University of Cambridge

Summary

Organization: University of Cambridge
Country: UK

Top Publications

  1. pmc Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals
    Ilias Kazanis
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    J Neurosci 30:9771-81. 2010
  2. pmc Basic concepts of depression
    Eugene S Paykel
    University of Cambridge, Department of Psychiatry, Cambridge, UK
    Dialogues Clin Neurosci 10:279-89. 2008
  3. doi Role of extracellular factors in axon regeneration in the CNS: implications for therapy
    Noreen M Gervasi
    Cambridge University Centre for Brain Repair, ED Adrian Building, Forvie Site, Robinson Way, Cambridge CB22PY, UK
    Regen Med 3:907-23. 2008
  4. ncbi Primordial germ cell specification: the importance of being 'blimped'
    Susana M Chuva de Sousa Lopes
    Hubrecht Institute, Developmental Biology and Stem Cell Research, CT Utrecht, The Netherlands
    Histol Histopathol 23:1553-61. 2008
  5. ncbi Time spent being sedentary and weight gain in healthy adults: reverse or bidirectional causality?
    Ulf Ekelund
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Am J Clin Nutr 88:612-7. 2008
  6. pmc Personal and environmental correlates of active travel and physical activity in a deprived urban population
    David Ogilvie
    Medical Research Council Social and Public Health Sciences Unit, Glasgow, UK
    Int J Behav Nutr Phys Act 5:43. 2008
  7. ncbi Non-invasive cardiac imaging
    David P Dutka
    Addenbrooke s Hospital, Cambridge
    Clin Med 8:173-4. 2008
  8. doi An improved algorithm for predicting free recalls
    Donald Laming
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, England CB2 3EB, UK
    Cogn Psychol 57:179-219. 2008
  9. doi Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart
    Andrew J Murray
    Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, England
    J Mol Cell Cardiol 44:694-700. 2008
  10. pmc Caspase-3-dependent phagocyte death during systemic Salmonella enterica serovar Typhimurium infection of mice
    Andrew J Grant
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK
    Immunology 125:28-37. 2008

Detail Information

Publications62

  1. pmc Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals
    Ilias Kazanis
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    J Neurosci 30:9771-81. 2010
    ....
  2. pmc Basic concepts of depression
    Eugene S Paykel
    University of Cambridge, Department of Psychiatry, Cambridge, UK
    Dialogues Clin Neurosci 10:279-89. 2008
    ..Life stress is common in various depressive pictures. Dysthymia, a valuable diagnosis, represents a form of what was regarded earlier as neurotic depression. Other subtypes are also discussed...
  3. doi Role of extracellular factors in axon regeneration in the CNS: implications for therapy
    Noreen M Gervasi
    Cambridge University Centre for Brain Repair, ED Adrian Building, Forvie Site, Robinson Way, Cambridge CB22PY, UK
    Regen Med 3:907-23. 2008
    ..Promising results have been obtained in animal models, and some therapies are undergoing clinical trials. This offers great hope for achievement of functional recovery after CNS injury...
  4. ncbi Primordial germ cell specification: the importance of being 'blimped'
    Susana M Chuva de Sousa Lopes
    Hubrecht Institute, Developmental Biology and Stem Cell Research, CT Utrecht, The Netherlands
    Histol Histopathol 23:1553-61. 2008
    ..Finally, we discuss the possible involvement of Blimp1 in the two know modes of germ line segregation (epigenesis and preformation)...
  5. ncbi Time spent being sedentary and weight gain in healthy adults: reverse or bidirectional causality?
    Ulf Ekelund
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Am J Clin Nutr 88:612-7. 2008
    ..Whether obesity is a cause or a consequence of a sedentary lifestyle has not yet been fully elucidated, which leaves uncertainty about the direction of causality...
  6. pmc Personal and environmental correlates of active travel and physical activity in a deprived urban population
    David Ogilvie
    Medical Research Council Social and Public Health Sciences Unit, Glasgow, UK
    Int J Behav Nutr Phys Act 5:43. 2008
    ....
