Genomes and Genes
University of Birmingham
Organization: University of Birmingham
- Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation?Alexandra J Sinclair
Academic Unit of Ophthalmology, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham and Midland Eye Centre, Dudley Road, Birmingham B18 7QU, United Kingdom
J Clin Endocrinol Metab 95:5348-56. 2010..The etiology of idiopathic intracranial hypertension (IIH) is unknown. We hypothesized that obesity and elevated intracranial pressure may be linked through increased 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity...
- Quality assurance for oral anticoagulation self management: a cluster randomized trialE T Murray
UK NEQAS for Blood Coagulation, Sheffield, UK
J Thromb Haemost 6:464-9. 2008..External quality assessment (EQA) should be an inherent component of patient self management (PSM) of oral anticoagulation. The aim of this study was to evaluate methods of EQA for patients within a cluster randomized trial...
- Chemotherapy compared with biochemotherapy for the treatment of metastatic melanoma: a meta-analysis of 18 trials involving 2,621 patientsNatalie J Ives
Birmingham Clinical Trials Unit, Division of Medical Sciences, Robert Aitken Institute, University of Birmingham, Edgbaston, Birmingham, United Kingdom
J Clin Oncol 25:5426-34. 2007..The only subgroup analysis performed was by type of immunotherapy, with trials divided according to whether IFN only or IFN and IL-2 were administered in the biochemotherapy arm...
- Adding fluoride to water suppliesK K Cheng
Public Health Building, University of Birmingham, Edgbaston, Birmingham B15 2TT
BMJ 335:699-702. 2007
- Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+Alistair K Brown
School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
BMC Struct Biol 7:55. 2007..Human IMPase, the putative target of lithium therapy, has been studied extensively, but the function of four IMPase-like genes in M. tuberculosis is unclear...
- Structures and functions of microbial lipid antigens presented by CD1B E Willcox
CRUK Institute for Cancer Studies, Edgbaston, B 15 2TT Birmingham, United Kingdom
Curr Top Microbiol Immunol 314:73-110. 2007....
- Cannabis use and symptom experience amongst people with mental illness: a commentary on Degenhardt et alJohn Macleod
Department of Primary Care and General Practice, Primary Care Clinical Sciences and Learning Centre Building, University of Birmingham, Edgbaston, Birmingham, UK
Psychol Med 37:913-6. 2007
- A prospective study to assess the value of MMP-9 in improving the appropriateness of urgent referrals for colorectal cancerAngela V Ryan
Department of Primary Care and General Practice, University of Birmingham, Birmingham B15 2TT, UK
BMC Cancer 6:251. 2006..This study aims to find out whether measuring MMP-9 levels could improve the appropriateness of urgent referrals for patients with bowel symptoms...
- Dissociating the effects of similarity, salience, and top-down processes in search for linearly separable size targetsJohn P Hodsoll
University of Birmingham, School of Psychology, Edgbaston, Birmingham B15 2TT, England
Percept Psychophys 68:558-70. 2006..The data indicate the role of top-down templates in search, which can be "tuned" more effectively for targets at the ends of feature dimensions...
- Cluster randomized pilot controlled trial of an occupational therapy intervention for residents with stroke in UK care homesCatherine Sackley
School of Health Sciences, University of Birmingham, UK
Stroke 37:2336-41. 2006..A pilot evaluation of an occupational therapy intervention to improve self-care independence for residents with stroke-related disability living in care homes was the basis of this study...
- Cardiovascular and respiratory responses to a panicogenic agent in anaesthetised female Wistar rats at different stages of the oestrous cycleK E Brack
Department of Physiology, University of Birmingham, Birmingham B15 2TT, UK
Eur J Neurosci 23:3309-18. 2006....
- Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiaraYotis A Senis
Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, Wolfson Drive, Edgbaston, Birmingham B15 2TT, UK
Biochim Biophys Acta 1764:863-71. 2006..Cotiaractivase is a unique low molecular weight snake venom prothrombin activator that likely belongs to the metalloproteinase family of proteins...
