Genomes and Genes
University of Liverpool
Organization: University of Liverpool
- Chromatographic determination of solubilities in superheated waterNeil Jones
Department of Chemistry, Centre for Materials Discovery, University of Liverpool, Liverpool, UK
J Sep Sci 33:3107-9. 2010..To validate the procedure, measurements of k were made between 100 and 200°C for toluene and correlated with literature solubilities; the solubilities at 170°C of a number of related aromatics were then determined from their k-values...
- Microdialysis as a window on interstitial reactive oxygen species in human tissues? A commentary on "Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA cMalcolm J Jackson
School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
Free Radic Biol Med 43:351-2. 2007
- The interface between biomaterials science and biotechnologyDavid Williams
University of Liverpool, UK
Med Device Technol 18:8, 10. 2007..Similarly, biomaterials science has moved forward from implantable medical device technology to drug and gene delivery and tissue engineering. It was perhaps inevitable that they should eventually meet...
- Hospital deaths in Sweden: are individual socioeconomic factors relevant?Barbara Hanratty
Division of Public Health, University of Liverpool, Liverpool, United Kingdom
J Pain Symptom Manage 33:317-23. 2007..In health systems wishing to reduce an already low proportion of deaths in acute hospitals, enhancing palliative and social support for older patients and people with noncancer diagnoses may merit attention...
- Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoproteinRuben C Hartkoorn
Department of Pharmacology and Therapeutics, University of Liverpool, 70 Pembroke Place, Liverpool L69 3GF, UK
Tuberculosis (Edinb) 87:248-55. 2007....
- Rat strain-related differences in myocardial adrenergic tone and the impact on cardiac fibrosis, adrenergic responsiveness and myocardial structure and functionOleg Osadchii
Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa
Pharmacol Res 55:287-94. 2007..In conclusion, rat strain-related differences in cardiac adrenergic tone do indeed exist, but in young animals these differences do not translate into cardiac phenotypes known to contribute to progressive cardiac dysfunction...
- HIV self-testing: a time to revise current policyLucy Frith
Division of Primary Care, University of Liverpool, Whelan Building, Brownlow Hill, Liverpool L69 3GB, UK
Lancet 369:243-5. 2007
- Apo calmodulin binding to the L-type voltage-gated calcium channel Cav1.2 IQ peptideLu Yun Lian
School of Biological Sciences, The University of Liverpool, P O Box 147, Liverpool L69 7ZB, UK
Biochem Biophys Res Commun 353:565-70. 2007..In addition, we have employed transmission electron microscopy of purified LTCC complexes which shows that both apoCaM and Ca2+CaM can bind to the intact channel...
- Lymphomas involving the eye and the ocular adnexaSarah E Coupland
Department of Pathology, Royal Liverpool Hospital, Liverpool, England, UK
Curr Opin Ophthalmol 17:523-31. 2006..To describe recent advances in the understanding of the pathogenesis of the most common malignant lymphomas that occur as primary and secondary tumors in ocular tissues...
- Material surfaces and MRSADavid Williams
Clinical Engineering Department, Royal Liverpool University Hospital, UK
Med Device Technol 17:8-9. 2006..In this article, some of the new materials related solutions to these threats are discussed..
- The pathophysiology of the hairy cellJ C Cawley
Department of Haematology, University of Liverpool, Third Floor Duncan Building, Daulby Street, Liverpool L69 3GA, UK
Hematol Oncol Clin North Am 20:1011-21. 2006..The signals that are responsible for several of the phenotypic features of HCs have been identified, but the nature of the underlying oncogenic events remains unknown...
- Postanaesthetic tracheal strictures in three rabbitsN J Grint
Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol, BS40 5DU, UK
Lab Anim 40:301-8. 2006..Iatrogenic tracheitis should be considered as a cause of dyspnoea, when clinical signs arise 2-3 weeks after anaesthesia...
- Free radical generation by skeletal muscle of adult and old mice: effect of contractile activityA Vasilaki
Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverppol L69 3GA, UK
Aging Cell 5:109-17. 2006..Thus, contractile activity increased skeletal muscle ROS generation in both adult and old mice with no evidence for an age-related exacerbation of ROS generation...
