Genomes and Genes
University of Manchester
Organization: University of Manchester
- Identification of early predictive imaging biomarkers and their relationship to serological angiogenic markers in patients with ovarian cancer with residual disease following cytotoxic therapyC L Mitchell
Cancer Research UK, Department of Medical Oncology, Christie Hospital and University of Manchester, Manchester, UK
Ann Oncol 21:1982-9. 2010..A subgroup of patients provided plasma samples within which a panel of angiogenic biomarkers was quantified...
- Constructing diffeomorphic representations of non-rigid registrations of medical imagesCarole Twining
Imaging Science and Biomedical Engineering, University of Manchester Manchester M13 9PT, UK
Inf Process Med Imaging 18:413-25. 2003..Furthermore, we show that the non-Euclidean metric inherent in this representation is superior to the usual ad hoc Euclidean metrics in that it enables more accurate classification of legal and illegal variations...
- Hereditary spherocytosis; new guidelinesP H B Bolton-Maggs
Department of Clinical Haematology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
Arch Dis Child 89:809-12. 2004
- Autoassociator networks: insights into infant cognitionSylvain Sirois
Department of Psychology, University of Manchester, UK
Dev Sci 7:133-40. 2004..A new, modular approach is presented in a third section. In the discussion, a role for these learning models in a broader developmental framework is proposed...
- The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregationStephen S Taylor
School of Biological Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
Chromosome Res 12:599-616. 2004..This article provides a brief historical overview before focusing on some of the outstanding issues and more recent developments in the field...
- Evaluation of a bedside blood ketone sensor: the effects of acidosis, hyperglycaemia and acetoacetate on sensor performanceA S A Khan
Department of Diabetes and Endocrinology, Hope Hospital, Stott Lane, Salford M6 8HD, UK
Diabet Med 21:782-5. 2004..To assess the performance of a handheld bedside ketone sensor in the face of likely metabolic disturbances in diabetic ketoacidosis, namely: pH, glucose and acetoacetate...
- Sex hormone patterns and serum retinol concentrations in adolescent girlsLoretta Brabin
Departments of Obstetrics and Gynaecology and Reproductive Health Care and of Epidemiology and Health Sciences, University of Manchester, Manchester, U K
J Reprod Med 49:41-51. 2004..To describe the pattern and relation of sex serum hormones and retinol concentrations over 1 menstrual cycle in adolescent girls living in a resource-poor setting...
- Emergency department management and outcome for self-poisoning: a cohort studyNavneet Kapur
Centre for Suicide Prevention, Department of Psychiatry and Behavioural Sciences, 7th Floor Williamson Building, University of Manchester, Oxford Road, M13 9PL, Manchester, UK
Gen Hosp Psychiatry 26:36-41. 2004..The implications of this finding are discussed. Further studies using both cohort and randomized controlled study designs will help inform management strategies for patients who poison themselves...
- Hyperinsulinism in infancy: from basic science to clinical diseaseMark J Dunne
Research Division of Physiology and Pharmacology, The School of Biological Sciences, University of Manchester, Manchester, United Kingdom
Physiol Rev 84:239-75. 2004....
- The organisation and re-organisation of human swallowing motor cortexShaheen Hamdy
Clinical Sciences Building, Department of GI Sciences, Hope Hospital, Eccles Old Road, Salford M6 8HD, UK
Suppl Clin Neurophysiol 56:204-10. 2003
- Seasonal variation of total dissolved arsenic and arsenic speciation in a polluted surface waterwayAndrew G Gault
Department of Earth Sciences, University of Manchester, M13 9PL, Manchester, UK
Environ Geochem Health 25:77-85. 2003..Deviations from conservative behaviour were more marked during the relatively dry April 2000 sampling period and suggest the increased importance of adsorption processes controlling arsenic availability during this time...
- Class solutions for conformal external beam prostate radiotherapyVincent S Khoo
Academic Unit of Radiotherapy and Oncology, Sutton, Surrey, United Kingdom
Int J Radiat Oncol Biol Phys 55:1109-20. 2003..To determine a class solution coplanar plan from comparisons of three-field (3F), four-field (4F), and six-field (6F) plans in conformal non-intensity-modulated prostate radiotherapy...
