D J Barker

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi Adult consequences of fetal growth restriction
    David J P Barker
    Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Clin Obstet Gynecol 49:270-83. 2006
  2. ncbi Growth in utero and blood pressure levels in the next generation
    D J Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    J Hypertens 18:843-6. 2000
  3. ncbi Developmental antecedents of cardiovascular disease: a historical perspective
    David J P Barker
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    J Am Soc Nephrol 16:2537-44. 2005
  4. ncbi Altered regional blood flow in the fetus: the origins of cardiovascular disease?
    D J P Barker
    Division of Developmental Origins of Adult Health and Disease, University of Southampton, Southampton, United Kingdom
    Acta Paediatr 93:1559-60. 2004
  5. ncbi Fetal origins of cardiovascular disease
    D J Barker
    MRC Environmental Epidemiology Unit, University of Southampton, UK
    Ann Med 31:3-6. 1999
  6. ncbi Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 83:757-60. 1998
  7. ncbi Fetal programming and adult health
    K M Godfrey
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Public Health Nutr 4:611-24. 2001
  8. ncbi The developmental origins of adult disease
    D J P Barker
    University of Southampton, MRC Epidemiology Centre, Southampton General Hospital, Southampton, SO16 6YD, England
    J Am Coll Nutr 23:588S-595S. 2004
  9. ncbi Are rates of ageing determined in utero?
    A A Sayer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton S016 6YD, UK
    Age Ageing 27:579-83. 1998
  10. pmc Fetal, infant, and childhood growth are predictors of coronary heart disease, diabetes, and hypertension in adult men and women
    C Osmond
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Environ Health Perspect 108:545-53. 2000

Collaborators

Detail Information

Publications86

  1. ncbi Adult consequences of fetal growth restriction
    David J P Barker
    Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Clin Obstet Gynecol 49:270-83. 2006
    ..Cardiovascular disease and type 2 diabetes arise through a series of interactions between environmental influences and the pathways of development that precede them...
  2. ncbi Growth in utero and blood pressure levels in the next generation
    D J Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    J Hypertens 18:843-6. 2000
    ..To determine whether blood pressure levels in adult life are related to the mother's fetal growth and size at birth...
  3. ncbi Developmental antecedents of cardiovascular disease: a historical perspective
    David J P Barker
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    J Am Soc Nephrol 16:2537-44. 2005
    ..One such process is altered renal development, with reduced nephron numbers, which may initiate hypertension...
  4. ncbi Altered regional blood flow in the fetus: the origins of cardiovascular disease?
    D J P Barker
    Division of Developmental Origins of Adult Health and Disease, University of Southampton, Southampton, United Kingdom
    Acta Paediatr 93:1559-60. 2004
    ..A fetal response to hypoxia and other adverse influences is to redistribute blood flow in order to "spare" the brain. This, however, is associated with reduced growth of the liver and kidneys...
  5. ncbi Fetal origins of cardiovascular disease
    D J Barker
    MRC Environmental Epidemiology Unit, University of Southampton, UK
    Ann Med 31:3-6. 1999
    ..Prevention of the diseases may depend on prevention of imbalances in fetal growth or imbalances between prenatal and postnatal growth, or imbalances in nutrient supply to the fetus...
  6. ncbi Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 83:757-60. 1998
    ..Moreover, this study provides the first evidence that intrauterine programming of the HPAA may be a mechanism underlying the association between low birth weight and the insulin resistance syndrome in adult life...
  7. ncbi Fetal programming and adult health
    K M Godfrey
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Public Health Nutr 4:611-24. 2001
    ..Although the influences that impair fetal development and programme adult cardiovascular disease remain to be defined, there are strong pointers to the importance of maternal body composition and dietary balance during pregnancy...
  8. ncbi The developmental origins of adult disease
    D J P Barker
    University of Southampton, MRC Epidemiology Centre, Southampton General Hospital, Southampton, SO16 6YD, England
    J Am Coll Nutr 23:588S-595S. 2004
    ..A new vision of optimal early human development is emerging which takes account of both short and long-term outcomes...
  9. ncbi Are rates of ageing determined in utero?
    A A Sayer
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton S016 6YD, UK
    Age Ageing 27:579-83. 1998
    ..The long-term effects of poor early nutrition on ageing have been demonstrated in animals but not studied in man...
  10. pmc Fetal, infant, and childhood growth are predictors of coronary heart disease, diabetes, and hypertension in adult men and women
    C Osmond
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Environ Health Perspect 108:545-53. 2000
    ..We argue for a research strategy that combines clinical, animal, and epidemiological studies...
