R Andrew

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Cortisol secretion and rate of bone loss in a population-based cohort of elderly men and women
    R M Reynolds
    Endocrinology Unit, University of Edinburgh, Queens Medical Research Institute, EH16 4TJ Edinburgh, UK
    Calcif Tissue Int 77:134-8. 2005
  2. ncbi request reprint Glucocorticoid metabolism and the Metabolic Syndrome: associations in an elderly cohort
    R Andrew
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU
    Exp Clin Endocrinol Diabetes 110:284-90. 2002
  3. ncbi request reprint Increased glucocorticoid activity in men with cardiovascular risk factors
    B R Walker
    University of Edinburgh, Department of Medicine, Western General Hospital, UK
    Hypertension 31:891-5. 1998
  4. ncbi request reprint Growth hormone replacement inhibits renal and hepatic 11 beta-hydroxysteroid dehydrogenases in ACTH-deficient patients
    B R Walker
    University of Edinburgh, Department of Medicine, Western General Hospital, UK
    Clin Endocrinol (Oxf) 49:257-63. 1998
  5. ncbi request reprint Distribution of glucocorticoid and mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenases in human and rat ocular tissues
    J Stokes
    Department of Medicine, University of Edinburgh, Western General Hospital, Scotland
    Invest Ophthalmol Vis Sci 41:1629-38. 2000
  6. ncbi request reprint Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors
    R M Reynolds
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 86:245-50. 2001
  7. ncbi request reprint Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease
    J L W Yau
    Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Neuroscience 121:307-14. 2003
  8. pmc Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with Type 2 diabetes with and without fatty liver
    D P Macfarlane
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 307:G760-8. 2014
  9. pmc 5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects
    C Yang
    Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Br J Pharmacol 164:1661-71. 2011
  10. ncbi request reprint Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases
    M J Finken
    University of Edinburgh, Department of Medical Sciences, Western General Hospital, United Kingdom
    J Clin Endocrinol Metab 84:3316-21. 1999

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Cortisol secretion and rate of bone loss in a population-based cohort of elderly men and women
    R M Reynolds
    Endocrinology Unit, University of Edinburgh, Queens Medical Research Institute, EH16 4TJ Edinburgh, UK
    Calcif Tissue Int 77:134-8. 2005
    ..These data provide evidence that circulating endogenous glucocorticoids influence the rate of involutional bone loss in healthy individuals...
  2. ncbi request reprint Glucocorticoid metabolism and the Metabolic Syndrome: associations in an elderly cohort
    R Andrew
    Endocrinology Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU
    Exp Clin Endocrinol Diabetes 110:284-90. 2002
    ..We have investigated relationships between glucocorticoid production and features of the Metabolic Syndrome in a cohort of elderly subjects...
  3. ncbi request reprint Increased glucocorticoid activity in men with cardiovascular risk factors
    B R Walker
    University of Edinburgh, Department of Medicine, Western General Hospital, UK
    Hypertension 31:891-5. 1998
    ..It may be mediated by an abnormal glucocorticoid receptor, and it may contribute to the association between hypertension and insulin resistance...
  4. ncbi request reprint Growth hormone replacement inhibits renal and hepatic 11 beta-hydroxysteroid dehydrogenases in ACTH-deficient patients
    B R Walker
    University of Edinburgh, Department of Medicine, Western General Hospital, UK
    Clin Endocrinol (Oxf) 49:257-63. 1998
    ..In this study, we examined the effects of GH replacement on cortisol metabolism...
  5. ncbi request reprint Distribution of glucocorticoid and mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenases in human and rat ocular tissues
    J Stokes
    Department of Medicine, University of Edinburgh, Western General Hospital, Scotland
    Invest Ophthalmol Vis Sci 41:1629-38. 2000
    ....
  6. ncbi request reprint Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors
    R M Reynolds
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 86:245-50. 2001
    ..This may be an important mechanism underpinning the effects of events in early life on later cardiovascular disease...
  7. ncbi request reprint Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease
    J L W Yau
    Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Neuroscience 121:307-14. 2003
    ..05) in dentate neurons from AD subjects compared with controls. A decline in CYP7B activity may contribute the loss of effects of DHEA with ageing and perhaps to the pathophysiology of AD...
  8. pmc Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with Type 2 diabetes with and without fatty liver
    D P Macfarlane
    University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 307:G760-8. 2014
    ..Glucocorticoid blockade had similar effects in those with and without high liver fat. Longer term treatments targeting glucocorticoid action may be useful in Type 2 diabetes with and without fatty liver...
  9. pmc 5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects
    C Yang
    Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Br J Pharmacol 164:1661-71. 2011
    ..5α-Tetrahydro-corticosterone (5αTHB), produced from corticosterone by 5α-reductases, activates glucocorticoid receptors. This study compares the effects of 5αTHB on inflammation and metabolism in vitro and in vivo...
  10. ncbi request reprint Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases
    M J Finken
    University of Edinburgh, Department of Medical Sciences, Western General Hospital, United Kingdom
    J Clin Endocrinol Metab 84:3316-21. 1999
    ..A-Ring reductases may have an equally important influence on metabolic clearance of cortisol and intracellular cortisol concentrations...
  11. ncbi request reprint Increased glucocorticoid production and altered cortisol metabolism in women with mild to moderate Alzheimer's disease
    S Rasmuson
    Department of Geriatric Medicine, , , Sweden
    Biol Psychiatry 49:547-52. 2001
    ..CONCLUSIONS: An increased glucocorticoid production is an early feature of Alzheimer's disease and may be secondary to enhanced metabolic clearance of cortisol by A-ring reduction...
  12. ncbi request reprint Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women
    J H Goedecke
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
    Clin Endocrinol (Oxf) 65:81-7. 2006
    ....
  13. ncbi request reprint Tissue-specific dysregulation of cortisol metabolism in human obesity
    E Rask
    Departments of Public Health and Clinical Medicine, , Sweden
    J Clin Endocrinol Metab 86:1418-21. 2001
    ....
  14. ncbi request reprint Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study
    E J Brunner
    International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, England
    Circulation 106:2659-65. 2002
    ..We examine reversibility and the power of psychosocial and behavioral factors to explain the neuroendocrine adaptations that accompany MS...
  15. ncbi request reprint Glucocorticoid metabolism and adrenocortical reactivity to ACTH in myotonic dystrophy
    R Andrew
    Department of Public Health, , , Sweden
    J Clin Endocrinol Metab 86:4276-83. 2001
    ..These disturbances may explain altered circulating cortisol levels and contribute to features of the metabolic syndrome in myotonic dystrophy...
  16. ncbi request reprint In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue
    J Sutinen
    Division of Diabetes, Department of Medicine, University of Helsinki, Helsinki, Finland
    Diabetologia 47:1668-71. 2004
    ....