Genomes and Genes
University of Aberdeen
Organization: University of Aberdeen
- The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE studyTatiana V Macfarlane
School of Medicine and Dentistry, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK
Cancer Causes Control 21:2213-21. 2010..To date the increases have been proportionally greatest among young people. Several reports have suggested that they often do not have a history of tobacco smoking or heavy alcohol consumption...
- Pro-inflammatory mechanisms in diabetic neuropathy: focus on the nuclear factor kappa B pathwayNorman E Cameron
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK
Curr Drug Targets 9:60-7. 2008..However preliminary results in animal models are encouraging and go some way in establishing the NFkappaB cascade as an important therapeutic target for diabetic vascular complications in general, and neuropathy in particular...
- Fear in grasslands: the effect of Eurasian kestrels on skylark abundancesJesús Martínez-Padilla
Aberdeen Centre for Environmental Sustainability ACES, University of Aberdeen and Macaulay Institute, School of Biological Sciences, Aberdeen, UK
Naturwissenschaften 95:391-8. 2008..We suggest that an increased breeding density of kestrels during their breeding period may force the skylarks to breed in other areas, which may explain the decline of their abundance...
- Trials of venous thromboembolism preventionJohn Norrie
Centre for Healthcare Randomised Trials CHaRT, Health Services Research Unit, Health Sciences Building, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
Lancet 370:915-7. 2007
- Resolution of juvenile idiopathic arthritis-associated uveitis after development of common variable immunodeficiencyR Amer
Department of Ophthalmology, Aberdeen Royal Infirmary, Foresterhill, Scotland, UK
Eur J Ophthalmol 17:666-8. 2007..To describe the occurrence of common variable immunodeficiency (CVID) in a patient with juvenile idiopathic arthritis (JIA) and JIA-associated uveitis...
- XML-based clinical data standardisation in the National Health Service ScotlandRaluca Bunduchi
University of Aberdeen Business School, Aberdeen, UK
Inform Prim Care 14:227-33; discussion 234. 2006....
- Molecular phylogenetics of Candida albicansFrank C Odds
Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
Eukaryot Cell 6:1041-52. 2007..Computational haplotype analysis showed a high frequency of recombination events, suggesting that isolates had mixed evolutionary histories resembling those of a sexually reproducing species...
- Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson studyF D Dick
Dr F Dick, Department of Environmental and Occupational Medicine, Aberdeen University Medical School, Foresterhill, Aberdeen AB25 2ZP, UK
Occup Environ Med 64:666-72. 2007..To investigate the associations between Parkinson's disease and other degenerative parkinsonian syndromes and environmental factors in five European countries...
- Wnt signalling: variety at the coreStefan Hoppler
Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK
J Cell Sci 120:385-93. 2007....
- Social transmission of face preferences among humansBenedict C Jones
Face Research Laboratory, School of Psychology, William Guild Building, University of Aberdeen, Aberdeen AB24 2UB, UK
Proc Biol Sci 274:899-903. 2007..Our findings demonstrate that social transmission of face preferences influences judgments of men's attractiveness, potentially demonstrating a mechanism for social transmission of mate preferences...
- Cloning, promoter analysis and expression in response to bacterial exposure of sea bass (Dicentrarchus labrax L.) interleukin-12 p40 and p35 subunitsDiana S Nascimento
IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
Mol Immunol 44:2277-91. 2007..piscicida (Phdp). Finally, the importance of nuclear factor (NF)-kappaB on UV-killed Phdp-induced IL-12 p40 and p35 gene transcription was shown by the use of pyrrolidine dithiocarbamate (PDTC)...
- Poor communication may impair optimal asthma care: a qualitative studyMandy Moffat
Department of General Practice and Primary Care, University of Aberdeen, Aberdeen, UK
Fam Pract 24:65-70. 2007..Despite asthma being primarily managed in general practice and primary care, there is little research into the issues and tools which may impact on managing poorly controlled asthma in this setting...
- Improving outcomes for asthma patients with allergic rhinitis: conclusions from the MetaForum conferencesDavid Price
Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY, UK
BMC Pulm Med 6:S7. 2006
- The health hazards of unemployment and poor education: the socioeconomic determinants of health duration in the European UnionD Cooper
Centre for European Labour Market Research CELMR, University of Aberdeen Business School, Dunbar Street, Old Aberdeen AB24 3QY, UK
Econ Hum Biol 4:273-97. 2006..Age and gender effects are also found...
