Solomon Tesfaye

Summary

Affiliation: Royal Hallamshire Hospital
Country: UK

Publications

  1. ncbi Painful diabetic neuropathy
    S Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Diabetologia 48:805-7. 2005
  2. pmc Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments
    Solomon Tesfaye
    Diabetes Research Unit, Sheffield Teaching Hospitals, Sheffield, UK
    Diabetes Care 33:2285-93. 2010
  3. ncbi Factors that impact symptomatic diabetic peripheral neuropathy in placebo-administered patients from two 1-year clinical trials
    Solomon Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Q Floor, Room 26, Glossop Road, Sheffield S102JF, UK
    Diabetes Care 30:2626-32. 2007
  4. doi Duloxetine and pregabalin: high-dose monotherapy or their combination? The "COMBO-DN study"--a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain
    Solomon Tesfaye
    University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK Electronic address
    Pain 154:2616-25. 2013
  5. doi Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy
    Solomon Tesfaye
    Sheffield Teaching Hospitals, Sheffield, UK
    Diabetes Metab Res Rev 28:8-14. 2012
  6. pmc Using dynamic pupillometry as a simple screening tool to detect autonomic neuropathy in patients with diabetes: a pilot study
    Giselle L Ferrari
    School of Electrical Engineering and Applied Computer Sciences CPGEI, Federal University of Technology Parana, Curitiba, PR Brazil
    Biomed Eng Online 9:26. 2010
  7. ncbi Advances in the management of painful diabetic neuropathy
    Solomon Tesfaye
    Royal Hallamshire Hospital, Sheffield
    Clin Med 7:113-4. 2007
  8. ncbi The Eurodiab study: what has this taught us about diabetic peripheral neuropathy?
    Solomon Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, United Kingdom
    Curr Diab Rep 9:432-4. 2009
  9. doi Advances in the management of diabetic peripheral neuropathy
    Solomon Tesfaye
    Diabetic Medicine, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, South Yorkshire, UK
    Curr Opin Support Palliat Care 3:136-43. 2009
  10. ncbi Vascular risk factors and diabetic neuropathy
    Solomon Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom
    N Engl J Med 352:341-50. 2005

