Genomes and Genes
University of Edinburgh
Organization: University of Edinburgh
- Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid functionJohn A Marwick
Section of Airways Disease, National Heart and Lung Institute, Imperial College London, UK
J Inflamm (Lond) 7:33. 2010..However, the impact of cigarette smoke exposure on the expression of mSin3a and Mi2alpha/beta and their role in glucocorticoid responsiveness is unknown...
- The phylogeographical clade trade: tracing the impact of human-mediated dispersal on the colonization of northern Europe by the oak gallwasp Andricus kollariGraham N Stone
Institute of Evolutionary Biology, University of Edinburgh, School of Biological Sciences, The King s Buildings, West Mains Road, Edinburgh, UK
Mol Ecol 16:2768-81. 2007..The strong spatial patterning in genetic diversity observed between different regions of northern Europe, and between sites in the UK, is compatible with leptokurtic models of population establishment...
- Data integration in eHealth: a domain/disease specific roadmapJenny Ure
Stud Health Technol Inform 126:144-53. 2007..It outlines emerging strategies, recommendations and objectives for collaboration on shared ontology-building and harmonization of data for multi-site trials in this domain...
- Value-based pricing of drugs in the UKDavid J Webb
Clinical Pharmacology Unit, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
Lancet 369:1415-6. 2007
- Genotypic selection in Daphnia populations consisting of inbred sibshipsC R Haag
Departement de Biologie, Universite de Fribourg, Fribourg, Switzerland
J Evol Biol 20:881-91. 2007....
- Global molecular phylogeography reveals persistent Arctic circumpolar isolation in a marine planktonic protistKate F Darling
School of GeoSciences and Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JW, United Kingdom
Proc Natl Acad Sci U S A 104:5002-7. 2007..These data provide perspective for interpretation and discussion of global gene flow and speciation patterns in the plankton...
- The meaning of patient involvement and participation in health care consultations: a taxonomyAndrew G H Thompson
School of Social and Political Studies, University of Edinburgh, Adam Ferguson Bldg, George Square, EH8 9LL Edinburgh, UK
Soc Sci Med 64:1297-310. 2007..These levels are seen to provide basic building blocks for a more sophisticated understanding of involvement within and between these contexts for use by professionals, managers, policy-makers and researchers...
- Reconnecting interpretation to reasoning through individual differencesKeith Stenning
Edinburgh University, Scotland, UK
Q J Exp Psychol (Hove) 59:1454-83. 2006..We conclude that most participants do not understand deductive tasks as experimenters intend, and just as there is no single logical model of reasoning, so there is no reason to expect a single "fundamental human reasoning mechanism"...
- Sexual systems and population genetic structure in an annual plant: testing the metapopulation modelDarren J Obbard
Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, United Kingdom
Am Nat 167:354-66. 2006..In contrast, regional diversity in M. annua appears to be primarily a product of postglacial range expansion from two refugia in the eastern and western Mediterranean Basin...
- Commentary: pre-morbid IQ and later health--the rapidly evolving field of cognitive epidemiologyIan J Deary
Department of Psychology, University of Edinburgh, UK
Int J Epidemiol 35:670-2. 2006
- Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safetyKen Donaldson
MRC University of Edinburgh Centre for Inflammation Research, ELEGI Colt Laboratory, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
Toxicol Sci 92:5-22. 2006..CNT represent a group of particles that are growing in production and use, and therefore, research into their toxicology and safe use is warranted...
- A cephalometric comparison of patients with the sleep apnea/hypopnea syndrome and their siblingsRenata L Riha
Department of Sleep Medicine, University of Edinburgh, Royal Infirmary Edinburgh, Scotland
Sleep 28:315-20. 2005....
- New approaches to quantifying the spread of infectionLouise Matthews
Veterinary Epidemiology Group, Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, Scotland
Nat Rev Microbiol 3:529-36. 2005..This signals a move towards a closer interplay between epidemiological modelling, surveillance and disease-management strategies...
- Role of inflammation in cardiopulmonary health effects of PMKen Donaldson
ELEGI Colt Laboratory, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH9 8AG, Scotland, UK
Toxicol Appl Pharmacol 207:483-8. 2005..Thirdly, inflammation could affect the autonomic nervous system activity in ways that could lead to alterations in the control of heart rhythm which could culminate in fatal dysrhythmia...
