G J Miller

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Cardiorespiratory fitness, all-cause mortality, and risk of cardiovascular disease in Trinidadian men--the St James survey
    George J Miller
    Medical Research Council Cardiovascular Group, Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London Queen Mary s School of Medicine and Dentistry, London, UK
    Int J Epidemiol 34:1387-94. 2005
  2. ncbi request reprint Dietary fatty acids and the haemostatic system
    George J Miller
    Medical Research Council Cardiovascular Group, Wolfson Institute of Preventive Medicine, Barts and the London Queen Mary s School of Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Atherosclerosis 179:213-27. 2005
  3. ncbi request reprint Increased incidence of neoplasia of the digestive tract in men with persistent activation of the coagulant pathway
    G J Miller
    Medical Research Council Cardiovascular Group, Wolfson Institute of Preventive Medicine, Barts, UK
    J Thromb Haemost 2:2107-14. 2004
  4. ncbi request reprint Relationship between markers of activated coagulation, their correlation with inflammation, and association with coronary heart disease (NPHSII)
    G J Miller
    MRC Cardiovascular Research Group, Wolfson Institute for Preventive Medicine, London, UK
    J Thromb Haemost 6:259-67. 2008
  5. ncbi request reprint The effects of quality and timing of venepuncture on markers of blood coagulation in healthy middle-aged men
    G J Miller
    Medical Research Council Epidemiology and Medical Care Unit, London, UK
    Thromb Haemost 73:82-6. 1995
  6. ncbi request reprint Haemostatic factors in human peripheral afferent lymph
    G J Miller
    Medical Research Council Epidemiology and Medical Care Unit, London, UK
    Thromb Haemost 83:427-32. 2000
  7. ncbi request reprint Factor VII activation, apolipoprotein A-I and reverse cholesterol transport: possible relevance for postprandial lipaemia
    G J Miller
    MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Thromb Haemost 87:477-82. 2002
  8. ncbi request reprint Haemostatic and lipid determinants of prothrombin fragment F1.2 and D-dimer in plasma
    P K MacCallum
    MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, St Bartholomew s and The Royal London School of Medicine, UK
    Thromb Haemost 83:421-6. 2000
  9. ncbi request reprint C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors
    D G Cook
    Department of Public Health Sciences, St George s Hospital Medical School, Cranmer Terrace, London, UK
    Atherosclerosis 149:139-50. 2000
  10. ncbi request reprint Substitution of asparagine for aspartic acid at residue 9 (D9N) of lipoprotein lipase markedly augments risk of ischaemic heart disease in male smokers
    P J Talmud
    Department of Medicine, Division of Cardiovascular Genetics, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London, UK
    Atherosclerosis 149:75-81. 2000

Detail Information

Publications65

  1. ncbi request reprint Cardiorespiratory fitness, all-cause mortality, and risk of cardiovascular disease in Trinidadian men--the St James survey
    George J Miller
    Medical Research Council Cardiovascular Group, Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London Queen Mary s School of Medicine and Dentistry, London, UK
    Int J Epidemiol 34:1387-94. 2005
    ..Those of Indian descent have a distinctively high rate of myocardial infarction...
  2. ncbi request reprint Dietary fatty acids and the haemostatic system
    George J Miller
    Medical Research Council Cardiovascular Group, Wolfson Institute of Preventive Medicine, Barts and the London Queen Mary s School of Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Atherosclerosis 179:213-27. 2005
    ..In the presence of unstable atheromatous plaques, increased levels of activated FVII and PAI-1 induced by diets rich in mixtures of saturated and unsaturated fats may raise the risk of occlusive thrombosis in the event of plaque rupture...
  3. ncbi request reprint Increased incidence of neoplasia of the digestive tract in men with persistent activation of the coagulant pathway
    G J Miller
    Medical Research Council Cardiovascular Group, Wolfson Institute of Preventive Medicine, Barts, UK
    J Thromb Haemost 2:2107-14. 2004
    ..Thrombin promotes angiogenesis and cell proliferation in cancer. Whether thrombin turnover influences cancer incidence is unknown...
  4. ncbi request reprint Relationship between markers of activated coagulation, their correlation with inflammation, and association with coronary heart disease (NPHSII)
    G J Miller
    MRC Cardiovascular Research Group, Wolfson Institute for Preventive Medicine, London, UK
    J Thromb Haemost 6:259-67. 2008
    ..To determine whether activation of coagulation increases in parallel with inflammation and whether coagulation activation markers (CAMs) are independently associated with coronary heart disease (CHD), in the prospective study, NPHSII...
