Sanjeev Krishna

Summary

Affiliation: St George's Hospital Medical School
Country: UK

Publications

  1. pmc Severe falciparum malaria in Gabonese children: clinical and laboratory features
    Arnaud Dzeing-Ella
    Department of Parasitology, Mycology and Tropical Medicine, Faculty of Medicine, University of Health Sciences USS, Libreville, Gabon
    Malar J 4:1. 2005
  2. ncbi request reprint Artemisinins: mechanisms of action and potential for resistance
    Sanjeev Krishna
    Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Drug Resist Updat 7:233-44. 2004
  3. ncbi request reprint Transport processes in Plasmodium falciparum-infected erythrocytes: potential as new drug targets
    Sanjeev Krishna
    Department of Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London, UK
    Int J Parasitol 32:1567-73. 2002
  4. ncbi request reprint Hexose transport in asexual stages of Plasmodium falciparum and kinetoplastidae
    S Krishna
    Department of Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
    Parasitol Today 16:516-21. 2000
  5. ncbi request reprint Transport proteins of Plasmodium falciparum: defining the limits of metabolism
    S Krishna
    Department of Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Int J Parasitol 31:1331-42. 2001
  6. ncbi request reprint Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms
    S Krishna
    Department of Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, United Kingdom
    J Biol Chem 276:10782-7. 2001
  7. ncbi request reprint Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon
    Anne Catrin Uhlemann
    Department of Cellular and Molecular Medicine, Infectious Diseases Group, St George s Hospital Medical School, London, UK
    J Infect Dis 192:1830-5. 2005
  8. pmc Analysis of Plasmodium vivax hexose transporters and effects of a parasitocidal inhibitor
    Thierry Joet
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Biochem J 381:905-9. 2004
  9. pmc Validation of the hexose transporter of Plasmodium falciparum as a novel drug target
    Thierry Joet
    Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, United Kingdom
    Proc Natl Acad Sci U S A 100:7476-9. 2003
  10. pmc Identification, expression and characterisation of a Babesia bovis hexose transporter
    Elvira T Derbyshire
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London, UK
    Mol Biochem Parasitol 161:124-9. 2008

Detail Information

Publications77

  1. pmc Severe falciparum malaria in Gabonese children: clinical and laboratory features
    Arnaud Dzeing-Ella
    Department of Parasitology, Mycology and Tropical Medicine, Faculty of Medicine, University of Health Sciences USS, Libreville, Gabon
    Malar J 4:1. 2005
    ..This study examined the prognostic indicators of severe falciparum malaria in Gabonese children...
  2. ncbi request reprint Artemisinins: mechanisms of action and potential for resistance
    Sanjeev Krishna
    Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Drug Resist Updat 7:233-44. 2004
    ....
  3. ncbi request reprint Transport processes in Plasmodium falciparum-infected erythrocytes: potential as new drug targets
    Sanjeev Krishna
    Department of Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London, UK
    Int J Parasitol 32:1567-73. 2002
    ..We review studies on these transport processes and examine their potential as novel drug targets...
  4. ncbi request reprint Hexose transport in asexual stages of Plasmodium falciparum and kinetoplastidae
    S Krishna
    Department of Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
    Parasitol Today 16:516-21. 2000
    ..In this review, Sanjeev Krishna and colleagues summarize current understanding of hexose transport processes in P...
  5. ncbi request reprint Transport proteins of Plasmodium falciparum: defining the limits of metabolism
    S Krishna
    Department of Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Int J Parasitol 31:1331-42. 2001
    ..The use of the Xenopus laevis expression system in the characterisation of a hexose transporter ("PfHT1") and a Ca(2+) ATPase ("PfATP4") of the parasite plasma membrane are described in detail...
  6. ncbi request reprint Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms
    S Krishna
    Department of Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, United Kingdom
    J Biol Chem 276:10782-7. 2001
    ..This analysis suggests that PfATP4 defines a novel subclass of Ca(2+)-ATPases unique to apicomplexan organisms and therefore offers potential as a drug target...