- High incidence of myelodysplasia and secondary leukaemia in the UK Medical Research Council Pilot of autografting in chronic lymphocytic leukaemiaDonald W Milligan
Department of Haematology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK
Br J Haematol 133:173-5. 2006..4% (95% confidence interval, 2.5-24%). No analysed potential risk factor was predictive for MDS/AML development. We hypothesise that potential causative factors are fludarabine, low cell dose and transplant conditioning...
- Family members of relatives with alcohol, drug and gambling problems: a set of standardized questionnaires for assessing stress, coping and strainJim Orford
Alcohol, Drugs and Addiction Research Group, School of Psychology, The University of Birmingham, Edgbaston, Birmingham, UK
Addiction 100:1611-24. 2005....
- Refractive index mismatch and monomer reactivity influence composite curing depthA C Shortall
The University of Birmingham, School of Dentistry, St Chad s Queensway, Birmingham B4 6NN, England
J Dent Res 87:84-8. 2008..Composites became more opaque or translucent on curing. Optimizing filler/resin refractive index mismatch provides increased curing depth and assists shade-matching...
- Meningococcal A vaccination response is enhanced by acute stress in menKate M Edwards
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, B15 2TT, UK
Psychosom Med 70:147-51. 2008..To determine if acute stress experienced at the time of antigenic challenge augments the subsequent immune response...
- Antiangiogenic therapy and surgical practiceA R John
Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
Br J Surg 95:281-93. 2008..Antiangiogenic therapy has become a reality with the recent introduction of bevacizumab, a monoclonal antibody against vascular endothelial growth factor...
- Morphologic characterization of cell neighborhoods in neoplastic and preneoplastic epitheliumGabriel Landini
Oral Pathology Unit, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, St Chad s Queensway, Birmingham B4 6NN, UK
Anal Quant Cytol Histol 32:30-8. 2010..To explore tissue organization based on the geometry of cell neighborhoods in histologic preparations...
- Gamma-glutamyl transferase: the silent partner?Dippica Mistry
University of Birmingham, UK
COPD 7:285-90. 2010..Future studies of systemic and local GGT function and genotypes in well characterised patients may lead to a better understanding of the processes involved and hence the development of new treatment strategies...
- Inducing preschool children's emotional eating: relations with parental feeding practicesJackie Blissett
School of Psychology, University of Birmingham, Birmingham, United Kingdom
Am J Clin Nutr 92:359-65. 2010..Children's emotional eating is related to greater body mass index and a less-healthy diet, but little is known about the early development of this behavior...
- Fluid exudates from inflamed bone-anchored hearing aids demonstrate elevated levels of cytokines and biomarkers of tissue and bone metabolismMelissa M Grant
School of Dentistry, University of Birmingham, St Chads Queensway, Birmingham, U K
Otol Neurotol 31:433-9. 2010....
- What is the real gain after liver transplantation?James Neuberger
Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, United Kingdom
Liver Transpl 15:S1-5. 2009..Understanding the associated increase in survival will allow for a rational approach to this complex area...
- Long-term survival and cost analysis of an annual Barrett's surveillance programmeKeith J Roberts
University Hospitals Coventry and Warwickshire NHS Trust, UK
Eur J Gastroenterol Hepatol 22:399-403. 2010..There are variations in surveillance practice, clinical outcomes and economic analyses. The study examined long-term survival and financial impact in patients undergoing annual surveillance of BM...
- A lentiviral vector that activates latent human immunodeficiency virus-1 proviruses by the overexpression of tat and that kills the infected cellsDavid Macías
Departamento de Biologia Experimental, Universidad de Jaen, Jaen, Spain
Hum Gene Ther 20:1259-68. 2009..In summary, we have developed a vector system that is efficient in activating latent HIV-1 proviruses but that needs further improvement to kill infected cells...
- Sound-induced flash illusion is resistant to feedback trainingOrna Rosenthal
School of Psychology, University of Birmingham, Birmingham, B15 2TT, UK
Brain Topogr 21:185-92. 2009....
