- Propofol and children--what we know and what we do not knowAnn E Rigby-Jones
Anaesthesia Research Group, Peninsula Medical School, Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth, UK
Paediatr Anaesth 21:247-54. 2011..K(eo) half-lives have been determined for pediatric kinetic models using time to peak effect techniques but are not currently incorporated into commercially available target-controlled infusion pumps...
- First human administration of MR04A3: a novel water-soluble nonbenzodiazepine sedativeJ Robert Sneyd
Peninsula Medical School, University of Plymouth, Plymouth, United Kingdom
Anesthesiology 116:385-95. 2012..49, is a novel isoindoline water-soluble benzodiazepine receptor agonist with favorable anesthetic/sedative properties in animals. MR04A3 is a 1% aqueous presentation of JM-1232(-)...
- First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical TrialAnn E Rigby-Jones
Peninsula College of Medicine and Dentistry, University of Plymouth, The John Bull Building, Research Way, Tamar Science Park, Plymouth PL6 8BU, UK
BMC Anesthesiol 10:10. 2010..This study aimed to assess the safety, tolerability and efficacy of Org 25435 and to obtain preliminary pharmacodynamic and pharmacokinetic data...
- Pharmacokinetics of propofol infusions in critically ill neonates, infants, and children in an intensive care unitAnn E Rigby-Jones
Department of Pharmacy, Derriford Hospital, Plymouth Postgraduate Medical School, Plymouth, UK
Anesthesiology 97:1393-400. 2002..Few data have described propofol kinetics in critically ill children...