  7. ncbi request reprint Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon
    Anne Catrin Uhlemann
    Department of Cellular and Molecular Medicine, Infectious Diseases Group, St George s Hospital Medical School, London, UK
    J Infect Dis 192:1830-5. 2005
    ..Nevertheless, the detection of multicopy pfmdr1 in African parasites suggests a high potential for rapid selection for resistance, implying that mefloquine use in Africa should be considered only as part of combination therapy...
  8. pmc Analysis of Plasmodium vivax hexose transporters and effects of a parasitocidal inhibitor
    Thierry Joet
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Biochem J 381:905-9. 2004
    ..vivax isolated from patients. These data provide unique insights into the function of hexose transporters of Plasmodium spp. as well as further evidence that they could be targeted by drugs...
  9. pmc Validation of the hexose transporter of Plasmodium falciparum as a novel drug target
    Thierry Joet
    Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, United Kingdom
    Proc Natl Acad Sci U S A 100:7476-9. 2003
    ..Our robust expression system conclusively validates PfHT as a novel drug target and is an important step in the development of novel antimalarials directed against membrane transport proteins...
  10. pmc Identification, expression and characterisation of a Babesia bovis hexose transporter
    Elvira T Derbyshire
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London, UK
    Mol Biochem Parasitol 161:124-9. 2008
    ..Taken together with results of inhibition studies with cytochalasin B and beta-glucogallin, these data provide new insights into glucose metabolism of erythrocytic-stage Babesia infections...
  11. pmc Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand
    Anne Catrin Uhlemann
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, London, United Kingdom
    J Infect Dis 195:134-41. 2007
    ..We assessed how administration of different antimalarial drugs altered pfmdr1 polymorphism in parasites from patients who experienced treatment failure...
  12. ncbi request reprint A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
    Anne Catrin Uhlemann
    Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, London SW17 0RE, UK
    Nat Struct Mol Biol 12:628-9. 2005
    ..Introducing residues found in other Plasmodium spp. also modulates artemisinin sensitivity, suggesting that artemisinins interact with the thapsigargin-binding cleft of susceptible SERCAs...
  13. pmc Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections
    Dylan R Pillai
    Centre for Infection and Immunity, Division of Clinical Sciences, St, George S, University of London, London SW17 0RE, UK
    Malar J 11:131. 2012
    ..Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins...
  14. ncbi request reprint Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum
    David K Muhia
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    J Biol Chem 278:22014-22. 2003
    ....
  15. doi request reprint Exploiting the therapeutic potential of Plasmodium falciparum solute transporters
    Henry M Staines
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London, UK
    Trends Parasitol 26:284-96. 2010
    ..It demonstrates the largely untapped potential of targeting these important pathways (including P-type ATPases, ABC transporters and K+ channels) and highlights where these parasites might be most vulnerable to intervention...
  16. doi request reprint Nitric oxide generation in children with malaria and the NOS2G-954C promoter polymorphism
    Timothy Planche
    Centre for Infection, St George s Hospital Medical School, London, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 299:R1248-53. 2010
    ..This study supports the idea that NOS2 genotype protects against severe malaria by increasing NO production during episodes of uncomplicated malaria...
  17. pmc Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    Ric N Price
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, UK
    Lancet 364:438-47. 2004
    ..A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known...
  18. doi request reprint Pumped up: reflections on PfATP6 as the target for artemisinins
    Sanjeev Krishna
    Centre for Infection and Immunity, Division of Clinical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK Electronic address
    Trends Pharmacol Sci 35:4-11. 2014
    ..These advances are discussed with their implications for our understanding of how parasites regulate calcium in different stages of asexual development and for the global challenge posed by artemisinin resistance. ..
  19. ncbi request reprint The hexose transporter of Plasmodium falciparum is a worthy drug target
    Thierry Joet
    Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Acta Trop 89:371-4. 2004
    ..We now aim to design a new class of antimalarials by the discovery of highly specific inhibitors which could act with a broad spectrum of action on different Plasmodium spp. infections...