- Direct restorative material use of selected practitioners in the United KingdomPaul A Brunton
Unit of Integrated Restorative Care, University Dental Hospital of Manchester, Higher Cambridge Street, Manchester M15 6FH
Prim Dent Care 9:133-7. 2002..To investigate, by questionnaire, the direct restorative materials used by a sample of practitioners from the United Kingdom...
- Lack of change in trauma care in England and Wales since 1994F E Lecky
Trauma Audit and Research Network, University of Manchester, Salford, Manchester, UK
Emerg Med J 19:520-3. 2002..To demonstrate trends in trauma care in England and Wales from 1989 to 2000...
- Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?A Paul Mould
Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
Curr Opin Cell Biol 16:544-51. 2004..This conformational complexity is likely to permit fine-tuning of integrin function through regulation of ligand-binding affinity and intracellular signalling...
- A demonstration of pattern formation without positional information in DictyosteliumChristopher R L Thompson
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, England
Dev Growth Differ 46:363-9. 2004....
- Blood pressure and the cystic fibrosis gene: evidence for lower pressure rises with age in female carriersMaurice Super
Department of Clinical Genetics, Royal Manchester Children s Hospital, Manchester, United Kingdom
Hypertension 44:878-83. 2004..This could result in significant reduction in stroke and heart disease. The effect on blood pressure is insufficient to prevent hypertension, though it remains conceivable that the severity might be ameliorated in carriers...
- An introduction to artificial neural networks in bioinformatics--application to complex microarray and mass spectrometry datasets in cancer studiesLee J Lancashire
Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK
Brief Bioinform 10:315-29. 2009....
- CD4+ T-cell recognition of human 5T4 oncofoetal antigen: implications for initial depletion of CD25+ T cellsEyad Elkord
Department of Immunology, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Cancer Immunol Immunother 57:833-47. 2008..We have recently shown that CD8(+) T cells recognizing h5T4 can be generated in the absence of CD4(+) T cells from peripheral blood lymphocytes of human healthy individuals...
- Quantification of dental fluorosis using fluorescence imagingI A Pretty
Dental Health Unit, University of Manchester, Manchester, UK
Caries Res 40:426-34. 2006..862). The fluorescence imaging method shows promise as an objective, potentially blinded system for the longitudinal assessment of enamel fluorosis in vivo...
- Alternans of intracellular calcium: mechanism and significanceDavid A Eisner
Unit of Cardiac Physiology, The University of Manchester, UK
Heart Rhythm 3:743-5. 2006
- The dynamic nature of mollusc egg surface architecture and its relation to the microtubule networkSheena E B Tyler
Faculty of Life Sciences, University of Manchester, England
Int J Dev Biol 50:405-12. 2006....
- Integrating non-drug treatments in early schizophreniaShon W Lewis
Division of Psychiatry, University of Manchester, Second Floor, Education and Research Centre, Wythenshaw Hospital, Manchester M23 9LT, UK
Br J Psychiatry Suppl 48:s65-71. 2005..Many trials of psychological treatments have design flaws and this tends to overestimate the treatment effect...
- Demonstration of histamine H1 and H2 receptors in chondrocytes of human osteoarthritic cartilageL C Tetlow
University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
Inflamm Res 54:S74-5. 2005
- Validity of the HSE stress tool: an investigation within four organizations by the Corporate Health and Performance GroupChris Main
University of Manchester, Manchester M20 3JQ, UK
Occup Med (Lond) 55:208-14. 2005..To examine the validity and accuracy of the HSE Management Standards Stress Tool...
- Neglect of dropout underestimates effects of death in longitudinal studiesPatrick Rabbitt
University of Manchester, Age and Cognitive Performance Research Centre, Zochonis Building, Brook St, Manchester, M13, 9PL, UK
J Gerontol B Psychol Sci Soc Sci 60:P106-9. 2005..Thus the effects of terminal decline, or indeed of any other variable affecting cognitive performance, are miscalculated if dropout is ignored...
