Richard Morgan

Summary

Affiliation: St George's Hospital Medical School
Country: UK

Publications

  1. ncbi request reprint The double life of HOXB4
    Richard Morgan
    Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    FEBS Lett 578:1-4. 2004
  2. ncbi request reprint HOXA9 expression increases with age in human haemopoietic cells
    Richard Morgan
    Department of Basic Medical Sciences Anatomy, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Leuk Res 29:1221-2. 2005
  3. ncbi request reprint Pbx genes are required in Xenopus lens development
    Richard Morgan
    Department of Basic Medical Sciences, St George s Hospital Medical School, London, UK
    Int J Dev Biol 48:623-7. 2004
  4. ncbi request reprint Pax6 is a direct, positively regulated target of the circadian gene Clock
    Richard Morgan
    Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London, United Kingdom
    Dev Dyn 230:643-50. 2004
  5. ncbi request reprint Conservation of sequence and function in the Pax6 regulatory elements
    Richard Morgan
    Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Trends Genet 20:283-7. 2004
  6. ncbi request reprint FLASH, a component of the FAS-CAPSASE8 apoptotic pathway, is directly regulated by Hoxb4 in the notochord
    Richard Morgan
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Dev Biol 265:105-12. 2004
  7. ncbi request reprint Flamingo, a cadherin-type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis
    Richard Morgan
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, London U K
    Int J Dev Biol 47:245-52. 2003
  8. ncbi request reprint The circadian gene Clock is required for the correct early expression of the head specific gene Otx2
    Richard Morgan
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, London, UK
    Int J Dev Biol 46:999-1004. 2002
  9. ncbi request reprint TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation
    Christopher Theokli
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, London, United Kingdom
    Dev Dyn 227:48-55. 2003
  10. ncbi request reprint The small GTPase Rap1 is an immediate downstream target for Hoxb4 transcriptional regulation
    Ali S Morsi El-Kadi
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Mech Dev 113:131-9. 2002

Collaborators

  • H S Pandha
  • Alfred Pingoud
  • Janusz M Bujnicki
  • Ali S Morsi El-Kadi
  • Liesl Shears
  • Vera Pingoud
  • Christopher Theokli
  • Christopher Thickett
  • Lynn Plowright
  • Kevin Harrington
  • Elena Kubareva
  • Rudi Lurz
  • Gerhild L├╝der
  • Hildegard Geyer
  • Anna Sudina
  • Antony Durston
  • Paul in der Reiden

