D Sebag-Montefiore

Summary

Affiliation: St James's University Hospital
Country: UK

Publications

  1. pmc Effective treatment of anal cancer in the elderly with low-dose chemoradiotherapy
    N Charnley
    Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds, West Yorkshire LS16 6QB, UK
    Br J Cancer 92:1221-5. 2005
  2. pmc Preoperative radiotherapy combined with 5 days per week capecitabine chemotherapy in locally advanced rectal cancer
    I Craven
    Leeds Cancer Centre, Cookridge Hospital Lane, Leeds LS16 6QB, UK
    Br J Cancer 97:1333-7. 2007
  3. pmc Concurrent chemoradiotherapy for squamous cell carcinoma of the anus using a shrinking field radiotherapy technique without a boost
    A A Melcher
    Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds, West Yorkshire LS16 6QB, UK
    Br J Cancer 88:1352-7. 2003
  4. pmc Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial
    David Sebag-Montefiore
    St James s University Hospital, Leeds, UK
    Lancet 373:811-20. 2009
  5. ncbi request reprint Developments in the use of chemoradiotherapy in rectal cancer
    D Sebag-Montefiore
    Leeds Cancer Centre, Cookridge Hospital, Leeds, West Yorkshire, UK
    Colorectal Dis 8:14-7. 2006
  6. pmc A phase I/II study of oxaliplatin when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group (CCOG) study
    D Sebag-Montefiore
    Cookridge Hospital, Hospital Lane, Cookridge, West Yorkshire LS16 6QB, UK
    Br J Cancer 93:993-8. 2005
  7. ncbi request reprint Treatment of T4 tumours: the role of radiotherapy
    David Sebag-Montefiore
    Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds LS16 6QB West Yorkshire, UK
    Colorectal Dis 5:432-5. 2003
  8. pmc Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial
    Matthew T Seymour
    St James s University Hospital and University of Leeds, Leeds, UK
    Lancet 377:1749-59. 2011
  9. doi request reprint Defunctioning stomas prior to chemoradiation for anal cancer are usually permanent
    R Cooper
    St James s Institute of Oncology, St James s University Hospital, Leeds, West Yorkshire, UK
    Colorectal Dis 14:87-91. 2012
  10. ncbi request reprint Omission of concurrent chemoradiation after a response to neoadjuvant chemotherapy in locally advanced rectal cancer with a synchronous liver metastasis: a note of caution
    I Craven
    Cookridge Hospital, Hospital Lane, Leeds LS16 6QB, UK
    Br J Radiol 80:e257-9. 2007

