M O Savage

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Growth hormone insensitivity: pathophysiology, diagnosis, clinical variation and future perspectives
    M O Savage
    Department of Endocrinology, St Bartholomew s Hospital, and the Royal London School of Medicine and Dentistry, UK
    Horm Res 55:32-5. 2001
  2. ncbi request reprint Growth abnormalities associated with adrenal disorders and their management
    M O Savage
    Department of Endocrinology, St Bartholomew s and Royal London School of Medicine and Dentistry, London EC1A 7BE, UK
    Horm Res 56:19-23. 2001
  3. ncbi request reprint Is there a medical need to explore the clinical use of insulin-like growth factor I?
    M O Savage
    St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Growth Horm IGF Res 11:S65-9. 2001
  4. ncbi request reprint Cushing's disease in childhood: presentation, investigation, treatment and long-term outcome
    M O Savage
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Horm Res 55:24-30. 2001
  5. doi request reprint Diagnosis, management and therapeutic outcome in prepubertal Cushing's disease
    R P Dias
    Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, London EC1A 7BE, UK
    Eur J Endocrinol 162:603-9. 2010
  6. ncbi request reprint Abnormal puberty in paediatric Cushing's disease: relationship with adrenal androgen, sex hormone binding globulin and gonadotrophin concentrations
    C C Dupuis
    Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, London, UK
    Clin Endocrinol (Oxf) 66:838-43. 2007
  7. ncbi request reprint Investigation, management and therapeutic outcome in 12 cases of childhood and adolescent Cushing's syndrome
    A Weber
    Division of Paediatric Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 43:19-28. 1995
  8. ncbi request reprint Comparison of continuation or cessation of growth hormone (GH) therapy on body composition and metabolic status in adolescents with severe GH deficiency at completion of linear growth
    P V Carroll
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 89:3890-5. 2004
  9. pmc Acid-labile subunit deficiency and growth failure: description of two novel cases
    A David
    Centre for Endocrinology, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK
    Horm Res Paediatr 73:328-34. 2010
  10. ncbi request reprint Final adult height and body mass index after cure of paediatric Cushing's disease
    J H Davies
    Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, London EC1A 7BE, UK
    Clin Endocrinol (Oxf) 62:466-72. 2005

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Growth hormone insensitivity: pathophysiology, diagnosis, clinical variation and future perspectives
    M O Savage
    Department of Endocrinology, St Bartholomew s Hospital, and the Royal London School of Medicine and Dentistry, UK
    Horm Res 55:32-5. 2001
    ..GH sensitivity, measured by IGF-I and IGFBP-3 responses in the IGF-I generation test, may reveal abnormalities in ISS, although it is likely that the dose of recombinant human GH and frequency of sampling in the test need to be modified...
  2. ncbi request reprint Growth abnormalities associated with adrenal disorders and their management
    M O Savage
    Department of Endocrinology, St Bartholomew s and Royal London School of Medicine and Dentistry, London EC1A 7BE, UK
    Horm Res 56:19-23. 2001
    ..Disturbance of linear growth is an important feature of many patients with adrenal disorders in childhood. Assessment of its pathogenesis and careful management are necessary to ensure optimal final adult height...
  3. ncbi request reprint Is there a medical need to explore the clinical use of insulin-like growth factor I?
    M O Savage
    St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Growth Horm IGF Res 11:S65-9. 2001
    ..It will probably be decided during the next decade whether use of IGF-I or the IGF-I-IGFBP-3 complex becomes firmly established as an accepted endocrine therapy...
  4. ncbi request reprint Cushing's disease in childhood: presentation, investigation, treatment and long-term outcome
    M O Savage
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Horm Res 55:24-30. 2001
    ..93 +/- 1.13, i.e. less (p = 0.005) than the difference between height SDS and target height SDS at presentation, i.e. 1.72 +/- 1.26, indicating long-term catch-up growth...
  5. doi request reprint Diagnosis, management and therapeutic outcome in prepubertal Cushing's disease
    R P Dias
    Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, London EC1A 7BE, UK
    Eur J Endocrinol 162:603-9. 2010
    ..Cushing's disease (CD) in prepubertal children is very rare and presents important diagnostic and therapeutic challenges. We report experience of the management of this subpopulation of CD patients...
