Affiliation: Royal Brompton Hospital
- What did we learn from the North American Cystic Fibrosis Conference?Diana Bilton
Department of Respiratory Medicine, Royal Brompton Hospital Sydney Street, London SW3 6NP, UK
J R Soc Med 101:S6-9. 2008
- Fertility issues in cystic fibrosisAngela Lyon
Adult CF Centre, Papworth Hospital NHS Trust, Cambridge, UK
Paediatr Respir Rev 3:236-40. 2002..For females, successful pregnancy is possible but careful planning is required. The practical and ethical aspects of reproductive health in CF are discussed...
- End of life care for adult cystic fibrosis patients: facilitating a good enough deathElizabeth Chapman
Adult Cystic Fibrosis Centre, Papworth NHS Trust, Papworth Everard, Cambridge CB3 8RE United Kingdom
J Cyst Fibros 4:249-57. 2005..This study examined how a number of recent deaths have been handled in an adult CF centre in the UK...
- Managing adults with cystic fibrosisDiana Bilton
Adult Cystic Fibrosis Centre, Papworth Hospital NHS Foundation Trust, Cambridge
Practitioner 251:46, 48, 50 passim. 2007
- A randomized controlled trial of a new behavioral home-based nutrition education program, "Eat Well with CF," in adults with cystic fibrosisHelen Watson
Department of Nutrition and Dietetics, Papworth Hospital, Papworth Everard, Cambridge, CB3 8RE, UK
J Am Diet Assoc 108:847-52. 2008..These need to be identified when subjects progress from pediatric to adult care, and programs such as "Eat Well with CF" are a useful adjunct for registered dietitians trying to manage this diverse but growing population...
- Personalised medicine in cystic fibrosis must be made affordableDiana Bilton
Department of Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP Electronic address
Paediatr Respir Rev 15:6-7. 2014..A process which engages industry, providers and patients will provide the best long term answers. ..
- Phase 3 randomized study of the efficacy and safety of inhaled dry powder mannitol for the symptomatic treatment of non-cystic fibrosis bronchiectasisDiana Bilton
Department of Respiratory Medicine, Royal Brompton Hospital, London, England
Chest 144:215-25. 2013..Inhaled dry powder mannitol enhanced mucus clearance and improved quality of life over 2 weeks in non-cystic fibrosis bronchiectasis. This study's objective was to investigate the efficacy and safety of dry powder mannitol over 12 weeks...
- Pooled analysis of two large randomised phase III inhaled mannitol studies in cystic fibrosisDiana Bilton
Royal Brompton Hospital, London, United Kingdom
J Cyst Fibros 12:367-76. 2013..To evaluate safety and efficacy of inhaled mannitol treatment in subgroups of a large global CF population...
- Pulmonary exacerbation: towards a definition for use in clinical trials. Report from the EuroCareCF Working Group on outcome parameters in clinical trialsD Bilton
Royal Brompton Hospital, Respiratory Medicine, London, UK
J Cyst Fibros 10:S79-81. 2011..Which parameters to include as well as the problems associated with the use of scoring systems and symptom clusters are being discussed...
- Inhaled dry powder mannitol in cystic fibrosis: an efficacy and safety studyD Bilton
Royal Brompton Hospital, London, SW3 6NP, UK
Eur Respir J 38:1071-80. 2011..Mannitol showed sustained, clinically meaningful benefit in airway function in CF, irrespective of concomitant rhDNase use. Mannitol appears to have an acceptable safety profile for patients with CF...
- Update on non-cystic fibrosis bronchiectasisDiana Bilton
Royal Brompton Hospital, Sydney Street, London, UK
Curr Opin Pulm Med 14:595-9. 2008..There has been debate regarding the requirement for investigations to establish an underlying cause of bronchiectasis. Furthermore, there has been growing interest in establishing the role of bacteria in disease progression...
- Antipseudomonal Bacteriophage Reduces Infective Burden and Inflammatory Response in Murine LungRishi Pabary
National Heart and Lung Institute, Imperial College London, London, United Kingdom Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, United Kingdom
Antimicrob Agents Chemother 60:744-51. 2016..Bacteriophages are efficacious in reducing both the bacterial load and inflammation in a murine model of P. aeruginosa lung infection. This study provides proof of concept for future clinical trials in patients with CF. ..
- Inhaled mannitol for the treatment of cystic fibrosisKatharine Hurt
Department of Cystic Fibrosis, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK
Expert Rev Respir Med 6:19-26. 2012..Its formulation as a dry powder makes it quick and convenient to take...
- Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary diseasePrina Ruparelia
Department of Respiratory Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
Eur J Nucl Med Mol Imaging 38:911-9. 2011..To quantify neutrophil migration into the lungs of patients with chronic pulmonary obstructive disease (COPD)...
