Robert D Murray

Summary

Affiliation: St James's University Hospital
Country: UK

Publications

  1. doi request reprint Serum vascular endothelial growth factor (VEGF) is elevated in GH deficient adults
    Robert D Murray
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Growth Horm IGF Res 21:96-101. 2011
  2. doi request reprint Lanreotide autogel in acromegaly - a decade on
    Nikolaos Kyriakakis
    St James s University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds Centre for Diabetes and Endocrinology, Department of Endocrinology, Beckett Street, Leeds LS9 7TF, UK 44 0 113 206 4578 44 0 113 206 5065
    Expert Opin Pharmacother 15:2681-92. 2014
  3. pmc European Adrenal Insufficiency Registry (EU-AIR): a comparative observational study of glucocorticoid replacement therapy
    Bertil Ekman
    ViroPharma Incorporated, Exton, Pennsylvania, USA
    BMC Endocr Disord 14:40. 2014
  4. doi request reprint Partial growth hormone deficiency is associated with an adverse cardiovascular risk profile and increased carotid intima-medial thickness
    Robert D Murray
    Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK
    Clin Endocrinol (Oxf) 73:508-15. 2010
  5. ncbi request reprint The phenotype of adults with partial growth hormone deficiency
    Robert D Murray
    Department of Endocrinology, Leeds Teaching Hospitals NHS Trust, St James s University Hospital, Leeds, UK
    Horm Res 64:12-7. 2005
  6. ncbi request reprint The diagnosis of partial growth hormone deficiency in adults with a putative insult to the hypothalamo-pituitary axis
    Robert D Murray
    Department of Endocrinology, Christie Hospital National Health Service Trust, Wilmslow Road, Manchester, United Kingdom
    J Clin Endocrinol Metab 92:1705-9. 2007
  7. ncbi request reprint A densitometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency
    Robert D Murray
    Department of Endocrinology, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 91:432-8. 2006
  8. ncbi request reprint Adults with partial growth hormone deficiency have an adverse body composition
    Robert D Murray
    Department of Endocrinology, Christie Hospital, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 89:1586-91. 2004
  9. ncbi request reprint Insulin sensitivity is impaired in adults with varying degrees of GH deficiency
    Robert D Murray
    Department of Endocrinology, The Christie Hospital, Manchester, UK
    Clin Endocrinol (Oxf) 62:182-8. 2005
  10. doi request reprint GH sensitivity of GH-deficient adults is dependent on gender but not timing of onset
    Breeda Columb
    Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK
    Clin Endocrinol (Oxf) 70:281-6. 2009

