- Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular diseaseJoanne L Rodford
Institute of Developmental Sciences, University of Southampton, Southampton, UK
J Physiol 586:4709-20. 2008..Our findings have established that PR induces significant phenotypic changes in male offspring that may be indicative of an adaptive response during development...
- Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal dietChristopher Torrens
Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland, New Zealand
Br J Nutr 101:27-33. 2009....
- Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependentChristopher Torrens
Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton SO16 6YD, UK
Exp Physiol 94:1024-33. 2009..The effect depends on the timing of the insult, but also on the vascular bed studied and vessel hierarchy in the vascular tree...
- Atorvastatin restores endothelial function in offspring of protein-restricted rats in a cholesterol-independent mannerChristopher Torrens
Vascular Biology Group, Institute of Developmental Sciences 887, University of Southampton, School of Medicine, Southampton General Hospital, Tremona Rd, Southampton S016 6YD, United Kingdom
Hypertension 53:661-7. 2009..These data suggest that atorvastatin can restore endothelial function in this model, but its effects are gender specific and dependent on the vascular bed...
- Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspringAdam J Watkins
School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK
Br J Nutr 103:1762-70. 2010....
- Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male miceChristopher Torrens
Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
PLoS ONE 7:e50671. 2012..To determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring...
- Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesisChristopher J Kelsall
Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Hampshire, United Kingdom
PLoS ONE 7:e34492. 2012....
- Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery functionOmar A Khan
Department of Cardiothoracic Surgery, Southampton General Hospital, UK
Eur J Cardiothorac Surg 28:811-5. 2005..We investigated the effect of pre- and post-natal nutrient restriction on the vascular reactivity of the left internal thoracic artery using a sheep model...
- Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspringKaren A Lillycrop
Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 100:278-82. 2008..These data show for the first time that prenatal nutrition induces differential changes to the methylation of individual CpG dinucleotides in juvenile rats which persist in adults...
- Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liverSamuel P Hoile
Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK
J Nutr Biochem 24:1213-20. 2013..Thus, epigenetic regulation of Fads2 may contribute to short- and long-term regulation of PUFA synthesis...
- Transmission of raised blood pressure and endothelial dysfunction to the F2 generation induced by maternal protein restriction in the F0, in the absence of dietary challenge in the F1 generationChristopher Torrens
Maternal, Fetal and Neonatal Physiology, Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK
Br J Nutr 100:760-6. 2008..Risk factors for chronic disease may therefore be heritable by non-genomic processes...
- Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthoodJane K Cleal
Institute of Developmental Sciences, University of Southampton, Tremona Road, Southampton SO16 6YD, United Kingdom
Proc Natl Acad Sci U S A 104:9529-33. 2007..Our findings have substantial implications for devising strategies to reduce the impact of a mismatch in nutrition levels in humans undergoing rapid socio-economic transitions in both developing and developed societies...
- Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restrictionChristopher Torrens
Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Southampton S016 5YA, United Kingdom
Hypertension 47:982-7. 2006..The concept of developmental origins of adult disease focuses predominately on fetal life but must also include a role for maternal cardiovascular function...
- Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspringChristopher Torrens
Centre for Fetal Origins of Adult Disease, University of Southampton, Southampton, SO16 5YA, UK
J Physiol 547:77-84. 2003..We conclude that dietary protein restriction in pregnancy programmes vasodilator dysfunction in isolated resistance arteries of female offspring when they become pregnant, but does not affect conduit arteries...
- Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generationsGraham C Burdge
Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
Br J Nutr 97:435-9. 2007..This may represent a mechanism for the transmission of induced phenotypes between generations..
- Polyunsaturated fatty acid biosynthesis is involved in phenylephrine-mediated calcium release in vascular smooth muscle cellsNicola A Irvine
Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK
Prostaglandins Leukot Essent Fatty Acids 101:31-9. 2015..Together these findings suggest that PUFA biosynthesis in VSM cells is involved in calcium release associated with vasoconstriction. ..
- Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspringAdam J Watkins
School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
J Physiol 586:2231-44. 2008..Similar and distinct postnatal outcomes were observed here compared with maternal LPD treatment during post-fertilization preimplantation development which may reflect the relative contribution of the paternal genome...
- Endogenous Reference Genes for Gene Expression Studies on Bicuspid Aortic Valve Associated Aortopathy in HumansOliver J Harrison
Institute of Developmental Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom
PLoS ONE 11:e0164329. 2016..The expression of B2M and SDHA were found to be the least stable HK genes. We propose the use of GAPDH, UBC and ACTB as reference genes for gene expression studies of BAV aortopathy using ascending aortic tissue...
- Developmental conditioning of endothelium-derived hyperpolarizing factor-mediated vasorelaxationRebecca Stead
aVascular Research Group bBone and Joint Research Group, Institute of Developmental Sciences cFaculty of Medicine, Biomedical Imaging Unit, University of Southampton, Southampton dCardiovascular Division, BHF Centre of Research Excellence, School of Medicine, King s College London, London, United Kingdom Rebecca Stead and Moji G Musa contributed equally to the writing of this article
J Hypertens 34:452-63; discussion 463. 2016....