Affiliation: Royal Free Hospital
- Successful treatment of HIV-associated multicentric Castleman's disease and multiple organ failure with rituximab and supportive care: a case reportRobin H Johns
Department of Intensive Care, Royal Free Hospital, London, UK
J Med Case Rep 4:32. 2010..A number of small studies have demonstrated the efficacy of the anti-CD20 monoclonal antibody, rituximab, in treating this condition...
- Immune reconstitution inflammatory syndrome in HIVMarc Lipman
Department of HIV and Respiratory Medicine, Royal Free Hospital, London, UK
Curr Opin Infect Dis 19:20-5. 2006..The purpose of this review is to describe the epidemiology, clinical features, putative immune mechanisms and management of immune reconstitution inflammatory syndrome (IRIS) using data published in the last 2 years...
- Does antiretroviral therapy reduce HIV-associated tuberculosis incidence to background rates? A national observational cohort study from England, Wales, and Northern IrelandRishi K Gupta
Division of Medicine, University College London, London, UK HIV STI Department, Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK Electronic address
Lancet HIV 2:e243-51. 2015..We compared tuberculosis incidence in people receiving ART with background rates in England, Wales, and Northern Ireland...
- Viral breakthrough after suppression with highly active antiretroviral therapy: experience from 233 individuals with viral loads of less than 50 copies/ml followed for up to 4 yearsFiona C Lampe
Royal Free Centre for HIV Medicine, London, UK
AIDS 17:768-70. 2003
- Impact of TB on the survival of people living with HIV infection in England, Wales and Northern IrelandDominik Zenner
Respiratory Diseases Department, Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK Research Department of Infection and Population Health, University College London, London, UK
Thorax 70:566-73. 2015..We calculated TB incidence rates and compared the mortality of persons with and without HIV-TB in a UK HIV cohort in the post-ART era, to determine the impact of HIV-TB on survival in the UK...
- Decreasing incidence of tuberculosis among heterosexuals living with diagnosed HIV in England and WalesBrian Rice
Department of HIV and STI, Health Protection Agency, Health Protection Services, London, UK
AIDS 27:1151-7. 2013..To calculate annual tuberculosis incidence rates, and investigate risk factors for tuberculosis, among heterosexual adults living with diagnosed HIV in England and Wales...
- The changing pattern of bronchoscopy in an HIV-infected populationSimon Taggart
Royal Free Hospital HIV Centre, Hampstead, London, UK
Chest 122:878-85. 2002..This study was performed to identify any changes to our pattern of use of bronchoscopy over the last decade, and how this might relate to the introduction of more effective ARTs to our center in 1996...
- Pneumocystis pneumonia revisited: delayed diagnosis in an HIV infected individual with high blood and low lung CD4 T cell countsBen Killingley
The Royal Free Centre for HIV Medicine, Royal Free Hospital, London, United Kingdom
J Infect 53:e159-60. 2006..On each occasion the possibility of PCP was discounted as he had a well-preserved blood CD4 count. Subsequent examination of his pulmonary T-lymphocyte subsets revealed marked CD4 lymphopenia...
- Migration and tuberculosis in the UK: targeting screening for latent infection to those at greatest risk of diseaseMichelle E Kruijshaar
Tuberculosis Section, Public Health England, London, UK
Thorax 68:1172-4. 2013..Numbers were the lowest in Somalian and the highest in South African and Filipino migrants, which contrasts with TB rates in these countries. Targeting screening on the basis of incidence in the UK may thus improve effectiveness. ..
- Decreasing cost effectiveness of testing for latent TB in HIV in a low TB incidence areaSantino Capocci
Department of HIV and Thoracic Medicine, Royal Free London NHS Foundation Trust, London, UK
Eur Respir J 46:165-74. 2015..Both UK testing regimens missed cases but are cost-effective compared with no testing. Using recent data, they all became more expensive, suggesting that alternative or more targeted TB testing strategies must be considered...
- MMP-1 drives immunopathology in human tuberculosis and transgenic micePaul Elkington
Department of Infectious Diseases and Immunity, Imperial College London, London, UK
J Clin Invest 121:1827-33. 2011..In summary, MMP-1 may drive tissue destruction in TB and represents a therapeutic target to limit immunopathology...
- Impaired antigen-specific CD4(+) T lymphocyte responses in cavitary tuberculosisSimon Barry
Department of Respiratory Medicine, Royal Free Hospital, Pond Street, London, UK
Tuberculosis (Edinb) 89:48-53. 2009..It remains unclear whether neutrophilia is a cause, or a result of cavitation in pulmonary tuberculosis...
- Pulmonary Mycobacterium avium-intracellulare is the main driver of the rise in non-tuberculous mycobacteria incidence in England, Wales and Northern Ireland, 2007-2012Neeraj M Shah
Division of Asthma, Allergy and Lung Biology, King s College London, London, UK
BMC Infect Dis 16:195. 2016..Here we report the incidence of NTM isolation in EW&NI between 2007 and 2012 from both pulmonary and extra-pulmonary samples obtained at a population level...