Collaborators

Detail Information

Publications26

  1. pmc Effective treatment of anal cancer in the elderly with low-dose chemoradiotherapy
    N Charnley
    Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds, West Yorkshire LS16 6QB, UK
    Br J Cancer 92:1221-5. 2005
    ..This is a well-tolerated regimen for elderly/poor performance patients with anal cancer, which can achieve high rates of local control and survival. Longer follow-up will determine whether these encouraging results are maintained...
  2. pmc Preoperative radiotherapy combined with 5 days per week capecitabine chemotherapy in locally advanced rectal cancer
    I Craven
    Leeds Cancer Centre, Cookridge Hospital Lane, Leeds LS16 6QB, UK
    Br J Cancer 97:1333-7. 2007
    ..Compared to studies using a 7-day per week capecitabine schedule, our results show increased compliance and less dose reductions with comparable pathological outcome...
  3. pmc Concurrent chemoradiotherapy for squamous cell carcinoma of the anus using a shrinking field radiotherapy technique without a boost
    A A Melcher
    Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds, West Yorkshire LS16 6QB, UK
    Br J Cancer 88:1352-7. 2003
    ..The CRT regimen described here provides the basis for the 'control arm' of the current UK-randomised CRT trial in anal cancer (ACT2)...
  4. pmc Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial
    David Sebag-Montefiore
    St James s University Hospital, Leeds, UK
    Lancet 373:811-20. 2009
    ..We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy...
  5. ncbi request reprint Developments in the use of chemoradiotherapy in rectal cancer
    D Sebag-Montefiore
    Leeds Cancer Centre, Cookridge Hospital, Leeds, West Yorkshire, UK
    Colorectal Dis 8:14-7. 2006
    ..There is clear evidence that CRT is superior to long-course radiotherapy (LRT). However, the end-points and definitions used must be standardized for future clinical trials of combination CRT...
  6. pmc A phase I/II study of oxaliplatin when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group (CCOG) study
    D Sebag-Montefiore
    Cookridge Hospital, Hospital Lane, Cookridge, West Yorkshire LS16 6QB, UK
    Br J Cancer 93:993-8. 2005
    ..The acceptable toxicity and compliance at 130 mg m(-2) recommend testing this dose in future phase II studies. The tumour downstaging and complete resection rates are encouragingly high for this very locally advanced group...
  7. ncbi request reprint Treatment of T4 tumours: the role of radiotherapy
    David Sebag-Montefiore
    Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds LS16 6QB West Yorkshire, UK
    Colorectal Dis 5:432-5. 2003
    ..Future studies are likely to assess agents directed against molecular targets. Careful consideration is required to define the best end points for successful pre-operative chemo-radiation leading to surgical excision...
  8. pmc Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial
    Matthew T Seymour
    St James s University Hospital and University of Leeds, Leeds, UK
    Lancet 377:1749-59. 2011
    ..We designed FOCUS2 to investigate reduced-dose chemotherapy options and to seek objective predictors of outcome in frail patients with advanced colorectal cancer...
  9. doi request reprint Defunctioning stomas prior to chemoradiation for anal cancer are usually permanent
    R Cooper
    St James s Institute of Oncology, St James s University Hospital, Leeds, West Yorkshire, UK
    Colorectal Dis 14:87-91. 2012
    ..A few patients with anal cancer will require a defunctioning stoma prior to chemoradiotherapy (CRT). The purpose of this retrospective review was to determine the frequency with which a pretreatment stoma was subsequently reversed...
  10. ncbi request reprint Omission of concurrent chemoradiation after a response to neoadjuvant chemotherapy in locally advanced rectal cancer with a synchronous liver metastasis: a note of caution
    I Craven
    Cookridge Hospital, Hospital Lane, Leeds LS16 6QB, UK
    Br J Radiol 80:e257-9. 2007
    ..This case illustrates the potential risk of omitting radiation following a good response to neoadjuvant systemic chemotherapy...
  11. ncbi request reprint Weekly 5-fluorouracil and leucovorin: achieving lower toxicity with higher dose-intensity in adjuvant chemotherapy after colorectal cancer resection
    K Patel
    Cancer Research UK Clinical Centre, Cookridge Hospital Leeds, Leeds LS16 6QB, UK
    Ann Oncol 15:568-73. 2004
    ..We present data for a weekly schedule that aims to provide moderately dose-intense treatment with low toxicity...
  12. ncbi request reprint The use of radiotherapy in rectal cancer
    P Hatfield
    Leeds Cancer Centre, Cookridge Hospital, Leeds, United Kingdom
    Scand J Surg 92:65-73. 2003
  13. pmc An evaluation of four CT-MRI co-registration techniques for radiotherapy treatment planning of prone rectal cancer patients
