Matthew H Todd
Affiliation: Queen Mary
- Asymmetric autocatalysis: product recruitment for the increase in the chiral environment (PRICE)Matthew H Todd
Department of Chemistry, Queen Mary, University of London, Mile End Road, London, UK E1 4NS
Chem Soc Rev 31:211-22. 2002..Such reactions, aside from their inherent interest, may offer clues into the origins of asymmetric molecular replication that predated the origin of life...
- The use of FTICR-MS to detect chemical tags from a combinatorial libraryMatthew H Todd
Department of Chemistry, Queen Mary, University of London, UK
Analyst 127:1399-406. 2002..The identities of the tags attached to a single bead are discovered by the high resolution, accurate mass technique of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS)...
- Computer-aided organic synthesisMatthew H Todd
Department of Chemistry, Queen Mary, University of London, Mile End Road, London, UKE1 4NS
Chem Soc Rev 34:247-66. 2005..Here the analogy between synthesis and chess is outlined. Achievements in the 35-year history of computer-aided synthetic design are described, followed by some more recent developments...
- Amino acid derived heterocycles: lewis acid catalyzed and radical cyclizations from peptide acetalsMatthew H Todd
Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley 94720 1460, USA
J Org Chem 67:3985-8. 2002..Additional versatility in this process was demonstrated by efficient synthesis of a different fused ring system, represented by the antihelmintic praziquantel, 8...
- Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT1 receptor antagonistsMohamed A H Ismail
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, ElKhalifa ElMaamoon St, 11566, Abbasseya, Cairo, Egypt
J Med Chem 49:1526-35. 2006..To obtain a highly active compound from a candidate set of only eight tested compounds illustrates the power and utility of our pharmacophore model...