Martin R Turner

Summary

Country: UK

Publications

  1. ncbi request reprint Cortical 5-HT1A receptor binding in patients with homozygous D90A SOD1 vs sporadic ALS
    M R Turner
    Department of Neurology, John Radcliffe Hospital, Headley Way, Oxford, UK
    Neurology 68:1233-5. 2007
  2. doi request reprint Teaching video NeuroImage: the "Fonzarelli" sign: focal thumb dystonia as an early manifestation of Parkinson disease
    Martin R Turner
    Department of Neurology, West Wing Level 3, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Neurology 71:e11. 2008
  3. ncbi request reprint Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis
    Martin R Turner
    Department of Neurology, John Radcliffe Hospital, Oxford, UK
    Amyotroph Lateral Scler 8:343-7. 2007
  4. ncbi request reprint Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET
    Martin R Turner
    Department of Neurology, The Radcliffe Infirmary, Oxford, UK
    J Neurol 254:1033-6. 2007
  5. pmc Delayed recovery of ulnar neuropathy due to elbow warming
    Martin R Turner
    Department of Neurology, The Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK
    J Neurol Neurosurg Psychiatry 76:1268. 2005
  6. doi request reprint Cardiovascular fitness as a risk factor for amyotrophic lateral sclerosis: indirect evidence from record linkage study
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 83:395-8. 2012
  7. pmc Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study
    Martin R Turner
    From the Oxford University Nuffield Department of Clinical Neurosciences M R T, K T, John Radcliffe Hospital Oxford University Unit of Health Care Epidemiology R G, M J G, Department of Public Health and Oxford University Department of Physiology, Anatomy and Genetics S R, Oxford, UK
    Neurology 81:1222-5. 2013
  8. pmc Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk
    Ricarda A L Menke
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK FMRIB Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 87:580-8. 2016
  9. pmc T₂-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS
    Matthew C Evans
    1 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK 2 CR UK MRC Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, UK
    J Cereb Blood Flow Metab 34:785-93. 2014
  10. doi request reprint Young-onset amyotrophic lateral sclerosis: historical and other observations
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Brain 135:2883-91. 2012

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Cortical 5-HT1A receptor binding in patients with homozygous D90A SOD1 vs sporadic ALS
    M R Turner
    Department of Neurology, John Radcliffe Hospital, Headley Way, Oxford, UK
    Neurology 68:1233-5. 2007
  2. doi request reprint Teaching video NeuroImage: the "Fonzarelli" sign: focal thumb dystonia as an early manifestation of Parkinson disease
    Martin R Turner
    Department of Neurology, West Wing Level 3, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Neurology 71:e11. 2008
  3. ncbi request reprint Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis
    Martin R Turner
    Department of Neurology, John Radcliffe Hospital, Oxford, UK
    Amyotroph Lateral Scler 8:343-7. 2007
    ..This study provides further evidence for a different pattern of cortical neuronal vulnerability in homD90A versus SALS patients that may provide insight as to their slower rate of disease progression...
  4. ncbi request reprint Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET
    Martin R Turner
    Department of Neurology, The Radcliffe Infirmary, Oxford, UK
    J Neurol 254:1033-6. 2007
    ....
  5. pmc Delayed recovery of ulnar neuropathy due to elbow warming
    Martin R Turner
    Department of Neurology, The Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK
    J Neurol Neurosurg Psychiatry 76:1268. 2005
  6. doi request reprint Cardiovascular fitness as a risk factor for amyotrophic lateral sclerosis: indirect evidence from record linkage study
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 83:395-8. 2012
    ..Hospital admission for coronary heart disease (CHD) might serve as an objective marker of reduced cardiovascular fitness...
  7. pmc Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study
    Martin R Turner
    From the Oxford University Nuffield Department of Clinical Neurosciences M R T, K T, John Radcliffe Hospital Oxford University Unit of Health Care Epidemiology R G, M J G, Department of Public Health and Oxford University Department of Physiology, Anatomy and Genetics S R, Oxford, UK
    Neurology 81:1222-5. 2013
    ..To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease...
  8. pmc Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk
    Ricarda A L Menke
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK FMRIB Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 87:580-8. 2016
    ..To discern presymptomatic changes in brain structure or function using advanced MRI in carriers of mutations predisposing to amyotrophic lateral sclerosis (ALS)...
  9. pmc T₂-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS
    Matthew C Evans
    1 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK 2 CR UK MRC Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, UK
    J Cereb Blood Flow Metab 34:785-93. 2014
    ....