- Clinical teachers and problem-based learning: a phenomenological studyTim Dornan
Hope Hospital, University of Manchester School of Medicine, Stott Lane, Salford, Manchester M6 8HD, UK
Med Educ 39:163-70. 2005..To explore how clinicians perceive their roles in problem-based medical education, and how closely those perceptions link to the curriculum they teach...
- Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCRH A Lacey
Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
Placenta 26:93-8. 2005..The expression of NHE and AE in the villous placenta is not altered concomitant with the onset of maternal blood flow. However, NHE2 transcripts appear to be gestationally regulated, which may contribute to changes in NHE activity...
- Risk and supervised exercise: the example of anorexia to illustrate a new ethical issue in the traditional debates of medical ethicsS Giordano
Centre for Social Ethics and Policy CSEP Institute of Medicine, Law and Bioethics IMLAB, The University of Manchester, The School of Law, Williamson Building, Oxford Road, Manchester M13 9PL, UK
J Med Ethics 31:15-20. 2005..However, the paper also explains why, despite these apparently cogent ethical reasons, there is no moral obligation to allow a person with anorexia to take part in exercise/sports activities...
- Developing methods for systematic reviewing in health services delivery and organization: an example from a review of access to health care for people with learning disabilities. Part 2. Evaluation of the literature--a practical guideAlison Alborz
National Primary Care Research and Development Centre, University of Manchester, Manchester, UK
Health Info Libr J 21:227-36. 2004..To develop methods to facilitate the 'systematic' review of evidence from a range of methodologies on diffuse or 'soft' topics, as exemplified by 'access to health care'...
- Dialysis bone diseaseJudith Elizabeth Adams
Imaging Science and Biomedical Engineering, University of Manchester, England
Semin Dial 15:277-89. 2002..Technical developments in computed tomography (rapid, multislice scanning) allow quantitation and monitoring of metastatic cardiac calcification in patients on hemodialysis, which has relevance to prognosis...
- Sperm DNA damage and cancer treatmentIan D Morris
School of Biological Sciences, University of Manchester, Manchester, UK
Int J Androl 25:255-61. 2002..The institution of better surveillance of genetic disease in the offspring of men surviving cytotoxic therapies may provide more robust risk assessment...
- Apoptosis and cancer chemotherapyG Makin
CRC Molecular and Cellular Pharmacology Group, School of Biological Sciences, University of Manchester, UK
Cell Tissue Res 301:143-52. 2000..These proteins may thus represent a logical target for new approaches to overcoming drug resistance...
- Membrane transport: tethers and TRAPPsM Lowe
School of Biological Sciences, University of Manchester, M13 9PT, UK
Curr Biol 10:R407-9. 2000..Transport vesicles are tethered to their target membrane prior to the interaction of v-SNAREs and t-SNAREs across the membrane junction. Recent evidence suggests tethering is a complex process requiring multiple components...
- Light intensity effects on resin-composite degree of conversion and shrinkage strainN Silikas
University of Manchester Dental School, Manchester, UK
Dent Mater 16:292-6. 2000..The aim of this study was to investigate the relationship between the degree of conversion (DC) and shrinkage strain values of two representative resin-composites when irradiated by two light intensity levels, for different time periods...
- An evaluation of a training programme in primary care research for general dental practitionersA S Blinkhorn
University Dental Hospital, Manchester
Br Dent J 188:333-6. 2000..To determine whether general dental practitioners would find seminars on research methods in primary care research of interest and whether they would be stimulated to plan their own research...
- Cytotoxicity of cyanoacrylate adhesives to cultured tendon cellsC E Evans
Department of Orthopaedic Surgery, University of Manchester, UK
J Hand Surg Br 24:658-61. 1999..This study shows that such adhesives in their present state may not be suitable for re-joining cut tendons as their initial and long-term toxicity may hinder the slow healing process of tendons...
- Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenograftsM R Middleton
Cancer Research Campaign Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK
Cancer Chemother Pharmacol 45:15-20. 2000....
- A short-term clinical evaluation of a tricure glass-ionomer system as a transitional restoration and core buildup materialN H Wilson
Department of Restorative Dentistry, Turner Dental School, University Dental Hospital of Manchester, England
Quintessence Int 30:405-11. 1999..A general dental practice study investigated the use of a resin-modified glass ionomer material as a transitional restoration and as a core buildup material. The study also assessed a resin-modified glass-ionomer luting system...
