Sandra M Eldridge
Affiliation: Queen Mary
- Informed patient consent to participation in cluster randomized trials: an empirical exploration of trials in primary careSandra M Eldridge
Centre for General Practice and Primary Care, Institute of Community Health Sciences, Queen Mary, University of London, UK
Clin Trials 2:91-8. 2005..A more public debate may clarify the general acceptability of not obtaining consent in certain situations...
- How big should the pilot study for my cluster randomised trial be?Sandra M Eldridge
Centre for Primary Care and Public Health, Queen Mary University of London, London, UK
Stat Methods Med Res 25:1039-56. 2016..g. the intra-cluster correlation coefficient) with sufficient precision and too small to provide reliable estimates of rates for process measures such as recruitment or follow-up rates. ..
- The Nkateko health service trial to improve hypertension management in rural South Africa: study protocol for a randomised controlled trialMargaret Thorogood
Division of Health Sciences, Warwick Medical School, University of Warwick, Gibett Hill Road, Coventry CV4 7AL, UK
Trials 15:435. 2014..Until recently, primary care clinics focused on maternal and child health and management of acute conditions, but new government initiatives have shifted the focus to chronic diseases, including HIV/AIDS and hypertension...
- Systematic techniques for assisting recruitment to trials (START): study protocol for embedded, randomized controlled trialsJo Rick
Medical Research Council North West Hub for Trials Methodology Research, Manchester Academic Health Science Centre, Centre for Primary Care, University of Manchester, Oxford Road, Manchester M13 9PL, UK
Trials 15:407. 2014....
- Coping with persistent pain, effectiveness research into self-management (COPERS): statistical analysis plan for a randomised controlled trialBrennan C Kahan
Pragmatic Clinical Trials Unit, Queen Mary University of London, 58 Turner St, London E1 2AB, UK
Trials 15:59. 2014..This article describes the statistical analysis plan for the COPERS trial...
- Study to assess the effect of a structured communication approach on quality of life in secure mental health settings (Comquol): study protocol for a pilot cluster randomized trialDouglas MacInnes
Canterbury Christ Church University, Canterbury, UK
Trials 14:257. 2013..This pilot study is evaluating a 6-month intervention combining DIALOG with principles of solution-focused therapy on quality of life in medium-secure settings...
- A systematic review and meta-synthesis of the impact of low back pain on people's livesRobert Froud
Warwick Clinical Trials Unit, Warwick Medical School, Gibbet Hill Road, Coventry CV4 7AL, UK
BMC Musculoskelet Disord 15:50. 2014....
- A systematic review of cluster randomised trials in residential facilities for older people suggests how to improve qualityKarla Diaz-Ordaz
Centre for Primary Care and Public Health, Queen Mary University of London, London, E1 2AB, UK
BMC Med Res Methodol 13:127. 2013....
- Effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia--a multi-centre randomised controlled trialStefan Priebe
Unit for Social and Community Psychiatry, Queen Mary University of London, Newham Centre for Mental Health, London E13 8SP, UK
BMC Psychiatry 13:26. 2013..We designed a large multi-site trial to assess the effectiveness of a manualised BPT intervention in reducing negative symptoms, compared to an active control...
- The OPERA trial: protocol for a randomised trial of an exercise intervention for older people in residential and nursing accommodationMartin Underwood
Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
Trials 12:27. 2011..Existing evidence comes from trials that are short, underpowered and not from RNH settings. The aim of the OPERA trial is to establish whether exercise is effective in reducing the prevalence of depression among older RNH residents...
- Withdrawal of inhaled corticosteroids in individuals with COPD--a systematic review and comment on trial methodologyNighat J Nadeem
Centre for Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary University of London 2 Newark Street, London, E1 2AT, UK
Respir Res 12:107. 2011..In trials where medication is withdrawn, investigators should report other medication use, definitions of exacerbations and management of patients clearly. Intention to treat analyses should be used and interpreted appropriately...
- Withdrawal of inhaled corticosteroids in people with COPD in primary care: a randomised controlled trialAklak B Choudhury
Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, 2 Newark Street, London, E1 2AT, UK
Respir Res 8:93. 2007..Most COPD patients are managed in primary care and receive ICS long-term and irrespective of severity. The effect of withdrawing ICS from COPD patients in primary care is unknown...