  20. pmc Cytoadherence and virulence - the case of Plasmodium knowlesi malaria
    Farrah A Fatih
    Centre for Infection and Immunity, St George s University of London, London SW17 0RE, UK
    Malar J 11:33. 2012
    ..The objective of this study was to determine the binding phenotype of Plasmodium knowlesi infected human erythrocytes to recombinant human ICAM-1, VCAM and CD36...
  21. ncbi request reprint Proteomic fingerprinting for the diagnosis of human African trypanosomiasis
    Dan Agranoff
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Trends Parasitol 21:154-7. 2005
    ....
  22. doi request reprint Blood volume and red cell mass in children with moderate and severe malaria measured by chromium-53 dilution and gas chromatography/mass spectrometric analysis
    Derek C Macallan
    Division of Cellular and Molecular Medicine, Centre for Infection, St George s Hospital Medical School, London SW17 0RE, UK
    Rapid Commun Mass Spectrom 23:2467-75. 2009
    ..Although the red cell mass is depleted in malaria, the blood volume appears relatively well preserved...
  23. pmc Artemisinins: their growing importance in medicine
    Sanjeev Krishna
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK
    Trends Pharmacol Sci 29:520-7. 2008
    ..This safe and cheap drug class that saves lives at risk from malaria can also have important potential in oncology...
  24. pmc Comparison of effects of green tea catechins on apicomplexan hexose transporters and mammalian orthologues
    Ksenija Slavic
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London, UK
    Mol Biochem Parasitol 168:113-6. 2009
    ..Our results provide new data on the inhibitory action of catechins against sugar transporters but were unable to elucidate the antimalarial mechanism of action of these agents...
  25. pmc Susceptibility of human Plasmodium knowlesi infections to anti-malarials
    Farrah A Fatih
    Division of Clinical Sciences, Centre for Infection and Immunity, St, George S, University of London, London SW17 0RE, UK
    Malar J 12:425. 2013
    ..Therefore, adequate response to available anti-malarial treatments is assumed...
  26. pmc Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277)
    Anne Catrin Uhlemann
    Division of Cellular and Molecular Medicine, Centre for Infection, St George s University of London, and Dept of Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, United Kingdom
    Antimicrob Agents Chemother 51:667-72. 2007
    ..These data demonstrate that there are both similarities and differences between the antimalarial properties of RBX11160 and those of semisynthetic antimalarials such as artesunate and artemisinin...
  27. pmc Artemisone uptake in Plasmodium falciparum-infected erythrocytes
    Sophie Pooley
    Division of Cellular and Molecular Medicine, Centre for Infection, St George s University of London, London, United Kingdom
    Antimicrob Agents Chemother 55:550-6. 2011
    ..These data are relevant to an understanding of the mechanisms of action of this important class of drugs...
  28. doi request reprint In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents
    Andrew M Gravett
    Department of Oncology, Division of Cellular and Molecular Medicine, St George s, University of London, London, UK
    Cancer Chemother Pharmacol 67:569-77. 2011
    ..We have investigated the role of artemisone (ATM), a novel derivative of artemisinin (ART) in a cancer setting both alone and in combination with established chemotherapeutic agents...
  29. doi request reprint New antimalarial targets: the example of glucose transport
    Asha Parbhu Patel
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Travel Med Infect Dis 6:58-66. 2008
    ..In conclusion PfHT represents one example of a rational approach in the drug discovery process to structure-base design of drugs...
  30. pmc Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality
    Ksenija Slavic
    Centre for Infection, Cellular and Molecular Medicine, St George s University of London, London, UK
    Mol Microbiol 75:1402-13. 2010
    ....
  31. pmc Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa
    Ksenija Slavic
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Malar J 10:165. 2011
    ..Therapeutic targeting potential of hexose transporters of other protozoan pathogens is also reviewed and discussed...