  11. ncbi Fetal growth and hyperinsulinaemia in adult life
    C N Martyn
    MRC Environmental Epidemiology Unit University of Southampton, Southampton General Hospital, UK
    Diabet Med 15:688-94. 1998
    ....
  12. ncbi Weight gain in pregnancy, triceps skinfold thickness, and blood pressure in offspring
    P M Clark
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Hampshire, United Kingdom
    Obstet Gynecol 91:103-7. 1998
    ..To determine whether women who are poorly nourished in early pregnancy, as determined by triceps skinfold thickness, or who have poor pregnancy weight gain have offspring with higher blood pressure (BP)...
  13. ncbi Body size at birth and blood pressure among children in developing countries
    C M Law
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Epidemiol 30:52-7. 2001
    ..Studies in developed countries have shown that reduced fetal growth is related to raised blood pressure in childhood and adult life. Little is known about this association in developing countries, where fetal growth retardation is common...
  14. ncbi Fetal nutrition and adult disease
    K M Godfrey
    MRC Environmental Epidemiology Unit University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Am J Clin Nutr 71:1344S-52S. 2000
    ....
  15. ncbi Coronary heart disease: a disorder of growth
    S M Robinson
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Proc Nutr Soc 61:537-42. 2002
    ..These effects are compounded by accelerated weight gain, which may represent 'compensatory growth' in childhood...
  16. pmc Poor housing in childhood and high rates of stomach cancer in England and Wales
    D J Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Br J Cancer 61:575-8. 1990
    ..We conclude that overcrowding in the home during childhood may be a major determinant of stomach cancer, and might act by promoting the transmission of causative organisms...
  17. ncbi Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, UK
    Hypertension 35:1301-6. 2000
    ..These results show that low birth weight is associated with raised fasting plasma cortisol concentrations. Increased activity of the hypothalamic-pituitary-adrenal axis may link low birth weight with raised blood pressure in adult life...
  18. ncbi The developmental origins of adult disease
    D J P Barker
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Eur J Epidemiol 18:733-6. 2003
  19. ncbi Behaviour, body composition and diet in adolescent girls
    M Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Appetite 35:161-70. 2000
    ..The eating habits of the girls were therefore influenced by the extent of their social lives and by their satisfaction with their weight...
  20. pmc Size at birth and resilience to effects of poor living conditions in adult life: longitudinal study
    D J Barker
    Medical Research Council, Environmental Epidemiology Unit, University of Southampton General Hospital, Southampton SO16 6YD, UK
    BMJ 323:1273-6. 2001
    ..To determine whether men who grew slowly in utero or during infancy are more vulnerable to the later effects of poor living conditions on coronary heart disease...
  21. ncbi The malnourished baby and infant
    D J Barker
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Br Med Bull 60:69-88. 2001
    ..In some circumstances, the placenta may enlarge. Adaptations to undernutrition that occur during development permanently alter the structure and function of the body...
  22. pmc Infant growth and income 50 years later
    D J P Barker
    DOHaD Division, University of Southampton, UK
    Arch Dis Child 90:272-3. 2005
    ..One interpretation of this is that biological processes linked to slow infant growth may lead to lifelong impairment of cognitive function...
  23. ncbi Commentary: Developmental origins of raised serum cholesterol
    D J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Epidemiol 32:876-7. 2003
  24. ncbi The origins of the developmental origins theory
    D J P Barker
    DOHaD Division, University of Southampton, UK
    J Intern Med 261:412-7. 2007
    ..The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward...
  25. pmc The developmental origins of well-being
    D J P Barker
    Division for Developmental Origins of Adult Health and Disease, University of Southampton, Mailpoint 95, Southampton General Hospital, Southampton SO16 6YD, UK
    Philos Trans R Soc Lond B Biol Sci 359:1359-66. 2004
    ..A new vision of optimal early human development is emerging, which takes account of health and well-being throughout life...
  26. ncbi The developmental origins of chronic adult disease
    D J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, United Kingdom
    Acta Paediatr Suppl 93:26-33. 2004
    ..These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth...
  27. pmc Growth of girls who later develop coronary heart disease
    T Forsen
    Southampton General Hospital, Tremona Road, Southampton, UK
    Heart 90:20-4. 2004
    ..To determine the path of growth of girls who later develop coronary heart disease...