  5. ncbi request reprint The effects of quality and timing of venepuncture on markers of blood coagulation in healthy middle-aged men
    G J Miller
    Medical Research Council Epidemiology and Medical Care Unit, London, UK
    Thromb Haemost 73:82-6. 1995
    ..The results emphasise the need for careful surveillance of the venepuncture procedure and the value of FPA when using F1 + 2 as a marker of risk of thrombosis...
  6. ncbi request reprint Haemostatic factors in human peripheral afferent lymph
    G J Miller
    Medical Research Council Epidemiology and Medical Care Unit, London, UK
    Thromb Haemost 83:427-32. 2000
    ..This high level in lymph was not explored but may indicate proteolysis of fibrinogen and fibrin with release of D-like and D-dimer-like fragments in interstitial fluid...
  7. ncbi request reprint Factor VII activation, apolipoprotein A-I and reverse cholesterol transport: possible relevance for postprandial lipaemia
    G J Miller
    MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Thromb Haemost 87:477-82. 2002
    ..Peak TAT post-infusion was associated inversely with peak HDL triglyceride concentration (p = 0.004). The coagulation responses to disc-infusion may be due to transfer of phosphatidylserine to cell surfaces during cholesterol efflux...
  8. ncbi request reprint Haemostatic and lipid determinants of prothrombin fragment F1.2 and D-dimer in plasma
    P K MacCallum
    MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, St Bartholomew s and The Royal London School of Medicine, UK
    Thromb Haemost 83:421-6. 2000
    ..e. F1.2). Determinants of D-dimer differ according to age and interpretation of the biological significance of D-dimer levels in epidemiological studies may therefore not be straightforward...
  9. ncbi request reprint C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors
    D G Cook
    Department of Public Health Sciences, St George s Hospital Medical School, Cranmer Terrace, London, UK
    Atherosclerosis 149:139-50. 2000
    ..Longitudinal studies are needed to determine whether these associations reflect long term elevations of these risk factors in some individuals, or short term fluctuations in different individuals...
  10. ncbi request reprint Substitution of asparagine for aspartic acid at residue 9 (D9N) of lipoprotein lipase markedly augments risk of ischaemic heart disease in male smokers
    P J Talmud
    Department of Medicine, Division of Cardiovascular Genetics, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London, UK
    Atherosclerosis 149:75-81. 2000
    ..Carriers of N9 appear to be especially vulnerable to the adverse effects of cigarette smoking on IHD risk, but this susceptibility is unrelated to the influence of this variant on plasma TG levels...
  11. ncbi request reprint The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men
    S E Humphries
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and University College London Medical School, London, UK
    Eur Heart J 22:2243-52. 2001
    ..K. men...
  12. ncbi request reprint The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II
    P J Talmud
    Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, 5 University Street, London, WC1E 6JF, UK
    Diabetologia 49:2337-40. 2006
    ....
  13. ncbi request reprint High intakes of trans monounsaturated fatty acids taken for 2 weeks do not influence procoagulant and fibrinolytic risk markers for CHD in young healthy men
    Thomas A B Sanders
    Nutrition Food and Health Research Centre, King s College London, Franklin Wilkins Building, 150 Stamford Street, London, SE1 9NN, UK
    Br J Nutr 89:767-76. 2003
    ....
  14. ncbi request reprint Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII)
    T A Sanders
    Nutrition Food and Health Research Centre, King s College London, Franklin Wilkins Building, 150 Stamford Street, London, UK
    Atherosclerosis 149:413-20. 2000
    ..These results do not support the hypothesis that dietary stearate and elaidate are responsible for the postprandial increases in FVII associated with high fat intakes...
  15. ncbi request reprint EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro
    H Ireland
    Cardiovascular Genetics, Department Medicine, University College London, 5 University St, London, WC1E 6JF, UK
    Atherosclerosis 183:283-92. 2005
    ..The increased CHD-risk and thrombin generation appears to be acting through increased shedding of the Gly allele from the cell surface...
  16. ncbi request reprint Does inflammatory proteolytic activity contribute to the increased factor IX activation peptide in men at high risk of coronary heart disease? A preliminary study
    G J Miller
    MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Thromb Haemost 87:415-20. 2002
    ..Direct evidence for this hypothesis requires development of assays for human elastase-specific factor IX inactivation peptides...
