging Sciences, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK Scottish Imaging Network, a Platform for Scientific Excellence SINAPSE Collaboration, Glasgow, United Kingodm
    Neurobiol Aging 42:116-23. 2016
    ..A focus on smoking cessation and lipid lowering, not just antihypertensives, may lead to a reduction in WMH growth in the eighth decade of life. ..
  27. pmc Does white matter structure or hippocampal volume mediate associations between cortisol and cognitive ageing?
    Simon R Cox
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK Department of Psychology, University of Edinburgh, UK Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, UK Electronic address
    Psychoneuroendocrinology 62:129-37. 2015
    ..These data support the hypothesis that GCs contribute to cognitive ageing differences from childhood to the early 70s, partly via brain WM structure. ..
  28. pmc Volumetric and Correlational Implications of Brain Parcellation Method Selection: A 3-Way Comparison in the Frontal Lobes
    Simon R Cox
    From the Brain Research Imaging Centre, Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, and College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom Department of Computer Science, Lagos State University, Lagos, Nigeria Scottish Imaging Network, a Platform for Scientific Excellence SINAPSE Collaboration and Geriatric Medicine, University of Edinburgh, Edinburgh, United Kingdom
    J Comput Assist Tomogr 40:53-60. 2016
    ..The aims of this study were to compare distinct brain frontal lobe parcellation methods across 90 brain magnetic resonance imaging scans and examine their associations with cognition in older age...
  29. pmc Association of allostatic load with brain structure and cognitive ability in later life
    Tom Booth
    Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK Department of Psychology, The University of Edinburgh, Edinburgh, UK Electronic address
    Neurobiol Aging 36:1390-9. 2015
    ..AL did not predict cognitive change from age 11 to approximately age 73. The findings suggest a link between AL and later life brain health and cognitive functioning...
  30. doi request reprint White matter integrity in individuals at high genetic risk of bipolar disorder
    Emma Sprooten
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, United Kingdom
    Biol Psychiatry 70:350-6. 2011
    ....
  31. doi request reprint White matter tractography in bipolar disorder and schizophrenia
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Edinburgh United Kingdom
    Biol Psychiatry 64:1088-92. 2008
    ....
  32. pmc Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects
    Benjamin S Aribisala
    Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Scottish Imaging Network, A Platform for Scientific Excellence SINAPSE, Edinburgh, UK Department of Computer Science, Lagos State University, Lagos, Nigeria
    Cortex 53:34-44. 2014
    ....
  33. pmc Blood pressure, internal carotid artery flow parameters, and age-related white matter hyperintensities
    Benjamin S Aribisala
    Neuroimaging Sciences, University of Edinburgh, Western General Hospital, Bramwell Dott Bldg, Crewe Rd, Edinburgh EH4 2XU, United Kingdom
    Hypertension 63:1011-8. 2014
    ..Reducing vascular stiffness may reduce WMH progression and should be tested in randomized trials, in addition to testing antihypertensive therapy. ..
  34. doi request reprint White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder
    Emma Sprooten
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Psychiatry Res 206:223-31. 2013
    ....
  35. doi request reprint Close correlation between quantitative and qualitative assessments of white matter lesions
    Maria Del C Valdés Hernández
    Brain Research Imaging Centre, Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Neuroepidemiology 40:13-22. 2013
    ..White matter lesions (WML) increase with age and are associated with stroke, cognitive decline and dementia. They can be visually rated or computationally assessed...
  36. ncbi request reprint DSC perfusion MRI-Quantification and reduction of systematic errors arising in areas of reduced cerebral blood flow
    Trevor K Carpenter
    Department of Clinical Neurosciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, UK
    Magn Reson Med 55:1342-9. 2006
    ..1% to 11.7%. However, the error is largest in the presence of noise and at MTTs that are likely to be encountered in areas of hypoperfusion; furthermore, even though it is reduced, it cannot be corrected for exactly...
  37. ncbi request reprint A quantitative comparison of two methods to correct eddy current-induced distortions in DT-MRI
    Susana Muñoz Maniega
    Medical and Radiological Sciences Medical Physics, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Magn Reson Imaging 25:341-9. 2007
    ....