  28. ncbi Obesity and early life
    D J P Barker
    University of Southampton, Southampton, UK
    Obes Rev 8:45-9. 2007
  29. ncbi Impact of educational attainment on the quality of young women's diets
    S M Robinson
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK
    Eur J Clin Nutr 58:1174-80. 2004
    ..This study examines the influence of sociodemographic and anthropometric factors on the quality of the diets of young women in the UK...
  30. doi Constraints on food choices of women in the UK with lower educational attainment
    M Barker
    Food Choice Group, MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Public Health Nutr 11:1229-37. 2008
    ..The present study aimed to identify factors that influence the food choices of women with lower educational attainment and how women could be helped to improve those choices...
  31. ncbi Coronary heart disease: a disorder of growth
    D J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Horm Res 59:35-41. 2003
    ....
  32. ncbi Fetal origins of adult disease: strength of effects and biological basis
    D J P Barker
    Medical Research Council Environmental Epidemiology Unit, Southampton SO16 6YD, UK
    Int J Epidemiol 31:1235-9. 2002
    ....
  33. ncbi Cohort profile: the Hertfordshire cohort study
    H E Syddall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Epidemiol 34:1234-42. 2005
  34. ncbi Maternal height, childhood growth and risk of hip fracture in later life: a longitudinal study
    C Cooper
    The MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Osteoporos Int 12:623-9. 2001
    ....
  35. ncbi A new model for the origins of chronic disease
    D J Barker
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, SO16 6YD, UK
    Med Health Care Philos 4:31-5. 2001
    ..These programmed changes may be the origins of a number of diseases in later life, including coronary heart disease, stroke, diabetes and hypertension...
  36. ncbi Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort Study
    H E Syddall
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Am J Epidemiol 161:1074-80. 2005
    ..Overall, a one-standard-deviation increase in birth weight reduced all-cause mortality risk by age 75 years by 0.86% for both men and women...
  37. ncbi High-meat, low-carbohydrate diet in pregnancy: relation to adult blood pressure in the offspring
    A W Shiell
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, United Kingdom
    Hypertension 38:1282-8. 2001
    ..These associations may reflect the metabolic stress imposed on the mother by an unbalanced diet in which high intakes of essential amino acids are not accompanied by the nutrients required to utilize them...
  38. ncbi Intra-uterine programming of the adult cardiovascular system
    D J Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Curr Opin Nephrol Hypertens 6:106-10. 1997
    ..Recent research, however, suggests that growth in utero may also play an important role...
  39. pmc Different indices of fetal growth predict bone size and volumetric density at 4 years of age
    Nicholas C Harvey
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J Bone Miner Res 25:920-7. 2010
    ..These results suggest a discordance between influences on skeletal size and volumetric density...
  40. ncbi Birth weight and the risk of depressive disorder in late life
    C Thompson
    MRC Environmental Epidemiology Unit and Community Clinical Sciences Research Division, University of Southampton, Southampton, UK
    Br J Psychiatry 179:450-5. 2001
    ..If replicated, these results would suggest a neurodevelopmental aetiology of depression, possibly mediated by programming of the hypothalamic-pituitary-adrenal axis...
  41. pmc Stomach cancer and migration within England and Wales
    D Coggon
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Br J Cancer 61:573-4. 1990
    ..We conclude that studies seeking to explain local differences in the incidence of stomach cancer within England and Wales should focus on the environment of patients in their youth...
  42. ncbi Components in the interpretation of the high mortality in the county of Finnmark
    D J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK
    Int J Epidemiol 31:309-10. 2002
  43. pmc Cohort profile: The Southampton Women's Survey
    Hazel M Inskip
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Epidemiol 35:42-8. 2006
  44. ncbi Cardiovascular disease in survivors of the Dutch famine
    Anita C J Ravelli
    Department Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nestle Nutr Workshop Ser Pediatr Program 55:183-91; discussion 191-5. 2005
  45. ncbi The developmental origins of insulin resistance
    David J P Barker
    Division of Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
    Horm Res 64:2-7. 2005
    ..Improving fetal nutrition remains an important long-term goal...
  46. ncbi Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene
    Anna Rautanen
    Department of Medical Genetics, University of Helsinki, FIN 00014 Helsinki, Finland
    J Clin Endocrinol Metab 91:4544-51. 2006
    ..Small body size at birth is associated with cardiovascular disease and type 2 diabetes in adult life. This link may be in part mediated by early-life programming of the hypothalamic-pituitary-adrenal axis (HPAA) function...