- An epithelial progenitor pool regulates thymus growthWilliam E Jenkinson
Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom
J Immunol 181:6101-8. 2008....
- Managing the anticoagulated patient with atrial fibrillation at high risk of stroke who needs coronary interventionGregory Y H Lip
University Department of Medicine, City Hospital, Birmingham B18 7QH
BMJ 337:a840. 2008
- A functional magnetic resonance imaging technique based on nulling extravascular gray matter signalYuji Shen
School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK
J Cereb Blood Flow Metab 29:144-56. 2009..It is shown that GMN fMRI is a convenient tool to assess CBV changes associated with brain activation...
- Advances in power driven pocket/root instrumentationA Damien Walmsley
School of Dentistry, The University of Birmingham, St Chad s Queensway, Birmingham, UK
J Clin Periodontol 35:22-8. 2008..The primary aim was: "Does power-driven pocket/root instrumentation offer a clinical advantage over hand instrumentation"? Secondary aim was to update knowledge base of power-driven instrumentation post Tunkel et al. (2002)...
- Drawing cartoon faces--a functional imaging study of the cognitive neuroscience of drawingR Chris Miall
Brain and Behaviour Centre, School of Psychology, University of Birmingham, Birmingham, UK
Cortex 45:394-406. 2009....
- Androgen replacement therapy in womenWiebke Arlt
Division of Medical Sciences, Institute of Biomedical Research, Endocrinology, Birmingham, UK
Curr Opin Investig Drugs 6:1028-36. 2005..Choosing both a convenient and efficient mode of androgen administration in women remains a challenge and currently none of the available preparations is officially approved for use in women...
- Well-being in rheumatoid arthritis: the effects of disease duration and psychosocial factorsGareth J Treharne
School of Psychology, University of Birmingham and Dudley Group of Hospitals NHS Trust, UK
J Health Psychol 10:457-74. 2005..Optimism related to lower pain in early and intermediate RA. Social support related to lower fatigue in established RA. Indications for interventions targeted by disease duration are discussed...
- Phenomenology of self-restraintChris Oliver
School of Psychology, University of Birmingham, Edgbaston, Birmingham, UK
Am J Ment Retard 108:71-81. 2003..Results are discussed with reference to the purely topographical definition of self-restraint employed and the potential equivalence of protective devices and self-restraint...
- Genomic organization of the Papaver rhoeas self-incompatibility S(1) locusM J Wheeler
Wolfson Laboratory for Plant Molecular Biology, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
J Exp Bot 54:131-9. 2003..An attempt to localize the P. rhoeas S-locus using fluorescence in situ hybridization (FISH) has also been made. The potential relevance of the findings to mechanisms of recombination suppression is discussed...
- Notch ligand-bearing thymic epithelial cells initiate and sustain Notch signaling in thymocytes independently of T cell receptor signalingG Anderson
Department of Anatomy, MRC Centre for Immune Regulation, Division of Immunity and Infection, Medical School, University of Birmingham, Edgbaston, Birmingham, GB
Eur J Immunol 31:3349-54. 2001....
- Vegetarian children and dental erosionY H Al-Dlaigan
Department of Paediatric Dentistry, University of Birmingham, Dental School, St Chads Queensway, Birmingham, B4 6NN, UK
Int J Paediatr Dent 11:184-92. 2001..There have been recent changes in teenage lifestyle and diet. The increasing consumption of soft drinks and foods containing significant acidic components may play a role in the development of dental erosion...
- Nitrate reduction in the periplasm of gram-negative bacteriaL Potter
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
Adv Microb Physiol 45:51-112. 2001..Evidence is emerging that Nap fulfills a novel role in nitrate scavenging by some pathogenic bacteria...
- Best face forward: similarity effects in repetition priming of face recognitionR A Johnston
School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Q J Exp Psychol A 54:383-96. 2001..In view of these findings the mechanism of repetition priming in familiar face recognition is discussed...