  6. ncbi request reprint Abnormal puberty in paediatric Cushing's disease: relationship with adrenal androgen, sex hormone binding globulin and gonadotrophin concentrations
    C C Dupuis
    Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, London, UK
    Clin Endocrinol (Oxf) 66:838-43. 2007
    ..Paediatric Cushing's disease is frequently associated with abnormal puberty. We addressed the hypothesis that prepubertal patients show excessive virilization and pubertal patients show suppression of LH and FSH secretion...
  7. ncbi request reprint Investigation, management and therapeutic outcome in 12 cases of childhood and adolescent Cushing's syndrome
    A Weber
    Division of Paediatric Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 43:19-28. 1995
    ..Cushing's syndrome in childhood and adolescence is rare. We analysed the clinical presentation, investigation, management and therapeutic outcome in 12 paediatric patients with Cushing's syndrome...
  8. ncbi request reprint Comparison of continuation or cessation of growth hormone (GH) therapy on body composition and metabolic status in adolescents with severe GH deficiency at completion of linear growth
    P V Carroll
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 89:3890-5. 2004
    ....
  9. pmc Acid-labile subunit deficiency and growth failure: description of two novel cases
    A David
    Centre for Endocrinology, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK
    Horm Res Paediatr 73:328-34. 2010
    ..Whether severe pubertal delay is also part of the phenotype remains controversial due to the small number of cases reported. We report 2 children with a history of growth failure due to novel IGFALS mutations...
  10. ncbi request reprint Final adult height and body mass index after cure of paediatric Cushing's disease
    J H Davies
    Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, London EC1A 7BE, UK
    Clin Endocrinol (Oxf) 62:466-72. 2005
    ..Linear growth data after cure of paediatric Cushing's disease (CD) have been reported infrequently. We evaluated final adult height (FH) and body mass index (BMI) in a cohort of paediatric patients treated successfully for CD...
  11. ncbi request reprint The effect of cessation of growth hormone (GH) therapy on bone mineral accretion in GH-deficient adolescents at the completion of linear growth
    W M Drake
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    J Clin Endocrinol Metab 88:1658-63. 2003
    ..This may predispose to clinically significant osteopenia in later adult life...
  12. ncbi request reprint Long-term anterior pituitary function in patients with paediatric Cushing's disease treated with pituitary radiotherapy
    L F Chan
    Departments of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Eur J Endocrinol 156:477-82. 2007
    ..Although the short-term effects of pituitary RT are well documented, there are less data on possible long-term sequelae. We report the long-term anterior pituitary function in a cohort of paediatric CD patients treated with pituitary RT...
  13. ncbi request reprint Linear growth and body mass index in pediatric patients with Cushing's disease or simple obesity
    J E Greening
    Department of Endocrinology, Barts and the London School of Medicine and Dentistry, London, UK
    J Endocrinol Invest 29:885-7. 2006
    ..The exclusion of Cushing's disease (CD) requires complex and potentially invasive investigations...
  14. ncbi request reprint Successful treatment of childhood-onset Cushing's disease is associated with persistent reduction in growth hormone secretion
    P V Carroll
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Clin Endocrinol (Oxf) 60:169-74. 2004
    ..Whether recovery of spontaneous GH secretion occurs following treatment of childhood CD has yet to be established...
  15. ncbi request reprint Transitional care of GH deficiency: when to stop GH therapy
    M O Savage
    Department of Endocrinology, Barts and the Royal London School of Medicine and Dentistry, London, UK
    Eur J Endocrinol 151:S61-5. 2004
    ..Quality of life does not appear to be decreased in adolescents with GHD who stop treatment, so achievement of satisfactory bone mass is a major determinant of the decision whether to continue therapy...
  16. ncbi request reprint Bone mineral density at diagnosis and following successful treatment of pediatric Cushing's disease
    S Scommegna
    Department of Endocrinology, St Bartholomew s Hospital, Birmingham, UK
    J Endocrinol Invest 28:231-5. 2005
    ..03 (-0.53-0.38). These findings show variability of BMD at diagnosis and near normal BMD after cure of pediatric CD, suggesting that with appropriate replacement of pituitary hormone deficiency normal peak bone mass is achievable...