- Mortality rate acceleration and post-reproductive lifespan in matrilineal whale speciesAndrew D Foote
Lighthouse Field Station, School of Biological Sciences, University of Aberdeen, George Street, Cromarty IV11 8YJ, UK
Biol Lett 4:189-91. 2008..Selection for a long post-reproductive female lifespan in matrilineal whales may therefore be determined by the proportion of females surviving past the point of reproductive cessation...
- Modulation of the neural network involved in the processing of anger prosody: the role of task-relevance and social phobiaSusanne Quadflieg
Department of Biological and Clinical Psychology, Friedrich Schiller University, Am Steiger 3 1, D 07743 Jena, Germany
Biol Psychol 78:129-37. 2008..These results suggest a disorder-associated increased involvement of the orbitofrontal cortex in response to threatening voices in social phobia...
- Absence of three known benzimidazole resistance mutations in Trichostrongylus tenuis, a nematode parasite of avian hostsLucy M I Webster
Division of Environmental and Evolutionary Biology, Institute of Biological and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow G128QQ, UK
Vet Parasitol 158:302-10. 2008..Alternative mechanisms may be responsible for BZ resistance in this system, or the method and timing of treatments may reduce selection pressure for BZ resistance by creating substantial refugia for susceptible genotypes...
- Costs of healthcare-associated methicillin-resistant Staphylococcus aureus and its controlI M Gould
Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
Clin Microbiol Infect 16:1721-8. 2010..Although the literature on the costs of MRSA and its control is suboptimal, it is clear that the control of MRSA is highly desirable and likely to be cost-effective. Any compromises in control are likely to be false economies...
- The use of surface-enhanced Raman scattering for detecting molecular evidence of life in rocks, sediments, and sedimentary depositsStephen A Bowden
Department of Geology and Petroleum Geology, Kings College, University of Aberdeen, Aberdeen, UK
Astrobiology 10:629-41. 2010....
- Discovery of biphenylketones as dual modulators of inflammation and bone lossIain R Greig
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
Bioorg Med Chem Lett 20:5548-51. 2010..Structure-activity studies led to the identification of compound 4c, which had good potency against osteoclasts (IC50=0.8 microM), showed oral activity, and was able to completely prevent inflammation and bone loss in vivo...
- Age-related changes in the integration of gaze direction and facial expressions of emotionGillian Slessor
School of Psychology, College of Life Sciences and Medicine, University of Aberdeen, Scotland, United Kingdom
Emotion 10:555-62. 2010..Age differences were greatest when interpreting angry expressions. Implications of these findings for older adults' social functioning are discussed...
- The putative RxLR effector protein SpHtp1 from the fish pathogenic oomycete Saprolegnia parasitica is translocated into fish cellsPieter van West
Aberdeen Oomycete Laboratory, College of Life Sciences and Medicine, Institute of Medical Sciences, University of Aberdeen School of Medical Sciences, Foresterhill, Aberdeen, UK
FEMS Microbiol Lett 310:127-37. 2010..parasitica, and also when the RTG-2 cells were treated with recombinant SpHtp1 fused to a C-terminal His-tag. These findings suggest that protein translocation could play an important role in Saprolegniosis...
- Management of drug misuse: an 8-year follow-up survey of Scottish GPsCatriona Matheson
Centre of Academic Primary Care, University of Aberdeen, School of Medicine and Dentistry, Foresterhill Health Centre, Westburn Road, Aberdeen, Scotland
Br J Gen Pract 60:517-20. 2010..Over 70% offered blood-borne virus screening and 71% were aware of patients using psychostimulants. Recent changes, particularly the new GP contract may have decreased GP involvement in treating drug misusers...
- The effect of tiotropium bromide on health-related quality of life in chronic obstructive pulmonary diseaseDavid Price
University of Aberdeen, Department of General Practice and Primary Care, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY, Scotland, UK
Expert Rev Pharmacoecon Outcomes Res 6:391-405. 2006..This article reviews the data currently available on the efficacy of tiotropium to improve the health-related quality of life of patients with chronic obstructive pulmonary disease...
