Norfolk and Norwich University Hospital
Organization: Norfolk and Norwich University Hospital
- Early failure of the Ultima metal-on-metal total hip replacement in the presence of normal plain radiographsS T Donell
Department of Trauma and Orthopaedics, Norfolk and Norwich University Hospital, Colney Lane, Colney, Norwich NR4 7UZ, UK
J Bone Joint Surg Br 92:1501-8. 2010..Metal artefact reduction sequence MRI proved to be useful when investigating these patients with pain in the absence of adverse plain radiological features...
- Can vastus medialis oblique be preferentially activated? A systematic review of electromyographic studiesToby O Smith
Physiotherapy Department, Norfolk and Norwich University Hospital, Colney Lane, Norwich, UK
Physiother Theory Pract 25:69-98. 2009..Accordingly, well-designed studies evaluating large samples of patients with patellofemoral joint disorders are required, to rectify the present limitations in the evidence-base, and to thoroughly investigate this topic...
- Pregnancy and multiple sclerosisM Lee
Department of Neurology, Norfolk and Norwich University Hospital, Norwich, UK
J Neurol Neurosurg Psychiatry 79:1308-11. 2008..The take-home message is that pregnancy does not hold adverse risks for the majority of patients with MS, or vice versa...
- Risk factors for first-ever stroke in the EPIC-Norfolk prospective population-based studyPhyo K Myint
School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
Eur J Cardiovasc Prev Rehabil 15:663-9. 2008..Many studies examining stroke risk factors have focused on men and younger age groups. We examined stroke risk factors over a wide age range including elderly and women in a British population...
- Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot studyElena Borzova
Dermatology Department, Norfolk and Norwich University Hospital, Norwich, United Kingdom
J Am Acad Dermatol 59:752-7. 2008..Photochemotherapy (psoralen plus ultraviolet [UV] A) may help the itch of dermographism but the effect of narrowband (NB) UVB therapy has not been previously studied...
- The impact of computerized prescribing on error rate in a department of Oncology/HematologyMatthew D C Small
Department of Pharmacy, Norfolk and Norwich University Hospital, Norwich, United Kingdom, United Kingdom
J Oncol Pharm Pract 14:181-7. 2008A comparison of prescribing errors detected for computerized and spreadsheet prescriptions in the Department of Hematology and Oncology of the Norfolk and Norwich University hospital.
- People with type 1 diabetes using short acting analogue insulins are less dehydrated than those with using human soluble insulin prior to onset of diabetic ketoacidosisKetan Dhatariya
Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital NHS Foundation Trust, Colney Lane, Norwich, Norfolk NR4 7UY, UK
Med Hypotheses 71:706-8. 2008..New rapid acting insulin analogues are becoming more widely used. This suggests that the volumes needed to replace those lost prior to the onset of significant DKA may be lower...
- An evaluation of the clinical tests and outcome measures used to assess patellar instabilityToby O Smith
Orthopaedic Physiotherapy Research Unit, Physiotherapy Department, Norfolk and Norwich University Hospital, Colney Lane, Norwich, NR4 7UY, UK
Knee 15:255-62. 2008..Further work is needed to assess the appropriateness of the identified tests and outcomes for patellar instability cohorts...
- Intracapsular (in situ) carcinoma ex pleomorphic adenoma with unusual clinical and histological featuresRajesh Logasundaram
Department of Histopathology, Norfolk and Norwich University Hospital NHS Trust, Cotman Centre, Norwich, NR47UB, UK
Eur Arch Otorhinolaryngol 265:1563-6. 2008..This case report elucidates the atypical clinical behaviour and interesting histological features encountered within this group of salivary neoplasm...
- Meconium per vagina: a rare presentation of meconium peritonitisNeil C Featherstone
Paediatric Surgery, Department of Paediatrics, Norfolk and Norwich University Hospital, Norwich, NR4 7UY, UK
J Pediatr Surg 43:e5-7. 2008..Possible explanations for the passage of meconium per vagina include decompression of a meconium cyst via the left fallopian tube or direct perforation of a collection into the vagina from the peritoneal cavity...
