Affiliation: University College London
- Effect of gene therapy on visual function in Leber's congenital amaurosisJames W B Bainbridge
Institute of Ophthalmology, University College London, London, United Kingdom
N Engl J Med 358:2231-9. 2008..These findings provide support for further clinical studies of this experimental approach in other patients with mutant RPE65. (ClinicalTrials.gov number, NCT00643747 [ClinicalTrials.gov].)...
- HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemiaFreya M Mowat
Department of Genetics, University College London Institute of Ophthalmology, London, United Kingdom
PLoS ONE 5:e11103. 2010....
- Gene therapy for ocular angiogenesisJames W B Bainbridge
Department of Molecular Genetics, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, U K
Clin Sci (Lond) 104:561-75. 2003..Recent progress has enabled the planning of clinical trials of gene therapy for ocular neovascular disorders...
- Prospects for gene therapy of inherited retinal diseaseJ W B Bainbridge
Division of Molecular Therapy, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
Eye (Lond) 23:1898-903. 2009....
- Macular holes: vitreoretinal relationships and surgical approachesJ Bainbridge
Moorfields Eye Hospital, London, UK
Eye (Lond) 22:1301-9. 2008..The use of long-acting gases, prolonged face-down positioning, and ILM peeling may be more valuable for larger holes, longstanding holes, and those that have failed to close following conventional surgery...
- Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapyFrank C Schlichtenbrede
Department of Molecular Genetics, Institute of Ophthalmology, University College London, UK
J Gene Med 5:757-64. 2003..Here we quantify the functional rescue over a 15-week time course and present a detailed analysis of the improvement in retinal function...
- Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent miceSusie E Barker
Division of Molecular Therapy, UCL Institute of Ophthalmology, London, UK
J Gene Med 11:486-97. 2009..However, one potential barrier to efficacious long-term therapy is the development of immune responses against the vector or transgene product...
- The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophagesUlrich F O Luhmann
Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
Invest Ophthalmol Vis Sci 50:5934-43. 2009..This study was conducted to investigate the nature of the drusenlike lesions in vivo and further evaluate the Ccl2(-/-) mouse as a model of AMD...
- Delivery of anti-angiogenic molecular therapies for retinal diseaseOwen A Anderson
UCL Institute of Ophthalmology, 11 43 Bath Street, London EC1V9EL, United Kingdom
Drug Discov Today 15:272-82. 2010..A range of new anti-angiogenics are on the horizon, offering new and varied modes of drug delivery. In addition, a range of new sustained-release drug delivery technologies are being developed...
- A pilot randomised controlled trial comparing the post-operative pain experience following vitrectomy with a 20-gauge system and the 25-gauge transconjunctival systemL Wickham
Moorfields Eye Hospital, City Road, London EC1V 2PD, UK
Br J Ophthalmol 94:36-40. 2010..To compare post-operative pain following 25-gauge (25G) and 20-gauge (20G) vitrectomy in the first week following surgery...
- A peptide encoded by exon 6 of VEGF (EG3306) inhibits VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivoJames W B Bainbridge
Institute of Ophthalmology, Bath Street, London, UK
Biochem Biophys Res Commun 302:793-9. 2003....
- Predicting visual outcome following retinectomy for retinal detachmentD J De Silva
Vitreoretinal Service, Moorfields Eye Hospital, City Road, London, UK
Br J Ophthalmol 92:954-8. 2008..To evaluate outcome following retinectomy surgery and to identify factors that predict visual outcome...
- Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cellsJ Lakowski
Developmental Biology Unit, UCL Institute of Child Health, University College London, 30 Guilford Street, London, UK
Hum Mol Genet 19:4545-59. 2010..We conclude that flow-sorted embryonic-stage Crx-positive donor cells have the potential to replace lost cones, as well as rods, an important requirement for retinal disease therapy...