Affiliation: St James's University Hospital
- Effective treatment of anal cancer in the elderly with low-dose chemoradiotherapyN Charnley
Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds, West Yorkshire LS16 6QB, UK
Br J Cancer 92:1221-5. 2005..This is a well-tolerated regimen for elderly/poor performance patients with anal cancer, which can achieve high rates of local control and survival. Longer follow-up will determine whether these encouraging results are maintained...
- Preoperative radiotherapy combined with 5 days per week capecitabine chemotherapy in locally advanced rectal cancerI Craven
Leeds Cancer Centre, Cookridge Hospital Lane, Leeds LS16 6QB, UK
Br J Cancer 97:1333-7. 2007..Compared to studies using a 7-day per week capecitabine schedule, our results show increased compliance and less dose reductions with comparable pathological outcome...
- Concurrent chemoradiotherapy for squamous cell carcinoma of the anus using a shrinking field radiotherapy technique without a boostA A Melcher
Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds, West Yorkshire LS16 6QB, UK
Br J Cancer 88:1352-7. 2003..The CRT regimen described here provides the basis for the 'control arm' of the current UK-randomised CRT trial in anal cancer (ACT2)...
- Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trialDavid Sebag-Montefiore
St James s University Hospital, Leeds, UK
Lancet 373:811-20. 2009..We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy...
- Developments in the use of chemoradiotherapy in rectal cancerD Sebag-Montefiore
Leeds Cancer Centre, Cookridge Hospital, Leeds, West Yorkshire, UK
Colorectal Dis 8:14-7. 2006..There is clear evidence that CRT is superior to long-course radiotherapy (LRT). However, the end-points and definitions used must be standardized for future clinical trials of combination CRT...
- A phase I/II study of oxaliplatin when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group (CCOG) studyD Sebag-Montefiore
Cookridge Hospital, Hospital Lane, Cookridge, West Yorkshire LS16 6QB, UK
Br J Cancer 93:993-8. 2005..The acceptable toxicity and compliance at 130 mg m(-2) recommend testing this dose in future phase II studies. The tumour downstaging and complete resection rates are encouragingly high for this very locally advanced group...
- Treatment of T4 tumours: the role of radiotherapyDavid Sebag-Montefiore
Leeds Cancer Centre, Cookridge Hospital, Hospital Lane, Leeds LS16 6QB West Yorkshire, UK
Colorectal Dis 5:432-5. 2003..Future studies are likely to assess agents directed against molecular targets. Careful consideration is required to define the best end points for successful pre-operative chemo-radiation leading to surgical excision...
- Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trialMatthew T Seymour
St James s University Hospital and University of Leeds, Leeds, UK
Lancet 377:1749-59. 2011..We designed FOCUS2 to investigate reduced-dose chemotherapy options and to seek objective predictors of outcome in frail patients with advanced colorectal cancer...
- Defunctioning stomas prior to chemoradiation for anal cancer are usually permanentR Cooper
St James s Institute of Oncology, St James s University Hospital, Leeds, West Yorkshire, UK
Colorectal Dis 14:87-91. 2012..A few patients with anal cancer will require a defunctioning stoma prior to chemoradiotherapy (CRT). The purpose of this retrospective review was to determine the frequency with which a pretreatment stoma was subsequently reversed...
- Omission of concurrent chemoradiation after a response to neoadjuvant chemotherapy in locally advanced rectal cancer with a synchronous liver metastasis: a note of cautionI Craven
Cookridge Hospital, Hospital Lane, Leeds LS16 6QB, UK
Br J Radiol 80:e257-9. 2007..This case illustrates the potential risk of omitting radiation following a good response to neoadjuvant systemic chemotherapy...
- Weekly 5-fluorouracil and leucovorin: achieving lower toxicity with higher dose-intensity in adjuvant chemotherapy after colorectal cancer resectionK Patel
Cancer Research UK Clinical Centre, Cookridge Hospital Leeds, Leeds LS16 6QB, UK
Ann Oncol 15:568-73. 2004..We present data for a weekly schedule that aims to provide moderately dose-intense treatment with low toxicity...
