S Kapas

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi request reprint Differentiation of the HaCaT keratinocyte cell line: modulation by adrenomedullin
    O Pleguezuelos
    Molecular Signalling Group, Clinical and Diagnostic Oral Sciences, Barts and The London, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Br J Dermatol 154:602-8. 2006
  2. ncbi request reprint Regulation of adrenomedullin secretion in cultured human skin and oral keratinocytes
    S Kapas
    Molecular Signalling Group, Clinical Sciences Research Center, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    J Invest Dermatol 117:353-9. 2001
  3. ncbi request reprint Adrenomedullin expression in pathogen-challenged oral epithelial cells
    S Kapas
    Molecular Signalling Group, Clinical Sciences Research Centre, 2 Newark Street, London E1 2AT, United Kingdom
    Peptides 22:1485-9. 2001
  4. ncbi request reprint Adrenomedullin has mitogenic effects on human oral keratinocytes: involvement of cyclic AMP
    S Kapas
    Oral Diseases Research Centre, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    FEBS Lett 418:287-90. 1997
  5. ncbi request reprint Direct effects of corticotrophin on oral keratinocyte cell proliferation
    S Kapas
    Molecular Signalling Group, Oral Diseases Research Centre, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Eur J Biochem 256:75-9. 1998
  6. ncbi request reprint An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora
    R P Allaker
    Department of Oral Microbiology, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    FEMS Immunol Med Microbiol 23:289-93. 1999
  7. ncbi request reprint Proadrenomedullin N-terminal 20-peptide (PAMP) receptors and signal transduction in the rat adrenal gland
    J P Hinson
    Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, London, UK
    Life Sci 62:439-43. 1998
  8. ncbi request reprint Adrenomedullin and calcitonin gene-related peptide receptors in the rat adrenal cortex
    S Kapas
    Clinical Sciences Research Centre, Bart's and The London, Queen Mary School of Medicine and Dentistry, 2 Newark Street, E1 2AD, London, UK
    Peptides 22:1903-7. 2001
  9. ncbi request reprint Regulation of rat adrenal vasoactive intestinal peptide content: effects of adrenocorticotropic hormone treatment and changes in dietary sodium intake
    J P Hinson
    Department of Endocrinology, Division of General and Developmental Medicine, Barts and The London, Queen Mary School of Medicine and Dentistry, London, UK
    J Neuroendocrinol 13:769-73. 2001
  10. ncbi request reprint Regulation of rat adrenal neuropeptide Y (NPY) content: effects of ACTH, dexamethasone and hypophysectomy
    J P Hinson
    Department of Biochemistry, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
    Regul Pept 75:175-80. 1998

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Differentiation of the HaCaT keratinocyte cell line: modulation by adrenomedullin
    O Pleguezuelos
    Molecular Signalling Group, Clinical and Diagnostic Oral Sciences, Barts and The London, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Br J Dermatol 154:602-8. 2006
    ..It is not known whether AM has a role in differentiating keratinocytes...
  2. ncbi request reprint Regulation of adrenomedullin secretion in cultured human skin and oral keratinocytes
    S Kapas
    Molecular Signalling Group, Clinical Sciences Research Center, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    J Invest Dermatol 117:353-9. 2001
    ..This raises the possibility that adrenomedullin may serve a different functions in oral mucosa and skin...
  3. ncbi request reprint Adrenomedullin expression in pathogen-challenged oral epithelial cells
    S Kapas
    Molecular Signalling Group, Clinical Sciences Research Centre, 2 Newark Street, London E1 2AT, United Kingdom
    Peptides 22:1485-9. 2001
    ..We propose there is a potential role for microbial products in enhancing mucosal defense mechanisms and that adrenomedullin participates in the prevention of local infection, thus contributing to host defense mechanisms...
  4. ncbi request reprint Adrenomedullin has mitogenic effects on human oral keratinocytes: involvement of cyclic AMP
    S Kapas
    Oral Diseases Research Centre, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    FEBS Lett 418:287-90. 1997
    ..These data identify adrenomedullin as a new mitogenic regulatory peptide of keratinocytes acting via the cAMP cascade...
  5. ncbi request reprint Direct effects of corticotrophin on oral keratinocyte cell proliferation
    S Kapas
    Molecular Signalling Group, Oral Diseases Research Centre, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Eur J Biochem 256:75-9. 1998
    ..These data identify corticotropin as a mitogenic regulatory peptide of keratinocytes acting via cAMP...
  6. ncbi request reprint An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora
    R P Allaker
    Department of Oral Microbiology, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    FEMS Immunol Med Microbiol 23:289-93. 1999
    ..75 x 10(-1) to 12.5 microg ml(-1) and 0.003 to > 25.0 microg ml(-1), respectively. We propose an antimicrobial role for adrenomedullin. participating in the prevention of local infection, thus contributing to host defence systems...
  7. ncbi request reprint Proadrenomedullin N-terminal 20-peptide (PAMP) receptors and signal transduction in the rat adrenal gland
    J P Hinson
    Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, London, UK
    Life Sci 62:439-43. 1998
    ..9 nmol/l: Bmax 556fmol/mg). PAMP caused an increase in cAMP generation by zona glomerulosa cells, but not inner zone/medulla cells. These data suggest that PAMP acts through a specific receptor to elevate cAMP levels in the rat adrenal...
  8. ncbi request reprint Adrenomedullin and calcitonin gene-related peptide receptors in the rat adrenal cortex
    S Kapas
    Clinical Sciences Research Centre, Bart's and The London, Queen Mary School of Medicine and Dentistry, 2 Newark Street, E1 2AD, London, UK
    Peptides 22:1903-7. 2001
    ..The finding of distinct and specific adrenomedullin and CGRP binding in this tissue may account for the different effects these peptides appear to exert on adrenal function...