- Seasonal 25-hydroxyvitamin D changes in British postmenopausal women at 57 degrees N and 51 degrees N: a longitudinal studyA Mavroeidi
Bone and Musculoskeletal Research Programme, University of Aberdeen, UK
J Steroid Biochem Mol Biol 121:459-61. 2010..The extent of vitamin D deficiency in Asian women residing in the South of England is of concern...
- Analysis of the UK recommendations on obesity based on a proposed implementation frameworkAmudha S Poobalan
Section of Population Health, Division of Applied Health Sciences, University of Aberdeen, Medical School, Polwarth Building, Aberdeen, UK
BMC Public Health 10:17. 2010..The recommendations, while based on evidence, are not formulated in a way that readily leads to implementation. This paper analyses the recent UK recommendations on obesity using a proposed implementation framework...
- Characterization and assessment of dermal and inhalable nickel exposures in nickel production and primary user industriesG W Hughson
Exposure Assessment Section, Institute of Occupational Medicine, Edinburgh EH14 4AP, UK
Ann Occup Hyg 54:8-22. 2010....
- Politicians in apron: case study of rebel health services in NepalBhimsen Devkota
Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland, UK
Asia Pac J Public Health 21:377-84. 2009..However, there has been no national discussion in Nepal of what kind of health reform and integration model is appropriate for a sustainable peace and improved service delivery...
- Experience matters: comparing novice and expert ratings of non-technical skills using the NOTSS systemSteven Yule
School of Psychology, University of Aberdeen, Aberdeen, Scotland, UK
ANZ J Surg 79:154-60. 2009..Where there was disagreement, novice raters tended to provide lower ratings than the experts. Novice raters require significant training in this emerging area of competence in order to accurately rate non-technical skills...
- Direct health services costs of providing assisted reproduction services in older womenAbha Maheshwari
Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen Maternity Hospital, Foresterhill, Aberdeen, AB25 2ZL, Scotland, UK
Fertil Steril 93:527-36. 2010..To assess the total health service costs incurred for each live birth achieved by older women undergoing IVF compared with costs in younger women...
- Managing low back pain presenting to primary care: where do we go from here?Gary J Macfarlane
Aberdeen Pain Research Collaboration, Epidemiology Group, University of Aberdeen, United Kingdom
Pain 122:219-22. 2006
- Chronic widespread pain and fibromyalgia: Should reports of increased mortality influence management?Gary J Macfarlane
Epidemiology Group, University of Aberdeen, Department of Public Health, School of Medicine, Polwarth Building, Aberdeen, AB25 2ZD, Scotland, UK
Curr Rheumatol Rep 7:339-41. 2005..Studies are currently underway which will determine whether initial observations of an increased mortality risk can be replicated...
- Survival of Escherichia coli O157:H7 in private drinking water wells: influences of protozoan grazing and elevated copper concentrationsRebekka R E Artz
Department of Plant and Soil Science, University of Aberdeen, Scotland, UK
FEMS Microbiol Lett 216:117-22. 2002..It therefore appears that wells with higher water quality as assessed using the European Union Drinking Water Directive standards will also allow survival of E. coli O157:H7 for much longer periods...
- Executive functioning as a predictor of children's mathematics ability: inhibition, switching, and working memoryR Bull
Department of Psychology, University ofAberdeen, Scotland
Dev Neuropsychol 19:273-93. 2001..The practical and theoretical implications of these results are discussed, along with suggestions for task changes and longitudinal studies that would clarify theoretical and developmental issues related to executive functioning...
- Review of unexplained infertility and obstetric outcome: a 10 year reviewZ Pandian
Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen AB25 2ZD, UK
Hum Reprod 16:2593-7. 2001..Our aims were to examine the obstetric and perinatal outcome of singleton pregnancies in couples with unexplained infertility and explore the impact of fertility treatment...
- Decoding photoperiodic time and melatonin in mammals: what can we learn from the pars tuberalis?D G Hazlerigg
Aberdeen Centre for Energy Regulation and Obesity, University of Aberdeen, Scotland, UK
J Biol Rhythms 16:326-35. 2001..Here, the authors review current knowledge and highlight critical gaps in our present understanding...
- Eosinophilic angiocentric fibrosis and Wegener's granulomatosis: a case report and literature reviewJ Loane
Department of Pathology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZD, UK
J Clin Pathol 54:640-1. 2001..This association suggests a possible mechanism for its pathogenesis...