  47. ncbi Trajectories of growth among children who have coronary events as adults
    David J P Barker
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    N Engl J Med 353:1802-9. 2005
    ..Low birth weight is a risk factor for coronary heart disease. It is uncertain how postnatal growth affects disease risk...
  48. ncbi Mechanisms of disease: in utero programming in the pathogenesis of hypertension
    David J P Barker
    Developmental Origins of Health and Disease Division MP 887, University of Southampton, Princess Anne Hospital, Southampton SO16 5YA, UK
    Nat Clin Pract Nephrol 2:700-7. 2006
    ..By monitoring blood pressure, weight, and renal function in children, it might be possible to reduce the risk of cardiovascular and renal disease in later life...
  49. ncbi Spontaneous hypothyroidism in adult women is predicted by small body size at birth and during childhood
    Eero Kajantie
    National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, 00300 Helsinki, Finland
    J Clin Endocrinol Metab 91:4953-6. 2006
    ..The relationships of early growth with coronary heart disease and type 2 diabetes have received considerable attention. It is not known whether fetal or childhood growth is linked with autoimmune disorders...
  50. ncbi Infant growth and stroke in adult life: the Helsinki birth cohort study
    Clive Osmond
    MRC Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, UK
    Stroke 38:264-70. 2007
    ..People who had low birth weight are at increased risk of stroke. Little is known about the effects of early postnatal growth on stroke risk...
  51. doi Body size at birth and socio-economic status in childhood: implications for Cloninger's psychobiological model of temperament at age 60
    Jari Lahti
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Psychiatry Res 160:167-74. 2008
    ....
  52. doi Infant growth and hostility in adult life
    Katri Rikkönen
    Department of Psychology, University of Helsinki, P O Box 9 Siltavuorenpenger 20 D, 00014 University of Helsinki, Finland
    Psychosom Med 70:306-13. 2008
    ..A common origin in suboptimal fetal and early postnatal life may lie beneath. This study tested whether prenatal and postnatal growth predicts hostility in adult life...
  53. ncbi Concluding remarks. The Window of Opportunity: Pre-Pregnancy to 24 Months of Age
    David J P Barker
    Developmental Origins of Health and Disease Division, University of Southampton, Princess Anne Hospital, Southampton, UK
    Nestle Nutr Workshop Ser Pediatr Program 61:255-60. 2008
    ..We discussed what is known and what needs to be known about (a) growth during this window, (b) critical periods of development, (c) the effects of nutrition, and (d) possible interventions to improve nutrition...
  54. doi Growth before 2 years of age and serum lipids 60 years later: the Helsinki Birth Cohort study
    Eero Kajantie
    The National Public Health Institute, Helsinki, Finland
    Int J Epidemiol 37:280-9. 2008
    ..We tested the hypothesis that this path of growth is associated with an atherogenic lipid profile in later life...
  55. doi Human growth and cardiovascular disease
    David J P Barker
    Department of Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Nestle Nutr Workshop Ser Pediatr Program 61:21-38. 2008
    ..CHD and the disorders related to it arise through a series of interactions between environmental influences and the pathways of growth and development that precede them...
  56. ncbi A possible link between the pubertal growth of girls and breast cancer in their daughters
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, OR, USA
    Am J Hum Biol 20:127-31. 2008
    ....
  57. ncbi Body size at birth predicts hypothalamic-pituitary-adrenal axis response to psychosocial stress at age 60 to 70 years
    Eero Kajantie
    National Public Health Institute, Department of Health Promotion and Chronic Disease Prevention, Mannerheimintie 166, 00300 Helsinki, Finland
    J Clin Endocrinol Metab 92:4094-100. 2007
    ..Studies in humans and animals have suggested intrauterine programming of hypothalamic-pituitary-adrenal axis (HPAA) function as an important mechanism in linking fetal life conditions with adult disease...
  58. ncbi Maternal and social origins of hypertension
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, USA
    Hypertension 50:565-71. 2007
    ....
  59. ncbi Length of gestation and depressive symptoms at age 60 years
    Katri Raikkonen
    Department of Psychology, University of Helsinki, PO Box 9, 00014 University of Helsinki, Finland
    Br J Psychiatry 190:469-74. 2007
    ..A non-optimal foetal environment, reflected in smaller birth size and shorter duration of gestation, is a risk factor for compromised health later in life...
