G E Morris

Summary

Affiliation: North East Wales Institute
Country: UK

Publications

  1. ncbi request reprint The role of the nuclear envelope in Emery-Dreifuss muscular dystrophy
    G E Morris
    MRIC Biochemistry Group, The North East Wales Institute, Wrexham, UK LL11 2AW
    Trends Mol Med 7:572-7. 2001
  2. ncbi request reprint Nuclear proteins and cell death in inherited neuromuscular disease
    G E Morris
    MRIC Biochemistry Group, The North East Wales Institute, LL11 2AW, Wrexham, UK
    Neuromuscul Disord 10:217-27. 2000
  3. ncbi request reprint Heart to heart: from nuclear proteins to Emery-Dreifuss muscular dystrophy
    G E Morris
    MRIC Biochemistry Group, NE Wales Institute, Wrexham, UK
    Hum Mol Genet 8:1847-51. 1999
  4. ncbi request reprint Dystrophin is replaced by utrophin in frog heart; implications for muscular dystrophy
    G E Morris
    MRIC Biochemistry Group, N E Wales Institute, Wrexham, UK
    Neuromuscul Disord 7:493-8. 1997
  5. ncbi request reprint The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein
    S Manilal
    MRIC Biotechnology Group, N E Wales Institute, UK
    Hum Mol Genet 5:801-8. 1996
  6. ncbi request reprint How does a g993t mutation in the emerin gene cause Emery-Dreifuss muscular dystrophy?
    I Holt
    MRIC Biochemistry Group, North East Wales Institute, Mold Road, Wrexham, Wales, LL11 2AW, United Kingdom
    Biochem Biophys Res Commun 287:1129-33. 2001
  7. ncbi request reprint Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart
    L T Lam
    MRIC Biochemistry Group, PP18, North East Wales Institute, Mold Road, Wrexham LL11 2AW, UK
    Hum Mol Genet 9:2167-73. 2000
  8. ncbi request reprint Utrophin-dystroglycan complex in membranes of adherent cultured cells
    M James
    MRIC Biotechnology Group, N E Wales Institute, Deeside, Clwyd, UK
    Cell Motil Cytoskeleton 33:163-74. 1996
  9. ncbi request reprint The relationship between SMN, the spinal muscular atrophy protein, and nuclear coiled bodies in differentiated tissues and cultured cells
    P J Young
    MRIC Biochemistry Group, North East Wales Institute, Mold Road, Wrexham, LL11 2AW, United Kingdom
    Exp Cell Res 256:365-74. 2000
  10. ncbi request reprint Absence of utrophin in intercalated discs of human cardiac muscle
    C A Sewry
    MRIC Biochemistry Group, NE Wales Institute, Wrexham, UK
    Histochem J 33:9-12. 2001