  32. doi request reprint Adjunctive management of malaria
    Sanjeev Krishna
    Division of Clinical Sciences, Centre for Infection and Immunity, St George s University of London, London, UK
    Curr Opin Infect Dis 25:484-8. 2012
    ..Identifying new adjunct approaches has been particularly difficult for severe malaria because most interventions have either caused harm or failed to confer benefit...
  33. doi request reprint Effect of artemisinins and amino alcohol partner antimalarials on mammalian sarcoendoplasmic reticulum calcium adenosine triphosphatase activity
    Stephen Toovey
    Academic Centre for Travel Medicine and Vaccines, WHO Collaborating Centre for Travel Medicine, Royal Free and University College Medical School, London, UK
    Basic Clin Pharmacol Toxicol 103:209-13. 2008
    ..Candidate antimalarials should be screened pre-clinically for SERCA inhibition...
  34. ncbi request reprint Identification of diagnostic markers for tuberculosis by proteomic fingerprinting of serum
    Dan Agranoff
    Division of Cellular and Molecular Medicine, Centre for Infection, St George s, University of London, London SW17 ORE, UK
    Lancet 368:1012-21. 2006
    ..We investigated the potential of proteomic fingerprinting with mass spectrometric serum profiling, coupled with pattern recognition methods, to identify biomarkers that could improve diagnosis of tuberculosis...
  35. pmc Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections
    Janet Cox-Singh
    Division of Clinical Sciences, Infection and Immunity Research Centre, St George s University of London, London, United Kingdom
    PLoS ONE 6:e20541. 2011
    ..knowlesi as well as P. falciparum malaria. Crucially, P. knowlesi may be the disease and experimental primate model for severe malaria...
  36. ncbi request reprint Metal ion transport and regulation in Mycobacterium tuberculosis
    Daniel Agranoff
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London, UK
    Front Biosci 9:2996-3006. 2004
    ..tuberculosis transporter gene expression during infection will provide important insights into the basic biology of intracellular parasitism and may help to shape novel therapeutic strategies...
  37. doi request reprint Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy
    Sanjeev Krishna
    Centre for Infection and Immunity, Division of Clinical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Trends Parasitol 29:313-7. 2013
    ....
  38. pmc Assessment of volume depletion in children with malaria
    Timothy Planche
    Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, London, United Kingdom
    PLoS Med 1:e18. 2004
    ..To assist management of severely ill children, and to test the hypothesis that volume changes in fluid compartments reflect disease severity, we measured body compartment volumes in Gabonese children with malaria...
  39. pmc Intramuscular bioavailability and clinical efficacy of artesunate in gabonese children with severe malaria
    Claire Nealon
    Department of Infectious Diseases, St George s Hospital Medical School, London SW17 ORE, United Kingdom
    Antimicrob Agents Chemother 46:3933-9. 2002
    ..001 to 1.58 liters/kg/min). There were no major adverse events attributable to ARS. Parasite clearance kinetics were comparable between the two treatment groups. These results support the use of i.m. ARS in children with severe malaria...
  40. doi request reprint Artemisinins and the biological basis for the PfATP6/SERCA hypothesis
    Sanjeev Krishna
    Centre for Infection, Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London, UK, SW17 0RE
    Trends Parasitol 26:517-23. 2010
    ..Herein, evidence is discussed that relates to this hypothesis as alternative suggestions for how artemisinins might act have been reviewed elsewhere...
  41. pmc Estimation of relevant variables on high-dimensional biological patterns using iterated weighted kernel functions
    Sergio Rojas-Galeano
    Division of Parasitology, National Institute for Medical Research, London, United Kingdom
    PLoS ONE 3:e1806. 2008
    ..The occurrence of noise, redundancy or combinatorial interactions in the profile makes the selection of relevant variables harder...