  60. ncbi Childhood growth and hypertension in later life
    Johan G Eriksson
    National Public Health Institute, Department of Health Promotion and Chronic Disease Prevention, Diabetes Unit, Helsinki, Finland
    Hypertension 49:1415-21. 2007
    ..28 to 1.57). We conclude that 2 different paths of childhood growth precede the development of hypertension. We suggest that they lead to hypertension through different biological mechanisms and may respond differently to medication...
  61. ncbi Adult mortality at age 57 after prenatal exposure to the Dutch famine
    Rebecca C Painter
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center at the University of Amsterdam, P O Box 22660, 1100 DD, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands
    Eur J Epidemiol 20:673-6. 2005
    ..Follow-up of this cohort will resolve whether famine exposure is linked to increased adult mortality...
  62. ncbi Anthropometric indicators of body composition in young adults: relation to size at birth and serial measurements of body mass index in childhood in the New Delhi birth cohort
    Harshpal S Sachdev
    Department of Pediatrics, Sunder Lal Jain Hospital, Delhi, India
    Am J Clin Nutr 82:456-66. 2005
    ..South Asians have a muscle-thin but adipose body phenotype and high rates of obesity-related disease. Adult body composition may be predictable in early life...
  63. ncbi Self-perpetuating effects of birth size on blood pressure levels in elderly people
    Hilkka Ylihärsilä
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsink, Finland
    Hypertension 41:446-50. 2003
    ..Among elderly people with established hypertension, these processes have a strong effect on blood pressure levels, because they are processes that do not respond well to treatment...
  64. ncbi Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growth
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 88:1059-65. 2003
    ..Prospective studies should address whether this group is susceptible to type 2 diabetes, coronary heart disease, and osteoporosis...
  65. ncbi Pathways of infant and childhood growth that lead to type 2 diabetes
    Johan G Eriksson
    National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
    Diabetes Care 26:3006-10. 2003
    ..The aim of this study was to explore the pathways of infant and early growth that lead to type 2 diabetes in adult life...
  66. ncbi Perceived health of adults after prenatal exposure to the Dutch famine
    Tessa J Roseboom
    Department of Clinical Epidemiology and Biostatistics, ObsteAcademic Medical Centre Amsterdam, The Netherlands
    Paediatr Perinat Epidemiol 17:391-7. 2003
    ..Because poor perceived health is a strong predictor of mortality, we may expect increased mortality in people who were exposed to famine in early gestation in the future...
  67. ncbi Birthsize, gestational age and adrenal function in adult life: studies of dexamethasone suppression and ACTH1-24 stimulation
    Eero Kajantie
    National Public Health Institute, 00300 Helsinki, Finland
    Eur J Endocrinol 149:569-75. 2003
    ..We have now extended these findings by examining the relationship between birthweight, gestational age and tests of adrenal suppression and stimulation...
  68. ncbi Fetal programming of coronary heart disease
    David J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, SO16 6YD, Southampton, UK
    Trends Endocrinol Metab 13:364-8. 2002
    ..Coronary heart disease appears to be a developmental disorder that originates through two widespread biological phenomena, developmental plasticity and compensatory growth...
  69. pmc Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood
    Santosh K Bhargava
    Department of Pediatrics, Sunder Lal Jain Hospital, Delhi, India
    N Engl J Med 350:865-75. 2004
    ..Understanding the origin of obesity may be especially important in developing countries, where type 2 diabetes is rapidly increasing yet public health messages still focus on reducing childhood "undernutrition."..
  70. ncbi The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth
    Agata Kubaszek
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 89:2044-7. 2004
    ..We conclude that the interaction between the K121Q polymorphism of the PC-1 gene and birth length affects insulin sensitivity and increases susceptibility to type 2 diabetes and hypertension in adulthood...
  71. ncbi Interactions between peroxisome proliferator-activated receptor-gamma 2 gene polymorphisms and size at birth on blood pressure and the use of antihypertensive medication
    Hilkka Ylihärsilä
    National Public Health Institute, Helsinki, University of Helsinki, Finland
    J Hypertens 22:1283-7. 2004
    ..We examined whether the association between small body size at birth and adult blood pressure is modulated by PPAR-gamma 2 gene polymorphism, and whether the use of any class of antihypertensive medication is related to birth size...
  72. ncbi Exercise protects against glucose intolerance in individuals with a small body size at birth
    Johan G Eriksson
    Department of Epidemiology and Health Promotion, National Public Health Institute, FIN 00300 Helsinki, Finland
    Prev Med 39:164-7. 2004
    ..We investigated whether regular exercise is related to lower rates of glucose intolerance in individuals with a small body size at birth and whether birth size affects exercise habits in adulthood...