- Change of refractive state and eye size in children of birth weight less than 1701 gA R O'Connor
Division of Orthoptics, Thompson Yates Building, Quadrangle, University of Liverpool, Liverpool L69 3GB, UK
Br J Ophthalmol 90:456-60. 2006..To determine the refractive status and ocular dimensions of a cohort of children at age 10-12 years with birth weight below 1701 g, and also the relation between the neonatal ophthalmic findings and subsequent refractive state...
- Putting equity center stage: challenging evidence-free reformsMargaret Whitehead
Division of Public Health, University of Liverpool, United Kingdom
Int J Health Serv 37:353-61. 2007....
- Association between sputum smear status and local immune responses at the site of disease in HIV-infected patients with pulmonary tuberculosisHenry C Mwandumba
Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Box 30096, Blantyre 3, Malawi
Tuberculosis (Edinb) 88:58-63. 2008..The local immune responses may affect the clinical presentation of active pulmonary TB in HIV-infected patients...
- A survey of users of a dental access centre situated in an area of mixed socioeconomic affluence and deprivationRebecca Harris
Liverpool University School of Dentistry, UK
Prim Dent Care 14:157-62. 2007..To describe the users of a Dental Access Centre (DAC) situated in an area of England with a mixed socioeconomic profile, their pattern of use, and their perception of the role of the service...
- Detecting interspecific macroparasite interactions from ecological data: patterns and processAndy Fenton
School of Biological Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK
Ecol Lett 13:606-15. 2010..However, application of the GLMM approach may provide a more robust method of detection for these potentially important interspecific interactions from ecological data...
- Noise levels required to mask stimuli used in auditory brainstem response testingGuy Lightfoot
Department of Medical Physics and Clinical Engineering, Royal Liverpool University Hospital, Liverpool, UK
Int J Audiol 49:794-8. 2010..This value is recommended when calculating the level of noise necessary to prevent cross-hearing during ABR testing...
- Multiple sclerosis-related central pain disordersTuro J Nurmikko
Neuroscience Research Unit, Clinical Sciences Centre, Lower Lane, Liverpool, L9 7AL, UK
Curr Pain Headache Rep 14:189-95. 2010..Overall, the lack of controlled clinical trials, together with our limited understanding of the pathophysiological mechanisms involved, form a hindrance to a systematic and rational management of MS-related pain...
- The use of misoprostol in obstetrics and gynaecologyA Elati
School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, UK
BJOG 116:61-9. 2009..Evidence-based information about the safest regimens for multiple pregnancy indications are therefore provided in this review...
- A meta-analytic investigation of the relationship between attentional bias and subjective craving in substance abuseMatt Field
School of Psychology, University of Liverpool, Liverpool, UK
Psychol Bull 135:589-607. 2009..These results suggest that attentional bias and craving are related phenomena, although the relationship is generally modest and appears to be moderated by various factors. Theoretical implications are discussed...
- Unlocking ylide reactivity in the metal-catalyzed allylic substitution reaction: stereospecific construction of primary allylic amines with aza-ylidesP Andrew Evans
Department of Chemistry, The University of Liverpool, Liverpool, L69 7ZD, UK
J Am Chem Soc 131:8722-3. 2009..Overall, this work provides an opportunity to investigate the utility of this new class of nucleophiles in related metal-catalyzed reactions...
- Risk factors for the occurrence of Escherichia coli virulence genes eae, stx1 and stx2 in wild bird populationsL A Hughes
National Centre for Zoonosis Research, University of Liverpool, Leahurst, Neston, Cheshire, UK
Epidemiol Infect 137:1574-82. 2009..This, coupled with their ability to act as long-distance vectors of STEC, means that wild birds have the potential to influence the spread and evolution of STEC...
- Suitability of simple human immunodeficiency virus rapid tests in clinical trials in community-based clinic settingsDean B Everett
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
J Clin Microbiol 47:1058-62. 2009..9 to 100%), and 100% for the parallel SR (95% CI, 99.4 to 100%). SR tests are suitable for use in community-based clinical research settings to assess eligibility both for trial participation and for the provision of on-site VCT services...