- Thy1 glomerulonephritis induced in young lewis rats accelerates age-related glomerulosclerosisK Stewart
Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK
Nephron 88:57-64. 2001....
- A dermal model for spray painters. Part II: estimating the deposition and uptake of solventsS Semple
Department of Environmental and Occupational Medicine, University of Aberdeen, AB25 2ZD, Aberdeen, UK
Ann Occup Hyg 45:25-33. 2001..Furthermore, it is envisaged that the model may provide the basis for generic assessment of dermal exposure and uptake...
- Correction of cubitus varus by French or dome osteotomy: a comparative studyK Kumar
Aberdeen Royal Hospitals, Scotland
J Trauma 49:717-21. 2000..The purpose of this study was to compare the outcomes of two different techniques of supracondylar osteotomy, French osteotomy and dome osteotomy, for the correction of posttraumatic cubitus varus...
- Small cell malignant melanoma: a variant of naevoid melanoma. Clinicopathological features and histological differential diagnosisK Blessing
Department of Pathology, Aberdeen University, Foresterhill, UK
J Clin Pathol 53:591-5. 2000..To describe the clinical and histopathological features of a rare variant of naevoid melanoma, small cell melanoma, and discuss the histological differential diagnoses...
- The effects of diffusates from the spores of Aspergillus fumigatus and A. terreus on human neutrophils, Naegleria gruberi and Acanthamoeba castellaniiR P Hobson
Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, UK
Med Mycol 38:133-41. 2000..Spore diffusate from A. fumigatus did not inhibit the growth of Acanthamoeba castellanii. The relevance of these findings to the pathogenicity of A. fumigatus and A. terreus is discussed...
- The clinical manipulation of angiogenesis: pathology, side-effects, surprises, and opportunities with novel human therapiesW D Thompson
Department of Pathology, University of Aberdeen Medical School, Aberdeen Royal Hospitals Trust, Foresterhill, Aberdeen AB25 2ZD, UK
J Pathol 190:330-7. 2000..Angiogenesis researchers await further feedback and ideas from the clinic to stimulate the next phase of basic and applied research...
- Monocyte plasminogen activator inhibitor 2 (PAI-2) inhibits u-PA-mediated fibrin clot lysis and is cross-linked to fibrinH Ritchie
Department of Molecular and Cell Biology, University of Aberdeen, UK
Thromb Haemost 81:96-103. 1999..This study defines a mechanism by which PAI-2 is localized to fibrin, where it acts as an effective inhibitor of u-PA-mediated fibrinolysis...
- Determinants of response to antibiotic therapyI M Gould
Dept of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Scotland, UK
J Chemother 10:347-53. 1998..Understanding the interaction of antibiotics with the immune system and the consequences of the differing actions of the various antibiotic classes on the immune response is another door that is opening for the future...
- Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)L Sharp
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill House Annex, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
Cancer Lett 181:65-71. 2002..Patterns in risk with regard to genotype and folate combinations are broadly similar those reported for colorectal neoplasia. The roles of MTHFR and folate in breast cancer aetiology are likely to be complex...
- Eyewitness recognition errors: the effects of mugshot viewing and choosing in young and old adultsAmina Memon
Department of Psychology, University of Aberdeen, Kings College, Old Aberdeen, Scotland
Mem Cognit 30:1219-27. 2002..Despite age-related increases in false choosing, age did not qualify other effects. The results are discussed in terms of commitment, source memory, and gist-based processing...
- Granule protein changes and membrane receptor phenotype in maturing human eosinophils cultured from CD34+ progenitorsM W Al-Rabia
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
Clin Exp Allergy 33:640-8. 2003..Eosinophils are now recognized as major effector cells in allergic and asthmatic disease with a potent armoury of mediators whose release makes a major contribution to the inflammation underlying these conditions...
- Screening for undiagnosed parkinsonism among older people in general practiceK S M Taylor
Department of Medicine and Therapeutics, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK
Age Ageing 34:501-4. 2005
- Surgical abortion using manual vacuum aspiration under local anaesthesia: a pilot study of feasibility and women's acceptabilityHaitham Hamoda
Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen, UK
J Fam Plann Reprod Health Care 31:185-8. 2005..The aim of this study was to assess the feasibility, acceptability and efficacy of surgical abortion using MVA under local anaesthesia for termination of pregnancy up to 63 days' gestation, within a UK National Health Service setting...