Detail Information

Publications19

  1. ncbi request reprint The double life of HOXB4
    Richard Morgan
    Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    FEBS Lett 578:1-4. 2004
    ..This review considers the basis for these differences in terms of the molecular biology of HOXB4 and the cells that express it...
  2. ncbi request reprint HOXA9 expression increases with age in human haemopoietic cells
    Richard Morgan
    Department of Basic Medical Sciences Anatomy, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Leuk Res 29:1221-2. 2005
    ..Here, we show that HOXA9 expression changes dramatically with age, whereby a uniformly low level of expression during early adulthood is replaced by a frequently very high expression in adults over sixty...
  3. ncbi request reprint Pbx genes are required in Xenopus lens development
    Richard Morgan
    Department of Basic Medical Sciences, St George s Hospital Medical School, London, UK
    Int J Dev Biol 48:623-7. 2004
    ..Here we show that the Pbx transcription factor plays a crucial role in this process, as it is required for FGF8 expression in the neural plate and is thus part of the complex hierarchy of genes involved in lens induction...
  4. ncbi request reprint Pax6 is a direct, positively regulated target of the circadian gene Clock
    Richard Morgan
    Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London, United Kingdom
    Dev Dyn 230:643-50. 2004
    ..In this report, the transcription factor Pax6, a highly conserved regulator of anterior development, is shown to be a direct target of Clock regulation...
  5. ncbi request reprint Conservation of sequence and function in the Pax6 regulatory elements
    Richard Morgan
    Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Trends Genet 20:283-7. 2004
  6. ncbi request reprint FLASH, a component of the FAS-CAPSASE8 apoptotic pathway, is directly regulated by Hoxb4 in the notochord
    Richard Morgan
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Dev Biol 265:105-12. 2004
    ..FLASH is a component of the FAS-CAPSASE8 apoptotic pathway, and blocking its activity, or that of Hoxb4, prevents apoptosis in the notochord...
  7. ncbi request reprint Flamingo, a cadherin-type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis
    Richard Morgan
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, London U K
    Int J Dev Biol 47:245-52. 2003
    ..We show that ectopic expression of the murine Flamingo gene can prevent the wnt mediated posteriorisation of the neural plate by interfering with the canonical wnt signalling pathway...
  8. ncbi request reprint The circadian gene Clock is required for the correct early expression of the head specific gene Otx2
    Richard Morgan
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, London, UK
    Int J Dev Biol 46:999-1004. 2002
    ..Together with previous work (Green et al. (2001) Mech. Dev. 105-110), these results suggest that a positive regulatory loop exists between Clock and Otx2...
  9. ncbi request reprint TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation
    Christopher Theokli
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, London, United Kingdom
    Dev Dyn 227:48-55. 2003
    ..Here, we show that the TALE class homeodomain transcription factor Irx5 is a direct, positively regulated target of Hoxb4...
  10. ncbi request reprint The small GTPase Rap1 is an immediate downstream target for Hoxb4 transcriptional regulation
    Ali S Morsi El-Kadi
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Mech Dev 113:131-9. 2002
    ..Here we show that the small GTPase Rap1 is a direct, negatively regulated target of Hoxb4 and is excluded from Hoxb4 expressing cells...
  11. ncbi request reprint Hoxc-8 expression shows left-right asymmetry in the posterior lateral plate mesoderm
    Christopher Thickett
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Gene Expr Patterns 2:5-6. 2002
    ....
  12. ncbi request reprint Hox genes: a continuation of embryonic patterning?
    Richard Morgan
    Department of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Trends Genet 22:67-9. 2006
    ..Furthermore, it is now apparent that Hox expression can determine the identity of malignant cells in some tumour types...
  13. doi request reprint Disrupting the interaction between HOX and PBX causes necrotic and apoptotic cell death in the renal cancer lines CaKi-2 and 769-P
    Liesl Shears
    Postgraduate Medical School, University of Surrey, Guildford and Head and Neck Unit, London, United Kingdom
    J Urol 180:2196-201. 2008
    ..We quantified the expression of HOX genes in normal kidney tissue, primary tumors and derived cell lines, and examined their role in renal cancer cell survival...
  14. ncbi request reprint Engrailed: complexity and economy of a multi-functional transcription factor
    Richard Morgan
    Postgraduate Medical School, University of Surrey, Guildford, Surrey GU2 7XH, UK
    FEBS Lett 580:2531-3. 2006
    ..Recent findings have shown how some of these functions relate to specific roles in development and disease...
  15. ncbi request reprint Antagonism of HOX/PBX dimer formation blocks the in vivo proliferation of melanoma
    Richard Morgan
    Postgraduate Medical School, University of Surrey, Guildford, United Kingdom
    Cancer Res 67:5806-13. 2007
    ..This antagonist can block the growth of murine B16 cells and trigger apoptosis both in vitro and in vivo when administered to mice with flank tumors...
  16. pmc Differential expression of HOX genes upon activation of leukocyte sub-populations
    Richard Morgan
    Postgraduate Medical School, University of Surrey, Guildford, Surrey, GU2 7WG, UK
    Int J Hematol 87:246-9. 2008
    ..This has revealed distinct patterns of expression between different cell types and resting and activated states. (Main category A: Erythrocytes, Leukocytes and Hematopoiesis, subcategory: 8: Lymphocytes)...
  17. ncbi request reprint Specificity changes in the evolution of type II restriction endonucleases: a biochemical and bioinformatic analysis of restriction enzymes that recognize unrelated sequences
    Vera Pingoud
    Institut fur Biochemie, Justus Liebig Universitat, Heinrich Buff Ring 58, D 35392 Giessen, Germany
    J Biol Chem 280:4289-98. 2005
    ..This is the first example of a relatively close evolutionary link between Type II restriction enzymes of widely different specificities...
  18. pmc Calcium insensitivity of FA-6, a cell line derived from a pancreatic cancer associated with humoral hypercalcemia, is mediated by the significantly reduced expression of the Calcium Sensitive Receptor transduction component p38 MAPK
    Richard Morgan
    Postgraduate Medical School, University of Surrey, UK
    Mol Cancer 5:51. 2006
    ..These results suggest that the low levels of p38 MAPK expression in FA-6 cells may serve to reduce their sensitivity to high concentrations of external Ca2+ that would otherwise block proliferation...
  19. ncbi request reprint A common element in epidermal expression?
    Richard Morgan
    Trends Genet 18:184-5. 2002
    ..Members of an epidermally expressed gene cluster on human chromosome 21 each contain a short sequence similar to an element that can drive ectoderm-specific gene expression...