- Expression and characterization of truncated forms of humanized L243 IgG1. Architectural features can influence synthesis of its oligosaccharide chains and affect superoxide production triggered through human Fcgamma receptor IJ Lund
Department of Immunology, The Medical School, Birmingham, UK
Eur J Biochem 267:7246-57. 2000..Thus, the L243 scFvhCH2 homo-dimer constitutes the minimal truncated form that binds the MHC Class II antigen and triggers superoxide production through FcgammaRI...
- CD69 expression discriminates MHC-dependent and -independent stages of thymocyte positive selectionK J Hare
Department of Anatomy, University of Birmingham Medical School, Edgbaston, United Kingdom
J Immunol 162:3978-83. 1999....
- Carbohydrate ingestion can completely suppress endogenous glucose production during exerciseA E Jeukendrup
Department of Human Biology, Nutrition Research Centre, Maastricht University, 6200 MD Maastricht, The Netherlands
Am J Physiol 276:E672-83. 1999..We conclude that 1) high rates of CHO ingestion can completely block EGP, 2) Ra gut may be a limiting factor for exogenous CHO oxidation, and 3) muscle glycogen oxidation was not reduced by large glucose feedings...
- Soluble adhesion molecules, endothelial markers and atherosclerosis risk factors in abdominal aortic aneurysm: a comparison with claudicants and healthy controlsA D Blann
University Department of Medicine, The City Hospital, Birmingham, UK
Blood Coagul Fibrinolysis 9:479-84. 1998..05). Levels were higher in AAA patients than in peripheral arterial disease patients (P < 0.05). Our laboratory data suggest that the pathophysiology AAA and peripheral arterial disease are not identical...
- Human cytotoxic T lymphocyte responses to Epstein-Barr virus infectionA B Rickinson
CRC Institute for Cancer Studies, University of Birmingham, United Kingdom
Annu Rev Immunol 15:405-31. 1997....
- Rate-drop response programmingM D Gammage
Department of Cardiovascular Medicine, University of Birmingham, United Kingdom
Pacing Clin Electrophysiol 20:841-3. 1997..Effective therapeutic settings are likely to result in an excess of pacing interventions; these, however, tend to be less symptomatic than the syncope or presyncope suffered by the patient and are generally well tolerated or not noticed...
- Transcription activation at class II CAP-dependent promotersS Busby
School of Biochemistry, University of Birmingham, UK
Mol Microbiol 23:853-9. 1997..This component involves direct contact between amino acids 19, 21 and 101 (activating region 2) of the downstream subunit of the CAP dimer and a target in the RNAP alpha subunit N-terminal domain (alpha NTD)...
- Review article: esomeprazole--the first proton pump inhibitor to be developed as an isomerM J Kendall
Clinical Pharmacology Section, Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
Aliment Pharmacol Ther 17:1-4. 2003..Clinical studies have confirmed the anticipated increased efficacy, but have shown no evidence of impaired tolerability or increased toxicity when compared with omeprazole...
- Trans-dentinal stimulation of tertiary dentinogenesisA J Smith
School of Dentistry, University of Birmingham, St Chads Queensway, Birmingham B4 6NN, UK
Adv Dent Res 15:51-4. 2001....
- Rac1 and Rac2 GTPases in haematopoiesisVictoria J Weston
CRUK Institute for Cancer Studies, Birmingham University, Edgbaston, UK
Bioessays 26:221-4. 2004..Consequently, two articles1,2 have recently elucidated some overlapping and unique key roles of Rac1 and Rac2 in haematopoietic processes including specialized roles in innate and humoral immunity...
- Was Rodney Ledward a statistical outlier? Retrospective analysis using routine hospital data to identify gynaecologists' performanceMike Harley
Inter Authority Comparisons and Consultancy, Health Services Management Centre, University of Birmingham, Birmingham B15 2RT
BMJ 330:929. 2005....
- The accuracy of maternal anthropometry measurements as predictor for spontaneous preterm birth--a systematic reviewHonest Honest
Academic Department of Obstetrics and Gynecology, Birmingham Women s Hospital, Edgbaston, Birmingham B15 2TG, UK
Eur J Obstet Gynecol Reprod Biol 119:11-20. 2005..To assess the accuracy with which antenatal maternal anthropometric measurements predict the risk spontaneous preterm birth...