Collaborators

Detail Information

Publications22

  1. doi request reprint Serum vascular endothelial growth factor (VEGF) is elevated in GH deficient adults
    Robert D Murray
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Growth Horm IGF Res 21:96-101. 2011
    ..Furthermore, serum levels decrease following GH replacement in GHD adults, though it remains unclear if levels are significantly elevated in untreated individuals...
  2. doi request reprint Lanreotide autogel in acromegaly - a decade on
    Nikolaos Kyriakakis
    St James s University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds Centre for Diabetes and Endocrinology, Department of Endocrinology, Beckett Street, Leeds LS9 7TF, UK 44 0 113 206 4578 44 0 113 206 5065
    Expert Opin Pharmacother 15:2681-92. 2014
    ..Data relating to the use of ATG in acromegaly, specifically relating to comparison to octreotide (OCT) LAR and patient acceptability and preference, have been slow to accumulate...
  3. pmc European Adrenal Insufficiency Registry (EU-AIR): a comparative observational study of glucocorticoid replacement therapy
    Bertil Ekman
    ViroPharma Incorporated, Exton, Pennsylvania, USA
    BMC Endocr Disord 14:40. 2014
    ..gov identifier: NCT01661387)...
  4. doi request reprint Partial growth hormone deficiency is associated with an adverse cardiovascular risk profile and increased carotid intima-medial thickness
    Robert D Murray
    Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK
    Clin Endocrinol (Oxf) 73:508-15. 2010
    ..To quantify the relative prevalence of surrogate markers of vascular risk in adults with partial GH deficiency (GH insufficiency, GHI)...
  5. ncbi request reprint The phenotype of adults with partial growth hormone deficiency
    Robert D Murray
    Department of Endocrinology, Leeds Teaching Hospitals NHS Trust, St James s University Hospital, Leeds, UK
    Horm Res 64:12-7. 2005
    ..Given the presence of similar sequelae in GHI and GHD adults, and the improvements during GH replacement in GHD adults, a randomized placebo-controlled study of GH replacement in GHI patients is warranted...
  6. ncbi request reprint The diagnosis of partial growth hormone deficiency in adults with a putative insult to the hypothalamo-pituitary axis
    Robert D Murray
    Department of Endocrinology, Christie Hospital National Health Service Trust, Wilmslow Road, Manchester, United Kingdom
    J Clin Endocrinol Metab 92:1705-9. 2007
    ..Given the inherent problems in the diagnosis of severe GHD, the situation is likely to be even more difficult in individuals with GHI...
  7. ncbi request reprint A densitometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency
    Robert D Murray
    Department of Endocrinology, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 91:432-8. 2006
    ....
  8. ncbi request reprint Adults with partial growth hormone deficiency have an adverse body composition
    Robert D Murray
    Department of Endocrinology, Christie Hospital, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 89:1586-91. 2004
    ..Any future trials of GH replacement in patients with GHI must await further studies to establish the exact impact of this relative deficiency on the broad spectrum of biological end points influenced by GH status...
  9. ncbi request reprint Insulin sensitivity is impaired in adults with varying degrees of GH deficiency
    Robert D Murray
    Department of Endocrinology, The Christie Hospital, Manchester, UK
    Clin Endocrinol (Oxf) 62:182-8. 2005
    ..Whether insulin action is impaired in the presence of lesser degrees of GHD (GH insufficiency, GHI) is not known...
  10. doi request reprint GH sensitivity of GH-deficient adults is dependent on gender but not timing of onset
    Breeda Columb
    Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK
    Clin Endocrinol (Oxf) 70:281-6. 2009
    ..We hypothesised CO-GHD adults to be less sensitive to GH than AO-GHD patients...
  11. ncbi request reprint The impact of short-term fasting on the dynamics of 24-hour growth hormone (GH) secretion in patients with severe radiation-induced GH deficiency
    Ken H Darzy
    Department of Endocrinology, Christie Hospital, Wilmslow Road, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 91:987-94. 2006
    ..A sensitive chemiluminescence GH assay was used with cluster analysis...
  12. ncbi request reprint Impact of growth hormone status on body composition and the skeleton
    Annice Mukherjee
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Horm Res 62:35-41. 2004
    ..Despite normal BMD, however, an increase in fracture prevalence may still be observed in elderly GHD adults as a consequence of increased falls related to muscle weakness and visual field defects...
  13. ncbi request reprint Low bone mass is an infrequent feature of the adult growth hormone deficiency syndrome in middle-age adults and the elderly
    Robert D Murray
    Department of Endocrinology, Christie Hospital, Manchester, M20 4BX, United Kingdom
    J Clin Endocrinol Metab 89:1124-30. 2004
    ..0 except patients aged less than 30 yr, which, in part, was explained by their shorter stature. Thus, significantly reduced bone mass is not a frequent observation in adults with GHD...
  14. doi request reprint Pituitary dysfunction following cranial radiotherapy for adult-onset nonpituitary brain tumours
    Nikolaos Kyriakakis
    Department of Endocrinology, Leeds Centre for Diabetes and Endocrinology, St James s University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK
    Clin Endocrinol (Oxf) 84:372-9. 2016
    ..We aim to characterize the pituitary-related outcomes following cranial radiotherapy (cXRT) for adult-onset primary nonpituitary brain tumours...
  15. doi request reprint Current therapy and drug pipeline for the treatment of patients with acromegaly
    Sampath Satish Kumar
    Department of Endocrinology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, UK
    Adv Ther 26:383-403. 2009
    ..The etiology is almost exclusively an underlying pituitary adenoma. Current therapeutic interventions include surgery, radiotherapy, and medical therapy...
  16. doi request reprint The effects of pituitary and thyroid disorders on haemostasis: potential clinical implications
    Nikolaos Kyriakakis
    Department of Endocrinology, Leeds Centre for Diabetes and Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
    Clin Endocrinol (Oxf) 84:473-84. 2016
    ..Given the rarity of some of the endocrine disorders, multicentre studies are required to achieve this target. ..
  17. doi request reprint Endocrine sequelae beyond 10 years in survivors of medulloblastoma
    Suma Uday
    Paediatric Endocrinology, Leeds Children s Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK
    Clin Endocrinol (Oxf) 83:663-70. 2015
    ..The complete picture of late effects, however, has been limited by short duration of follow-up...
  18. doi request reprint Hypogonadotropic hypogonadism: a consequence of Chiari-I malformation
    Sampath Satish Kumar
    Department of Endocrinology, Leeds Teaching Hospitals NHS Trust, D Floor, Brotherton Wing, Leeds General Infirmary, Great George Street, Leeds, UK
    Pituitary 13:183-5. 2010
    ..The biochemical picture was characterized by hypogonadotropic hypogonadism. Resolution of the amenorrhea was observed to occur following 3rd ventriculostomy...
  19. ncbi request reprint Acquired prolactin deficiency indicates severe hypopituitarism in patients with disease of the hypothalamic-pituitary axis
    Annice Mukherjee
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Clin Endocrinol (Oxf) 59:743-8. 2003
    ..In this report, adults with disease of the hypothalamic-pituitary axis (HPA) were studied to determine the prevalence of severe acquired prolactin deficiency (APD) and the pathophysiological characteristics associated with it...
  20. ncbi request reprint The novel somatostatin ligand (SOM230) regulates human and rat anterior pituitary hormone secretion
    Robert D Murray
    Cedars Sinai Research Institute, University of California Los Angeles School of Medicine, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 89:3027-32. 2004
    ..As a consequence of its broader binding profile, SOM230 is likely to find clinical utility in treating tumors resistant to SSTR-2-preferential analogs...
  21. ncbi request reprint Plasma total homocysteine concentrations in adults with growth hormone (GH) deficiency: effects of GH replacement
    Krzysztof C Lewandowski
    Molecular Medicine Research Group, Biomedical Research Institute, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK
    Mol Genet Metab 80:330-7. 2003
    ..Before firm conclusions can be drawn about the contribution of changes in plasma homocysteine concentrations to cardiovascular prognosis in adult GHD patients receiving GH replacement, further controlled studies are required...
  22. ncbi request reprint Adult growth hormone replacement: current understanding
    Robert D Murray
    Department of Endocrinology, Room 3027, Davis Building, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90036, USA
    Curr Opin Pharmacol 3:642-9. 2003
    ..A depot preparation of GH is currently under investigation and, if proven to be efficacious and safe, might be a more acceptable therapy to a proportion of patients...