  38. doi request reprint Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke
    Susana Muñoz Maniega
    University of Edinburgh, Division of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Stroke 39:2467-9. 2008
    ..Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change. We investigated their concentration variation over time after stroke...
  39. pmc Association between preterm brain injury and exposure to chorioamnionitis during fetal life
    Devasuda Anblagan
    MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Sci Rep 6:37932. 2016
    ....
  40. pmc Brain white matter structure and information processing speed in healthy older age
    Ksenia A Kuznetsova
    Doctoral Training Centre in Neuroinformatics and Computational Neuroscience, School of Informatics, University of Edinburgh, Edinburgh, UK
    Brain Struct Funct 221:3223-35. 2016
    ....
  41. pmc Brain iron deposits and lifespan cognitive ability
    Maria Del C Valdés Hernández
    Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, 49 Little France Crescent, Chancellor s Building, Edinburgh, EH16 4SB, UK
    Age (Dordr) 37:100. 2015
    ..Iron deposits might be an indicator of small vessel disease that affects the neuronal networks underlying higher cognitive functioning...
  42. pmc Total MRI load of cerebral small vessel disease and cognitive ability in older people
    Julie Staals
    Department of Neurology and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands Brain Research Imaging Centre, Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Neurobiol Aging 36:2806-11. 2015
    ..The total SVD score performed consistently with the more complex latent variable model, suggesting validity and potential utility in future research for determining total SVD load...
  43. pmc Brain white matter integrity and cortisol in older men: the Lothian Birth Cohort 1936
    Simon R Cox
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK Department of Psychology, University of Edinburgh, Edinburgh, UK Electronic address
    Neurobiol Aging 36:257-64. 2015
    ..The cognitive sequelae of these relationships, above other covariates, are a priority for future study...
  44. pmc Compensation or inhibitory failure? Testing hypotheses of age-related right frontal lobe involvement in verbal memory ability using structural and diffusion MRI
    Simon R Cox
    Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Department of Psychology, University of Edinburgh, Edinburgh, UK Electronic address
    Cortex 63:4-15. 2015
    ....
  45. pmc An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain
    Emma Sprooten
    Division of Psychiatry, University of Edinburgh, EH10 5HF, United Kingdom
    Magn Reson Imaging 30:1373-80. 2012
    ..These data therefore suggest that it is unlikely that the effects of genetic variation at rs1344706 on functional connectivity are mediated by structural integrity differences in large, long-range white matter fiber connections...
  46. doi request reprint Automatic segmentation of brain white matter and white matter lesions in normal aging: comparison of five multispectral techniques
    Maria Del C Valdés Hernández
    Brain Research Imaging Centre, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Magn Reson Imaging 30:222-9. 2012
    ....
  47. doi request reprint Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936
    Maria Del Carmen Valdés Hernández
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Scottish Imaging Network, a Platform for Scientific Excellence SINAPSE Collaboration, Edinburgh, UK
    Neurobiol Aging 52:1-11. 2016
    ....
  48. pmc Ageing and brain white matter structure in 3,513 UK Biobank participants
    Simon R Cox
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Nat Commun 7:13629. 2016
    ..Results from this unusually large, single-scanner sample provide one of the most extensive characterizations of age associations with major white matter tracts in the human brain...
  49. doi request reprint White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2
    Lars Penke
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Behav Genet 40:146-56. 2010
    ..While the effects of the SNP and splenium integrity on cognitive aging were largely independent, there was some evidence for a partial mediation effect of ADRB2 status via splenium integrity...
  50. pmc Incidental findings on brain MR imaging in older community-dwelling subjects are common but serious medical consequences are rare: a cohort study
    Elaine M Sandeman
    Brain Research Imaging Centre, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e71467. 2013
    ..We determined the prevalence and medical consequences of incidental findings found in community-dwelling older subjects on brain magnetic resonance imaging...