  73. ncbi The infant growth of boys who later develop coronary heart disease
    Tom J Forsen
    National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
    Ann Med 36:389-92. 2004
    ..The association between low birth-weight and coronary heart disease has been repeatedly shown. Only two previous studies have examined the effects of weight gain during infancy and later coronary heart disease...
  74. ncbi Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster
    Ian N M Day
    Human Genetics Division, Duthie Building Mp808, Tremona Road, School of Medicine, Southampton University Hospital, Southampton, United Kingdom SO16 6YD
    J Clin Endocrinol Metab 89:5569-76. 2004
    ..GH-CSH genotype adds substantially to, but does not account for, the associations between low body weight, at birth and in infancy, and the metabolic syndrome...
  75. ncbi Growth and living conditions in childhood and hypertension in adult life: a longitudinal study
    David J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    J Hypertens 20:1951-6. 2002
    ..To examine the interplay between childhood growth and living conditions in the development of hypertension...
  76. ncbi The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth
    Johan G Eriksson
    Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Diabetes 51:2321-4. 2002
    ..We suggest that these findings reflect gene-environment interaction...
  77. ncbi Microalbuminuria in adults after prenatal exposure to the Dutch famine
    Rebecca C Painter
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center at the University of Amsterdam, The Netherlands
    J Am Soc Nephrol 16:189-94. 2005
    ..Midgestation is a period of rapid increase in nephron number, which is critical in determining nephron endowment at birth. Fetal undernutrition may lead to lower nephron endowment with consequent MA in adult life...
  78. ncbi Prenatal influences on stroke mortality in England and Wales
    David J P Barker
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Stroke 34:1598-602. 2003
    ..We report on the geographic distribution of stroke mortality in England and Wales and compare it with that in the United States...
  79. ncbi Size at birth as a predictor of mortality in adulthood: a follow-up of 350 000 person-years
    Eero Kajantie
    National Public Health Institute, Helsinki, Finland
    Int J Epidemiol 34:655-63. 2005
    ..Our aim was to study the relationship between small size at birth and all-cause and non-cardiovascular mortality, which has been poorly documented...
  80. ncbi Size at birth, gestational age and cortisol secretion in adult life: foetal programming of both hyper- and hypocortisolism?
    Eero Kajantie
    The Hospital for Children and Adolescents, Helsinki University Central Hospital, Finland
    Clin Endocrinol (Oxf) 57:635-41. 2002
    ..We set out to study reasons for this discrepancy by examining the relationship between adult HPA axis function and birthweight and body proportions at birth in a group of elderly subjects with detailed birth records...
  81. doi Paternal skeletal size predicts intrauterine bone mineral accrual
    N C Harvey
    Medical Research Council Epidemiology Resource Centre, University of Southampton, and Southampton General Hospital, Southampton, United Kingdom
    J Clin Endocrinol Metab 93:1676-81. 2008
    ..However, the paternal determinants of neonatal bone mass are not known. In this study we explored the relationship between a father's bone mass and that of his offspring...
  82. ncbi Relationship between polycystic ovaries, body mass index and insulin resistance
    Janet Cresswell
    University Department of Obstetrics and Gynecology, Northern General Hospital, Sheffield, UK
    Acta Obstet Gynecol Scand 82:61-4. 2003
    ..To investigate insulin levels in lean and overweight women with and without polycystic ovaries. An observational, cross-sectional study at The Northem General Hospital, Sheffield, UK...
  83. ncbi Size at birth, the metabolic syndrome and 24-h salivary cortisol profile
    Eero Kajantie
    National Public Health Institute, Helsinki, Finland
    Clin Endocrinol (Oxf) 60:201-7. 2004
    ..Our aim was to assess whether HPAA activity in everyday living circumstances is related to the metabolic syndrome and size at birth...
  84. ncbi Birth weight and hypertension
    David J P Barker
    Hypertension 48:357-8. 2006
  85. ncbi The effects of the ACE gene insertion/deletion polymorphism on glucose tolerance and insulin secretion in elderly people are modified by birth weight
    Eero Kajantie
    National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    J Clin Endocrinol Metab 89:5738-41. 2004
    ..We suggest that these findings reflect interactions between genotype and intrauterine environment with resulting changes in gene expression...
  86. ncbi Associations between birth weight and antihypertensive medication in black and white medicaid recipients
    Daniel T Lackland
    Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 39:179-83. 2002
    ....