- Variation in C - reactive protein response according to host and mycobacterial characteristics in active tuberculosisJames Brown
Department of Respiratory Medicine, Royal Free London NHS Foundation Trust, London, UK
BMC Infect Dis 16:265. 2016..tb) strain types. We report the relationship between baseline serum CRP prior to treatment and disease characteristics in a metropolitan population with TB resident in a low TB incidence region...
- Respiratory symptoms in people living with HIV and the effect of antiretroviral therapy: a systematic review and meta-analysisJames Brown
Departments of HIV and Respiratory Medicine, Royal Free London NHS Foundation Trust, London, UK
Thorax . 2016..However, it is not clear what this means in terms of respiratory symptoms. We sought to investigate the association between HIV status and respiratory symptoms and how these have changed with the availability of ART...
- Raising standards in UK TB control: introducing cohort reviewCharlotte Anderson
Field Epidemiology Services Victoria, Public Health England, London, UK
Thorax 69:187-9. 2014..Cohort review enables whole system review and improvement. It has subsequently been adopted across the UK. ..
- Respiratory infections in HIV-infected adults: epidemiology, clinical features, diagnosis and treatmentSantino Capocci
Respiratory and HIV Medicine, University College London, Royal Free London NHS Foundation Trust, London, UK
Curr Opin Pulm Med 19:238-43. 2013..Using the evidence published over the last 2 years, this review discusses the epidemiology, diagnosis, treatment and prevention of HIV-related pulmonary infections other than mycobacterial disease...
- Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistanceGiovanni Satta
Department of Infection, Centre for Clinical Microbiology, University College London, London, UK
BMC Med 14:117. 2016..In the current study, we evaluated the genetic variation in a subset of clinical samples from the outbreak with the hypothesis that these isolates have unique biological characteristics that have served to prolong the outbreak...
- Uniting to end the TB epidemic: advances in disease control from prevention to better diagnosis and treatmentIbrahim Abubakar
Centre for Infectious Disease Epidemiology and MRC Clinical Trials Unit, University College London, London, UK
BMC Med 14:47. 2016..New research is urgently needed to support development of new vaccines and better diagnostics tools and shorter treatment for drug sensitive and resistant tuberculosis. ..
- Incidence and risk factors for drug intolerance and association with incomplete treatment for tuberculosis: analysis of national case registers for England, Wales and Northern Ireland, 2001-2010Catherine Smith
Field Epidemiology Services Cambridge, Public Health England, UK Department of Infection and Population Health, Centre for Infectious Disease Epidemiology, University College London, London, UK
Thorax 69:956-8. 2014..001). These results highlight the need for better-tolerated drug regimens and close case management of patients at risk of drug intolerance to improve treatment completion rates and contribute to more effective disease control...
- Evidence for a national problem: continued rise in tuberculosis case numbers in urban areas outside LondonMichelle E Kruijshaar
TB Section, Respiratory Diseases Department, Health Protection Agency, Health Protection Services Colindale, London, UK
Thorax 67:275-7. 2012..Many TB control efforts focus on the capital, but with rates rising elsewhere in the country, this strategy is likely to fail in the long term...
- CD4 cell count changes in individuals with counts above 500 cells/mm and viral loads below 50 copies/ml on antiretroviral therapyAndrew N Phillips
Royal Free Centre for HIV Medicine, London, UK
AIDS 16:1073-5. 2002
- HIV and respiratory medicineSwapna Mandal
The London Chest Hospital, London
Br J Hosp Med (Lond) 69:132-6. 2008..Anti-HIV drug therapy has improved the lives of many, although HIV-related respiratory complications remain extremely common worldwide...
- The role of flow cytometry in the interferon-gamma-based diagnosis of active tuberculosis and its coinfection with HIV-1--A technically oriented reviewGeorge Janossy
Department of Immunology, Royal Free and University College Medical School, London, United Kingdom
Cytometry B Clin Cytom 74:S141-51. 2008..In active TB, but not in BCG vaccinees, TB-specific memory CD4+ T cells can be found in blood that are dominantly CD27-negative and probably lung seeking and can be diagnostically useful...
- The growing impact of HIV infection on the epidemiology of tuberculosis in England and Wales: 1999 2003Aliko B Ahmed
Centre for Infections, Health Protection Agency, London NW9 5EQ, UK
Thorax 62:672-6. 2007..This study was undertaken to describe recent trends in the proportion of individuals with HIV infection among reported cases of tuberculosis in England and Wales, and to review the implications for clinical and public health care...
- Pseudomonal sepsis with subcutaneous nodules in an HIV-infected individual with high CD4 countsShema Tariq
J Infect 51:419-20. 2005
- Raised viral load in patients with viral suppression on highly active antiretroviral therapy: transient increase or treatment failure?Antonia L Moore
Department of Primary Care and Population Sciences and Centre for HIV Medicine, Royal Free and University College School of Medicine, Hampstead, London NW3 2PF, UK
AIDS 16:615-8. 2002....