- Primary care summary of the British Thoracic Society Guideline on the management of non-cystic fibrosis bronchiectasisAdam T Hill
Department of Respiratory Medicine, Royal Infirmary and University of Edinburgh, Scotland, UK
Prim Care Respir J 20:135-40. 2011..Management in primary care is aimed at improving morbidity, and includes; patient education, treatment and monitoring, as well as appropriate referral to secondary care including assessment for long term antibiotics...
- HbA1c as a screening tool for cystic fibrosis related diabetesJuliana C Burgess
National Heart and Lung Institute, Imperial College, London, United Kingdom Adult Cystic Fibrosis Centre, Royal Brompton Hospital, London, United Kingdom
J Cyst Fibros 15:251-7. 2016..The aim of this study was to develop an effective screening tool and reduce the need for a universal OGTT...
- Predictors of outcome in patients with cystic fibrosis requiring endotracheal intubationAndrew Jones
Department of Cystic Fibrosis, Royal Brompton Hospital, London, UK
Respirology 18:630-6. 2013....
- Bugs, biofilms, and resistance in cystic fibrosisJane C Davies
Department of Gene Therapy, Imperial College, Emmanuel Kaye Building, Manresa Road, London SW3 6NP, United Kingdom
Respir Care 54:628-40. 2009..Future work should aim to develop clinically applicable methods to identify these and to determine which have the potential to impact pulmonary health. We outline the basic tenets of infection control and treatment...
- Oral contraceptives do not appear to affect cystic fibrosis disease severityNatalie G Kernan
Dept of Gene Therapy, Imperial College London, London, UK
Eur Respir J 41:67-73. 2013..Our data suggests that the use of OCs does not affect CF disease severity...
- Chest physiotherapy techniques in bronchiectasisLizzie J Flude
Physiotherapy Department, The Royal Brompton and Harefield NHS Foundation Trust, Royal Brompton Hospital, London, UK
Clin Chest Med 33:351-61. 2012..Physiotherapists aim to teach patients one of a variety of airway clearance techniques to regularly perform as part of their daily management...
- Genetic determinants and epidemiology of cystic fibrosis-related diabetes: results from a British cohort of children and adultsAmanda I Adler
Addenbrooke s Hospital, Cambridge, UK
Diabetes Care 31:1789-94. 2008..In this study we documented the incidence of CFRD and evaluated the association between mutations responsible for cystic fibrosis and incident CFRD, while identifying potential risk factors...
- The relationship of clinical and inflammatory markers to outcome in stable patients with cystic fibrosisDamian G Downey
Adult Cystic Fibrosis Centre, Belfast City Hospital and Queens University, Belfast, Northern Ireland
Pediatr Pulmonol 42:216-20. 2007..3 pM/mg creatinine (P = 0.001), in those patients who subsequently died compared to those that survived. These data suggest there is increased neutrophil degranulation in patients infected with Bc and these patients have a poor outcome...
- Addition of inhaled tobramycin to ciprofloxacin for acute exacerbations of Pseudomonas aeruginosa infection in adult bronchiectasisDiana Bilton
Papworth Hospital, Adult CF Centre, Papworth Everard Cambridge, Cambridge CB38RE, UK
Chest 130:1503-10. 2006....
- Osteoclastogenesis during infective exacerbations in patients with cystic fibrosisElizabeth F Shead
Department of Haematology, NHS Foundation Trust, Addenbrooke s Hospital, Cambridge, United Kingdom
Am J Respir Crit Care Med 174:306-11. 2006..Adults with cystic fibrosis (CF) are at increased risk of developing osteoporosis. During infective exacerbations, increased production of proinflammatory cytokines and markers of bone resorption have been reported...
- Safety and efficacy of recombinant alpha(1)-antitrypsin therapy in cystic fibrosisS Lorraine Martin
School of Pharmacy, Queen s University Belfast, Belfast, Northern Ireland, UK
Pediatr Pulmonol 41:177-83. 2006..This study demonstrated that nebulized rAAT is safe and well-tolerated, but has a limited effect on NE activity and other markers of inflammation...
- Cystic fibrosis pulmonary disease is not a contra-indication to live-related renal transplantationDamian J McKeon
Nephrol Dial Transplant 20:664. 2005
- Patients' knowledge of cystic fibrosis: genetic determinism and implications for treatmentElizabeth Chapman
Centre for Family Research, University of Cambridge, Cambridge, UK
J Genet Couns 13:369-85. 2004..Any important gaps in patient knowledge could usefully be discussed at transition from pediatric to adult care and issues relating to control and genetic determinism discussed with the patients individually...