Affiliation: St George's
- Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?J Barwell
1Medical and Molecular Genetics Department, Guy s Hospital, London SE1 9RT, UK
Br J Cancer 97:1696-700. 2007..53). This suggests that TRF lengths in WBC, is not a marker of breast cancer susceptibility and does not vary significantly between affected women before and after treatment...
- Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriersAntonis C Antoniou
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
Breast Cancer Res 14:R33. 2012..2)...
- Familial risk of early and late onset cancerS Hodgson
S Hodgson, 40 Onslow Gardens, Muswell Hill, London N10 3JU, UK
J R Coll Physicians Edinb 43:134-5. 2013..Title: Familial risk of early and late onset cancer: nationwide prospective study. Authors: Kharazmi E, Fallah M, Sundquist K et al. Journal: BMJ 2012; 345:e8076...
- Exploring the link between MORF4L1 and risk of breast cancerGriselda Martrat
Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research IDIBELL, Gran Via 199, L Hospitalet del Llobregat 08908, Spain
Breast Cancer Res 13:R40. 2011..To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens...
- Cancer incidence in relatives of British Fanconi Anaemia patientsMarc Tischkowitz
Cancer Genetics Program, Departments of Human Genetics and Oncology, Sir M B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
BMC Cancer 8:257. 2008....
- Psychosocial and ethical issues relating to genetic testing for BRCA1 and BRCA2 breast cancer susceptibility genesE Winchester
St George s Hospital Medical School, Cranmer Terrace, London, SW17 0RE, UK
Womens Health (Lond Engl) 2:357-73. 2006..Female carriers will also face complex and challenging decisions concerning cancer risk management...
- Mechanisms of inherited cancer susceptibilityShirley Hodgson
Department of Cancer Genetics, St Georges Hospital, University of London, London SW17 ORE, UK
J Zhejiang Univ Sci B 9:1-4. 2008..This review discusses examples of some of these genes and the associated clinical conditions caused by the inheritance of mutations in such genes...
- Emberger syndrome-primary lymphedema with myelodysplasia: report of seven new casesSahar Mansour
SW Thames Regional Genetics Service, St George s, University of London, London, UK
Am J Med Genet A 152:2287-96. 2010..Children with lower limb and genital lymphedema should be screened for hematological abnormalities and immunodeficiency...
- A viral aetiology for breast cancer: time to re-examine the postulateChristine Mant
Infection and Immunity Laboratory, Guy s College and St Thomas School of Medicine, King s College London, London, UK
Intervirology 47:2-13. 2004..These two viruses have been reported to occur in up to 37 and 50% of breast cancer cases, respectively. Here we present the background to the infectious hypothesis for the aetiology of breast cancer and review recent findings...
- 'Over-the-counter' genetic testing: what does it really mean for primary care?Imran Rafi
St George s, University of London, Department of Community Health Sciences General Practice, Cranmer Terrace, London SW17 0RE
Br J Gen Pract 59:283-7. 2009..The authors recommend caution in the premature introduction of over-the-counter testing without a sound evidence base...
- Does the occurrence of certain rare cancers indicate an inherited cancer susceptibility?Sara Levene
Genetics Centre, Guy s and St Thomas s Hospitals Trust, Guy s Hospital, London, UK
Fam Cancer 2:15-25. 2003..This study supports the premise that the occurrence of rare (especially double primary) cancers does indicate an increased cancer susceptibility, although the numbers of cases ascertained were too small to draw firm conclusions...
- Nurse-led cancer genetics clinics in primary and secondary care in varied ethnic population areas: interaction with primary care to improve ascertainment of individuals from ethnic minoritiesZohra Gulzar
Clinical Genetics Department, St George s Hospital Medical School, St Georges Hospital NHS Trust, South West Thames Regional Genetics Service, Jenner Wing, Cranmer Terrace, London, SW17 0RE, UK
Fam Cancer 6:205-12. 2007..These proportions were similar for black and ethnic minority patients. Most patients reported high satisfaction with the service...
- Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients: Identification of a novel deletion consistent with BRCA1:psiBRCA1 recombinationMelissa A Brown
Department of Medical and Molecular Genetics, King s College London Guy s Campus, Guy s Hospital, London, UK
Hum Mutat 19:435-42. 2002..These findings indicate that germline BRCA1 promoter deletions are a rare and yet significant mutation event and that they could arise via a novel genetic mechanism...
- Genetic predisposition to cancerClare Turnbull
Clinical Genetics, Great Ormond Street Hospital, London
Clin Med 5:491-8. 2005..In this article the issues surrounding genetic predisposition to cancer are considered by examining two common cancers: colorectal and breast cancer...
- Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial casesPaivi Laiho
Department of Medical Genetics, Biomedicum Helsinki, Haartmanikatu, University of Helsinki, Finland
Oncogene 22:2206-14. 2003..The approach provides an alternative strategy for detecting cancer predisposition genes solely reliant on the molecular analysis of single cases obviating the requirement to collect multiple samples from families...
- AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 studyFergus J Couch
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 16:1416-21. 2007..In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers...
- Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriersGillian Mitchell
Translational Cancer Genetics Team, Institute of Cancer Research and Cancer Genetics Unit, Royal Marsden NHS Hospital, United Kingdom
Cancer Res 66:1866-72. 2006..Use of mammographic density could improve individual risk prediction in carriers...
- Patients' and professionals' opinions of services for people at an increased risk of colorectal cancer: an exploratory qualitative studyTamar Stermer
Department of General Practice and Primary Care, Guy s, King s and St Thomas School of Medicine, King s College Campus, King s College London, UK
Fam Cancer 3:49-53. 2004..To explore the views and opinions of patients with a family history of colorectal cancer, and of primary and secondary care health professionals, on how to improve current services for individuals with a family history of colorectal cancer...
- No news is (not necessarily) good news: impact of preliminary results for BRCA1 mutation searchesAlison Bish
Cancer Research UK London Psychosocial Oncology Group, St Thomas s Hospital, London, England
Genet Med 4:353-8. 2002..As this continuing uncertainty may have a detrimental effect on their psychological well-being and it is possible that such results will be misinterpreted as indicating that no mutation is present, studying their effect is important...
- Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer riskEmma Jaeger
Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK
Nat Genet 40:26-8. 2008..In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14))...