  51. doi request reprint A systematic review of the utility of 1.5 versus 3 Tesla magnetic resonance brain imaging in clinical practice and research
    Joanna M Wardlaw
    Scottish Imaging Network, A Platform for Scientific Excellence collaboration, Edinburgh, UK
    Eur Radiol 22:2295-303. 2012
    ..MRI at 3 T is said to be more accurate than 1.5 T MR, but costs and other practical differences mean that it is unclear which to use...
  52. doi request reprint A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity
    Lorna M Lopez
    Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK
    Neurobiol Aging 33:1847.e1-14. 2012
    ..Although no gene passed correction for multiple comparisons in single gene-based testing, biological pathways analysis suggested evidence for an over-representation of neuronal transmission and cell adhesion pathways relating to g(FA)...
  53. doi request reprint Pretreatment tumoural perfusion correlates with an imaging-based response to dexamethasone in patients with glioblastoma multiforme
    Paul A Armitage
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 81:446-8. 2010
    ..These preliminary results indicate that measurements of tumoural perfusion may provide useful imaging biomarkers for predicting treatment response to dexamethasone and would therefore also be worth evaluating in newer emerging therapies...
  54. ncbi request reprint Improved segmentation reproducibility in group tractography using a quantitative tract similarity measure
    Jonathan D Clayden
    Neuroinformatics Doctoral Training Centre, School of Informatics, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    Neuroimage 33:482-92. 2006
    ....
  55. ncbi request reprint Measurement of regional brain temperature using proton spectroscopic imaging: validation and application to acute ischemic stroke
    Ian Marshall
    SHEFC Brain Imaging Research Centre for Scotland, University of Edinburgh, Edinburgh, UK
    Magn Reson Imaging 24:699-706. 2006
    ..45 degrees C (hotter)-2.17 degrees C (cooler)]. Noninvasive temperature measurement by SI has sufficient precision to be used in studies of pathophysiology in stroke and in other brain disorders and to monitor therapies...
  56. doi request reprint Reliability of two techniques for assessing cerebral iron deposits with structural magnetic resonance imaging
    Maria C Valdés Hernández
    SINAPSE Collaboration, SFC Brain Imaging Research Centre, Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    J Magn Reson Imaging 33:54-61. 2011
    ....
  57. pmc Automated segmentation of multifocal basal ganglia T2*-weighted MRI hypointensities
    Andreas Glatz
    Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK SINAPSE Collaboration, Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Neuroimage 105:332-46. 2015
    ..62 ± 0.40). These promising results suggest that this method may have use in automatic segmentation of basal ganglia T2*w hypointensities in studies of small vessel disease and ageing...
  58. doi request reprint White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging
    Jessika E Sussmann
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Bipolar Disord 11:11-8. 2009
    ..Diffusion tensor imaging (DTI) studies suggest altered connectivity in both disorders. We aim to address the diagnostic specificity of white matter abnormalities in these disorders...
  59. pmc Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats
    Philip R Holland
    1 Centre for Neuroregeneration, University of Edinburgh, Edinburgh, UK 2 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK 3 Present address Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, UK
    J Cereb Blood Flow Metab 35:188-92. 2015
    ..Herein we show that moderate hypertension alone or with additional risk factors has minimal impact on white matter integrity in this model. ..
  60. pmc Quantitative serial MRI of the treated fibroid uterus
    Kirsty I Munro
    MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 9:e89809. 2014
    ..Our secondary aim was to determine whether rapid suppression of ovarian activity by combining GnRH agonist and antagonist therapies results in faster volume reduction...
  61. ncbi request reprint Quantitative assessment of intracranial tumor response to dexamethasone using diffusion, perfusion and permeability magnetic resonance imaging
    Paul A Armitage
    Clinical Neurosciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK
    Magn Reson Imaging 25:303-10. 2007
    ..The yielded parameters provide a wealth of physiologic information and contribute to the understanding of dexamethasone actions on different types of intracranial tumors...
  62. doi request reprint Reduced structural connectivity within a prefrontal-motor-subcortical network in amyotrophic lateral sclerosis
    Colin R Buchanan
    Doctoral Training Center in Neuroinformatics and Computational Neuroscience, School of Informatics, University of Edinburgh, Edinburgh, United Kingdom Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh, Edinburgh, United Kingdom
    J Magn Reson Imaging 41:1342-52. 2015
    ....