  17. ncbi request reprint Risk of coronary heart disease and activation of factor XII in middle-aged men
    G J Miller
    Medical Research Council Epidemiology and Medical Care Unit, St Bartholomew s, London, UK
    Arterioscler Thromb Vasc Biol 17:2103-6. 1997
    ..1 to 12.5 ng/mL), combined with a relatively low day-to-day variability in individuals (the within-person component of its total variation being 14.7%), suggest its potential usefulness as a marker of atherosclerotic vascular damage...
  18. ncbi request reprint Postprandial lipaemia and haemostatic factors
    G J Miller
    MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, London, UK
    Atherosclerosis 141:S47-51. 1998
    ..Because FVIIa initiates the thrombotic response to rupture of an atheromatous plaque, a raised postprandial level may represent a transient rise in the likelihood of a clinically significant coronary thrombosis...
  19. ncbi request reprint Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study
    S E Humphries
    Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, Rayne Institute, WC1E 6JJ, London, UK
    Lancet 358:115-9. 2001
    ..We investigated whether the effect of smoking on coronary heart disease risk is affected by APOE genotype...
  20. ncbi request reprint An association between plasma free protein s concentration and risk of coronary heart disease in middle-aged men
    A R Rudnicka
    Department of Environmental and Preventive Medicine, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, UK
    Thromb Res 101:1-11. 2001
    ..15 (0.98-1.35) for CHD, of borderline conventional statistical significance. This association of free protein S with risk of CHD may reflect effects of plaque-destabilising inflammatory activity on protein S levels...
  21. ncbi request reprint Epidemiological and genetic associations of activated factor XII concentration with factor VII activity, fibrinopeptide A concentration, and risk of coronary heart disease in men
    F Zito
    Department of Medicine, University College London Medical School, Rayne Institute, London, UK
    Circulation 102:2058-62. 2000
    ..The relations of plasma activated factor XII (FXIIa) concentration and a common polymorphism (C46T) of the factor XII gene with hemostatic status and risk of coronary heart disease (CHD) were examined by prospective surveillance...
  22. ncbi request reprint Effect of interesterification of palmitic acid-rich triacylglycerol on postprandial lipid and factor VII response
    Sarah E E Berry
    Department of Nutrition and Dietetics, Nutritional Sciences Research Division, King s College London, Franklin Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK
    Lipids 42:315-23. 2007
    ..It is concluded that interesterification of palm oil does not result in adverse changes in postprandial lipids, insulin or FVIIa compared to high oleate and native palm oils...
  23. ncbi request reprint Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women
    Steve E Humphries
    Department of Medicine, Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, WC1E 6JF, UK
    J Mol Med (Berl) 84:1005-14. 2006
    ..17) and haplotype frequencies differed markedly in this group. These results extend previous observations to other ethnic groups, and strongly confirm that TCF7L2 genotype is a major risk factor for development of T2D...
  24. ncbi request reprint Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension
    Alun Jones
    Centre for Cardiovascular Genetics, Royal Free and University College Medical School, London, UK
    Hypertension 42:500-6. 2003
    ..These data are important to our understanding of the divergent role of angiotensin II acting at its receptor subtypes and coronary disease pathogenesis and for the development of future cardiovascular therapies...
  25. ncbi request reprint Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension
    Sukhbir S Dhamrait
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, Rayne Building, London, UK
    Eur Heart J 24:1672-80. 2003
    ..We tested whether these gene variants influenced hypertensive coronary risk in a large prospective study...
  26. ncbi request reprint A comparison of the PROCAM and Framingham point-scoring systems for estimation of individual risk of coronary heart disease in the Second Northwick Park Heart Study
    Jackie A Cooper
    Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, London, UK
    Atherosclerosis 181:93-100. 2005
    ..80 (p = 0.01), although no score had a high sensitivity. Any novel factors added to these algorithms will need to have a major impact on risk to increase sensitivity above that given by classical risk factors...
  27. ncbi request reprint A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus
    Jeffrey W Stephens
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London, UK
    Mol Genet Metab 82:180-6. 2004
    ..The increased cardiovascular risk associated with the -174C allele may account for the lower frequency of this allele in those with type 2 diabetes...
  28. ncbi request reprint Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at UCL, University College London, London, UK
    Ann Hum Genet 70:145-69. 2006
    ..This review lays out the framework for the candidate gene approach for CAD and illustrates this with published results from a UK prospective study of 3000 middle-aged men...