  7. ncbi Non-invasive cardiac imaging
    David P Dutka
    Addenbrooke s Hospital, Cambridge
    Clin Med 8:173-4. 2008
  8. doi An improved algorithm for predicting free recalls
    Donald Laming
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, England CB2 3EB, UK
    Cogn Psychol 57:179-219. 2008
    ..Some implications are drawn, from the use of rehearsal data by the predictive algorithm, for some of the constituent assumptions embodied in those three models...
  9. doi Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart
    Andrew J Murray
    Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, England
    J Mol Cell Cardiol 44:694-700. 2008
    ..Thus, respiratory uncoupling may underlie the abnormal energetics and low efficiency in the failing heart, although whether this is maladaptive or adaptive would require direct investigation...
  10. pmc Caspase-3-dependent phagocyte death during systemic Salmonella enterica serovar Typhimurium infection of mice
    Andrew J Grant
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK
    Immunology 125:28-37. 2008
    ....
  11. doi Protein misfolding and disease: from the test tube to the organism
    Leila M Luheshi
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Curr Opin Chem Biol 12:25-31. 2008
    ....
  12. doi The properties of foams and lattices
    M F Ashby
    Engineering Department, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK
    Philos Trans A Math Phys Eng Sci 364:15-30. 2006
    ..This paper summarizes a little of the way in which the mechanical properties of cellular solids are analysed and illustrates the range of properties offered by alternative configurations...
  13. doi Evaluating docking programs: keeping the playing field level
    John W Liebeschuetz
    Cambridge Crystallographic Data Centre, 12 Union Rd, Cambridge CB2 1EZ, UK
    J Comput Aided Mol Des 22:229-38. 2008
    ..Overall there is much to consider in the experimental design of enrichment studies. Hopefully this study will be of benefit in helping others plan such experiments...
  14. ncbi The missing link in the eukaryotic ribosome cycle
    Richard J Jackson
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    Mol Cell 28:356-8. 2007
    ..A truly groundbreaking paper by Pisarev et al. (2007), recently published in Cell, has solved a wide gap in our knowledge of eukaryotic mRNA translation, by elucidating how ribosomes are released from mRNA after the termination step...
  15. pmc Nonequilibrium scale selection mechanism for columnar jointing
    Lucas Goehring
    Department of Physics, University of Toronto, 60 St George Street, Toronto, Ontario, Canada
    Proc Natl Acad Sci U S A 106:387-92. 2009
    ....
  16. pmc Unbiased estimation of odds ratios: combining genomewide association scans with replication studies
    Jack Bowden
    Institute of Public Health, Cambridge, UK
    Genet Epidemiol 33:406-18. 2009
    ..We illustrate our approach on some recently completed scans and explore its efficiency by simulation...
  17. doi Carbon nanotube array: a new MIP platform
    Chwee Lin Choong
    Electrical Engineering Division, Department of Engineering, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0FA, UK
    Biosens Bioelectron 25:652-6. 2009
    ..The resistance value derived from the I-V plot provides insight into the electrical conductivity of the CNT transducer and also the effective surface area for caffeine imprinting...
  18. doi Synchrotron X-ray microtomographic study of tablet swelling
    P R Laity
    Department of Materials Science and Metallurgy, University of Cambridge, Cambridge, UK
    Eur J Pharm Biopharm 75:263-76. 2010
    ..e. Fickian or Case II). These observations also suggested that axial expansion, initiated by water ingress, may be an important mechanism during tablet swelling...
  19. doi Acquired facial palsy with hypertension secondary to Guillain-Barre syndrome
    Nicholas Smith
    Department of Neurology, Sydney Children s Hospital, Randwick, New South Wales, Australia
    J Paediatr Child Health 46:125-7. 2010
    ..A diagnosis of Guillain-Barre syndrome was made in both; literature linking facial nerve palsy in childhood with hypertension and Guillain-Barre syndrome is reviewed...
  20. doi Designing packaging to support the safe use of medicines at home
    James Ward
    Engineering Design Centre, Engineering Department, University of Cambridge, Trumpington Street, Cambridge CB21PZ, UK
    Appl Ergon 41:682-94. 2010
    ....
  21. doi Energy landscapes: some new horizons
    David J Wales
    University Chemical Laboratories, Cambridge, UK
    Curr Opin Struct Biol 20:3-10. 2010
    ..Free energy projections that preserve barriers and rates can be obtained from the network representation, and global kinetics can be addressed on the experimental time scale...