  17. doi request reprint Use of intravenous etomidate to control acute psychosis induced by the hypercortisolaemia in severe paediatric Cushing's disease
    L F Chan
    Paediatric Endocrinology, Barts and the London School of Medicine and Dentistry, London, UK
    Horm Res Paediatr 75:441-6. 2011
    ..Psychosis secondary to paediatric Cushing's disease (CD) is extremely rare and presents a significant management challenge...
  18. ncbi request reprint Normal final height and apparent cure after pituitary irradiation for Cushing's disease in childhood: long-term follow-up of anterior pituitary function
    L B Johnston
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 48:663-7. 1998
    ..Collaboration between the paediatric and adult departments and an experienced radiotherapist contributed to the successful outcome of these two patients...
  19. ncbi request reprint Relative contributions of inferior petrosal sinus sampling and pituitary imaging in the investigation of children and adolescents with ACTH-dependent Cushing's syndrome
    A Lienhardt
    Department of Endocrinology, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, United Kingdom EC1 7BE
    J Clin Endocrinol Metab 86:5711-4. 2001
    ..In experienced hands, however, IPSS was feasible in this age group, safe, and strongly predictive of the site of the adenoma, leading to a high rate of successful surgical outcome...
  20. doi request reprint Comparisons in the epidemiology, diagnostic features and cure rate by transsphenoidal surgery between paediatric and adult-onset Cushing's disease
    H L Storr
    Department of Paediatric Endocrinology, Barts and the London School of Medicine and Dentistry, London EC1A 7BE, UK
    Eur J Endocrinol 164:667-74. 2011
    ..There are few published comparisons between paediatric and adult-onset Cushing's disease (CD). We compare the epidemiology, diagnostic features and cure rate by transsphenoidal surgery (TSS) in these groups...
  21. ncbi request reprint Treatment with GHRH(1-29)NH2 in children with idiopathic short stature induces a sustained increase in growth velocity
    J M Kirk
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 41:487-93. 1994
    ..We, therefore, studied the clinical response of children with idiopathic short stature to treatment with GHRH(1-29)NH2 (GHRHa) for a period of 12 months...
  22. ncbi request reprint Factors influencing skeletal maturation at diagnosis of paediatric Cushing's disease
    C J Peters
    Department of Paediatric, The Royal London Hospital, London, UK
    Horm Res 68:231-5. 2007
    ..We assessed factors contributing to skeletal maturation in patients with paediatric CD...
  23. pmc Identification and characterisation of a novel GHR defect disrupting the polypyrimidine tract and resulting in GH insensitivity
    A David
    William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, Barts and The London, London, UK
    Eur J Endocrinol 162:37-42. 2010
    ..All but one known GHR mutation are in the coding sequence or the exon/intron boundaries. We identified and characterised the first intronic defect occurring in the polypyrimidine tract of the GHR in a patient with severe GHI...
  24. ncbi request reprint Clinical and endocrine characteristics in atypical and classical growth hormone insensitivity syndrome
    C P Burren
    Paediatric Section, Dept. of Endocrinology, St. Bartholomew's Hospital, London EC1A 7BE, UK
    Horm Res 55:125-30. 2001
    ..GH insensitivity may be present in children with short stature and an otherwise normal appearance...
  25. ncbi request reprint IGFs and IGFBPs in GH insensitivity
    M O Savage
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Endocr Dev 9:100-6. 2005
    ..In our experience, IGF-I is more sensitive to disturbance of GH action that IGFBP-3, however in severe GHIS cases, IGF-I is usually undetectable and measurement of IGFBP-3 is valuable as a guide to the severity of the biological defect...
  26. ncbi request reprint Cosegregation of a novel homozygous CYP11B1 mutation with the phenotype of non-classical congenital adrenal hyperplasia in a consanguineous family
    C J Peters
    Department of Endocrinology, Royal London Hospital, London, UK
    Horm Res 67:189-93. 2007
    ..These findings suggest that this homozygous mutation affects 11beta-hydroxylase function, resulting in the clinical features of non-classical adrenal hyperplasia in this family...
  27. ncbi request reprint Response to growth hormone-releasing hormone as evidence of hypothalamic defect in optic nerve hypoplasia
    A A Leaf
    Department of Child Health, St Bartholomew s Hospital, London, UK
    Acta Paediatr Scand 78:436-9. 1989
    ..One child has shown an excellent response to treatment with subcutaneous GHRH, which is physiologically the most appropriate treatment for this condition...