- Risk factors of parents abused as children: a mediational analysis of the intergenerational continuity of child maltreatment (Part I)Louise Dixon
Centre for Forensic and Family Psychology, School of Psychology, University of Birmingham, UK
J Child Psychol Psychiatry 46:47-57. 2005..The mediational properties of risk factors in the intergenerational cycle of maltreatment were then explored...
- A randomized, controlled trial of open versus closed vaginal vault at vaginal hysterectomyJanesh K Gupta
Minimal Access Surgical Training Unit MAST, Birmingham Women s Hospital, Birmingham, UK
Acta Obstet Gynecol Scand 84:90-1. 2005
- Is inter-school variation in smoking uptake and cessation due to differences in pupil composition? A cohort studyPaul Aveyard
Department of Public Health and Epidemiology, University of Birmingham, Birmingham B15 2TT, UK
Health Place 11:55-65. 2005....
- Prognostic significance of raised plasma levels of interleukin-6 and C-reactive protein in atrial fibrillationDwayne S G Conway
Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
Am Heart J 148:462-6. 2004..We hypothesized that increased plasma levels of IL-6 and CRP, as indexes of an inflammatory state, would be associated with an increased risk of stroke and death among patients with AF...
- The nasal loop provides an alternative to percutaneous endoscopic gastrostomy in high-risk dysphagic stroke patientsMark R Anderson
Selly Oak Hospital, University Hospital Birmingham, Birmingham, UK
Clin Nutr 23:501-6. 2004..PEG insertion is a procedure with significant mortality and morbidity. We adapted a novel technique of securing NGTs (a nasal loop) which is non-invasive, allows successful NG feeding and may avoid the need for PEG placement...
- A phase I/II study of gemcitabine and fractionated cisplatin in an outpatient setting using a 21-day schedule in patients with advanced and metastatic bladder cancerS A Hussain
Cancer Research UK Institute for Cancer Studies, University of Birmingham B15 2TT, UK
Br J Cancer 91:844-9. 2004..The overall median survival was 16 months (range 10.1-26.6 months). G plus C every 3 weeks is active and well tolerated in an outpatient setting, even in patients receiving prior platinum-based regimens and with poor renal reserve...
- The skin in radiological protection--recent advances and residual unresolved issuesM W Charles
School of Physics and Astronomy, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Radiat Prot Dosimetry 109:323-30. 2004..Some of the main advances in skin dose limitation in radiological protection and some of the remaining unresolved issues are reviewed...
- Hypoxia sensing and pathways of cytosolic Ca2+ increasesEmil C Toescu
Department of Physiology, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Cell Calcium 36:187-99. 2004....
- Integrated primary mental health care: threat or opportunity in the new NHS?Helen Lester
Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Br J Gen Pract 54:285-91. 2004....
- Use and misuse of process and outcome data in managing performance of acute medical care: avoiding institutional stigmaRichard Lilford
Department of Public Health and Epidemiology, University of Birmingham, UK
Lancet 363:1147-54. 2004....
- Activation of c-Jun N-terminal kinase in A549 lung carcinoma cells by sodium dichromate: role of dissociation of apoptosis signal regulating kinase-1 from its physiological inhibitor thioredoxinN J Hodges
School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Toxicology 197:101-12. 2004..We hypothesise that dissociation of apoptosis signal regulating kinase-1 from thioredoxin may be at least partially responsible for Jun N-terminal kinase activation...
- Spectral regularity as a factor distinct from harmonic relations in auditory groupingB Roberts
School of Psychology, University of Birmingham, England
J Exp Psychol Hum Percept Perform 22:604-14. 1996..These findings suggest that spectral regularity is a factor distinct from harmonic relations in auditory grouping...
- Lymphocyte recruitment in alcoholic hepatitisDavid Adams; Fiscal Year: 2009..abstract_text> ..