Collaborators

Detail Information

Publications22

  1. ncbi request reprint The role of the nuclear envelope in Emery-Dreifuss muscular dystrophy
    G E Morris
    MRIC Biochemistry Group, The North East Wales Institute, Wrexham, UK LL11 2AW
    Trends Mol Med 7:572-7. 2001
    ..Why only heart and skeletal muscle, and possibly connective tissue, are affected in EDMD and why expression of the disease is so extremely variable between individuals remains to be explained...
  2. ncbi request reprint Nuclear proteins and cell death in inherited neuromuscular disease
    G E Morris
    MRIC Biochemistry Group, The North East Wales Institute, LL11 2AW, Wrexham, UK
    Neuromuscul Disord 10:217-27. 2000
    ..This review compares the molecular basis for these various disorders and considers the role of cell death, including apoptosis, in their pathogenesis...
  3. ncbi request reprint Heart to heart: from nuclear proteins to Emery-Dreifuss muscular dystrophy
    G E Morris
    MRIC Biochemistry Group, NE Wales Institute, Wrexham, UK
    Hum Mol Genet 8:1847-51. 1999
    ..How do mutations in proteins at the heart of the cell lead to stiff joints and sudden heart failure? This and related questions are the subject of this review...
  4. ncbi request reprint Dystrophin is replaced by utrophin in frog heart; implications for muscular dystrophy
    G E Morris
    MRIC Biochemistry Group, N E Wales Institute, Wrexham, UK
    Neuromuscul Disord 7:493-8. 1997
    ..In skeletal muscle, however, Xenopus resembles mammals in expressing dystrophin at the sarcolemma and very little utrophin...
  5. ncbi request reprint The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein
    S Manilal
    MRIC Biotechnology Group, N E Wales Institute, UK
    Hum Mol Genet 5:801-8. 1996
    ....
  6. ncbi request reprint How does a g993t mutation in the emerin gene cause Emery-Dreifuss muscular dystrophy?
    I Holt
    MRIC Biochemistry Group, North East Wales Institute, Mold Road, Wrexham, Wales, LL11 2AW, United Kingdom
    Biochem Biophys Res Commun 287:1129-33. 2001
    ..Reduced emerin levels due to altered splicing or defective interaction with an unidentified binding partner remain possible pathogenic mechanisms...
  7. ncbi request reprint Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart
    L T Lam
    MRIC Biochemistry Group, PP18, North East Wales Institute, Mold Road, Wrexham LL11 2AW, UK
    Hum Mol Genet 9:2167-73. 2000
    ..The results suggest that effects of the repeat expansion on the DMPK gene may be responsible for muscle and heart features of DM, whereas clinical changes in other tissues may be due to effects on the other two genes...
  8. ncbi request reprint Utrophin-dystroglycan complex in membranes of adherent cultured cells
    M James
    MRIC Biotechnology Group, N E Wales Institute, Deeside, Clwyd, UK
    Cell Motil Cytoskeleton 33:163-74. 1996
    ....
  9. ncbi request reprint The relationship between SMN, the spinal muscular atrophy protein, and nuclear coiled bodies in differentiated tissues and cultured cells
    P J Young
    MRIC Biochemistry Group, North East Wales Institute, Mold Road, Wrexham, LL11 2AW, United Kingdom
    Exp Cell Res 256:365-74. 2000
    ..Overall, the data suggest that gem/coiled body formation is not determined by high cytoplasmic SMN concentrations or high metabolic activity alone and that a differentiation-specific factor may control their formation...
  10. ncbi request reprint Absence of utrophin in intercalated discs of human cardiac muscle
    C A Sewry
    MRIC Biochemistry Group, NE Wales Institute, Wrexham, UK
    Histochem J 33:9-12. 2001
    ..We conclude that the primary location of utrophin in normal heart is in the vascular system. In addition, our results show that the utrophin on cardiac blood vessels is full length, similar to that of skeletal muscle blood vessels...
  11. ncbi request reprint An epitope structure for the C-terminal domain of dystrophin and utrophin
    G E Morris
    MRIC Biochemistry Group, North East Wales Institute, Wrexham, UK
    Biochemistry 37:11117-27. 1998
    ....
  12. ncbi request reprint The R482Q lamin A/C mutation that causes lipodystrophy does not prevent nuclear targeting of lamin A in adipocytes or its interaction with emerin
    I Holt
    MRIC Biochemistry Group, North East Wales Institute, Wrexham, LL11 2AW, UK
    Eur J Hum Genet 9:204-8. 2001
    ..The results show that the loss of function of R482 in lamin A/C in FPLD does not involve loss of ability to form a nuclear lamina or to interact with the nuclear membrane protein, emerin...
  13. ncbi request reprint Epitopes in the interacting regions of beta-dystroglycan (PPxY motif) and dystrophin (WW domain)
    A V Pereboev
    MRIC Biochemistry Group, North East Wales Institute, Mold Road, LL11 2AW, Wrexham, UK
    Biochim Biophys Acta 1527:54-60. 2001
    ....
  14. ncbi request reprint Direct interaction between emerin and lamin A
    L Clements
    MRIC Biochemistry Group, N E Wales Institute, Wrexham, LL11 2AW, United Kingdom
    Biochem Biophys Res Commun 267:709-14. 2000
    ..An emerin-lamin A interaction system may be related in function to the LAP2-lamin B system at the inner nuclear rim...
  15. pmc Disruption of the utrophin-actin interaction by monoclonal antibodies and prediction of an actin-binding surface of utrophin
    G E Morris
    MRIC Biochemistry Group, N E Wales Institute, Mold Road, Wrexham LL1 2AW, Wales, U K
    Biochem J 337:119-23. 1999
    ..Using the known three-dimensional structure of the homologous actin-binding domain of fimbrin, these results have enabled us to determine the likely orientation of the utrophin actin-binding domain with respect to the actin filament...
  16. ncbi request reprint Monoclonal antibody evidence for structural similarities between the central rod regions of actinin and dystrophin
    T M Nguyen
    Research Division, NE Wales Institute, Deeside, Clwyd, UK
    FEBS Lett 272:109-12. 1990
    ..The results suggest that structural homologies between actinin and dystrophin occur more than once in their central helical regions and provide experimental support for an actinin-like central rod model for dystrophin...
  17. ncbi request reprint Apo-dystrophins (Dp140 and Dp71) and dystrophin splicing isoforms in developing brain
    G E Morris
    MRIC Biotechnology Group, N E Wales Institute, Deeside, Clwyd, UK
    Biochem Biophys Res Commun 215:361-7. 1995
    ....
  18. ncbi request reprint The exon 2b region of the spinal muscular atrophy protein, SMN, is involved in self-association and SIP1 binding
    P J Young
    MRIC Biochemistry Group, North East Wales Institute, Mold Road, Wrexham LL11 2AW, UK
    Hum Mol Genet 9:2869-77. 2000
    ..The presence of two separate self-association sites suggests a novel mechanism by which linear oligomers or closed rings might be formed from SMN monomers...
  19. ncbi request reprint A quantitative ELISA for dystrophin
    G E Morris
    Research Division, N E Wales Institute, Deeside, Clwyd, UK
    J Immunol Methods 161:23-8. 1993
    ..Dystrophin is assayed in its native form by extracting with non-ionic detergents and avoiding the use of SDS...
  20. ncbi request reprint Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies
    Y C Pham
    MRIC Biochemistry Group, NE Wales Institute, Mold Road, Wrexham LL11 2AW, UK
    Hum Mol Genet 7:1957-65. 1998
    ..Subcellular fractionation and sedimentation analysis suggest that a major proportion of the DMPK in skeletal muscle and brain is cytosolic...
  21. ncbi request reprint Utrophin, the autosomal homologue of dystrophin, is widely-expressed and membrane-associated in cultured cell lines
    T M Nguyen
    Research Division, N E Wales Institute, Deeside, Clwyd, UK
    FEBS Lett 313:19-22. 1992
    ..After subcellular fractionation of BC3H1 or glioma cells, nearly all of the utrophin was found in the Triton-soluble fraction, suggesting an association with cell membranes...
  22. ncbi request reprint The molecular basis for cross-reaction of an anti-dystrophin antibody with alpha-actinin
    M James
    MRIC Biochemistry Group, The North East Wales Institute, Wrexham, Clwyd, UK
    Biochim Biophys Acta 1360:169-76. 1997
    ..The antibody cross-reaction between dystrophin and alpha-actinin is likely to be fortuitous and not due to any structural homology that exists between these two members of the spectrin superfamily...