  28. ncbi request reprint Growth hormone deficiency following radiotherapy for orbital and parameningeal sarcomas
    A G Goddard
    Department of Paediatric Oncology, St Bartholomew s Hospital, London, UK
    Pediatr Hematol Oncol 16:23-33. 1999
    ..7 years. Treatment with hGH resulted in a median increase in height SDS of 0.9. Careful surveillance with timely introduction of GH replacement is required for treatment of GHD following treatment of orbital and parameningeal sarcomas...
  29. ncbi request reprint Growth in disorders of adrenal hyperfunction
    M O Savage
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Horm Res 58:39-43. 2002
    ..After cure by TSS or pituitary irradiation, GH deficiency was frequent and persisted for many years. Treatment with hGH induced significant long-term catch-up growth leading to reasonable final height...
  30. ncbi request reprint Clinical and endocrine features and long-term outcome of Graves' disease in early childhood
    A T Bossowski
    Department of Paediatric Endocrinology Barts and London School of Medicine and Dentistry, London, UK
    J Endocrinol Invest 30:388-92. 2007
    ..2) or radioiodine (no.=2). In conclusion, disturbance of growth, behavioral difficulties and infrequent spontaneous remission are key features of Graves' disease in early childhood...
  31. doi request reprint Pediatric endocrine screening for von Hippel-Lindau disease: benefits and the challenge of compliance
    R Prasad
    Paediatric Endocrine Unit, St Bartholomew s and Royal London Hospitals, London, UK
    J Endocrinol Invest 34:296-9. 2011
    ..A formal screening programme for this at-risk population of pediatric patients, despite being intensive, can identify VHL lesions during a pre-morbid phase and may thus have a beneficial impact on prognosis in this serious disorder...
  32. ncbi request reprint Benefits of screening in von Hippel-Lindau disease--comparison of morbidity associated with initial tumours in affected parents and children
    M Priesemann
    Department of Endocrinology, Barts and The London NHS Trust, London, UK
    Horm Res 66:1-5. 2006
    ..These observations strongly support the recommendation to undertake screening of the children of VHL patients...
  33. ncbi request reprint Standard and low-dose IGF-I generation tests and spontaneous growth hormone secretion in children with idiopathic short stature
    J C Blair
    Paediatric Endocrinology Section, Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Clin Endocrinol (Oxf) 60:163-8; discussion 161-2. 2004
    ..The aim of this study was to investigate the GH-IGF-I axis in ISS by performing standard and novel low-dose IGFGTs together with determination of spontaneous GH secretion...
  34. ncbi request reprint Excellent growth response to growth hormone therapy in a child with PTPN11-negative Noonan syndrome and features of growth hormone resistance
    S Walton-Betancourth
    Department of Endocrinology, St Bartholomew s and The Royal London Hospitals, London, UK
    J Endocrinol Invest 30:439-41. 2007
    ..This case shows that the potential value of GH therapy must be evaluated in each patient individually and that an excellent response may occur in a child with a PTPN11-negative genotype...
  35. ncbi request reprint Bilateral testicular tumours in congenital adrenal hyperplasia: a continuing diagnostic and therapeutic dilemma
    D Cunnah
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 30:141-7. 1989
    ..To our knowledge, this is the first time in this clinical setting that fertility has been achieved. This case highlights the need for both a functional and histological assessment of such 'tumours' in CAH prior to orchidectomy...
  36. ncbi request reprint Treatment of radiation-induced growth hormone deficiency with growth hormone-releasing hormone
    A L Ogilvy-Stuart
    Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK
    Clin Endocrinol (Oxf) 46:571-8. 1997
    ..In children with hypothalamic causes for GH deficiency there are theoretical reasons why a GHRH analogue might be better than conventional GH therapy in promoting growth...
  37. ncbi request reprint The discriminatory value of the low-dose dexamethasone suppression test in the investigation of paediatric Cushing's syndrome
    R Dias
    Department of Endocrinology, Barts and the London School of Medicine and Dentistry, London, UK
    Horm Res 65:159-62. 2006
    ..Low- and high-dose dexamethasone suppression tests (LDDST, HDDST) are used in the investigation of Cushing's syndrome (CS). In adults with Cushing's disease (CD), cortisol suppression during LDDST predicts suppression during the HDDST...