- Mental health in the tropicsA Rahman
Division of Psychiatry, School of Population, Community and Behavioural Sciences, University of Liverpool, Child Mental Health Unit, Alder Hey Children s NHS Foundation Trust, Mulberry House, Eaton Road, Liverpool L12 2AP, U K
Ann Trop Med Parasitol 103:95-110. 2009..Most of all, there needs to be awareness amongst health providers and planners that mental health is an integral part of general health concerns, and that there can be no health without mental health...
- Leishmania sand fly interaction: progress and challengesPaul A Bates
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK
Curr Opin Microbiol 11:340-4. 2008..Further, the parasites can manipulate the behaviour of the vector to maximise their transmission, and flies may even deliver altruistic apoptotic forms to aid transmission of infective stages...
- Living and working with sickness: a qualitative studySuzanne Edwards
Division of Primary Care, School of Population, Community and Behavioural Sciences, University of Liverpool, Liverpool L69 3GB, UK
Chronic Illn 3:155-66. 2007..To explore patients' views and experiences of long-term sickness absence, and their attitudes with regard to return to work...
- Density-driven generalized regression neural networks (DD-GRNN) for function approximationJohn Y Goulermas
Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool L69 3GJ, UK
IEEE Trans Neural Netw 18:1683-96. 2007....
- The influence of temperature on the development, hatching and survival of Nematodirus battus larvaeJ Van Dijk
School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
Parasitology 135:269-83. 2008..Probable changes and adaptations of parasite behaviour in the temperate regions, and the driving forces behind them, are discussed, as well as factors affecting persistence and geographical spread against a background of climate change...
- Are there any real differences between enteral feed formulations used in the critically ill?Thomas Bongers
ICU Whiston Hospital and School of Clinical Science, University of Liverpool, Liverpool, UK
Curr Opin Crit Care 12:131-5. 2006..The purpose of this review is to highlight recent advances in enteral nutrition in the critically ill adult patient...
- Warning displays in spiny animals: one (more) evolutionary route to aposematismMichael P Speed
School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, United Kingdom
Evolution 59:2499-508. 2005..Finally, one (more) route by which aposematism may initially evolve is by spiny rather than purely chemically defended species, spreading to species with other forms of secondary defense as the signal becomes common...
- The use of silicon gel for treating children's burn scars in Saudi Arabia: a case studyCary A Brown
Division of Occupational Therapy, University of Liverpool, UK
Occup Ther Int 9:121-30. 2002..Further research with a wider sample is indicated, given the high incidence of childhood burn injuries in Saudi Arabia...
- Biological, psychological and social processes in the conduct disordersJonathan Hill
Liverpool University, UK
J Child Psychol Psychiatry 43:133-64. 2002..It considers the relative merits of several different ways of conceptualising such problems, in relation to the contribution of biological, psychological and social factors...
- Treatment of oesophago-gastric tumoursK Leiper
Department of Gastroenterology, Royal Liverpool University Hospital, Liverpool, United Kingdom
Endoscopy 34:139-45. 2002..Long-term follow up of these patients is required because of high rates of metachronous tumour formation and at present there are no randomised trial data comparing endoscopic mucosal resection with conventional surgery...
- Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytesA Mobasheri
Connective Tissue Research Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, United Kingdom
Cell Biol Int 26:1-18. 2002....
- ASCOT: a comprehensive clinical database for gastro-oesophageal cancer surgeryJ Cummins
University Department of Surgery, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
Eur J Surg Oncol 27:709-13. 2001..The collection of detailed comparable data, including co-morbidity evaluation, on a large scale is likely to prove valuable for unit specialist accreditation, surgeon re-validation, audit and research...
- Inflammatory mediators as therapeutic targets in acute pancreatitisM Bhatia
Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, UK
Curr Opin Investig Drugs 2:496-501. 2001..Elucidation of the key mediators in acute pancreatitis coupled with the discovery of specific inhibitors may make it possible to develop clinically effective anti-inflammatory therapy...
- A clinical minimum data set for primary dental careR S Ireland
University of Liverpool, Liverpool Dental Hospital and School of Dentistry
Br Dent J 190:663-7. 2001..To achieve consensus within primary dental care on the contents of a clinical minimum data set to measure oral health status...