- What will be the radiotherapy machine capacity required for optimal delivery of radiotherapy in Scotland in 2015?Sara C Erridge
University of Edinburgh, Edinburgh Cancer Centre, Crewe Road South, Edinburgh EH4 2XU, United Kingdom
Eur J Cancer 43:1802-9. 2007..Lack of radiotherapy capacity has been cited as a reason for poor cancer outcomes reported in the United Kingdom. This modelling study was conducted to ensure sufficient capacity in the future and to aid health service planning...
- Collaborative learning: comparison of outcomes for typically developing children and children with intellectual disabilitiesJ G Wishart
Simon Laurie House, Moray House School of Education, University of Edinburgh, Scotland, UK
Am J Ment Retard 112:361-74. 2007..Neither partner improved significantly in DS-NSID pairings, suggesting that the sociability attributed to children with DS did not necessarily support either their or their partner's learning in this social context...
- Assessment of factors affecting MRI measurement of intracranial volume changes and elastance indexI Marshall
Medical Physics, Division of Medical and Radiological Sciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
Br J Neurosurg 22:389-97. 2008..Because of these difficulties, caution is required in the interpretation of results obtained from a single examination. Techniques and methods that may reduce the variability in the derived hydrodynamic parameters are discussed...
- The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivoAymen I Idris
Bone Research Group, Institute of Genetic and Molecular Medicine, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU, UK
Bone 46:1089-99. 2010..We conclude that pharmacological blockade of TRPV1 ion channels by capsazepine inhibits osteoclastic bone resorption and protects against ovariectomy induced bone loss in mice, but also inhibits osteoblast activity and bone formation...
- Translational mini-review series on Th17 cells: CD4 T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulationR A O'Connor
University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen s Medical Research Institute, Edinburgh, UK
Clin Exp Immunol 159:137-47. 2010....
- Regulation of pathogenesis and immunity in helminth infectionsRick M Maizels
Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, Scotland, UK
J Exp Med 206:2059-66. 2009..A recent international meeting focused on how these parasites modulate host immunity and how control of parasitic and immunopathological disease might be achieved...
- Peripheral levels of fibrinogen, C-reactive protein, and plasma viscosity predict future cognitive decline in individuals without dementiaRiccardo E Marioni
Centre for Population Health Sciences, Public Health Sciences Section, University of Edinburgh, Edinburgh, EH8 9AG, Scotland, UK
Psychosom Med 71:901-6. 2009..To determine whether circulating levels of the biomarkers C-reactive protein (CRP), fibrinogen, plasma viscosity, and hematocrit were associated with cognitive decline in middle-aged to elderly people...
- Transmissions of variant Creutzfeldt-Jakob disease from brain and lymphoreticular tissue show uniform and conserved bovine spongiform encephalopathy-related phenotypic properties on primary and secondary passage in wild-type miceDiane L Ritchie
National CJD Surveillance Unit, School of Molecular and Clinical Medicine Pathology, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
J Gen Virol 90:3075-82. 2009..Overall, the results closely resembled those of previously reported transmissions of BSE in the same mouse strains, consistent with BSE being the origin of all of these vCJD cases...
- Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)William MacNee
MRC Centre for Inflammation Research, The Queen s Medical Research Institute Level 2, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Biochem Soc Trans 37:819-23. 2009..The processes involved in accelerated aging may provide novel targets for therapy in COPD. The present article reviews the evidence for accelerated aging as a mechanism in the pathogenesis of COPD...
- Genetic and environmental transactions linking cognitive ability, physical fitness, and education in late lifeWendy Johnson
MRC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
Psychol Aging 24:48-62. 2009..Results provide some support for all 3 explanations for the physical-cognitive correlation and indicate the ways in which better education may support better function and lack of education may undermine it...
- Novel interventions to reduce re-infection in women with chlamydia: a randomized controlled trialS T Cameron
Department of Reproductive and Developmental Sciences, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 5SU, UK
Hum Reprod 24:888-95. 2009....
- Practitioner perspectives on tackling health inequalities: findings from an evaluation of healthy living centres in ScotlandDavid Rankin
The University of Edinburgh, Medical School, Edinburgh EH8 9AG, UK
Soc Sci Med 68:925-32. 2009....