  10. doi request reprint Young-onset amyotrophic lateral sclerosis: historical and other observations
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Brain 135:2883-91. 2012
    ..The timing of initiating pathological processes in relation to the emergence of symptoms is discussed, including the potential role of very early development and the interaction of epigenetic and environmental factors...
  11. pmc Pattern of spread and prognosis in lower limb-onset ALS
    Martin R Turner
    Oxford University Department of Clinical Neurology, Oxford, UK
    Amyotroph Lateral Scler 11:369-73. 2010
    ..The time interval to this initial spread is a powerful factor in predicting overall survival, and could be used to facilitate decision-making and effective care planning...
  12. pmc Eye-tracking in amyotrophic lateral sclerosis: A longitudinal study of saccadic and cognitive tasks
    Malcolm Proudfoot
    a Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Amyotroph Lateral Scler Frontotemporal Degener 17:101-11. 2015
    ..PLS patients may have more cortical dysfunction than has been previously appreciated. ..
  13. pmc Advances in motor neurone disease
    Dirk Bäumer
    Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J R Soc Med 107:14-21. 2014
    ..A major gap remains in understanding how such fundamental processes appear to function without obvious deficit in the decades prior to symptom emergence, and the study of pre-symptomatic gene carriers is an important new initiative. ..
  14. doi request reprint Head and other physical trauma requiring hospitalisation is not a significant risk factor in the development of ALS
    Martin R Turner
    Oxford University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    J Neurol Sci 288:45-8. 2010
    ..The high risk of head injury observed in the immediate post-diagnosis period may be amenable to primary prevention...
  15. doi request reprint Extracellular vesicles in neurodegenerative disease - pathogenesis to biomarkers
    Alexander G Thompson
    Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Rev Neurol 12:346-57. 2016
    ..This Review examines the current knowledge of the biology and function of EVs, discusses the evidence for their involvement in the pathogenesis of neurodegenerative diseases, and considers their potential as biomarkers of disease. ..
  16. pmc Cerebrovascular injury as a risk factor for amyotrophic lateral sclerosis
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 87:244-6. 2016
    ..To use an unbiased method to test a previously reported association between cerebral arteriovenous malformation (AVM) embolisation and the subsequent development of amyotrophic lateral sclerosis (ALS)...
  17. pmc Mimics and chameleons in motor neurone disease
    Martin R Turner
    University of Oxford Nuffield Department of Clinical Neurosciences, Oxford, UK
    Pract Neurol 13:153-64. 2013
    ....
  18. doi request reprint Does interneuronal dysfunction contribute to neurodegeneration in amyotrophic lateral sclerosis?
    Martin R Turner
    Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    Amyotroph Lateral Scler 13:245-50. 2012
    ..An excitotoxic final common pathway might then result from unopposed glutamatergic activity. If correct, therapies aimed specifically at supporting interneuronal function may provide a novel therapeutic strategy...
  19. doi request reprint Magnetic resonance imaging of pathological processes in rodent models of amyotrophic lateral sclerosis
    Matthew C Evans
    Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    Amyotroph Lateral Scler 13:288-301. 2012
    ..These are potentially important steps towards the ultimate goal of human therapeutic translation...
  20. doi request reprint Epilepsy and the subsequent risk of cerebral tumour: record linkage retrospective cohort study
    Tasneem Khan
    University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 82:1041-5. 2011
    ..Studies suggest that seizures may precede the detection of cerebral tumour by several years. Aim To quantify the risk of cerebral tumour after new onset seizures, with particular interest in long term risk...
  21. doi request reprint The diagnostic pathway and prognosis in bulbar-onset amyotrophic lateral sclerosis
    Martin R Turner
    Oxford University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    J Neurol Sci 294:81-5. 2010
    ..Diagnostic delay is a common occurrence in ALS, and many BO patients report having attended other specialist clinics prior to diagnosis...
  22. ncbi request reprint [11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS
    M R Turner
    Department of Neurology, PO Box 41, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Brain 128:896-905. 2005
    ..Further investigation into the role of the 5-HT1A receptor and the potential of [11C]-WAY100635 PET as a marker of cortical dysfunction in ALS is warranted...
  23. doi request reprint A risk stratifying tool to facilitate safe late-stage percutaneous endoscopic gastrostomy in ALS
    Alexander G Thompson
    a Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Amyotroph Lateral Scler Frontotemporal Degener . 2017
    ..The safety of percutaneous endoscopic gastrostomy (PEG) insertion in amyotrophic lateral sclerosis (ALS) patients with significant respiratory compromise has been questioned...