- Chlamydia trachomatis RNA in the environment: is there potential for false-positive nucleic acid amplification test results?E Meader
Norfolk and Norwich University Hospital, Microbiology Department, Bowthorpe Road, Norwich, Norfolk NR2 3TX, UK
Sex Transm Infect 84:107-10. 2008..There is thus the need to characterise the risk of false-positive results caused by environmental contamination in these areas...
- Haemosiderotic fibrohistiocytic lipomatous lesion/tumour of the foot: MRI and histopathologyAndrew T West
Department of Radiology, Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK
Skeletal Radiol 37:71-4. 2008..This is a recently described and rare entity that occurs typically in the subcutaneous tissues of the foot or ankle of middle-aged women. To our knowledge this is the first description of the imaging findings in this lesion...
- Unknown primary site of serous papillary adenocarcinoma involving inguinal, iliac and obturator lymph nodes co-existing with endometrial adenocarcinomaN Burbos
Departments of Obstetrics and Gynaecology, Norfolk and Norwich University Hospital, Norwich, UK
J Obstet Gynaecol 27:542-3. 2007
- Outcomes of medial patellofemoral ligament reconstruction for patellar instability: a systematic reviewToby O Smith
Orthopaedic Physiotherapy Research Unit, Physiotherapy Department, Out Patients East, Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK
Knee Surg Sports Traumatol Arthrosc 15:1301-14. 2007..Future study is recommended to address these methodological flaws, in addition to beginning to assess the effectiveness of this procedure, in different patient groups...
- Competent to care. A train-the-trainer method of teaching as a way of implementing the correct use of the 'Malnutrition Universal Screening Tool' in Norfolk: is it effective?Rachel Lee
Norfolk and Norwich University Hospitals NHS Foundation Trust, Colney Lane, Norwich NR4 7UY, UK
Proc Nutr Soc 68:300-5. 2009..One of the unexpected benefits observed was the ownership taken by the trainers, which was demonstrated by the enthusiasm and confidence with which they subsequently trained their colleagues...
- Limitations of single slice dynamic contrast enhanced MR in pharmacokinetic modeling of bone sarcomasAndoni P Toms
Department of Radiology, The Norfolk and Norwich University Hospital, Norwich, Norfolk, UK
Acta Radiol 50:512-20. 2009..However, sarcomas are heterogeneous and therefore single slice DCE-MRI may not correlate with total tumor necrosis...
- The clinical and radiological outcomes of the LISS plate for distal femoral fractures: a systematic reviewT O Smith
Institute of Orthopaedics, Norfolk and Norwich University Hospital, Norwich NR4 7UY, Norfolk, UK
Injury 40:1049-63. 2009..The purpose of this systematic review was to assess the literature evaluating the clinical and radiological outcomes following less invasive surgical stabilisation system (LISS) fixation of distal femoral fractures (AO 32/33)...
- Practical guidelines for routine intensity-modulated radiotherapy verification: pre-treatment verification with portal dosimetry and treatment verification with in vivo dosimetryA J Vinall
Radiotherapy Physics Department, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich UK
Br J Radiol 83:949-57. 2010..Both methods are now easily absorbed into the routine work of the department...
- Aggressive tumoral calcinosis in an infant thoracotomy scarJakub Kadlec
Department of Thoracic Surgery, Norfolk and Norwich University Hospital, Colney Lane, Colney, Norwich NR4 7UY, UK
Interact Cardiovasc Thorac Surg 11:864-5. 2010..This is the first report of TC that developed in a postoperative scar and is unusual in its recurrence and aggressive growth. Pathogenesis, diagnosis and treatment of this rare event is discussed...
- Investigation of nuclear factor-κB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytesJ J O Turner
Kennedy Institute of Rheumatology, Charing Cross Hospital, London, UK
Clin Exp Immunol 162:487-93. 2010....
- Phalangeal fractures of the handP Yoong
Norwich Radiology Academy, Norfolk and Norwich University Hospital, Cotman Centre, Colney Lane, Norwich, Norfolk, UK
Clin Radiol 65:773-80. 2010....