  38. ncbi request reprint Clinical features, diagnosis, treatment and molecular studies in paediatric Cushing's syndrome due to primary nodular adrenocortical hyperplasia
    H L Storr
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Clin Endocrinol (Oxf) 61:553-9. 2004
    ..Primary nodular adrenocortical hyperplasia (PNAH) is a well recognized, but infrequently studied cause of paediatric Cushing's syndrome (CS)...
  39. ncbi request reprint Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene
    K A Woods
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom
    N Engl J Med 335:1363-7. 1996
  40. ncbi request reprint Efficient short-term control of hypercortisolaemia by low-dose etomidate in severe paediatric Cushing's disease
    J E Greening
    Department of Paediatric, St Bartholomew s and The Royal London Hospitals, London, UK
    Horm Res 64:140-3. 2005
    ..Control of cortisol with metyrapone and ketoconazole was ineffective, and due to his deteriorating condition, the decision was taken to proceed to bilateral adrenalectomy...
  41. pmc Testicular function following the treatment of Hodgkin's disease in childhood
    E A Shafford
    Department of Paediatric Oncology, St Bartholomew s Hospital, West Smithfield, London, UK
    Br J Cancer 68:1199-204. 1993
    ..Appropriate counselling of these patients with regard to their reproductive capabilities is essential...
  42. ncbi request reprint Pseudo-precocious puberty caused by a juvenile granulosa cell tumour secreting androstenedione, inhibin and insulin-like growth factor-I
    L F Chan
    Department of Paediatric Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    J Pediatr Endocrinol Metab 17:679-84. 2004
    ..Histological changes were consistent with JGCT. Immunohistochemical studies revealed positive reactivity to MIC-2, inhibin, melan A, IGF-I and IGFBP-2...
  43. ncbi request reprint Embryology of the adrenal glands and its relevance to diagnostic imaging
    T D Barwick
    Department of Diagnostic Radiology, St Bartholomew s Hospital, London, UK
    Clin Radiol 60:953-9. 2005
    ..This review article illustrates the embryology of the adrenal with particular emphasis on the relevance of embryology to pathology...
  44. ncbi request reprint Two brothers with non-classical 21-hydroxylase deficiency: to treat or not to treat?
    F Oberender
    Department of Paediatric Endocrinology and Clinical Biochemistry, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Horm Res 62:241-4. 2004
    ..5 years. Because of actual or incipient virilization, both patients were treated with glucocorticoid replacement 8-12 mg/m(2)/day. This decision is discussed in the context of published guidelines for the management of 21OHD...
  45. ncbi request reprint Pathophysiology, assessment and management of the child with growth hormone resistance
    M O Savage
    Department of Endocrinology, William Harvey Research Institute, Barts and Royal London School of Medicine and Dentistry, London, UK
    Pediatr Endocrinol Rev 7:347-56. 2010
    ..Finally we discuss therapy with IGF-I within the limits of the USA Food and Drug Administration and European Medicines Agency labels for GH resistance...
  46. ncbi request reprint Investigating familial endocrine neoplasia syndromes in children
    L B Johnston
    St Bartholomew s Hospital, London, UK
    Horm Res 55:31-5. 2001
    ..This paper provides an overview of the major features of these syndromes and suggests protocols for regular screening of children known to be at risk of developing these disorders...
  47. pmc Should recombinant human growth hormone therapy be used in short small for gestational age children?
    L B Johnston
    Paediatric Endocrine Section, Department of Endocrinology, William Harvey Research Institute, Barts and the London Queen Mary School of Medicine, London, UK
    Arch Dis Child 89:740-4. 2004
    ..This article examines the role of GH therapy in short SGA children with particular reference to selection of patients, effectiveness, safety, and its potential metabolic implications...
  48. doi request reprint Heterogeneity of the growth phenotype and birth size in acid-labile subunit (ALS) deficiency
    H L Storr
    Centre for Endocrinology, John Vane Science Centre, William Harvey Research Institute WHRI, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK
    J Endocrinol Invest 38:407-12. 2015
    ..Prenatal growth impairment is not a recognised feature of this disorder, but heterozygous carriers may show an intermediate phenotype...