- Ability of the Fire Propagation Apparatus to characterise the heat release rate of energetic materialsH Biteau
BRE Centre for Fire Safety Engineering, School of Engineering and Electronics, The University of Edinburgh, The King s Buildings, EH9 3JL, Edinburgh, UK
J Hazard Mater 166:916-24. 2009..Results are presented in this study...
- Factors facilitating and challenging access and adherence to antiretroviral therapy in a township in the Zambian Copperbelt: a qualitative studyElizabeth Grant
Primary Palliative Care Research Group, Division of Community Health Sciences, General Practice Section, University of Edinburgh, Edinburgh, UK
AIDS Care 20:1155-60. 2008..The increase in the number of people who were expected to die but were now looking well also shifted community attitudes. HIV/AIDS is beginning to move from a hidden terminal disease to a chronic condition that is treatable...
- A genome scan to detect quantitative trait loci for economically important traits in Holstein cattle using two methods and a dense single nucleotide polymorphism mapH D Daetwyler
Centre for Genetic Improvement of Livestock, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada
J Dairy Sci 91:3225-36. 2008..The LDRM was well suited for a first genome scan due to its approximately 8 times lower computational demands. Further fine mapping should be applied on the chromosomal regions of interest found in this study...
- High-pressure structural study of L-alpha-glutamine and the use of Hirshfeld surfaces and graph-set notation to investigate the hydrogen bonding present in the structure up to 4.9 GPaP Lozano-Casal
Institute for Materials and Processes, School of Science and Engineering, The University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JL, Scotland
Acta Crystallogr B 64:466-75. 2008..Hirshfeld surfaces and fingerprint plots have been used to rapidly assess the structural changes that occur on application of pressure...
- Reduced activity of the noradrenergic system in the paraventricular nucleus at the end of pregnancy: implications for stress hyporesponsivenessA J Douglas
Laboratory of Neuroendocrinology, Centre for Integrative Physiology, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Edinburgh, UK
J Neuroendocrinol 17:40-8. 2005....
- Leniency and halo effects in marking undergraduate short research projectsBrian H McKinstry
Community Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK
BMC Med Educ 4:28. 2004..We set out to determine if, despite using such a marking schedule, leniency and halo effects were evident in the supervisors' marking of undergraduate short research projects (special study modules (SSM))...
- Haemorheological, platelet and endothelial factors in essential hypertensionA J Lee
Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
J Hum Hypertens 16:529-31. 2002
- Understanding patterns of genetic diversity in the oak gallwasp Biorhiza pallida: demographic history or a Wolbachia selective sweep?A Rokas
Institute of Cell, Animal and Population Biology, Ashworth Laboratories, University of Edinburgh, King s Buildings, West Mains Road EH9 3JT, UK
Heredity (Edinb) 87:294-304. 2001....
- Contrast agent stability: a continuous B-mode imaging approachV Sboros
Department of Medical Physics and Medical Engineering, Royal Infirmary, University of Edinburgh, 1 Lauriston Place, Edinburgh EH3 9YW, UK
Ultrasound Med Biol 27:1367-77. 2001..Single frame insonation is suggested to avoid the effects of decay due to the ultrasonic field, and to measure a tank-representative backscatter. The definition of OB was useful, however, in understanding the behaviour of the agents...
- Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosisD E Newby
Departments of Cardiology, University of Edinburgh, Royal Infirmary, United Kingdom
Circulation 103:1936-41. 2001..The aim of the study was to establish the influence of proximal coronary artery atheroma and smoking habit on the stimulated release of tissue plasminogen activator (tPA) from the heart...
- Fiber intake, constipation, and risk of varicose veins in the general population: Edinburgh Vein StudyA J Lee
Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, Teviot Place, EH8 9AG, Edinburgh, UK
J Clin Epidemiol 54:423-9. 2001..58). In contrast, no consistent relationships were seen among women. Overall, within this Western general population, an association between dietary fiber, constipation and the presence or severity of varicose veins was not supported...
- Musing on the structural organization of the exosome complexP Mitchell
Wellcome Trust Centre for Cell Biology, ICMB, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JR, UK
Nat Struct Biol 7:843-6. 2000..As no detailed structural data are yet available for the exosome complex, or any of its constituent enzymes, this discussion will rely heavily on rather speculative models...
- A pilot study of protein sparing in healthy dogs using peripheral parenteral nutritionM L Chandler
Institute for Veterinary Animal and Biomedical Science, Massey University, Palmerston North, New Zealand
Res Vet Sci 69:47-52. 2000..In conclusion, these findings suggest that PPN increases nitrogen balance in healthy dogs undergoing short-term fasting...