  63. pmc Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse
    Christopher M Henstridge
    Centre for Cognitive and Neural Systems, University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, UK
    Acta Neuropathol Commun 3:53. 2015
    ..Here we present data from the first donated LBC1936 brain andcompare our findings to Alzheimer's diseased tissue to highlight the differences between healthy andpathological brain ageing...
  64. pmc Intelligence in childhood and atherosclerosis of the carotid and peripheral arteries in later life: the Lothian Birth Cohort 1936
    Catharine R Gale
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom
    PLoS ONE 10:e0125280. 2015
    ..These findings need replicating in other, older populations. We investigated the prospective relationship between intelligence in childhood and atherosclerosis in the carotid and peripheral arteries at age 73 years...
  65. pmc White matter integrity and its association with affective and interpersonal symptoms in borderline personality disorder
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Edinburgh, UK
    Neuroimage Clin 7:476-81. 2015
    ....
  66. pmc Genes from a translational analysis support a multifactorial nature of white matter hyperintensities
    Lorna M Lopez
    From the Centre for Cognitive Ageing and Cognitive Epidemiology L M L, M V H, S M M, M E B, J S, I J D, J M W, Division of Neuroimaging Sciences, Brain Research Imaging Centre, M V H, S M M, M E B, J M W and Academic Neuropathology C S, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom Centre for Cognitive Ageing and Cognitive Epidemiology, Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom W D H, S E H, D J P Department of Bioengineering, Imperial College London, London, United Kingdom E B BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom M M, J M, D G, A D Department of Biostatistics, Boston University School of Public Health, MA Q Y The Framingham Heart Study
    Stroke 46:341-7. 2015
    ..White matter hyperintensities (WMH) of presumed vascular origin increase the risk of stroke and dementia. Despite strong WMH heritability, few gene associations have been identified. Relevant experimental models may be informative...
  67. pmc Characterization of multifocal T2*-weighted MRI hypointensities in the basal ganglia of elderly, community-dwelling subjects
    Andreas Glatz
    Brain Research Imaging Centre BRIC, Neuroimaging Sciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Neuroimage 82:470-80. 2013
    ....
  68. doi request reprint Executive deficits, not processing speed relates to abnormalities in distinct prefrontal tracts in amyotrophic lateral sclerosis
    Lewis D Pettit
    1 Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK
    Brain 136:3290-304. 2013
    ....
  69. pmc Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936
    Donald M Lyall
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, United Kingdom Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom Medical Genetics Section, Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e80513. 2013
    ....
  70. doi request reprint Birth parameters are associated with late-life white matter integrity in community-dwelling older people
    Susan D Shenkin
    Department of Clinical and Surgical Sciences, Geriatric Medicine, University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, Scotland, UK
    Stroke 40:1225-8. 2009
    ..We investigated whether there was an association between birth parameters and imaging markers of white matter integrity in community-dwelling older people...
  71. doi request reprint MR diffusion and perfusion parameters: relationship to metabolites in acute ischaemic stroke
    Vera Cvoro
    SFC Brain Imaging Research Centre, SINAPSE Collaboration, Division of Clinical Neuroscience, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 81:185-91. 2010
    ..The authors compared N-acetyl aspartate (NAA, found in intact neurons) and lactate (anaerobic metabolism) with diffusion/perfusion parameters...
  72. ncbi request reprint On the application of a non-CPMG single-shot fast spin-echo sequence to diffusion tensor MRI of the human brain
    Mark E Bastin
    Department of Medical and Radiological Sciences Medical Physics, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Magn Reson Med 48:6-14. 2002
    ..This approach provides high SNR diffusion-weighted images that have little or no susceptibility to poor B(0) magnetic field homogeneity and the strong eddy currents typically present in DT-MRI experiments...