  42. pmc The Nramp orthologue of Cryptococcus neoformans is a pH-dependent transporter of manganese, iron, cobalt and nickel
    Daniel Agranoff
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Biochem J 385:225-32. 2005
    ..Insights afforded by these findings will allow the formulation of new hypotheses regarding the role of metal ions in the pathophysiology of cryptococcosis...
  43. pmc Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities
    Serena Pulcini
    Institute for Infection and Immunity, St George s, University of London, London SW17 0RE, UK
    Sci Rep 5:14552. 2015
    ..Taken together, these findings provide new insights into PfCRT function and PfCRT-mediated drug resistance, as well as the food vacuole, which is an important target of many antimalarial drugs. ..
  44. ncbi request reprint The relevance of malaria pathophysiology to strategies of clinical management
    Tim Planche
    Department of Cellular and Molecular Medicine, Centre for Infection, St George s Hospital Medical School, London SW17 0RE, UK
    Curr Opin Infect Dis 18:369-75. 2005
    ..It is sobering, however, that despite many trials over the last quarter of a century all large trials of adjunctive therapy so far have resulted in either increased morbidity or mortality, or both...
  45. ncbi request reprint A novel and accurate diagnostic test for human African trypanosomiasis
    Marios C Papadopoulos
    Department of Cellular and Molecular Sciences, St George s Hospital Medical School, London, UK
    Lancet 363:1358-63. 2004
    ..Because current diagnostic tests for the disease have low accuracy, we sought to develop a novel test that can diagnose human African trypanosomiasis with high sensitivity and specificity...
  46. pmc Comparative characterization of hexose transporters of Plasmodium knowlesi, Plasmodium yoelii and Toxoplasma gondii highlights functional differences within the apicomplexan family
    Thierry Joet
    Department of Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Biochem J 368:923-9. 2002
    ..This study defines models useful to study the biology of apicomplexan hexose permeation pathways, as well as contributing to drug development...
  47. doi request reprint Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review
    Tim Planche
    Department of Medical Microbiology, St George s Hospital, London, UK
    Lancet Infect Dis 8:777-84. 2008
    ..To improve diagnosis, we suggest a two-stage testing strategy for C difficile toxin with an initial highly sensitive rapid screening test to identify positive samples that are then confirmed by a reference method...
  48. pmc Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report
    Janet Cox-Singh
    Division of Cellular and Molecular Medicine, Centre for Infection, St George s University of London, London SW17 0RE, UK
    Malar J 9:10. 2010
    ..Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post-mortem findings from a fatal case of knowlesi malaria are reported here...
  49. doi request reprint Proteomic approaches in the search for biomarkers of liver fibrosis
    Matthew L Cowan
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Trends Mol Med 16:171-83. 2010
    ..We critically discuss the challenges and priorities for future research that are of critical importance to clinical hepatology...
  50. pmc The prognostic value of measures of acid/base balance in pediatric falciparum malaria, compared with other clinical and laboratory parameters
    Charles R J C Newton
    Institute of Child Health, St George s Hospital Medical School, London, United Kingdom
    Clin Infect Dis 41:948-57. 2005
    ..In this large, prospective study, we examined the prognostic value of acidosis and hyperlactatemia and compared these markers to clinically assessed variables...
  51. ncbi request reprint Case reports: pernicious complications of benign tertian malaria
    Stephen D Lawn
    Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, London, UK
    Trans R Soc Trop Med Hyg 97:551-3. 2003
    ..One required mechanical ventilation because of life-threatening hypoxia due to acute respiratory distress syndrome...
  52. ncbi request reprint A prospective comparison of malaria with other severe diseases in African children: prognosis and optimization of management
    Tim Planche
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, United Kingdom
    Clin Infect Dis 37:890-7. 2003
    ..77). Predictors of mortality in children with malaria differ from those for other severe illnesses and reflect differences in underlying pathophysiological processes...
  53. pmc Short-course artesunate treatment of uncomplicated Plasmodium falciparum malaria in Gabon
    Steffen Borrmann
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Antimicrob Agents Chemother 47:901-4. 2003
    ..We conclude that a 3-day course of artesunate fails to achieve sufficiently high cure rates for uncomplicated falciparum malaria in Gabonese children...