- Multilevel survival analysis of health inequalities in life expectancyMin Yang
Centre for Psychiatry, Barts and The London, Queen Mary s School of Medicine and Dentistry, William Harvey House, 61 Bartholomew Close, London EC1A 7BE, UK
Int J Equity Health 8:31. 2009..Beta-binomial models were also limited in relation to measuring inequalities of life expectancy (LE) directly...
- The translation research in a dental setting (TRiaDS) programme protocolJan E Clarkson
Dental Health Services and Research Unit, University of Dundee, Mackenzie Building, Kirsty Semple Way, Dundee, DD2 4BF, UK
Implement Sci 5:57. 2010....
- Primary care identification and referral to improve safety of women experiencing domestic violence (IRIS): protocol for a pragmatic cluster randomised controlled trialAlison Gregory
Academic Unit of Primary Health Care, University of Bristol, 25 27 Belgrave Road, Clifton, Bristol, BS8 2AA, UK
BMC Public Health 10:54. 2010..Yet health professionals rarely ask about domestic violence and have little or no training in how to respond to disclosure of abuse...
- Financial incentives to improve adherence to anti-psychotic maintenance medication in non-adherent patients - a cluster randomised controlled trial (FIAT)Stefan Priebe
Unit for Social and Community Psychiatry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Newham Centre for Mental Health, London, UK
BMC Psychiatry 9:61. 2009....
- Estimating the number needed to treat from continuous outcomes in randomised controlled trials: methodological challenges and worked example using data from the UK Back Pain Exercise and Manipulation (BEAM) trialRobert Froud
Centre for Health Sciences, Barts and the London School of Medicine and Dentistry, London, E1 2AT, UK
BMC Med Res Methodol 9:35. 2009..We consider how numbers needed to treat can be derived from continuous outcomes; illustrated with a worked example showing the methods and challenges...
- The sensitivity and specificity of four questions (HARK) to identify intimate partner violence: a diagnostic accuracy study in general practiceHardip Sohal
Centre for Health Sciences, Barts and The London, Queen Mary s School of Medicine and Dentistry, 2 Newark Street, London, E1 2AT, UK
BMC Fam Pract 8:49. 2007..We estimated the sensitivity and specificity of four questions (HARK) developed from the Abuse Assessment screen, compared to a 30-item abuse questionnaire, the Composite Abuse Scale (CAS)...
- Internal and external validity of cluster randomised trials: systematic review of recent trialsSandra Eldridge
Centre for Health Sciences, Barts and the London School of Medicine and Dentistry, London E1 2AT
BMJ 336:876-80. 2008..To assess aspects of the internal validity of recently published cluster randomised trials and explore the reporting of information useful in assessing the external validity of these trials...
- Lessons for cluster randomized trials in the twenty-first century: a systematic review of trials in primary careSandra M Eldridge
Centre for General Practice and Primary Care, Institute of Community Health Sciences, Bar and the London, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
Clin Trials 1:80-90. 2004..There is little recent research on the methodologic quality of cluster randomized trials and none focuses on primary health care where these trials are increasingly common...
- Sample size for cluster randomized trials: effect of coefficient of variation of cluster size and analysis methodSandra M Eldridge
Centre for Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
Int J Epidemiol 35:1292-300. 2006..This can affect trial power, but standard sample size formulae for these trials ignore this. Previous studies addressing this issue have mostly focused on continuous outcomes or methods that are sometimes difficult to use in practice...
- CONSORT 2010 statement: extension to randomised pilot and feasibility trialsSandra M Eldridge
Centre for Primary Care and Public Health, Queen Mary University of London, London, UK
Pilot Feasibility Stud 2:64. 2016..Editor's note: In order to encourage its wide dissemination this article is freely accessible on the BMJ and Pilot and Feasibility Studies journal websites...
- High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trialAdrian R Martineau
Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK
Lancet 377:242-50. 2011..Vitamin D was used to treat tuberculosis in the pre-antibiotic era, and its metabolites induce antimycobacterial immunity in vitro. Clinical trials investigating the effect of adjunctive vitamin D on sputum culture conversion are absent...