  73. doi request reprint Carotid intima-media thickness and cerebrovascular disease in community-dwelling older people without stroke
    Susan D Shenkin
    Geriatric Medicine, Department of Clinical and Surgical Sciences, University of Edinburgh, Scotland
    Stroke 41:2083-6. 2010
    ..Carotid intima-media thickness (CIMT) is a noninvasive measure of atherosclerosis, but it is unclear whether it is a stronger risk factor for large vessel disease or small vessel disease...
  74. pmc Seropositivity for CMV and IL-6 levels are associated with grip strength and muscle size in the elderly
    Alixe Hm Kilgour
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Immun Ageing 10:33. 2013
    ..We investigated the relationship between latent cytomegalovirus (CMV) infection, Interleukin 6 (IL-6) levels, muscle size and strength in a group of healthy older community-dwelling people...
  75. doi request reprint Test-retest reliability of structural brain networks from diffusion MRI
    Colin R Buchanan
    Doctoral Training Centre in Neuroinformatics and Computational Neuroscience, School of Informatics, University of Edinburgh, Edinburgh, UK Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh, Edinburgh, UK
    Neuroimage 86:231-43. 2014
    ..Overall, these findings suggest that whilst current techniques produce networks capable of characterising the genuine between-subject differences in connectivity, future work must be undertaken to improve network reliability. ..
  76. pmc A test-retest fMRI dataset for motor, language and spatial attention functions
    Krzysztof J Gorgolewski
    Institute for Adaptive and Neural Computation, University of Edinburgh, 10 Crichton Street, Edinburgh, EH8 9AB, UK
    Gigascience 2:6. 2013
    ..In addition to the fMRI sessions, high-angular resolution diffusion tensor MRI (DTI), and high-resolution 3D T1-weighted volume scans were acquired...
  77. doi request reprint MRI is a sensitive marker of subtle white matter pathology in hypoperfused mice
    Philip R Holland
    Centre for Cognitive Ageing and Cognitive Epidemiology, Centre for Cognitive and Neural Systems, University of Edinburgh, Edinburgh, UK
    Neurobiol Aging 32:2325.e1-6. 2011
    ..The study demonstrates that in vivo MRI is a sensitive measure of diffuse, subtle WM changes in the murine brain...
  78. doi request reprint Ex vivo water diffusion tensor properties of the fibroid uterus at 7 T and their relation to tissue morphology
    Michael J Thrippleton
    MRC Centre for Reproductive Health, University of Edinburgh, UK
    J Magn Reson Imaging 34:1445-51. 2011
    ..To investigate the water diffusion tensor properties of ex vivo tissue in the fibroid uterus, including the influence of degeneration, and the relevance of the principal eigenvector orientation to the underlying tissue structure...
  79. ncbi request reprint Persistent infarct hyperintensity on diffusion-weighted imaging late after stroke indicates heterogeneous, delayed, infarct evolution
    Carly S Rivers
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Stroke 37:1418-23. 2006
    ..We hypothesized that late DWI hyperintensity reflected different infarct evolution compared with areas that were isointense by 1 month...
  80. doi request reprint Single subject fMRI test-retest reliability metrics and confounding factors
    Krzysztof J Gorgolewski
    Neuroinformatics Doctoral Training Centre, University of Edinburgh, UK
    Neuroimage 69:231-43. 2013
    ..This suggests that between-session variance in fMRI is mostly caused by the variability of underlying cognitive processes and motion correlated with the stimuli rather than technical limitations of data processing...
  81. ncbi request reprint Apparent diffusion coefficient (ADC) measurements may be more reliable and reproducible than lesion volume on diffusion-weighted images from patients with acute ischaemic stroke-implications for study design
    Arnab K Rana
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospitals NHS Trust, Scotland, Edinburgh EH4 2XU, UK
    Magn Reson Imaging 21:617-24. 2003
    ..This effect is greatest in large lesions...
  82. ncbi request reprint Measurements of water diffusion and T1 values in peritumoural oedematous brain
    Mark E Bastin
    Department of Medical and Radiological Sciences Medical Physics, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Neuroreport 13:1335-40. 2002
    ..Such results illustrate the potential of MR imaging to improve not only the characterization of brain oedema, but also the monitoring of treatment response...