  22. pmc Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis
    Paul A Lyons
    Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY, UK
    Ann Rheum Dis 69:1208-13. 2010
    ....
  23. doi Ironic effects of emotion suppression when recounting distressing memories
    Tim Dalgleish
    Emotion Research Group, Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
    Emotion 9:744-9. 2009
    ..This first demonstration of ironic effects of emotion suppression in response to personal material in those with emotional problems sheds light into how certain emotion regulation strategies may maintain and exacerbate such conditions...
  24. ncbi The child as the presenting symptom, and what happens when things go wrong?
    Mark Agius
    Bedfordshire and Luton Partnership Trust, UK
    Psychiatr Danub 21:137-41. 2009
    ....
  25. doi Age at menarche and the risk of operative first delivery
    G C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, UK
    BJOG 116:1613-21. 2009
    ..The aim of this study was to test a prediction from the hypothesis, namely, that the risk of operative first delivery would decline with later age at menarche...
  26. pmc Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain
    Jonathan H Clarke
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD United Kingdom
    J Comp Neurol 517:296-312. 2009
    ..Overall, our data suggest that PIP4Kgamma may have a role in neuron function, specifically in the regulation of vesicular transport, in specific regions of the developed brain...
  27. doi [Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease
    Janet J Maguire
    Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, United Kingdom
    Hypertension 54:598-604. 2009
    ..Furthermore, in human cardiac tissue, the apelin peptides are among the most potent endogenous positive inotropic agents yet reported...
  28. doi Effect of aged garlic extract on wound healing: a new frontier in wound management
    Sohail Ejaz
    Department of Clinical Neurosciences, Neurology Unit, Addenbrookes Hospital, University of Cambridge, Cambridge, UK
    Drug Chem Toxicol 32:191-203. 2009
    ..These observations substantiate the beneficial use of AGS in the treatment of wounds. Additional studies are needed to study the specific wound-healing mechanisms of chemical, or group of chemicals, present in AGS...
  29. doi Polygenic susceptibility to breast cancer: current state-of-the-art
    Maya Ghoussaini
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    Future Oncol 5:689-701. 2009
    ....
  30. pmc Case-controlled structure validation
    Randy J Read
    Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Cambridge, England
    Acta Crystallogr D Biol Crystallogr 65:140-7. 2009
    ..In both cases, once factors influencing quality have been controlled in the comparison, there is little evidence for a systematic difference in quality...
  31. ncbi William Harvey, an Aristotelian anatomist
    Patricia Fara
    Clare College, Cambridge CB2 1TL, UK
    Endeavour 31:43-4. 2007
    ..Yet after his training at Padua, he became a committed Aristotelian: although strongly influencing the new observational sciences of the seventeenth century, Harvey himself looked back towards the classical past...
  32. ncbi From 'public service' to artificial insemination: animal breeding science and reproductive research in early twentieth-century Britain
    Sarah Wilmot
    Department of History and Philosophy of Science, University of Cambridge, Free School Lane, Cambridge, UK
    Stud Hist Philos Biol Biomed Sci 38:411-41. 2007
    ..The example of AI shows that by combining the history of reproductive technology in agriculture and medicine we can give a richer account of modern reproduction...
  33. ncbi Endorectal MR imaging before salvage prostatectomy: tumor localization and staging
    Evis Sala
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 238:176-83. 2006
    ....
  34. ncbi Sudden infant death syndrome and complications in other pregnancies
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Rosie Hospital, Cambridge CB2 2SW, UK
    Lancet 366:2107-11. 2005
    ..We postulated that women whose infants died from SIDS would be more likely to have had obstetric complications in their other pregnancies...
  35. pmc The contribution of leading diseases and risk factors to excess losses of healthy life in Eastern Europe: burden of disease study
    John W Powles
    Department of Public Health and Primary Care, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    BMC Public Health 5:116. 2005
    ..The East/West gradient in health across Europe has been described often, but not using metrics as comprehensive and comparable as those of the Global Burden of Disease 2000 and Comparative Risk Assessment studies...
  36. pmc 'Coming down the line'-- patients' understanding of their family history of common chronic disease
    Fiona M Walter
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Ann Fam Med 3:405-14. 2005
    ....