  49. ncbi request reprint Growth hormone therapy in Noonan's syndrome: non-cardiomyopathic congenital heart disease does not adversely affect growth improvement
    D C Brown
    Child Life and Health, University of Edinburgh, London, UK
    J Pediatr Endocrinol Metab 15:851-2. 2002
    ..None of the 23 children developed hypertrophic cardiomyopathy during GH treatment. Children with any cardiac abnormality at the start of treatment did not show a reduced growth trend when compared with patients with normal hearts...
  50. ncbi request reprint TPIT mutations are associated with early-onset, but not late-onset isolated ACTH deficiency
    L A Metherell
    Department of Endocrinology, Barts and The London, Queen Mary University of London, London, UK
    Eur J Endocrinol 151:463-5. 2004
    ..Recently, mutations in the TPIT gene, a T-box factor selectively expressed in developing corticotroph cells, have been found in cases of early-onset IAD...
  51. ncbi request reprint Influence of growth hormone on accretion of bone mass
    J P Monson
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Horm Res 58:52-6. 2002
    ..To date, this has been difficult to assess in adult GHD of childhood-onset because the relative contributions of low peak bone mass and increased loss of bone in later life could not be distinguished...
  52. ncbi request reprint Neonatal thyrotoxicosis and maternal infertility in thyroid hormone resistance due to a mutation in the TRbeta gene (M313T)
    J C Blair
    Department of Endocrinology, St Barthoomew s and the Royal London School of Medicine and Dentistry, UK
    Clin Endocrinol (Oxf) 57:405-9. 2002
    ..To our knowledge, these are the first case reports of RTH associated with added features of a hypermetabolic state in infancy and secondary infertility...
  53. ncbi request reprint Interleukin-1beta (IL-1beta) and IL-6 modulate insulin-like growth factor-binding protein (IGFBP) secretion in colon cancer epithelial (Caco-2) cells
    M E Street
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    J Endocrinol 179:405-15. 2003
    ..These findings suggest that interleukins modulate the IGF-IGFBP system in Caco-2 cells in vitro...
  54. ncbi request reprint Familial salivary gland insensitivity to aldosterone: a variant of pseudohypoaldosteronism
    I R Sanderson
    Queen Elizabeth Hospital for Children, London, UK
    Horm Res 32:145-7. 1989
    ..Excess salivary sodium loss accounted for sodium depletion in these cases who present a new variant of pseudohypoaldosteronism associated with normal renal sodium transport...
  55. ncbi request reprint Genetic, phenotypic, metabolic and endocrine features in small for gestational age and very low birth weight children
    P G Chatelain
    J Endocrinol Invest 29:1. 2006
  56. doi request reprint Idiopathic short stature: management and growth hormone treatment
    J M Wit
    Department of Pediatrics, Leiden University Medical Center, P O Box 9600, Leiden, Zuid Holland, The Netherlands
    Growth Horm IGF Res 18:111-35. 2008
    ..In case of a low predicted adult height at the onset of puberty, addition of a GnRH analogue can be considered. Although GH therapy appears safe, long-term monitoring is recommended...
  57. ncbi request reprint Growth hormone (GH) insensitivity syndrome due to a GH receptor truncated after Box1, resulting in isolated failure of STAT 5 signal transduction
    A Milward
    Division of Clinical Sciences North, University of Sheffield, Sheffield S5 7AU, United Kingdom
    J Clin Endocrinol Metab 89:1259-66. 2004
    ..Results are consistent with the hypothesis that the loss of signaling through the Stat5 pathway results in GHIS...
  58. ncbi request reprint An intronic growth hormone receptor mutation causing activation of a pseudoexon is associated with a broad spectrum of growth hormone insensitivity phenotypes
    A David
    Centre for Endocrinology, William Harvey Research Institute, University of London, London EC1M 6BQ, United Kingdom
    J Clin Endocrinol Metab 92:655-9. 2007
    ..We previously described four mildly affected GHI patients with an intronic mutation in the GHR gene (A(-1)-->G(-1) substitution in intron 6), resulting in the activation of a pseudoexon (6Psi) and inclusion of 36 amino acids...