  9. ncbi request reprint Regulation of rat adrenal vasoactive intestinal peptide content: effects of adrenocorticotropic hormone treatment and changes in dietary sodium intake
    J P Hinson
    Department of Endocrinology, Division of General and Developmental Medicine, Barts and The London, Queen Mary School of Medicine and Dentistry, London, UK
    J Neuroendocrinol 13:769-73. 2001
    ....
  10. ncbi request reprint Regulation of rat adrenal neuropeptide Y (NPY) content: effects of ACTH, dexamethasone and hypophysectomy
    J P Hinson
    Department of Biochemistry, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
    Regul Pept 75:175-80. 1998
    ..These results suggest that there is differential regulation of adrenal irNPY content, with irNPY in the zona glomerulosa regulated directly by ACTH, while the irNPY content of the inner zones/medulla is regulated by glucocorticoids...
  11. ncbi request reprint Expression of adrenomedullin and its receptors in human salivary tissue
    S Kapas
    Molecular Signalling Group, Clinical Sciences Research Centre, Queen Mary s School of Medicine and Dentistry, Bartholomew Close, London, UK
    J Dent Res 83:333-7. 2004
    ..These findings suggest a paracrine/autocrine role for adrenomedullin in these tissues; however, the concentration of adrenomedullin in saliva was insufficient to suggest a significant antimicrobial action in the healthy oral cavity...
  12. ncbi request reprint Protease-activated receptors and their role in IL-6 and NF-IL-6 expression in human gingival fibroblasts
    L Hou
    Oral Diseases Research Centre, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    J Periodontal Res 33:205-11. 1998
    ..These findings add weight to the importance of the cytokine-like role played by thrombin and raise the possibility that protease-activated receptors may play a role in the pathogenesis of inflammatory periodontal disease...
  13. ncbi request reprint Expression of the mouse ACTH receptor gene and characterisation of its promoter
    A J Clark
    Department of Chemical Endocrinology, St Bartholomew s, London, UK
    Endocr Res 22:333-5. 1996
  14. ncbi request reprint Differential effects of endogenous and exogenous nitric oxide on the release of endothelin-1 from the intact perfused rat adrenal gland in situ
    J P Hinson
    Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, London, UK
    FEBS Lett 379:7-10. 1996
    ..These data demonstrate that endogenous NO inhibits of irET-1, in a manner which is independent of cGMP, and suggest that this action may contribute to the vasodilatory effect of NO...
  15. ncbi request reprint Cloning, characterization and expression of a functional mouse ACTH receptor
    F M Cammas
    Department of Chemical Endocrinology, St Bartholomew s Hospital Medical College, London, United Kingdom
    Biochem Biophys Res Commun 212:912-8. 1995
    ..alpha-MSH was without effect on this receptor. In conclusion we have cloned a mouse ACTH receptor gene and demonstrated for the first time its expression and functional effect in HeLa cells...
  16. ncbi request reprint Cloning and expression of cDNA encoding a rat adrenomedullin receptor
    S Kapas
    Department of Chemical Endocrinology, Medical College, St Bartholomew s Hospital, London, United Kingdom
    J Biol Chem 270:25344-7. 1995
    ..Identification of this receptor cDNA should facilitate further investigation of the cellular actions of adrenomedullin and its regulatory effects in normal and disordered states of cardiovascular function...
  17. ncbi request reprint Adrenomedullin, a multifunctional regulatory peptide
    J P Hinson
    Department of Molecular and Cellular Biology, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London, United Kingdom
    Endocr Rev 21:138-67. 2000
    ..Finally, in Section V, we consider some unresolved issues and propose future areas for research...
  18. ncbi request reprint The role of endothelial cell products in the regulation of adrenocortical function: actions of endothelin, nitric oxide, adrenomedullin and PAMP
    J P Hinson
    Department of Biochemistry, Faculty of Basic Medical Sciences, St Bartholomew's School of Medicine, Queen Mary and Westfield College, London, UK
    Horm Metab Res 30:334-40. 1998
    ....
  19. ncbi request reprint Adrenomedullin: expression and possible role in human skin and hair growth
    F B Muller
    Department of Dermatology, University of Cologne, Germany
    Br J Dermatol 148:30-8. 2003
    ..Two receptors, L1 and calcitonin receptor-like receptor (CRLR), which are able to bind AM, have been cloned and characterized...
  20. ncbi request reprint Autocrine role of adrenomedullin in the human adrenal cortex
    L M Thomson
    Department of Endocrinology, Division of General and Developmental Medicine, St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London EC1A 7BE, UK
    J Endocrinol 170:259-65. 2001
    ....
  21. ncbi request reprint Aldosterone secretion by the rat adrenal cortex is stimulated by the activation of protease-activated receptor 1
    P W Raven
    Department of Psychiatry and Behavioural Sciences, Royal Free and University College Medical School, UCL, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Endocrinol 169:581-5. 2001
    ..These data suggest that the actions of trypsin on aldosterone secretion are mediated by PAR-1...
  22. pmc A human oral keratinocyte cell line responds to human heat shock protein 60 through activation of ERK1/2 MAP kinases and up- regulation of IL-1beta
    O Pleguezuelos
    Oral Microbiology and Host Responses Group, School of Dental Sciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4BW, UK
    Clin Exp Immunol 141:307-14. 2005
    ..These results highlight the importance of oral keratinocytes and HSPs in the development of an immune response against bacterial infection...