- Airway closure: occluding liquid bridges in strongly buckled elastic tubesM Heil
DAMTP, University of Cambridge, United Kingdom
J Biomech Eng 121:487-93. 1999..Buckling is shown to occur over a short axial length with moderate circumferential wavenumbers. Finally, further implications of the results for the airway collapse/reopening problem are discussed...
- Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer?S A Roberts
Cancer Research Campaign Biomathematics and Computing Unit, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 4BX, United Kingdom
Am J Hum Genet 65:784-94. 1999..Novel genes involved in predisposition to breast cancer can now be sought through linkage studies using this quantitative trait...
- Thesauri and formal classifications: terminologies for people and machinesA L Rector
Department of Computer Science, University of Manchester, UK
Methods Inf Med 37:501-9. 1998..The test of the resulting terminologies is how well they support software for key functions: including data entry, information retrieval, mediation, indexing, and authoring...
- Radiation-induced p53 and p21WAF-1/CIP1 expression in the murine intestinal epithelium: apoptosis and cell cycle arrestJ W Wilson
CRC Epithelial Biology Laboratory, Paterson Institute for Cancer Research, Manchester, United Kingdom
Am J Pathol 153:899-909. 1998..The differential expression of p21WAF-1/CIP1, observed between the large and small bowel and within the small intestinal crypts, is discussed...
- A critical role for IL-13 in resistance to intestinal nematode infectionA J Bancroft
School of Biological Science, University of Manchester, United Kingdom
J Immunol 160:3453-61. 1998..The IL-13 KO mouse had a separate phenotype to that of the IL-4 KO mouse, suggesting that both IL-4 and IL-13 play important yet different roles in mediating immunity to intestinal helminths...
- Estrogen sensitivity of normal human breast tissue in vivo and implanted into athymic nude mice: analysis of the relationship between estrogen-induced proliferation and progesterone receptor expressionR B Clarke
Clinical Research Department, Christie Hospital NHS Trust, Withington, Manchester, UK
Breast Cancer Res Treat 45:121-33. 1997....
- Heparin and heparan sulfate bind interleukin-10 and modulate its activityS Salek-Ardakani
CRC Molecular Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK
Blood 96:1879-88. 2000..Taken together, these findings support the hypothesis that soluble and cell-surface GAG and, in particular, their sulfate groups are important in binding and modulation of hIL-10 activity. (Blood. 2000;96:1879-1888)..
- Docking domains and substrate-specificity determination for MAP kinasesA D Sharrocks
School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester, UK M13 9PT
Trends Biochem Sci 25:448-53. 2000..Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further...
- Elderly drivers and their accidents: the Aging Driver QuestionnaireD Parker
Department of Psychology, University of Manchester, UK
Accid Anal Prev 32:751-9. 2000..Relatively high scores on the error factor and the lapse factor were predictive of involvement in an active accident, while passive accident involvement was associated with high scores on the lapse factor...
- Stimulated production of vowel-like LX-waveforms and spectral damping in the absence of phonationChristopher Moore
North Western Medical Physics, Christie Hospital, Manchester, UK
Med Eng Phys 24:461-5. 2002..It is postulated that this is initial evidence suggesting that both pressure waves and vocal fold contact components contribute to the production of the classical 'LX' waveform...
- Effect of deproteination on bone mineral morphology: implications for biomaterials and agingD H Carter
Unit of Oral Pathology, Turner Dental School, University of Manchester, Manchester, UK
Bone 31:389-95. 2002..This marked change may also provide preliminary insight into a more modest natural aging phenomenon with the localized lateral fusion of calcified filaments into less flexible, more immunologically reactive fenestrated plates...
- The role of oestrogen and progesterone receptors in human mammary development and tumorigenesisElizabeth Anderson
Tumour Biochemistry Laboratory, Christie Hospital NHS Trust, Manchester, UK
Breast Cancer Res 4:197-201. 2002....