  29. ncbi request reprint Insight into the nature of the CRP-coronary event association using Mendelian randomization
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at University College London, UCL, London, UK
    Int J Epidemiol 35:922-31. 2006
    ..Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or confounded...
  30. ncbi request reprint Nonfasting apolipoprotein B and triglyceride levels as a useful predictor of coronary heart disease risk in middle-aged UK men
    Philippa J Talmud
    Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, London, UK
    Arterioscler Thromb Vasc Biol 22:1918-23. 2002
    ..We have compared the pairwise combinations of total cholesterol, triglycerides (TGs), apoB, high density lipoprotein (HDL) cholesterol, low density lipoprotein cholesterol, and apoA-I on CHD risk prediction in middle-aged men...
  31. ncbi request reprint Associations of haemostatic variables with body mass index: a community-based study
    Louise K Bowles
    MRC Cardiovascular Research Group, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, UK
    Blood Coagul Fibrinolysis 14:569-73. 2003
    ..Gender influences the association of certain inflammatory variables with BMI so the sexes should be considered separately in studies of inflammation and obesity...
  32. ncbi request reprint A common interleukin 18 haplotype is associated with higher body mass index in subjects with diabetes and coronary heart disease
    Simon R Thompson
    Department of Cardiovascular Genetics, The Rayne Institute, London, UK
    Metabolism 56:662-9. 2007
    ..Therefore, variation within IL18, previously shown to be associated with lower IL18 levels, is influencing measures of obesity both in men with type 2 diabetes mellitus and those with advanced coronary heart disease...
  33. ncbi request reprint Apolipoprotein AIV gene variant S347 is associated with increased risk of coronary heart disease and lower plasma apolipoprotein AIV levels
    Wai Man R Wong
    Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, UK
    Circ Res 92:969-75. 2003
    ..90+/-0.12 mg/dL) (P=0.035). These results demonstrate that genetic variation in and around APOA4, independent of the effects of triglyceride, is associated with risk of CHD and apoAIV levels, supporting an antiatherogenic role for apoAIV...
  34. ncbi request reprint The solid fat content of stearic acid-rich fats determines their postprandial effects
    Sarah E E Berry
    Nutritional Sciences Research Division, King s College London, London, United Kingdom
    Am J Clin Nutr 85:1486-94. 2007
    ..The process of randomization is used commercially to harden fats as an alternative to partial hydrogenation, but its effects on cardiovascular disease risk factors are uncertain...
  35. ncbi request reprint Chylomicron particle size and number, factor VII activation and dietary monounsaturated fatty acids
    K D Renuka R Silva
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights, P O Box 226, Reading, Berkshire RG6 6AP, UK
    Atherosclerosis 166:73-84. 2003
    ..Smaller numbers of larger chylomicrons may explain attenuated activation of factor VII during the postprandial state when the background diet is rich in MUFA...
  36. ncbi request reprint The factor VII activating protease G511E (Marburg) variant and cardiovascular risk
    Helen Ireland
    Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London WC1E 6JF, UK
    Thromb Haemost 92:986-92. 2004
    ..Fibrinogen could substitute for triglyceride levels in this risk-interaction analysis. The findings support the proposal that the FSAP 511E allele exacerbates atherosclerosis or its clinical sequelae...
  37. ncbi request reprint Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men
    Tine Tholstrup
    Research Department of Human Nutrition and the Center of Advanced Food Research, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 77:1125-32. 2003
    ..Plasminogen activator inhibitor type 1 (PAI-1) is increased in the presence of hypertriglyceridemia. Free fatty acids (FFAs) in plasma may promote factor VII (FVII) activation...
  38. ncbi request reprint Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP study
    Thomas A B Sanders
    Nutritional Sciences Research Division, King s College London, London, United Kingdom
    Am J Clin Nutr 84:513-22. 2006
    ..This study tested the hypothesis that lowering the dietary ratio of n-6 to n-3 polyunsaturated fatty acids (n-6:n-3) would modify these risk factors in older men and women...
  39. ncbi request reprint Influence of an algal triacylglycerol containing docosahexaenoic acid (22 : 6n-3) and docosapentaenoic acid (22 : 5n-6) on cardiovascular risk factors in healthy men and women
    Thomas A B Sanders
    Nutritional Sciences Research Division, Franklin Wilkins Building, King s College London, UK
    Br J Nutr 95:525-31. 2006
    ..Overall, the oil was well tolerated and did not adversely affect cardiovascular risk...