- Molecular evidence for genetic mixing of Arctic and Antarctic subpolar populations of planktonic foraminifersK F Darling
Department of Geology and Geophysics, University of Edinburgh, UK
Nature 405:43-7. 2000....
- Evolutionary lability of context-dependent codon bias in bacteriaG A McVean
Institute of Cell, Animal and Population Biology, King s Buildings, West Mains Road, University of Edinburgh, Edinburgh EH9 3JT, UK
J Mol Evol 50:264-75. 2000..These results demonstrate that strong context-dependent forces, both selective and mutational, operate on synonymous codon usage but that these differ considerably between genomes...
- Exposure to cigarette smoke, a major risk factor for sudden infant death syndrome: effects of cigarette smoke on inflammatory responses to viral infection and bacterial toxinsM W Raza
Department of Medical Microbiology, University of Edinburgh, Medical School, UK
FEMS Immunol Med Microbiol 25:145-54. 1999....
- Amino-terminal sequencing of sheep CD1 antigens and identification of a sheep CD1D geneS M Rhind
Department of Veterinary Pathology, University of Edinburgh, Summerhall, Edinburgh, EH9 1QH, Scotland
Immunogenetics 49:225-30. 1999..The predicted amino acid sequence of this gene shows that it is not identical to the SBU-T6 peptide, indicating that a different, CD1D-like gene was cloned...
- mraY is an essential gene for cell growth in Escherichia coliD S Boyle
Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland
J Bacteriol 180:6429-32. 1998..Cells depleted of MraY first swell and then lyse. The expression of mraY DNA in vitro produces a 40-kDa polypeptide detectable by sodium dodecyl sulfate-polyacrylamide gel electrophoresis...
- The drug trials that have influenced our clinical practice in acute ischaemic strokeC Warlow
Department of Clinical Neurosciences, University of Edinburgh, Scotland, UK
Thromb Haemost 78:558-61. 1997....
- Redislocation of the shoulder during the first six weeks after a primary anterior dislocation: risk factors and results of treatmentC M Robinson
The Royal Infirmary of Edinburgh, Scotland, United Kingdom
J Bone Joint Surg Am 84:1552-9. 2002....
- Drosophila yolk protein produced in E. coli is accumulated by mosquito ovariesM Bownes
Institute of Cell and Molecular Biology, The University of Edinburgh, Edinburgh, UK
Insect Mol Biol 11:487-96. 2002..coli expression vector and showed that the yolk protein produced by E. coli is taken up into ovaries of both Drosophila melanogaster and the malaria mosquito Anopheles gambiae, which normally uses vitellogenin...
- Lithium carbonate as a potential pharmacological vehicle: intravenous kinetics of single-dose administration in healthy subjectsW Stephen Waring
Clinical Pharmacology Unit and Research Centre, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
Eur J Clin Pharmacol 58:431-4. 2002..We wished to determine the pharmacokinetics of a single systemic administration of 500 mg lithium carbonate (13.5 mmol free Li(+)) in healthy subjects...
- Competitive release of drug resistance following drug treatment of mixed Plasmodium chabaudi infectionsJacobus C de Roode
Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3 JT, Scotland, United Kingdom
Malar J 3:33. 2004..Malaria infections are often genetically diverse, potentially leading to competition between co-infecting strains. Such competition is of key importance in the spread of drug resistance...
- The role of Plasmodium falciparum var genes in malaria in pregnancyJ A Rowe
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
Mol Microbiol 53:1011-9. 2004..This review examines the evidence for and against the involvement of var genes in placental adhesion, and considers whether the most appropriate vaccine candidates have yet been identified...
- Cyanogen bromide cleavage generates fragments suitable for expressed protein and glycoprotein ligationDerek Macmillan
School of Chemistry, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh, Scotland, UK
J Am Chem Soc 126:9530-1. 2004..We provide three examples of efficient CNBr cleavage of fragments of the glycoprotein erythropoietin that can be ligated with peptides or glycopeptide mimetics potentially giving rise to semisynthetic glycoprotein therapeutics...