  37. pmc Blockade of chemokine-induced signalling inhibits CCR5-dependent HIV infection in vitro without blocking gp120/CCR5 interaction
    David J Grainger
    Department of Medicine, University of Cambridge, Box 157, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Retrovirology 2:23. 2005
    ..However, it is presently unclear to what extent the interaction of HIV proteins with chemokine receptors generates intracellular signals that are important for productive infection...
  38. ncbi Denaturing gradient gel electrophoresis and its use in the detection of major histocompatibility complex polymorphism
    L A Knapp
    Primate Immunogenetics and Molecular Ecology Research Group, Department of Biological Anthropology, University of Cambridge, Cambridge, UK
    Tissue Antigens 65:211-9. 2005
    ..The advantages, problems, pitfalls and limitations of DGGE are considered and future perspectives on the use of DGGE for MHC typing are discussed...
  39. ncbi Fitness correlates of song repertoire size in free-living song sparrows (Melospiza melodia)
    Jane M Reid
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
    Am Nat 165:299-310. 2005
    ....
  40. ncbi DNA supercoiling - a global transcriptional regulator for enterobacterial growth?
    Andrew Travers
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Rev Microbiol 3:157-69. 2005
    ....
  41. ncbi Towards therapeutic applications of engineered zinc finger proteins
    A Klug
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    FEBS Lett 579:892-4. 2005
    ..The aim is to replace them in each case by a correct copy from an extrachromosomal DNA donor by means of homologous recombination. Promising results are reported...
  42. pmc Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor-induced astrocyte differentiation
    Takao Setoguchi
    Centre for Brain Repair, University of Cambridge, E D Adrian Building, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    J Cell Biol 166:963-8. 2004
    ..We propose that the AKT-stimulated export of OLIG2 from the nucleus of NSCs is essential for the astrocyte differentiation...
  43. pmc Informed consent and public health
    Onora O'Neill
    Newnham College, University of Cambridge, Cambridge CB3 9DF, UK
    Philos Trans R Soc Lond B Biol Sci 359:1133-6. 2004
    ..It will therefore gain more from engaging with work in political philosophy than with individualistic work in ethics...
  44. ncbi Incidental bronchogenic cyst detected on F-18 FDG positron emission tomography
    Evis Sala
    Department of Radiology, Addenbrooke s Hospital, Cambridge, UK
    Clin Nucl Med 29:494-5. 2004
  45. ncbi Effects of modafinil on working memory processes in humans
    Ulrich Muller
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Psychopharmacology (Berl) 177:161-9. 2004
    ..So far, understanding of the cognitive enhancing effects of modafinil and the relevant neurobiological mechanisms are incomplete...
  46. ncbi Pregnancy-associated plasma protein A and alpha-fetoprotein and prediction of adverse perinatal outcome
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
    Obstet Gynecol 107:161-6. 2006
    ..To describe the association between pregnancy associated plasma protein A (PAPP-A), alpha-fetoprotein (AFP) and adverse perinatal outcome...
  47. pmc BRCA1 and BRCA2 mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high-risk French-Canadian families
    Antonis C Antoniou
    Cancer Research UK Genetic Epidemiology Unit, Strangeways Research Laboratory, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Breast Cancer Res 8:R3. 2006
    ..We also used this data set to estimate the age-specific risks for breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers...
  48. pmc Cognitive ornithology: the evolution of avian intelligence
    Nathan J Emery
    Sub Department of Animal Behaviour, University of Cambridge, Madingley, Cambridge CB3 8AA, UK
    Philos Trans R Soc Lond B Biol Sci 361:23-43. 2006
    ....
  49. ncbi Strategy for improved [(11)C]DAA1106 radiosynthesis and in vivo peripheral benzodiazepine receptor imaging using microPET, evaluation of [(11)C]DAA1106
    Katrin C Probst
    Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, CB2 2QQ Cambridge, UK
    Nucl Med Biol 34:439-46. 2007
    ..11)C]DAA1106 ([(11)C]N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)-acetamide) is a promising positron emission tomography (PET) radioligand for imaging PBRs...
