Richard J Thomas
Affiliation: Porton Down
- Particle size and pathogenicity in the respiratory tractRichard James Thomas
Defence Science and Technology Laboratories Dstl Salisbury, Wiltshire, UK
Virulence 4:847-58. 2013..The olfactory, gastrointestinal, and ophthalmic systems are also infected in a pathogen-dependent manner. The relevant literature is reviewed with respect to particle size and infection of the URT in animal models and humans. ..
- Particle-size dependent effects in the Balb/c murine model of inhalational melioidosisRichard J Thomas
Department of Biomedical Sciences, Defence Science and Technology Laboratory, Salisbury Wiltshire, UK
Front Cell Infect Microbiol 2:101. 2012..However, both treatment regimes exhibited significant relapse when therapy was discontinued with massive enlargement and abscessation of the lungs, spleen, and cervical lymph nodes observed...
- Influence of particle size on the pathology and efficacy of vaccination in a murine model of inhalational anthraxRichard Thomas
Defence, Science and Technology Laboratory Dstl, Porton Down, Salisbury SP4 0JQ, UK
J Med Microbiol 59:1415-27. 2010..anthracis infections arising from the inhalation of 1 and 12 μm particle aerosols, providing 73-80% survival under a suboptimum immunization schedule...
- Different pathologies but equal levels of responsiveness to the recombinant F1 and V antigen vaccine and ciprofloxacin in a murine model of plague caused by small- and large-particle aerosolsRichard J Thomas
Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire SP40JQ, United Kingdom
Infect Immun 77:1315-23. 2009..Although there were major differences in pathogenesis, the recombinant F1 and V antigen vaccine and ciprofloxacin protected against plague infections caused by small- and large-particle aerosols...
- Characterization and deposition of respirable large- and small-particle bioaerosolsRichard J Thomas
Defence Science and Technology Laboratory, Salisbury, Wiltshire, United Kingdom
Appl Environ Microbiol 74:6437-43. 2008..The aerosols generated by the Collison nebulizer and the FFAG differ with respect to mass distribution, distribution of the entrapped particulates, bacterial survival, and deposition within the murine respiratory tract...
- Receptor mimicry as novel therapeutic treatment for biothreat agentsRichard J Thomas
Biomedical Sciences, Dstl Porton Down, Salisbury, Wiltshire UK
Bioeng Bugs 1:17-30. 2010..A cocktail of multivalent oligosaccharides based on the minimal binding structures of identified adhesins would offer the best candidates for anti-adhesion therapy...
- Structural modification of a base disaccharide alters antiadhesion properties towards Yersinia pestisRichard J Thomas
Defence, Science and Technology Laboratories Dstl, Wiltshire, UK
FEMS Immunol Med Microbiol 49:410-4. 2007..The data indicate that targeted modification of receptor ligands could offer a novel therapeutic preventing Y. pestis attachment to host cells...
- Attachment of Yersinia pestis to human respiratory cell lines is inhibited by certain oligosaccharidesRichard Thomas
Defence, Science and Technology Laboratories, Porton Down, Salisbury SP4 0JQ, UK
J Med Microbiol 55:309-15. 2006..Disaccharides such as GalNAcbeta1-3Gal and GalNAcbeta1-4Gal were also good inhibitors, particularly for the RPMI-2650 cell line. This demonstrates the potential of oligosaccharides as potential anti-adhesion therapeutics...
- Common oligosaccharide moieties inhibit the adherence of typical and atypical respiratory pathogensRichard Thomas
Defence Science and Technology Laboratories Dstl, Biomedical Sciences, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
J Med Microbiol 53:833-40. 2004..Burkholderia pseudomallei attachment was particularly susceptible to oligosaccharide inhibition. Combinations of such compounds may serve as a novel generic therapeutics for respiratory tract infections...
- The cell membrane as a major site of damage during aerosolization of Escherichia coliRichard J Thomas
Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
Appl Environ Microbiol 77:920-5. 2011..The results indicate that the physiology of an aerosolized bacterium is linked to the method of aerosol generation and may affect the interpretation of a range of aerobiological phenomenon...
- Oligosaccharide receptor mimics inhibit Legionella pneumophila attachment to human respiratory epithelial cellsRichard J Thomas
Defence, Science and Technology Laboratories, Biomedical Sciences, CBS Porton Down, Salisbury, Wiltshire
Microb Pathog 36:83-92. 2004..The identified compounds have the potential to be used as novel treatments for Legionnaire's disease...
- A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivoAngela E Essex-Lopresti
Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
Infect Immun 73:1260-4. 2005..A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence...
- 2-phenylimidazopyridines, a new series of Golgi compounds with potent antiviral activityHomayon Banie
Avanir Pharmaceuticals, 101 Enterprise, Aliso Viejo, CA 92656, USA
J Med Chem 50:5984-93. 2007..These agents may provide an alternative antiviral approach, particularly for treating resistant strains...
- Substituted 2-phenyl-benzimidazole derivatives: novel compounds that suppress key markers of allergyMark L Richards
Avanir Pharmaceuticals, 11388 Sorrento Valley Road, San Diego, CA 92121, USA
Eur J Med Chem 41:950-69. 2006..The broad profile of these compounds thus underscores their potential for treating the multifarious pathology of asthma...
- Synthesis and NMR studies of (13)C-labeled vitamin D metabolitesWilliam H Okamura
Department of Chemistry, University of California, Riverside, California 92521, USA
J Org Chem 67:1637-50. 2002....