  54. pmc Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance
    Sanjeev Krishna
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London SW17 0RE, UK
    Trends Mol Med 12:200-5. 2006
    ..falciparum...
  55. ncbi request reprint The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates
    Richard K Haynes
    Department of Chemistry, Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China
    ChemMedChem 2:1480-97. 2007
    ..The general basis for the exceptional antimalarial activities of artemisinins in relation to the intrinsic activity of the peroxide within the uniquely stressed environment of the malaria parasite is thereby adumbrated...
  56. ncbi request reprint Antimalarial cocktails--tropical flavours of the month
    Peter Gottfried Kremsner
    Department of Parasitology, Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany
    Lancet 360:1998-9. 2002
  57. ncbi request reprint The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa
    Christin Sisowath
    Malaria Research Unit, Division of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Trop Med Int Health 12:736-42. 2007
    ..e. pfmdr1 gene amplification, pfmdr1 Y184F, S1034C, N1042D, D1246Y, pfcrt S163R and PfATP6 S769N...
  58. ncbi request reprint Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O-3-hexose derivative
    Kevin J Saliba
    School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra ACT 0200, Australia
    FEBS Lett 570:93-6. 2004
    ..They support the notion that the transporter mediates uptake of glucose into the intraerythrocytic parasite and provide further support for the view that it is a suitable antimalarial drug target...
  59. pmc Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria
    Ric N Price
    Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Clin Infect Dis 42:1570-7. 2006
    ..Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining the therapeutic response to artemether-lumefantrine (AL)...
  60. pmc Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
    Amar bir Singh Sidhu
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, Bronx, NY 10461, USA
    J Infect Dis 194:528-35. 2006
    ..These results highlight the importance of pfmdr1 copy number in determining P. falciparum susceptibility to multiple agents currently being used to combat malaria caused by multidrug-resistant parasites...
  61. ncbi request reprint Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test
    Mhairi L Stewart
    University of Glasgow, Division of Infection and Immunity, Institute of Biomedical and Life Sciences, The Joseph Black Building, Glasgow G12 8QQ, UK
    Lancet 366:486-7. 2005
    ..The two DNA-containing structures in the trypanosome--the nucleus and the kinetoplast--begin to fluoresce within 1 min of introduction of DB99, unless drug resistant...
  62. ncbi request reprint Artesunate-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: a randomized controlled trial
    Michael Ramharter
    Albert Schweitzer Hospital, Lambarene, Gabon, Germany
    Clin Infect Dis 40:1777-84. 2005
    ..We tested the potential value of artemisinin-based combination therapy with a short elimination half-life for the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa...
  63. ncbi request reprint Artemisinins: activities and actions
    Richard K Haynes
    Department of Chemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    Microbes Infect 6:1339-46. 2004
    ..Artemisinins are still effective for treating uncomplicated as well as severe malaria, because resistance is not yet clinically apparent. This article reviews some clinically useful properties of artemisinins and how they might work...
  64. ncbi request reprint Antimalarial combinations
    Peter Gottfried Kremsner
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Lancet 364:285-94. 2004
    ..New antimalarial regimens are, therefore, urgently needed. We review the various antimalarial combinations that can be used to treat otherwise drug-resistant disease, and discuss what defines an ideal antimalarial combination regimen...
  65. ncbi request reprint Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children
    Tsiri Agbenyega
    Department of Physiology, University of Science and Technology, School of Medical Sciences, Departments of Child Health and Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana
    J Clin Pharmacol 43:386-96. 2003
    ..DCA significantly reduces the concentration of blood lactate, an independent predictor of mortality in malaria. Its prospective evaluation in affecting mortality in this disorder appears warranted...