- An exploration of midwives' and obstetricians' knowledge of genetic screening in pregnancy and their perception of appropriate counsellingR Bramwell
Department of Clinical Psychology, University of Liverpool, Whelan Building, Brownlow Hill, Liverpool, L69 3BX, UK
Midwifery 17:133-41. 2001....
- Self-discrepancies and causal attributions: studies of hypothesized relationshipsP Kinderman
Department of Clinical Psychology, University of Liverpool, UK
Br J Clin Psychol 39:255-73. 2000..They show that self-representations and causal attributions are closely coupled cognitive domains. The results also suggest that paranoid ideation might be specifically associated with external-personal attributions for negative events...
- Temperature elevation regulates iron protoporphyrin IX and hemoglobin binding by Porphyromonas gingivalisJ W Smalley
Unit of Oral Biology, Department of Clinical Dental Sciences, The Edwards Building, The University of Liverpool, Liverpool L69 3GN, UK
Curr Microbiol 41:328-35. 2000..The increased binding of mu-oxo bishaem and monomeric forms of FePPIX at 39 degrees C may reflect a defense strategy against reactive oxidants and a mechanism of dampening down the inflammatory response to maintain an ecological balance...
- Enamel demineralisation assessed by computerised image analysis of clinical photographsP E Benson
Cariology Research Group, Department of Clinical Dental Sciences, University of Liverpool, Liverpool, UK
J Dent 28:319-26. 2000....
- The effect of prior experience on recognition thresholds for plane-disoriented pictures of familiar objectsR Lawson
Department of Psychology, University of Liverpool, England
Mem Cognit 27:751-8. 1999..The results bridge the findings from unspeeded verification and speeded naming tasks. They suggest that the same orientation-sensitive processes are tapped in both cases, and that practice effects on these processes are object specific...
- Effects on the hepatocyte [Ca2+]i oscillator of inhibition of the plasma membrane Ca2+ pump by carboxyeosin or glucagon-(19-29)A K Green
Department of Human Anatomy and Cell Biology, University of Liverpool, UK
Cell Calcium 22:99-109. 1997..Furthermore, we demonstrate that inhibition of the hepatocyte PM Ca2+ pump enables the continued generation of [Ca2+]i oscillations for a prolonged period following the removal of extracellular Ca2+...
- Characterization of olanzapine-induced weight gain in ratsAndrew J Goudie
Psychology Department, Eleanor Rathbone Building, Liverpool University, Liverpool, UK
J Psychopharmacol 16:291-6. 2002..However, it remains to be determined how closely rodent models mimic the clinical situation and whether the mechanism(s) involved in the weight gain we have observed are the same as those involved in the clinical use of these drugs...
- The Dunlop phenomena: a lesson in risk management from an unlikely sourceDavid Williams
Department of Clinical Engineering, University of Liverpool
Med Device Technol 14:9-10. 2003..In these circumstances, associations between cause and effect can become distorted and are often difficult to overcome...
- Debate that "this house believes the essential drug concept hinders the effective deployment of drugs in developing countries". IntroductionAlasdair Breckenridge
Department of Pharmacology and Therapeutics, University of Liverpool, New Medical Building, Ashton Street, P O Box 147, Liverpool L69 3GE, UK
Trans R Soc Trop Med Hyg 97:1. 2003
- Gender, equity: new approaches for effective management of communicable diseasesSally Theobald
International Health Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Trans R Soc Trop Med Hyg 100:299-304. 2006....
- HIV-1 infection is associated with altered innate pulmonary immunityStephen B Gordon
Wellcome Trust Research and Department of Medicine, University of Malawi College of Medicine, Blantyre, Malawi
J Infect Dis 192:1412-6. 2005..Concentrations of RANTES (R2=0.68 and P<.0001) and SLPI (R2=0.29 and P=.001) correlated with BAL fluid HIV-1 load but not with plasma HIV-1 load...
- Histopathological prognosticators in oral and oropharyngeal squamous cell carcinomaJulia A Woolgar
Oral Pathology, Liverpool University Dental Hospital, Pembroke Place, Liverpool L3 5PS, United Kingdom
Oral Oncol 42:229-39. 2006....