- A single dose of vitamin D enhances immunity to mycobacteriaAdrian R Martineau
Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, and Department of Clinical Biochemistry, North West London Hospitals NHS Trust, Northwick Park Hospital, Harrow, E1 2AT, UK
Am J Respir Crit Care Med 176:208-13. 2007..Vitamin D was used to treat tuberculosis (TB) in the preantibiotic era. Prospective studies to evaluate the effect of vitamin D supplementation on antimycobacterial immunity have not previously been performed...
- Specialist nurse intervention to reduce unscheduled asthma care in a deprived multiethnic area: the east London randomised controlled trial for high risk asthma (ELECTRA)Chris Griffiths
Centre for General Practice and Primary Care, Institute of Community Health Sciences, Barts and The London, Medical Sciences, Queen Mary s School of Medicine and Dentistry, Queen Mary, University of London E1 4NS
BMJ 328:144. 2004..To determine whether asthma specialist nurses, using a liaison model of care, reduce unscheduled care in a deprived multiethnic area...
- Why modelling a complex intervention is an important precursor to trial design: lessons from studying an intervention to reduce falls-related injuries in older peopleSandra Eldridge
Department of General Practice and Primary Care, Queen Mary University of London, UK
J Health Serv Res Policy 10:133-42. 2005..To develop a cost-effectiveness model of a complex intervention from pilot study data in order to inform the viability and design of a subsequent falls prevention trial...
- Randomised controlled trial of a lay-led self-management programme for Bangladeshi patients with chronic diseaseChris Griffiths
Interdisciplinary Research Centre in Health, School of Health and Social Sciences, Coventry University
Br J Gen Pract 55:831-7. 2005..We report the first randomised trial of a lay-led self-management programme - the Chronic Disease Self-Management Programme (CDSMP) (Expert Patient Programme) - in a south Asian group...
- Educational outreach to promote screening for tuberculosis in primary care: a cluster randomised controlled trialChris Griffiths
Centre for Health Sciences, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
Lancet 369:1528-34. 2007..Uncertainty surrounds the effect of public-health control options. We therefore aimed to assess a programme to promote screening for tuberculosis in a UK primary health care district...
- How effective are expert patient (lay led) education programmes for chronic disease?Chris Griffiths
Centre for Health Sciences, Barts and The London, Queen Mary s School of Medicine and Dentistry, London E1 2AT
BMJ 334:1254-6. 2007
- Defining Feasibility and Pilot Studies in Preparation for Randomised Controlled Trials: Development of a Conceptual FrameworkSandra M Eldridge
Centre for Primary Care and Public Health, Queen Mary University of London, London, United Kingdom
PLoS ONE 11:e0150205. 2016....
- Increased risk of type I errors in cluster randomised trials with small or medium numbers of clusters: a review, reanalysis, and simulation studyBrennan C Kahan
Pragmatic Clinical Trials Unit, Queen Mary University of London, 58 Turner St, E1 2AB, London, UK
Trials 17:438. 2016..They can lead to increased risk of a type I error (finding a statistically significant treatment effect when it does not exist) if appropriate corrections are not used...
- Asking older people about fear of falling did not have a negative effectMartin R Underwood
Centre for Health Sciences, Barts and The London, Queen Mary s School of Medicine and Dentistry, Queen Mary University of London, Abernethy Building, London E1 2AT
J Clin Epidemiol 59:629-34. 2006..To assess whether completing a questionnaire on risk of falling could affect outcome measures: fear of falling, reported falls, and health service contacts in older people (panel conditioning)...
- The Myocardial Ischaemia National Audit Project (MINAP)Emily Herrett
Department of Epidemiology and Population Health, Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK
Heart 96:1264-7. 2010..AIMS OF MINAP: To audit the quality of care of patients with acute coronary syndrome and provide a resource for academic research...
- Randomised controlled trial of support from volunteer counsellors for mothers considering breast feedingJonathan Graffy
Department of General Practice and Primary Care, Barts and The London, Queen Mary, University of London, London E1 4NS
BMJ 328:26. 2004..To investigate whether offering volunteer support from counsellors in breast feeding would result in more women breast feeding...