  40. ncbi request reprint Postprandial variations in fibrinolytic activity in middle-aged men are modulated by plasminogen activator inhibitor I 4G-675/5G genotype but not by the fat content of a meal
    Thomas A B Sanders
    Nutrition Food and Health Research Centre, King s College London, United Kingdom
    Am J Clin Nutr 79:577-81. 2004
    ..Decreased fibrinolytic activity is associated with an increased risk of ischemic heart disease and elevated plasma triacylglycerol concentrations...
  41. ncbi request reprint Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype
    Paul Wilkinson
    Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Atherosclerosis 181:115-24. 2005
    ..Membrane DHA levels appeared to be an important determinant of these fish-oil-induced effects...
  42. ncbi request reprint Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits
    Santiago Rodriguez
    Human Genetics Division, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK
    Hum Mol Genet 13:715-25. 2004
    ..The functional element(s) of *5 for weight-lowering could reside in any of the three genes...
  43. ncbi request reprint Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects
    Ruth D Smith
    School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Br J Nutr 90:597-606. 2003
    ..Moderate or high substitution of MUFA for SFA achieves similar reductions in fasting blood lipids in young healthy subjects...
  44. ncbi request reprint Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes in healthy middle-aged men
    David R Gable
    Centre for Cardiovascular Genetics, Royal Free and University College London Medical School, The Rayne Institute, 5 University Street, London WC1E 6JJ, U K
    Diabetes 55:1504-11. 2006
    ..Both effects are exacerbated by obesity...
  45. ncbi request reprint Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women
    Carmel S Moore
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Nutrition 22:1012-24. 2006
    ..It tested whether decreases in LA:LNA modulate effects of LC omega-3 PUFA...
  46. ncbi request reprint The A370T variant (StuI polymorphism) in the LDL receptor gene is not associated with plasma lipid levels or cardiovascular risk in UK men
    José Ricardo S Vieira
    Department of Physiology, Federal University of Para, Av Augusto Correa, 01 Belém Pará 66075 110, Brazil
    Ann Hum Genet 70:697-704. 2006
    ..Thus, these data confirm the absence of a significant impact of the A370T polymorphism on LDL receptor function, at least as measured by the effect on plasma lipid levels and CHD risk...
  47. ncbi request reprint Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men
    Steve E Humphries
    Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, United Kingdom
    Clin Chem 53:8-16. 2007
    ..We therefore investigated whether inclusion of a set of common variants in candidate genes along with conventional risk factor (CRF) assessment enhanced coronary heart disease (CHD)-risk algorithms...
  48. ncbi request reprint Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study
    Margaret D Griffin
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, United Kingdom
    Am J Clin Nutr 84:1290-8. 2006
    ..It has been hypothesized that the dietary ratio of n-6 to n-3 (n-6:n-3) polyunsaturated fatty acids (PUFAs) may have favorable effects on these risk factors by increasing insulin sensitivity...
  49. ncbi request reprint Increased plasma markers of oxidative stress are associated with coronary heart disease in males with diabetes mellitus and with 10-year risk in a prospective sample of males
    Jeffrey W Stephens
    The Medical School, University of Wales Swansea, Swansea, United Kingdom
    Clin Chem 52:446-52. 2006
    ..We examined the association between plasma markers of oxidative stress and CHD in a cross-sectional sample of patients with diabetes and prospective CHD risk in a sample of men predominantly without diabetes...
  50. ncbi request reprint Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circ Res 98:590-2. 2006
    ..44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63)...
  51. ncbi request reprint Estrogen receptor alpha gene variation and the risk of stroke
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Stroke 36:2281-2. 2005
    ..Given that there is a significantly higher risk of myocardial infarction among men with the CC genotype (PP of PvuII) of c.454-397T>C (rs2234693), we asked whether this genotype is associated with a higher risk of stroke...
  52. ncbi request reprint Moderate intakes of intact soy protein rich in isoflavones compared with ethanol-extracted soy protein increase HDL but do not influence transforming growth factor beta(1) concentrations and hemostatic risk factors for coronary heart disease in healthy su
    Thomas A B Sanders
    Nutrition, Food and Health Research Centre, King s College London, United Kingdom
    Am J Clin Nutr 76:373-7. 2002
    ..Soybeans contain estrogenic isoflavones that may influence plasma concentrations of transforming growth factor beta(1) (TGF-beta(1)) and plasma lipid and hemostatic risk factors for coronary heart disease...