- Medical science teaching needs stronger support from universities and a better career structure for anatomistsPeter H Dangerfield
University of Liverpool, UK
Clin Anat 18:468-9. 2005
- Expression of the GLUT1 and GLUT9 facilitative glucose transporters in embryonic chondroblasts and mature chondrocytes in ovine articular cartilageA Mobasheri
Connective Tissue, Molecular Pathogenesis, Reproduction and Stress Research Groups, Department of Veterinary Preclinical Sciences, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 7ZJ, UK
Cell Biol Int 29:249-60. 2005..Expression of these GLUT isoforms may be an important bioenergetic adaptation for chondrocytes in the extracellular matrix of developing cartilage...
- Fish as models for environmental genomicsAndrew R Cossins
Andrew R Cossins is at the Liverpool Microarray Facility and Centre for BioArray Innovation, School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom
Nat Rev Genet 6:324-33. 2005..The range of fish species for which genomic resources are available is increasing, but will require significant further expansion for the optimal application of fish environmental genomics...
- The dual PPARalpha/gamma agonist, ragaglitazar, improves insulin sensitivity and metabolic profile equally with pioglitazone in diabetic and dietary obese ZDF ratsLucy C Pickavance
Department of Veterinary Preclinical Sciences, University of Liverpool, Brownlow Hill Crown St, Liverpool L69 7ZJ, UK
Br J Pharmacol 144:308-16. 2005..They also improve beta-cell function, although this is better demonstrated through indices incorporating fasting insulin and glucose concentrations than through the hyperglycaemic clamp technique in this model...
- Evaluation and costs of different haemoglobin methods for use in district hospitals in MalawiA Medina Lara
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
J Clin Pathol 58:56-60. 2005..To evaluate the characteristics of manual haemoglobin methods in use in Malawi and provide evidence for the Ministry of Health in Malawi to enable them to choose a suitable method for district hospitals...
- Gastrin: old hormone, new functionsGraham Dockray
Physiological Laboratory, University of Liverpool, Liverpool, UK
Pflugers Arch 449:344-55. 2005..The present review focuses on recent progress in understanding the biology of both classical and non-classical gastrins...
- Is there a north-south divide in social class inequalities in health in Great Britain? Cross sectional study using data from the 2001 censusTim Doran
Department of Public Health, University of Liverpool, Liverpool L69 3GB
BMJ 328:1043-5. 2004..To examine individual social class inequalities in self rated general health within and between the constituent countries of Great Britain and the regions of England...
- International comparisons of health inequalities in childhood dental cariesCynthia M Pine
WHO Collaborating Centre on Oral Health in Deprived Communities, University of Liverpool Dental School, England, UK
Community Dent Health 21:121-30. 2004..To undertake formative studies investigating how the experience of dental caries in young children living in diverse settings relates to familial and cultural perceptions and beliefs, oral health-related behaviour and oral microflora...
- Parasitology. New ways to control malariaJanet Hemingway
Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
Science 303:1984-5. 2004
- Identification of sites in the cysteine-rich domain of the class P-III snake venom metalloproteinases responsible for inhibition of platelet functionAura S Kamiguti
Department of Haematology, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK
FEBS Lett 549:129-34. 2003..These results identify, for the first time, sites in the cysteine-rich domain of SVMPs that inhibit cell responses to collagen and reveal the complexity of the potential biological effects of these enzymes with multifunctional domains...
- Immunoepidemiology of the equine tapeworm Anoplocephala perfoliata: age-intensity profile and age-dependency of antibody subtype responsesC J Proudman
Liverpool School of Tropical Medicine Faculty of Veterinary Science
Parasitology 114:89-94. 1997..The relative importance of exposure to infection and the development of acquired immunity as determinants of the observed age-intensity pattern is considered...
- NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONSP Evans; Fiscal Year: 2006..The development of a temporary silicon-tethered (TST) rhodium-catalyzed [4+2+2] carbocyclization approach to the diterpene, epoxydictymene. ..
- STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERSP Evans; Fiscal Year: 2006..Finally, we will examine a series bismuth-catalyzed bis-reductive etherification reactions for the construction of linear fused polycyclic ethers. ..
- NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONSP Evans; Fiscal Year: 2001..Preliminary studies will focus on the examination of stabilized carbon and nitrogen nucleophiles. ..