Detail Information

Publications42

  1. ncbi Painful diabetic neuropathy
    S Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Diabetologia 48:805-7. 2005
  2. pmc Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments
    Solomon Tesfaye
    Diabetes Research Unit, Sheffield Teaching Hospitals, Sheffield, UK
    Diabetes Care 33:2285-93. 2010
    ....
  3. ncbi Factors that impact symptomatic diabetic peripheral neuropathy in placebo-administered patients from two 1-year clinical trials
    Solomon Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Q Floor, Room 26, Glossop Road, Sheffield S102JF, UK
    Diabetes Care 30:2626-32. 2007
    ....
  4. doi Duloxetine and pregabalin: high-dose monotherapy or their combination? The "COMBO-DN study"--a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain
    Solomon Tesfaye
    University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK Electronic address
    Pain 154:2616-25. 2013
    ..001). Both drugs and their combination were well tolerated. Although not significantly superior to high-dose monotherapy, combination therapy was considered to be effective, safe, and well tolerated...
  5. doi Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy
    Solomon Tesfaye
    Sheffield Teaching Hospitals, Sheffield, UK
    Diabetes Metab Res Rev 28:8-14. 2012
    ..Management of patients with painful neuropathy must be tailored to individual requirements and will depend on the presence of other co-morbidities. There is limited literature with regard to combination treatment...
  6. pmc Using dynamic pupillometry as a simple screening tool to detect autonomic neuropathy in patients with diabetes: a pilot study
    Giselle L Ferrari
    School of Electrical Engineering and Applied Computer Sciences CPGEI, Federal University of Technology Parana, Curitiba, PR Brazil
    Biomed Eng Online 9:26. 2010
    ..The aim of this study was to investigate pupil responsiveness in diabetic subjects with and without cardiovascular autonomic neuropathy (CAN) using dynamic pupillometry in two sets of experiments...
  7. ncbi Advances in the management of painful diabetic neuropathy
    Solomon Tesfaye
    Royal Hallamshire Hospital, Sheffield
    Clin Med 7:113-4. 2007
  8. ncbi The Eurodiab study: what has this taught us about diabetic peripheral neuropathy?
    Solomon Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, United Kingdom
    Curr Diab Rep 9:432-4. 2009
    ..The study was published in the New England Journal of Medicine and suggested that a need exists for clinical trials to confirm if modifying cardiovascular risk factors is an effective treatment for DPN...
  9. doi Advances in the management of diabetic peripheral neuropathy
    Solomon Tesfaye
    Diabetic Medicine, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, South Yorkshire, UK
    Curr Opin Support Palliat Care 3:136-43. 2009
    ..Over the past 5 years there have been significant advances in the pathogenesis and management of diabetic peripheral neuropathic pain (DPNP) and this review attempts to summarize these...
  10. ncbi Vascular risk factors and diabetic neuropathy
    Solomon Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom
    N Engl J Med 352:341-50. 2005
    ..We studied risk factors for the development of distal symmetric neuropathy in 1172 patients with type 1 diabetes mellitus from 31 centers participating in the European Diabetes (EURODIAB) Prospective Complications Study...
  11. ncbi Impaired skin microvascular reactivity in painful diabetic neuropathy
    Cristian Quattrini
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Diabetes Care 30:655-9. 2007
    ....
  12. pmc Large-fiber dysfunction in diabetic peripheral neuropathy is predicted by cardiovascular risk factors
    Jackie Elliott
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, UK
    Diabetes Care 32:1896-900. 2009
    ..Diabetic large-nerve fiber dysfunction, as measured by vibration perception threshold (VPT), predicts foot ulceration, amputation, and mortality. Thus, determination of modifiable risk factors is of great clinical importance...
  13. pmc Painful diabetic neuropathy is associated with greater autonomic dysfunction than painless diabetic neuropathy
    Rajiv A Gandhi
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, UK
    Diabetes Care 33:1585-90. 2010
    ..This study aimed to investigate the relationship of autonomic neuropathy with painless and painful DPN...
  14. pmc Randomized placebo-controlled double-blind clinical trial of cannabis-based medicinal product (Sativex) in painful diabetic neuropathy: depression is a major confounding factor
    Dinesh Selvarajah
    Diabetes Research Department, Royal Hallamshire Hospital, Sheffield, UK
    Diabetes Care 33:128-30. 2010
    ..To assess the efficacy of Sativex, a cannabis-based medicinal extract, as adjuvant treatment in painful diabetic peripheral neuropathy (DPN)...
  15. pmc Microvascular perfusion abnormalities of the Thalamus in painful but not painless diabetic polyneuropathy: a clue to the pathogenesis of pain in type 1 diabetes
    Dinesh Selvarajah
    Diabetes Research Department, Royal Hallamshire Hospital, Sheffield, UK
    Diabetes Care 34:718-20. 2011
    ..The pathogenesis of painful diabetic neuropathy (DN) remains undetermined, with both central and peripheral mechanisms implicated. This study investigates whether thalamic perfusion abnormalities occur in painful DN...
  16. ncbi Early involvement of the spinal cord in diabetic peripheral neuropathy
    Dinesh Selvarajah
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield S10 2JF, U K
    Diabetes Care 29:2664-9. 2006