  53. ncbi request reprint Factor XIII A-subunit concentration predicts outcome in stroke subjects and vascular outcome in healthy, middle-aged men
    Hans P Kohler
    Unit of Molecular Vascular Medicine, Leeds General Infirmary, University of Leeds, UK
    Br J Haematol 118:825-32. 2002
    ..Low in vitro concentrations of FXIII A-subunit antigen wererelated to increased thrombin generation and, thus, increased risk of thrombotic events...
  54. ncbi request reprint Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides
    Philippa J Talmud
    Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, 5 University Street, London WC1E 6JJ, UK
    Hum Mol Genet 11:3039-46. 2002
    ..The molecular mechanisms for these effects remain to be determined...
  55. ncbi request reprint Influence of triacylglycerol structure on the postprandial response of factor VII to stearic acid-rich fats
    Thomas A B Sanders
    Department of Nutrition and Dietetics, Nutrition Food and Health Research Centre, King s College London, United Kingdom
    Am J Clin Nutr 77:777-82. 2003
    ..It was hypothesized that this difference is a consequence of the differences in structure between the 2 triacylglycerols...
  56. ncbi request reprint In search of genetic precision
    Steve E Humphries
    Lancet 361:1908-9; author reply 1909-10. 2003
  57. ncbi request reprint Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans
    Yvonne E Finnegan
    Hugh Sinclair Unit of Human Nutrition, University of Reading, Reading, UK
    J Nutr 133:2210-3. 2003
    ..n-3) PUFA of plant or marine origin do not differ from one another or from LA in their effect on a range of blood coagulation and fibrinolytic factors...
  58. ncbi request reprint Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II
    Kirsty S Robertson
    Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, 5 University St, London WC1E 6JF, UK
    Biochim Biophys Acta 1639:203-12. 2003
    ..004). These effects were independent of classical risk factors. These data demonstrate the importance of stratifying by environmental factors and the use of multiple SNPs for genetic analysis...
  59. ncbi request reprint Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2
    Sukhbir S Dhamrait
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, Rayne Building, 5 University Street, London WC1E 6JF, UK
    Eur Heart J 25:468-75. 2004
    ..Mitochondrial uncoupling protein 2 (UCP2) negatively regulates reactive oxygen species generation. The UCP2 gene demonstrates a common functional promoter variant (-866G>A)...
  60. ncbi request reprint Evidence of admixture from haplotyping in an epidemiological study of UK Caucasian males: implications for association analyses
    Xiao He Chen
    Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, England
    Hum Hered 57:142-55. 2004
    ....
  61. ncbi request reprint R643G polymorphism in PECAM-1 influences transendothelial migration of monocytes and is associated with progression of CHD and CHD events
    Mohamed A Elrayess
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Rayne Building, 5 University Street, UCL, London WC1E 6JF, UK
    Atherosclerosis 177:127-35. 2004
    ..01) or TNF-alpha (10% higher, P=0.05). These data confirm the association of the R643G polymorphism with MI and CAS and suggest that greater influx of monocytes in individuals homozygous for the 643G may explain the association with CAS...
  62. ncbi request reprint The D allele of the ACE I/D common gene variant is associated with Type 2 diabetes mellitus in Caucasian subjects
    Jeffrey W Stephens
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, 5 University Street, London WC1E 6JF, United Kingdom
    Mol Genet Metab 84:83-9. 2005
    ..The odds ratio for a family history of diabetes in DD compared to II subjects was 1.52 [0.89-2.60], p=0.03. This study clearly shows an association between the ACE I/D common gene variant and Type 2DM...
  63. ncbi request reprint Non-recombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2,743 middle-aged Caucasian men from the UK
    Santiago Rodriguez
    Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, Duthie Building MP 808, Tremona Road, Southampton, SO16 6YD, UK
    Hum Genet 116:311-8. 2005
    ..However, this study does not support a causal effect on BP, although association of one or more Y haplogroups cannot be excluded...
  64. ncbi request reprint A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus
    Tony Hayek
    Lipid Research Unit, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Atherosclerosis 184:404-12. 2006
    ....
  65. pmc Early evidence of ethnic differences in cardiovascular risk: cross sectional comparison of British South Asian and white children
    Peter H Whincup
    Department of Public Health Sciences, St George s Hospital Medical School, London SW17
    BMJ 324:635. 2002
    ..To examine whether British South Asian children differ in insulin resistance, adiposity, and cardiovascular risk profile from white children...