    C J Dean
    Department of Medical Physics, St James s Institute of Oncology, Leeds, UK
    Br J Radiol 85:61-8. 2012
    ..This work assesses the CT-MRI co-registration accuracy of four commercial rigid-body techniques for external beam radiotherapy treatment planning for patients treated in the prone position without fiducial markers...
  14. ncbi request reprint Is there a role for radiotherapy in operable rectal cancer?
    I Craven
    Leeds Cancer Centre, Cookridge Hospital Lane, Leeds, UK
    Clin Oncol (R Coll Radiol) 19:687-92. 2007
    ..Here we summarise the important trials both before and after the introduction of mesorectal excision. We highlight some of the important issues, including treatment-related toxicity and patient selection for preoperative treatment...
  15. doi request reprint Superiority of Deformable Image Co-registration in the Integration of Diagnostic Positron Emission Tomography-Computed Tomography to the Radiotherapy Treatment Planning Pathway for Oesophageal Carcinoma
    G Ward
    Medical Physics and Engineering, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK Electronic address
    Clin Oncol (R Coll Radiol) 28:655-62. 2016
    ....
  16. ncbi request reprint Involved-field, low-dose chemoradiotherapy for early-stage anal carcinoma
    Paul Hatfield
    Leeds Cancer Centre, Cookridge Hospital, Leeds, West Yorkshire, United Kingdom
    Int J Radiat Oncol Biol Phys 70:419-24. 2008
    ..To report the results of patients with early-stage anal cancer treated using a low-dose, reduced-volume, involved-field chemoradiotherapy protocol...
  17. pmc Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trial
    Martin F Muers
    Leeds General Infirmary, Leeds, UK
    Lancet 371:1685-94. 2008
    ..We investigated whether the addition of chemotherapy to ASC improved survival and quality of life...
  18. pmc Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial
    Phil Quirke
    Leeds University, Leeds, UK
    Lancet 373:821-8. 2009
    ..However, the contributions of surgery and radiotherapy to outcomes are unclear. We assessed the effect of the involvement of the circumferential resection margin and the plane of surgery achieved...
  19. ncbi request reprint Role of neoadjuvant chemotherapy in rectal cancer: interpretation of the EXPERT study
    Rob Glynne-Jones
    J Clin Oncol 24:4664-5; author reply 4665-6. 2006
  20. pmc The modern abdominoperineal excision: the next challenge after total mesorectal excision
    Roger Marr
    Department of Histopathology, Leeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, UK
    Ann Surg 242:74-82. 2005
    ..Examine the cause of local recurrence (LR) and patient survival (S) following abdominoperineal resection (APR) and anterior resection (AR) for rectal carcinoma and the effect of introduction of total mesorectal excision (TME) on APR...
  21. doi request reprint EXTRA--a multicenter phase II study of chemoradiation using a 5 day per week oral regimen of capecitabine and intravenous mitomycin C in anal cancer
    Rob Glynne-Jones
    Mount Vernon Cancer Centre, Mount Vernon Hospital, Middlesex, United Kingdom
    Int J Radiat Oncol Biol Phys 72:119-26. 2008
    ..This phase II trial aimed to determine the feasibility, toxicity, and efficacy of capecitabine, MMC and radiotherapy (RT) in anal cancer patients...
  22. ncbi request reprint Surgery for locally recurrent rectal cancer
    Kirsten M Boyle
    Department of Surgery, The General Infirmary at Leeds, Leeds LS1 3EX, UK
    Dis Colon Rectum 48:929-37. 2005
    ..The aim of this study was to assess the outcome of a series of patients who underwent resection of locally recurrent rectal cancer with curative intent...
  23. ncbi request reprint Evaluation of a protocol-based management of rectal cancer
    Kishore K Sasapu
    Department of Colorectal Surgery, The General Infirmary at Leeds, Leeds, West Yorkshire, United Kingdom
    Dis Colon Rectum 49:1703-9. 2006
    ..The management of rectal cancer is multidisciplinary. We have devised and implemented a standardized protocol. This study was designed to evaluate the protocol and identify areas for improvement...
  24. ncbi request reprint Sphincter saving is the primary objective for local treatment of cancer of the lower rectum
    Eric Rullier
    University of Victor Segalen, Saint Andre Hospital, 33075 Bordeaux, France
    Lancet Oncol 7:775-7. 2006
  25. ncbi request reprint Adjuvant radiation therapy for rectal cancer: selecting the right cases
    David Sebag-Montefiore
    Leeds Cancer Centre
    Curr Probl Cancer 27:54-9. 2003
  26. ncbi request reprint Rectal cancer: what can we learn from the Dutch TME Study? How will this study impact on current practice in the U.K?
    Rob Glynne-Jones
    Clin Oncol (R Coll Radiol) 14:170-3. 2002