- The clinical development of the bryostatinsA Clamp
Cancer Research UK Department of Medical Oncology, Christie Hospital NHS Trust, Manchester M20 4BX, UK
Anticancer Drugs 13:673-83. 2002..Preliminary results of phase I studies support these observations but further work needs to be done to define the future role of the bryostatins in the clinic...
- Sequence analysis of MHC DRB alleles in domestic cats from the United KingdomLorna J Kennedy
Mammalian Immunogenetics Research Group, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool, L69 7ZJ, UK
Immunogenetics 54:348-52. 2002..Analysis of these 24 alleles reveals a similar pattern of MHC polymorphism to that seen in other mammals, with three regions of hypervariability...
- Assessment of three methods of pH probe positioning in preterm infantsAnthony J B Emmerson
Neonatal Medical Unit, St Mary s Hospital, Whitworth Park, Manchester, UK
J Pediatr Gastroenterol Nutr 35:69-72. 2002..Accepted modes of assessing correct positioning can be problematic in this population of infants and alternative methods were investigated...
- Implementing clinical governance in English primary care groups/trusts: reconciling quality improvement and quality assuranceS M Campbell
National Primary Care Research and Development Centre, University of Manchester, Manchester M13 9PL, UK
Qual Saf Health Care 11:9-14. 2002..To investigate the concept of clinical governance being advocated by primary care groups/trusts (PCG/Ts), approaches being used to implement clinical governance, and potential barriers to its successful implementation in primary care...
- Interactions of the female hormonal environment, susceptibility to viral infections, and disease progressionLoretta Brabin
Academic Unit of Obstetrics and Gynaecology and Reproductive Health Care, University of Manchester, Manchester, United Kingdom
AIDS Patient Care STDS 16:211-21. 2002..Clinicians with patients at high risk of sexually transmitted infections, especially HIV, require better information on the risks associated with different hormonal contraceptive regimes...
- Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptorAndrew P Gilmore
School of Biological Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom
J Biol Chem 277:27643-50. 2002..Our results indicate that by targeting a growth factor-mediated survival signaling pathway, BAD phosphorylation can be manipulated therapeutically to induce apoptosis...
- Pseudoachondroplasia and multiple epiphyseal dysplasia: mutation review, molecular interactions, and genotype to phenotype correlationsMichael D Briggs
Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Manchester, UK
Hum Mutat 19:465-78. 2002....
- Cytokines and acute neurodegenerationS M Allan
School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
Nat Rev Neurosci 2:734-44. 2001..Understanding cytokine action in acute neurodegeneration could lead to novel and effective therapeutic strategies, some of which are already in clinical trials...
- 'What do our patients really want from us?': Investigating patients perceptions of the validity of the Chartermark criteriaM L Crossley
Turner Dental School, University of Manchester
Br Dent J 190:602-6. 2001..One of the ways in which quality care has been assessed within NHS Trusts is through the national 'Chartermark' award, which identifies national centres of excellence in health care and research...
- Determination of U-236 in sediment samples by accelerator mass spectrometryO J Marsden
Department of Chemistry, University of Manchester, Manchester, UK M13 9PL
Analyst 126:633-6. 2001..Uncertainties based on propagation of measurement errors were less than +/- 10% although +/- 15% is perhaps a more realistic estimate of overall uncertainty...
- What will a primary care led NHS mean for GP workload? The problem of the lack of an evidence baseL L Pedersen
National Primary Care Research and Development Centre, University of Manchester
BMJ 314:1337-41. 1997..Lack of evidence does not, however, mean that there is no problem with workload. It will be increasingly important to identify mechanisms for ensuring that resources follow workload...
- 2005 Elastin and Elastic Fibers Gordon ConferenceCATHERINE KIELTY; Fiscal Year: 2005..As in past years, these personal interactions will result in new collaborative studies and stimulate novel avenues of elastic fiber investigation. ..
- Protocol for Multicentre Trials of Cleft Palate SurgeryWilliam Shaw; Fiscal Year: 2005..abstract_text> ..
- Targeted mouse models for studying skeletal dysplasiaMichael Briggs; Fiscal Year: 2005..abstract_text> ..