  50. ncbi Repeatability and reproducibility of determination of the nitrogen content of fishmeal by the combustion (Dumas) method and comparison with the Kjeldahl method: interlaboratory study
    Eric L Miller
    Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 OES United Kingdom
    J AOAC Int 90:6-20. 2007
    ..64% by Kjeldahl. It is concluded that with fishmeal, Dumas gives a more reliable measure of organic nitrogen than Kjeldahl, and, therefore, Dumas should be the method of choice...
  51. pmc Alterations in triad ultrastructure following repetitive stimulation and intracellular changes associated with exercise in amphibian skeletal muscle
    Juliet A Usher-Smith
    Physiological Laboratory, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Muscle Res Cell Motil 28:19-28. 2007
    ....
  52. ncbi Psychosocial issues for patients with ventricular assist devices: a qualitative pilot study
    Elizabeth Chapman
    The Centre for Family Research, University of Cambridge, UK
    Am J Crit Care 16:72-81. 2007
    ..Surgical implantation of a ventricular assist device is being used increasingly in patients in the United Kingdom, yet few studies have focused on patients' experiences from a phenomenological (psychological) perspective...
  53. pmc A quantum leap in our knowledge of breast cancer mutations
    Carlos Caldas
    Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 0RE, UK
    Breast Cancer Res 8:304. 2006
  54. ncbi Chernobyl and thyroid cancer
    E D Williams
    Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom
    J Surg Oncol 94:670-7. 2006
    ....
  55. ncbi Glycated hemoglobin as a marker of cardiovascular risk
    Kay Tee Khaw
    School of Clinical Medicine, University of Cambridge, UK
    Curr Opin Lipidol 17:637-43. 2006
    ..Diabetes mellitus is an established risk factor for cardiovascular disease. This review examines glycated hemoglobin, an indicator of long-term average blood glucose concentrations, in risk prediction for cardiovascular disease...
  56. ncbi The evolution of cooperation and altruism--a general framework and a classification of models
    L Lehmann
    Department of Ecology and Evolution, University of Lausanne, Biophore, 1015 Lausanne, Switzerland
    J Evol Biol 19:1365-76. 2006
    ..All the models proposed so far are explicitly or implicitly built on these general principles, allowing us to classify them into four general categories...
  57. ncbi Monogenic human obesity syndromes
    I S Farooqi
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Prog Brain Res 153:119-25. 2006
    ....
  58. ncbi Osteoclast formation and bone resorption are inhibited by megakaryocytes
    C A Beeton
    Department of Medicine, School of Clinical Medicine, University of Cambridge, Addenbrooke s Hospital, Box 157, Hills Road, Cambridge CB2 2QQ, UK
    Bone 39:985-90. 2006
    ..These results show that MKs inhibit osteoclast formation and activity. The most pronounced effects were seen when MKs and osteoclasts were co-cultured from day 0, suggesting that MKs act primarily on osteoclast precursors...
  59. ncbi Escaping the tyranny of the embryo? A new approach to ART regulation based on UK and Australian experiences
    Martin H Johnson
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, UK
    Hum Reprod 21:2756-65. 2006
    ....
  60. ncbi Understanding mouse models of disease through metabolomics
    Julian L Griffin
    Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK
    Curr Opin Chem Biol 10:309-15. 2006
    ..This versatile tool is set to increase in popularity as functional genomic approaches produce more mouse models for phenotyping...
  61. ncbi Neuroanatomical correlates of memory deficits in tuberous sclerosis complex
    K Ridler
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, UK
    Cereb Cortex 17:261-71. 2007
    ..Normal intelligence quotient patients with TSC show a profile of long-term and working memory impairment that is related to gray matter deficits in thalamus and basal ganglia components of fronto-striatal circuits...
  62. ncbi A review of NAPL source zone remediation efficiency and the mass flux approach
    K Soga
    Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ, UK
    J Hazard Mater 110:13-27. 2004
    ..Thus, accurate site characterization is essential for predicting NAPL dissolution and mass flux relationships as well as for assigning site-specific remediation target values...

Research Grants62

  1. Metabolomics and metabolic compartmentation in the brain
    Julian Griffin; Fiscal Year: 2006
    ..To correlate NMR observable metabolite changes with transcriptional changes. Our data will provide proof-of principle for this methodology, and establish a means for exploring other neurolodegenerative disorders. ..