- Experimental evidence of a link between breeding conditions and the decision to breed or to help in a colonial cooperative birdRita Covas
Percy FitzPatrick Institute, University of Cape Town, Rondebosch 7701, South Africa
Proc Biol Sci 271:827-32. 2004..Hence, these results also provide evidence for a direct influence of reproductive costs on life-history decisions such as age at first reproduction and breeding and helping behaviours...
- Glossary of terms relating to ethnicity and race: for reflection and debateR Bhopal
Section of Public Health Sciences, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
J Epidemiol Community Health 58:441-5. 2004..This glossary focuses on the concepts and terminology used in the study of the health of minority ethnic and racial groups. It is hoped that it will stimulate debate on this subject so that an internationally applicable glossary may emerge...
- Randomised controlled trial of long term portographic follow up versus variceal band ligation following transjugular intrahepatic portosystemic stent shunt for preventing oesophageal variceal rebleedingD Tripathi
Liver Unit, The Royal Infirmary, Edinburgh, UK
Gut 53:431-7. 2004....
- Hyperuricaemia does not impair cardiovascular function in healthy adultsW S Waring
Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK
Heart 90:155-9. 2004..To investigate the possibility that uric acid (UA) can impair endothelial function, an important surrogate for atherosclerosis...
- Yeast two-hybrid screens implicate DISC1 in brain development and functionJ Kirsty Millar
Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, UK
Biochem Biophys Res Commun 311:1019-25. 2003..Intriguingly, mutations in one of the proteins identified, WKL1, have been previously suggested to underlie the aetiology of catatonic schizophrenia...
- Experiments using microarray technology: limitations and standard operating proceduresT Forster
Scottish Centre for Genomic Technology and Informatics GTI, The University of Edinburgh, Medical School, Little France Crescent, Edinburgh EH16 4SB, UK
J Endocrinol 178:195-204. 2003..We hope that this overview will provide practical initial guidance for those embarking on microarray studies...
- Commentary: an imperfect compromiseMartin Dennis
Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU
BMJ 327:286. 2003
- The short-term clinical efficacy of amitriptyline in the management of idiopathic feline lower urinary tract disease: a controlled clinical studyM Kraijer
Hospital for Small Animals, University of Edinburgh, Easter Bush, Roslin, Edinburgh EH25 9RG, Scotland, UK
J Feline Med Surg 5:191-6. 2003..Long-term effects may be expected 4 or more weeks after the start of therapy and need to be further investigated...
- The electron transfer complexes of cytochrome c peroxidase from Paracoccus denitrificansGraham W Pettigrew
Department of Preclinical Veterinary Sciences, Royal Dick School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
Biochemistry 42:2046-55. 2003..We propose that, at low ionic strength, horse cytochrome c is trapped in a nonproductive orientation on a broad capture surface of the peroxidase...
- Long-term divergent selection on fatness in mice indicates a regulation system independent of leptin production and receptionLutz Bunger
Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
FASEB J 17:85-7. 2003....
- Characterisation of atherosclerotic plaque by spectral analysis of intravascular ultrasound: an in vitro methodologyT Spencer
Department of Medical Physics, Edinburgh University, Western General Hospital, Scotland, UK
Ultrasound Med Biol 23:191-203. 1997..However, the greatest discriminative power was given by the y-axis (0 Hz) intercept of the spectral slope: LFT/DFT (p = 0.001); LFT/CA (p = 0.0001); and DFT/CA (p = 0.089)...
- Trafficking, persistence and evolution of HIV in the CNSPeter Simmonds; Fiscal Year: 2005....
- Biomarkers of oxidative stress and inflammation in COPDWilliam MacNee; Fiscal Year: 2005..Such information will allow the identification of novel biomarkers and the fingerprints themselves may represent a mechanism to stratify COPD patients and allow the assessment of novel therapies. ..
- Colorectal Cancer Screening - Primary Care StrategiesDavid Weller; Fiscal Year: 2006....
- NEURODEGENERATION IN HIV INFECTED DRUG USERSJeanne Bell; Fiscal Year: 2003..Elucidation of the interaction between drugs and HIV infection of the CNS could lead to more focused strategies to prevent cognitive decline in drug users, particularly those who are also HIV infected. ..
- DRUG RELATED CNS DAMAGE-SYNERGY WITH EFFECTS OF HIVJeanne Bell; Fiscal Year: 2002..Identification of particularly hazardous patterns of illicit drug(s) use, and of possible genetic susceptibility, could lead to more focused prevention and intervention strategies in at risk cohorts and individuals. ..