  24. pmc The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis
    Elizabeth Gray
    a Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK
    Amyotroph Lateral Scler Frontotemporal Degener 16:456-63. 2015
    ..Endogenous ethanol in the CSF may be an unrecognized novel marker of neuronal tissue injury in ALS. ..
  25. doi request reprint Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis
    Gwenaelle Douaud
    Oxford Centre for Functional Magnetic Resonance of the Brain FMRIB, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Brain 134:3470-9. 2011
    ....
  26. pmc Lockhart Clarke's contribution to the description of amyotrophic lateral sclerosis
    Martin R Turner
    Department of Clinical Neurology, West Wing Level 3, John Radcliffe Hospital, Oxford University, Oxford OX3 9DU, UK
    Brain 133:3470-9. 2010
    ..These 'past masters' still have much to teach us...
  27. doi request reprint Cancer in patients with motor neuron disease, multiple sclerosis and Parkinson's disease: record linkage studies
    Alessandro F Fois
    Unit of Health Care Epidemiology, Department of Public Health, University of Oxford, Old Road Campus, Old Road, Oxford, UK
    J Neurol Neurosurg Psychiatry 81:215-21. 2010
    ..To determine the risk of cancer before and after the diagnosis of motor neuron disease (MND), multiple sclerosis (MS) and Parkinson's disease (PD)...
  28. doi request reprint Biomarkers in amyotrophic lateral sclerosis
    Martin R Turner
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet Neurol 8:94-109. 2009
    ..Such biomarkers might also resolve complexities of phenotypic heterogeneity in clinical trials. In this Review, we discuss the development of biomarkers in ALS and consider potential future directions for research...
  29. doi request reprint Oculomotor dysfunction in amyotrophic lateral sclerosis: a comprehensive review
    Rakesh Sharma
    Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom
    Arch Neurol 68:857-61. 2011
    ..The study of oculomotor dysfunction holds significant promise as an additional source of much needed prognostic, monitoring, and mechanistic biomarkers for ALS...
  30. pmc Reduction of elevated IGF-1 levels in coincident amyotrophic lateral sclerosis and acromegaly
    Erlick A C Pereira
    University of Oxford Department of Clinical Neurology, John Radcliffe Hospital, UK
    Amyotroph Lateral Scler 11:255-7. 2010
    ..Through clinical observation and prognostic modelling we suggest that this concern was unfounded. The potential interaction of these two rarely coincident disorders in our patient is discussed...
  31. ncbi request reprint Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET
    M R Turner
    Department of Neurology, Institute of Psychiatry, King s College, De Crespigny Park, London, UK
    Brain 128:1323-9. 2005
    ..This study provides evidence for differences in the distribution of reduced cortical [11C]flumazenil binding in homD90A compared with sALS patients. We hypothesize that this might reflect differences in cortical neuronal vulnerability...
  32. pmc Neuroimaging Endpoints in Amyotrophic Lateral Sclerosis
    Ricarda A L Menke
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Neurotherapeutics . 2016
    ..Further multicenter research is now needed to establish their validity as therapeutic outcome measures...
  33. pmc The expanding syndrome of amyotrophic lateral sclerosis: a clinical and molecular odyssey
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 86:667-73. 2015
    ..Nonetheless, there is a common clinical core to ALS, as clear today as it was to Charcot and others. We stress the continuing relevance of clinical observations amid the increasing molecular complexity of ALS. ..
  34. pmc Ensuring continued progress in biomarkers for amyotrophic lateral sclerosis
    Martin R Turner
    Oxford University, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, West Wing Level 3, Oxford, OX3 9DU, UK
    Muscle Nerve 51:14-8. 2015
    ..Appropriate application of multimodal approaches, international collaboration, presymptomatic studies, and biomarker integration into future therapeutic trials are among the essential priorities going forward...
  35. pmc Controversies and priorities in amyotrophic lateral sclerosis
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Lancet Neurol 12:310-22. 2013
    ....
  36. pmc The internet for self-diagnosis and prognostication in ALS
    Zhongbo Chen
    Oxford University Medical School, John Radcliffe Hospital, Oxford, UK
    Amyotroph Lateral Scler 11:565-7. 2010
    ..Results in relation to 'cure' were misleading and may promulgate false hopes. There is a need to guide those with ALS (and particularly their children) to sources of reliable web-based information in addition to open discussion...