  2. Gordon Research Conference on Calcium Signaling
    Colin Taylor; Fiscal Year: 2005
    ..abstract_text> ..
  3. Structural Mechanisms for the Inhibition of Thrombosis
    JAMES HUNTINGTON; Fiscal Year: 2007
    ....
  4. Structural Mechanisms for the Inhibition of Thrombosis
    JAMES HUNTINGTON; Fiscal Year: 2004
    ..9) To determine the conformational basis for cleavage of the N-terminal tail from the final heparin cofactor II-thrombin complex. ..
  5. Structural Mechanisms for the Inhibition of Thrombosis
    JAMES HUNTINGTON; Fiscal Year: 2009
    ....
  6. Families created by assisted reproduction: parenting and child development
    Susan Golombok; Fiscal Year: 2009
    ..These samples are the first of their kind to be followed up from infancy, thus providing an opportunity to examine the influence of early experience on later development in these new family forms. ..
  7. Families created by assisted reproduction: parenting and child development
    SUSAN ESTHER GOLOMBOK; Fiscal Year: 2010
    ..These samples are the first of their kind to be followed up from infancy, thus providing an opportunity to examine the influence of early experience on later development in these new family forms. ..
  8. Families created by assisted reproduction: parenting and child development
    Susan Golombok; Fiscal Year: 2007
    ..These samples are the first of their kind to be followed up from infancy, thus providing an opportunity to examine the influence of early experience on later development in these new family forms. ..
  9. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2007
    ..We will also test hypotheses concerning the main effect of aging and the interactive effect of drugs and age on brain adaptivity. ..
  10. BIOLOGY OF HUMAN UTERINE NK CELLS
    Ashley Moffett; Fiscal Year: 2004
    ..It could lead to novel therapeutic approaches in a wide range of disorders including infertility, miscarriage, disorders due to defective placentation (pre-eclampsia and IUGR) and menstrual disorders. ..
  11. Home testing of 24/7 closed-loop control in children and adolescents with type 1
    Roman Hovorka; Fiscal Year: 2010
    ..This will be preceded by evaluating 24/7 closed-loop control in compliant and non-compliant subjects in clinical research centre settings to collect data supporting regulatory submission for home testing. ..
  12. GENETIC ANALYSIS OF NICOTINE ADAPTATION IN C ELEGANS
    William Schafer; Fiscal Year: 2006
    ..abstract_text> ..
  13. Analysis of Touch Response & Habituation in C. elegans
    William Schafer; Fiscal Year: 2007
    ..These studies will also provide a proving ground for improvements in optical imaging methodologies, which could facilitate the application of this cutting-edge technology to other genetically tractable organisms. ..
  14. Central Serotonergic Pathways Regulating Energy Balance
    LORA HEISLER; Fiscal Year: 2007
    ....
  15. BACTERIAL CHEMOTAXIS: A COMPUTER-BASED STUDY
    Dennis Bray; Fiscal Year: 2007
    ..Moreover, the intimate involvement of computational and experimental approaches in our study will both contribute to, and derive benefit from, the raidly expanding area of systems biology. ..
  16. MOLECULAR EVENTS IN A DISCRETE CYTOPLASMIC SPACE
    Dennis Bray; Fiscal Year: 2004
    ....
  17. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    ..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. ..
  18. Machine vision analysis of C.elegans phenotypic patterns
    William Schafer; Fiscal Year: 2005
    ....
  19. Machine vision analysis of nematode behavioral patterns.
    William Schafer; Fiscal Year: 2003
    ..These analytical tools will also be used to precisely define the long-term effects of neuroactive drugs on behavioral, opening the possibility of genetic screening for mutants with defects in tolerance and dependence. ..
  20. Hormonal Influences on Neural/Behavioral Development
    Melissa Hines; Fiscal Year: 2009
    ..Finally, the research will further basic scientific understanding of the roles of hormones and social/cognitive processes in childrens acquisition of gender role behavior. ..
  21. Programming of gene expression during fetal life
    S Ozanne; Fiscal Year: 2005
    ....
  22. Structural studies on ribosomes and antibiotics
    VENKATRAMAN RAMAKRISHNAN; Fiscal Year: 2006
    ..Such knowledge could help improve existing antibiotics and could also lead to the design of new ones. ..