- Identification and bioactivities of IFN-gamma in rainbow trout Oncorhynchus mykiss: the first Th1-type cytokine characterized functionally in fishJun Zou
Scottish Fish Immunology Research Centre, University of Aberdeen, Aberdeen, Scotland, United Kingdom
J Immunol 175:2484-94. 2005..Taken together, the present study has demonstrated for the first time a functional IFN-gamma homologue in a fish species, strongly suggesting a conserved Th1 immune response is most likely present in lower vertebrates...
- The prevalence of ear, nose and throat problems in the community: results from a national cross-sectional postal survey in ScotlandPhilip C Hannaford
Department of General Practice and Primary Care, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY, UK
Fam Pract 22:227-33. 2005..To assess the prevalence of ear, nose and throat (ENT) symptoms experienced by individuals living in Scotland, and their use of GP or hospital services for these problems...
- Elevated amino acid biosynthesis in Phytophthora infestans during appressorium formation and potato infectionLaura J Grenville-Briggs
Aberdeen Oomycete Group, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
Fungal Genet Biol 42:244-56. 2005..Amino acid biosynthesis would appear to be important for pathogenicity in P. infestans, providing a potential metabolic target for chemical control...
- Modification of assisted reproduction techniques to prevent preterm birthZabeena Pandian
University of Aberdeen, Aberdeen, United Kingdom
Clin Obstet Gynecol 47:833-41; discussion 881-2. 2004
- Bernardino Ramazzini: the father of occupational medicineMalcolm H Pope
Liberty Safework Centre, University of Aberdeen, Aberdeen, AB25 2ZB, Scotland
Spine (Phila Pa 1976) 29:2335-8. 2004..In particular, he warned of the problems of inactivity and poor postures inherent in some jobs...
- Development of an instrument to measure the surgical operating theatre learning environment as perceived by basic surgical traineesKevin Cassar
Department of Vascular Surgery, University of Aberdeen, Foresterhill, UK
Med Teach 26:260-4. 2004..This instrument was found to have high reliability and validity. Its potential usefulness for informing committees responsible for overseeing surgical training is discussed...
- Is the prevalence and shedding concentrations of E. coli O157 in beef cattle in Scotland seasonal?Iain D Ogden
Applied Food Microbiology Group, Department of Medical Microbiology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
FEMS Microbiol Lett 233:297-300. 2004..However, high shedding beef cattle (excreting 10(-4) g(-1)) appear to shed greater concentrations of E. coli O157 in the warmer months which may partly explain increased human infection seasonality at this time...
- Limits to sustained energy intake. VI. Energetics of lactation in laboratory mice at thermoneutralityE Krol
Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
J Exp Biol 206:4255-66. 2003..1 g day(-1)) was also lower than at 21 degrees C (3.1 g day(-1)). The reduced food intake and low reproductive output in mice lactating at 30 degrees C are consistent with the heat dissipation limit hypothesis...
- The importance of setting and evaluating standards of telemedicine trainingE M Brebner
Telemedicine Laboratory, Remote Health Care Unit, Department of General Practice and Primary Care, University of Aberdeen, Aberdeen, UK
J Telemed Telecare 9:S7-9. 2003....
- Commentary: The context and outcome of nutrition campaigning in 1934David F Smith
University of Aberdeen, Department of History, Meston Walk, Aberdeen AB24 3FX, UK
Int J Epidemiol 32:500-2. 2003
- Antenatal factors in the development of the lumbar vertebral canal: a magnetic resonance imaging studyJanet E Jeffrey
Department of Orthopaedic Surgery, University of Aberdeen, UK
Spine (Phila Pa 1976) 28:1418-23. 2003..The lumbar vertebral canal was measured in two cohorts of 10-year-old children (n = 161) using magnetic resonance imaging (MRI) and compared with obstetric records...
- Modelling antibody side chain conformations using heuristic database searchD W Ritchie
Department of Computing Science, King s College, University of Aberdeen, UK
Proc Int Conf Intell Syst Mol Biol 5:237-40. 1997..We expect our approach could be used with other homologous protein families, in addition to antibodies, both to improve the quality of model structures and to give a "smart start" to the side chain placement problem...