    ..We have recently reported a significant reduction in spinal cord cross-sectional area at the stage of clinically detectable DPN. In this study, we investigated whether spinal cord atrophy occurs in early (subclinical) DPN...
  17. doi A preliminary study of brain macrovascular reactivity in impaired glucose tolerance and type-2 diabetes: Quantitative internal carotid artery blood flow using magnetic resonance phase contrast angiography
    Dinesh Selvarajah
    Department of Human Metabolism, The University of Sheffield, Sheffield, UK
    Diab Vasc Dis Res 13:367-72. 2016
    ....
  18. ncbi The contributors of emotional distress in painful diabetic neuropathy
    Dinesh Selvarajah
    Department of Human Metabolism, The Medical School, University of Sheffield, Sheffield, UK
    Diab Vasc Dis Res 11:218-225. 2014
    ..To examine the contribution of demographic, social, clinical and psychological factors to emotional distress in patients with painful diabetic neuropathy (DN)...
  19. doi Diabetic peripheral neuropathy may not be as its name suggests: evidence from magnetic resonance imaging
    Solomon Tesfaye
    aDiabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United KingdombDepartment of Human Metabolism Unit, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United KingdomcAcademic Unit of Radiology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom
    Pain 157:S72-80. 2016
    ..This review will focus on this emerging evidence for central changes in DPN, hitherto considered a peripheral nerve disease only. ..
  20. doi Magnetic resonance imaging of the central nervous system in diabetic neuropathy
    Iain D Wilkinson
    Academic Radiology, University of Sheffield, C Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
    Curr Diab Rep 13:509-16. 2013
    ..With that comes great potential for not only furthering our understanding of involvement of the CNS in neuropathic etiology but also most importantly aiding the development of new and more effective, targeted, analgesic interventions. ..
  21. pmc Mechanisms and management of diabetic painful distal symmetrical polyneuropathy
    Solomon Tesfaye
    Diabetes Research Unit, Sheffield Teaching Hospitals, Royal Hallamshire Hospital, Sheffield, UK
    Diabetes Care 36:2456-65. 2013
    ..S. and several European countries. All patients with DSPN are at increased risk of foot ulceration and require foot care, education, and if possible, regular podiatry assessment. ..
  22. doi Magnetic resonance neuroimaging study of brain structural differences in diabetic peripheral neuropathy
    Dinesh Selvarajah
    Department of Human Metabolism, University of Sheffield, Sheffield, U K Academic Unit of Radiology, University of Sheffield, Sheffield, U K
    Diabetes Care 37:1681-8. 2014
    ..The aim of this study was to investigate any differences in brain structure in subjects with DPN...
  23. doi Central nervous system involvement in diabetic neuropathy
    Dinesh Selvarajah
    Diabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Curr Diab Rep 11:310-22. 2011
    ..Recognition that diabetic neuropathy is, in part, a disease that affects the whole nervous system is resulting in a critical rethinking of this disorder, opening a new direction for further research...
  24. pmc SUDOSCAN: A Simple, Rapid, and Objective Method with Potential for Screening for Diabetic Peripheral Neuropathy
    Dinesh Selvarajah
    Department of Human Metabolism, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 10:e0138224. 2015
    ....
  25. doi Insights into the pathogenesis and treatment of painful diabetic neuropathy
    Marni Greig
    Diabetes Department, Royal Hallamshire Hospital, Sheffield, UK
    Handb Clin Neurol 126:559-78. 2014
    ..Research is focusing on these areas of enquiry in the hope that answers will lead to effective treatments to alleviate pain and reverse pathology for those suffering from painful DPN. ..
  26. ncbi Understanding the impact of painful diabetic neuropathy
    Cristian Quattrini
    Diabetes Research Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield, UK
    Diabetes Metab Res Rev 19:S2-8. 2003
    ..Health care professionals need to assess the full impact of painful neuropathy. In this article we review a number of instruments that are used to assess the severity of painful neuropathy and its impact on the quality of life...
  27. pmc High prevalence of microvascular complications in adults with type 1 diabetes and newly diagnosed celiac disease
    John S Leeds
    Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK
    Diabetes Care 34:2158-63. 2011
    ..We identified CD in adults with type 1 diabetes and investigated the effect of a GFD on diabetes-related complications...
  28. pmc Central pain processing in chronic chemotherapy-induced peripheral neuropathy: a functional magnetic resonance imaging study
    Elaine G Boland
    Academic Unit of Radiology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom Academic Unit of Supportive Care, Department of Oncology, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 9:e96474. 2014
    ..Functional MRI provides a tool for monitoring cerebral changes during anti-cancer and analgesic treatment. ..
  29. ncbi Increased sural nerve epineurial blood flow in human subjects with painful diabetic neuropathy
    S E M Eaton
    Diabetes Research Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield, UK
    Diabetologia 46:934-9. 2003
    ..The aim of this study was to compare epineurial haemodynamics in patients with chronic painful and painless neuropathy...
  30. pmc The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathy
    Andreas C Themistocleous
    aNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdombDiabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United KingdomcStructural and Molecular Biology, Division of Biosciences, University College London, London, United KingdomdPain Research Group, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, United KingdomePain Medicine, Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom
    Pain 157:1132-45. 2016
    ..3%) with NeuP. This study provides a firm basis to rationalise further phenotyping of painful DPN, for instance, stratification of patients with DPN for analgesic drug trials. ..
  31. doi Thalamic neuronal dysfunction and chronic sensorimotor distal symmetrical polyneuropathy in patients with type 1 diabetes mellitus
    D Selvarajah
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
    Diabetologia 51:2088-92. 2008
    ..Our aim was to use in vivo proton magnetic resonance specroscopy (H-MRS) in patients with DPN in order to assess the neuro-chemical status of the thalamus, which acts as the gateway to the brain for somatosensory information...
  32. ncbi Autonomic neuropathy is associated with increased cardiovascular risk factors: the EURODIAB IDDM Complications Study
    P Kempler
    Department of Medicine, Semmelweis University, Budapest, Hungary, Royal Hallamshire Hospital, Sheffield, London, UK
    Diabet Med 19:900-9. 2002
    ..To assess the prevalence of and risk factors for autonomic neuropathy in the EURODIAB IDDM Complications Study...
  33. ncbi 'Sausage toe': a reliable sign of underlying osteomyelitis
    S M Rajbhandari
    Diabetes Centre, Royal Hallamshire Hospital, Sheffield, UK
    Diabet Med 17:74-7. 2000
    ..This was based on our observation that some diabetic patients with suspected pedal osteomyelitis with a local neuropathic ulcer have a 'sausage' deformity of a toe...
  34. ncbi Measurement of somatic neuropathy for clinical practice and clinical trials
    L V Scott
    Diabetes Centre, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Curr Diab Rep 1:208-15. 2001
    ..If this observation proves to be an early feature, then a relatively rapid, noninvasive MRI technique may be used in the future to characterize diabetic neuropathy...
  35. doi Abnormal liver function tests in patients with Type 1 diabetes mellitus: prevalence, clinical correlations and underlying pathologies
    J S Leeds
    Departments of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK
    Diabet Med 26:1235-41. 2009
    ..Methods Patients with Type 1 diabetes mellitus were prospectively recruited and ALT, glycated haemoglobin and lipid profile were measured. Patients with Type 2 diabetes mellitus were recruited as a comparison group...
  36. ncbi Diagnosis of diabetic peripheral neuropathy among patients with type 1 and type 2 diabetes in France, Italy, Spain, and the United Kingdom
    Annalisa Rubino
    RTI Health Solutions, Manchester Science Park, Manchester, UK
    Prim Care Diabetes 1:129-34. 2007
    ..The objective of this study was to describe the proportion and characteristics of patients with type 1 and type 2 diabetes diagnosed with diabetic peripheral neuropathy (DPN) in France, Italy, Spain, and the United Kingdom (UK)...
  37. ncbi Morphine, gabapentin, or their combination for neuropathic pain
    Solomon Tesfaye
    N Engl J Med 352:2650-1; author reply 2650-1. 2005
  38. ncbi New perspectives on the management of diabetic peripheral neuropathic pain
    Troels S Jensen
    Department of Endocrinology, Diabetology and Nutrition, Hôpital Jean Verdier APHP Paris Nord University, Bondy, France
    Diab Vasc Dis Res 3:108-19. 2006
    ..Irrespective of which treatment is offered, only about one third of patients are likely to achieve more than 50% pain relief. Further research to improve the diagnosis and management of DPNP is needed...
  39. ncbi An accurate and portable system for glycated haemoglobin measurement in the tropics
    Atakilt Gebrekidan
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trop Doct 34:94-5. 2004
    ..Though still relatively expensive (pound 4 per test), this meter does give the opportunity for practical and appropriate HbA1c testing in tropical climes, and should be considered for at least intermittent use in diabetic patients...
  40. ncbi Surrogate markers of small fiber damage in human diabetic neuropathy
    Cristian Quattrini
    Division of Cardiovascular Medicine, University of Manchester, Manchester Diabetes Centre and Manchester Royal Infirmary, Manchester, UK
    Diabetes 56:2148-54. 2007
    ..This may make it an ideal technique to accurately diagnose and assess progression of human diabetic neuropathy...
  41. ncbi An approach to the assessment of diabetic neuropathy based on dynamic pupillometry
    Giselle L Ferrari
    Federal University of Technology Parana, Curitiba, Brazil
    Conf Proc IEEE Eng Med Biol Soc 2007:557-60. 2007
    ..Latency time from the tenth and twenty-fifth flash exposure to the start of constriction was significantly shorter in healthy volunteers than in diabetic subjects with DPN...
  42. doi Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials
    Nish Chaturvedi
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK
    Lancet 372:1394-402. 2008
    ..We therefore designed the DIabetic REtinopathy Candesartan Trials (DIRECT) Programme to assess whether candesartan could reduce the incidence and progression of retinopathy in type 1 diabetes...

Research Grants1

  1. Can dynamic pupillography and/or spectral analysis of heart rate variability prov
    Solomon Tesfaye; Fiscal Year: 2008
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