  66. ncbi request reprint Probing structure/affinity relationships for the Plasmodium falciparum hexose transporter with glucose derivatives
    Martine Fayolle
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité LEDSS, UMR 5616 IFR 2607, Universite Joseph Fourier Grenoble 1, 38402 St Martin d Heres, France
    Bioorg Med Chem Lett 16:1267-71. 2006
    ..As no derivatives show significant affinity for the mammalian glucose transporter (GLUT1), these structure/affinity assays contribute to design of potent PfHT inhibitors and eventual development of antimalarials...
  67. ncbi request reprint Artesunate versus quinine for severe falciparum malaria
    Charles J Woodrow
    Lancet 367:110-1; author reply 111-2. 2006
  68. pmc Antimalarial activity of a synthetic endoperoxide (RBx-11160/OZ277) against Plasmodium falciparum isolates from Gabon
    Andrea Kreidenweiss
    Medical Research Laboratory, Albert Schweitzer Hospital, Lambarene, Gabon, and Department of Parasitology, University of Tubingen, Wilhelmstr 27, D 72074 Tubingen, Germany
    Antimicrob Agents Chemother 50:1535-7. 2006
    ..Artesunate and mefloquine also showed potent antiparasitic activity, but all isolates were chloroquine resistant...
  69. ncbi request reprint Differences in presentation of severe malaria in urban and rural Gabon
    Saadou Issifou
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Am J Trop Med Hyg 77:1015-9. 2007
    ..0001). In both sites, cerebral malaria associated with respiratory distress was the most important predictor of fatal malaria (odds ratio = 10.7, 95% confidence interval = 4.8-23.8 P < 0.0001)...
  70. ncbi request reprint Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites
    Shalini Nair
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Mol Biol Evol 24:562-73. 2007
    ..This may be particularly likely when mutation rate is high, as appears to be the case for gene duplications, and in pathogen populations where effective population sizes are typically very large...
  71. pmc Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients
    Julie A Simpson
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia
    PLoS Med 3:e444. 2006
    ..We studied the population pharmacokinetics of intra-rectal artesunate and the relationship with parasitological responses in patients with moderately severe falciparum malaria...
  72. pmc Genome variation and evolution of the malaria parasite Plasmodium falciparum
    Daniel C Jeffares
    Informatics Division, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA Hinxton, UK
    Nat Genet 39:120-5. 2007
    ..This analysis uncovers the primary evolutionary changes that have occurred since the P. falciparum-P. reichenowi speciation and changes that are occurring within P. falciparum...
  73. ncbi request reprint Delayed parasite elimination in human infections treated with clindamycin parallels 'delayed death' of Plasmodium falciparum in vitro
    Dominik Burkhardt
    Department of Parasitology, Institute of Tropical Medicine, University of Tubingen, Germany
    Int J Parasitol 37:777-85. 2007
    ..The delayed, but potent, antimalarial effect of clindamycin appears to be of greatest potential benefit in new combinations of clindamycin with rapidly acting antimalarial combination partners...
  74. pmc Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth
    Yuliya V Mishina
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MI 39216, USA
    Antimicrob Agents Chemother 51:1852-4. 2007
    ..Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens...
  75. ncbi request reprint Interaction of O-(undec-10-en)-yl-D-glucose derivatives with the Plasmodium falciparum hexose transporter (PfHT)
    Marina Ionita
    Département de Chimie Moléculaire SERCO, UMR 5250, ICMG FR 2607, CNRS, Universite Joseph Fourier, BP 53, 38041, Grenoble Cedex, France
    Bioorg Med Chem Lett 17:4934-7. 2007
    ..This selectivity points to position -2 of glucose as an appropriate substitution site for the development of inhibitors of P. falciparum glucose uptake...
  76. ncbi request reprint Mutational analysis of the hexose transporter of Plasmodium falciparum and development of a three-dimensional model
    Suzanne K Manning
    Department of Biochemistry, University of Pretoria, Pretoria 0002, South Africa
    J Biol Chem 277:30942-9. 2002
    ..The development of specific inhibitors for PfHT1 will also be aided by these insights...