  37. pmc Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration
    Claire L Simpson
    Department of Neurology, King s College London, London SE5 8AF, UK
    Hum Mol Genet 18:472-81. 2009
    ..01). These findings add to the growing body of evidence implicating the RNA processing pathway in neurodegeneration and suggest a critical role for ELP3 in neuron biology and of ELP3 variants in ALS...
  38. ncbi request reprint Microvasculitic paraproteinaemic polyneuropathy and B-cell lymphoma
    Martin R Turner
    Department of Neurology, Institute of Psychiatry, King s College, De Crespigny Park, London SE5 8AF, UK
    J Peripher Nerv Syst 8:100-7. 2003
    ..A 2-stage pathogenic cascade is postulated and explored with a review of the relevant literature...
  39. ncbi request reprint A case of celiac disease mimicking amyotrophic lateral sclerosis
    Martin R Turner
    Department of Neurology, John Radcliffe Hospital, Oxford, UK
    Nat Clin Pract Neurol 3:581-4. 2007
    ..The thigh muscle in the affected leg showed signs of wasting. The patient had a remote family history of celiac disease...
  40. ncbi request reprint Clinical trials in ALS: an overview
    M R Turner
    Department of Neurology, Institute of Psychiatry, London, UK
    Semin Neurol 21:167-75. 2001
    ..The problems in the design of trials in ALS are discussed, including the selection of end points and surrogate markers of disease progression, and the major parameters in ALS assessment are reviewed...
  41. pmc Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis
    N Filippini
    University of Oxford Centre for Functional Magnetic Resonance of the Brain, John Radcliffe Hospital, Oxford, UK
    Neurology 75:1645-52. 2010
    ..We sought to establish whether there is a consistent signature of cerebral white matter abnormalities in heterogeneous ALS cases...
  42. ncbi request reprint Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study
    M R Turner
    Department of Neurology, Institute of Psychiatry, King s College, London, UK
    Neurobiol Dis 15:601-9. 2004
    ..They also argue for the development of therapeutic strategies aimed at inflammatory pathways...
  43. pmc Juvenile ALS with basophilic inclusions is a FUS proteinopathy with FUS mutations
    D Baumer
    Department of Neuropathology, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Neurology 75:611-8. 2010
    ..The nosologic position of this type of ALS in the molecular pathologic and genetic classification of ALS is unknown...
  44. ncbi request reprint A novel central motor conduction abnormality in D90A-homozygous patients with amyotrophic lateral sclerosis
    Abena D Osei-Lah
    Department of Clinical Neurophysiology, Guy s, King s, and St Thomas School of Medicine, London SE5 9ES, UK
    Muscle Nerve 29:790-4. 2004
    ..Apart from further defining the phenotype of familial ALS, these findings may have importance in understanding the pathogenesis of central motor abnormalities in these patients...
  45. ncbi request reprint Reversible diffusion MRI abnormalities and transient mutism after liver transplantation
    Martin R Turner
    Neurology 64:177; author reply 177. 2005
  46. ncbi request reprint Large-scale pathways-based association study in amyotrophic lateral sclerosis
    Dalia Kasperaviciute
    Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK
    Brain 130:2292-301. 2007
    ..It is reliable for large scale genotyping studies of diseases such as ALS, where DNA sample collections are limited because of low disease prevalence and short survival time...
  47. ncbi request reprint Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis
    Ammar Al-Chalabi
    Department of Neurology, Academic Neuroscience Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Ann Neurol 54:130-4. 2003
    ..There was no difference in age of onset, clinical presentation, rate of progression, or disease duration for those with one or two copies of the null allele, excluding CNTF as a major disease modifier in ALS...
  48. ncbi request reprint Comparison of two percutaneous radiological gastrostomy tubes in the nutritional management of ALS patients
    Alan Rio
    Department of Nutrition and Dietetics, King s College Hospital, London, UK
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:177-81. 2005
    ..We conclude that the Entristar skin level gastrostomy tube is associated with a reduction in peristomal infection, tube failure and blockage compared with the Wills-Oglesby tube...
  49. ncbi request reprint Amyotrophic lateral sclerosis in an urban setting: a population based study of inner city London
    Clare A Johnston
    J Neurol 253:1642-3. 2006
  50. doi request reprint Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study
    Paul Wicks
    MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, Department of Psychology, London
    Amyotroph Lateral Scler 9:43-9. 2008
    ..This study indicates that [11C]-flumazenil PET can be used to help localize cortical regions associated with cognitive deficits in ALS...