- The use of radiotherapy in rectal cancerP Hatfield
Leeds Cancer Centre, Cookridge Hospital, Leeds, United Kingdom
Scand J Surg 92:65-73. 2003
- An evaluation of four CT-MRI co-registration techniques for radiotherapy treatment planning of prone rectal cancer patientsC J Dean
Department of Medical Physics, St James s Institute of Oncology, Leeds, UK
Br J Radiol 85:61-8. 2012..This work assesses the CT-MRI co-registration accuracy of four commercial rigid-body techniques for external beam radiotherapy treatment planning for patients treated in the prone position without fiducial markers...
- Is there a role for radiotherapy in operable rectal cancer?I Craven
Leeds Cancer Centre, Cookridge Hospital Lane, Leeds, UK
Clin Oncol (R Coll Radiol) 19:687-92. 2007..Here we summarise the important trials both before and after the introduction of mesorectal excision. We highlight some of the important issues, including treatment-related toxicity and patient selection for preoperative treatment...
- Superiority of Deformable Image Co-registration in the Integration of Diagnostic Positron Emission Tomography-Computed Tomography to the Radiotherapy Treatment Planning Pathway for Oesophageal CarcinomaG Ward
Medical Physics and Engineering, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK Electronic address
Clin Oncol (R Coll Radiol) 28:655-62. 2016....
- Involved-field, low-dose chemoradiotherapy for early-stage anal carcinomaPaul Hatfield
Leeds Cancer Centre, Cookridge Hospital, Leeds, West Yorkshire, United Kingdom
Int J Radiat Oncol Biol Phys 70:419-24. 2008..To report the results of patients with early-stage anal cancer treated using a low-dose, reduced-volume, involved-field chemoradiotherapy protocol...
- Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trialMartin F Muers
Leeds General Infirmary, Leeds, UK
Lancet 371:1685-94. 2008..We investigated whether the addition of chemotherapy to ASC improved survival and quality of life...
- Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trialPhil Quirke
Leeds University, Leeds, UK
Lancet 373:821-8. 2009..However, the contributions of surgery and radiotherapy to outcomes are unclear. We assessed the effect of the involvement of the circumferential resection margin and the plane of surgery achieved...
- Role of neoadjuvant chemotherapy in rectal cancer: interpretation of the EXPERT studyRob Glynne-Jones
J Clin Oncol 24:4664-5; author reply 4665-6. 2006
- The modern abdominoperineal excision: the next challenge after total mesorectal excisionRoger Marr
Department of Histopathology, Leeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, UK
Ann Surg 242:74-82. 2005..Examine the cause of local recurrence (LR) and patient survival (S) following abdominoperineal resection (APR) and anterior resection (AR) for rectal carcinoma and the effect of introduction of total mesorectal excision (TME) on APR...
- EXTRA--a multicenter phase II study of chemoradiation using a 5 day per week oral regimen of capecitabine and intravenous mitomycin C in anal cancerRob Glynne-Jones
Mount Vernon Cancer Centre, Mount Vernon Hospital, Middlesex, United Kingdom
Int J Radiat Oncol Biol Phys 72:119-26. 2008..This phase II trial aimed to determine the feasibility, toxicity, and efficacy of capecitabine, MMC and radiotherapy (RT) in anal cancer patients...
- Surgery for locally recurrent rectal cancerKirsten M Boyle
Department of Surgery, The General Infirmary at Leeds, Leeds LS1 3EX, UK
Dis Colon Rectum 48:929-37. 2005..The aim of this study was to assess the outcome of a series of patients who underwent resection of locally recurrent rectal cancer with curative intent...
- Evaluation of a protocol-based management of rectal cancerKishore K Sasapu
Department of Colorectal Surgery, The General Infirmary at Leeds, Leeds, West Yorkshire, United Kingdom
Dis Colon Rectum 49:1703-9. 2006..The management of rectal cancer is multidisciplinary. We have devised and implemented a standardized protocol. This study was designed to evaluate the protocol and identify areas for improvement...
- Sphincter saving is the primary objective for local treatment of cancer of the lower rectumEric Rullier
University of Victor Segalen, Saint Andre Hospital, 33075 Bordeaux, France
Lancet Oncol 7:775-7. 2006
- Adjuvant radiation therapy for rectal cancer: selecting the right casesDavid Sebag-Montefiore
Leeds Cancer Centre
Curr Probl Cancer 27:54-9. 2003
- Rectal cancer: what can we learn from the Dutch TME Study? How will this study impact on current practice in the U.K?Rob Glynne-Jones
Clin Oncol (R Coll Radiol) 14:170-3. 2002