- Age-related differential diagnosis of vaginal bleeding in postmenopausal women: a series of 3047 symptomatic postmenopausal womenNikolaos Burbos
Department of Obstetrics and Gynaecology, Norfolk and Norwich University Hospital NHS Foundation Trust, Colney Lane, Norwich NR4 7UY, UK
Menopause Int 16:5-8. 2010..Also, we attempt to estimate the incidence of postmenopausal vaginal bleeding and endometrial cancer in a defined geographical area...
- Predicting the risk of endometrial cancer in postmenopausal women presenting with vaginal bleeding: the Norwich DEFAB risk assessment toolN Burbos
Department of Obstetrics and Gynaecology, Norfolk and Norwich University Hospital NHS Foundation Trust, UK
Br J Cancer 102:1201-6. 2010....
- Regular clinical dermatoscope use with training improves melanoma diagnosis by dermatologistsE Tan
Norfolk and Norwich University Hospital, Colney Lane, Norwich, UK
Clin Exp Dermatol 34:e876-8. 2009..This practical study supports the use of dermatoscopy in pigmented-lesion diagnosis and demonstrates how dermatoscopy training could be incorporated into UK specialist training programmes...
- Fixed versus mobile bearing unicompartmental knee replacement: a meta-analysisT O Smith
Institute of Orthopaedics, Norfolk and Norwich University Hospital, Colney Lane, Norwich, Norfolk Island, NR2 7UY, UK
Orthop Traumatol Surg Res 95:599-605. 2009..However, the evidence reviewed presented with a number of methodological limitations. Areas for further study are recommended...
- Seroprevalence of hepatitis E virus in the UK farming populationE Meader
The Norfolk and Norwich University Hospital NHS Trust, Colney, Norfolk, NR4 7UY, UK
Zoonoses Public Health 57:504-9. 2010..The results of this study suggest that UK farming populations are exposed to HEV, but the predominant route of transmission remains elusive...
- A doctor's experience of resuscitation decision making for older patients: coping with changeL Bowker
Department of Medicine for the Elderly, Norfolk and Norwich University Foundation Trust Hospital, Norfolk, UK
Postgrad Med J 85:569-72. 2009..The solution lies in better undergraduate and postgraduate training which enhances skills (such as consultation skills and ethical reasoning) and not just knowledge of laws, principles and guidelines...
- Clinical and radiological outcomes of fixed- versus mobile-bearing total knee replacement: a meta-analysisToby O Smith
Institute of Orthopaedics, Norfolk and Norwich University Hospital, Colney Lane, Norwich, Norfolk NR2 7UY, UK
Knee Surg Sports Traumatol Arthrosc 18:325-40. 2010..Thirty-three studies were eligible, assessing the outcomes of 3532 TKRs. Analysis suggested that there was no significant difference in clinical or radiological outcomes and complication rates between fixed- and mobile-bearing TKRs...
- Reconstruction after wide excision of primary cutaneous melanomas: part I-the head and neckMarc D Moncrieff
Department of Plastic and Reconstructive Surgery, Norfolk and Norwich University Hospital, Norwich, UK
Lancet Oncol 10:700-8. 2009..In part I of this series, we review current literature and available evidence on reconstruction after wide excision of primary cutaneous melanoma in the head and neck region...
- Midcarpal instability: a diagnostic role for dynamic ultrasound?A Toms
Radiology, Norfolk Norwich University Hospital
Ultraschall Med 30:286-90. 2009..The aim of this study was to describe the technique of dynamic ultrasound (US) examination of the triquetral clunk, and to illustrate the range of findings in four patients with midcarpal instability (MCI)...
- Efficacy of tibolone as "add-back therapy" in conjunction with a gonadotropin-releasing hormone analogue in the treatment of uterine fibroidsEdward Patrick Morris
Menopause Research Unit, Department of Obstetrics and Gynaecology, Norfolk and Norwich University Hospital, Colney Lane, Norwich, UK
Fertil Steril 89:421-8. 2008..To assess the efficacy of tibolone add-back therapy with Goserelin treatment of uterine fibroids...
- Bimodal electric tissue ablation (BETA) - in-vivo evaluation of the effect of applying direct current before and during radiofrequency ablation of porcine liverJ F Cockburn
Department of Radiology, Norfolk and Norwich University Hospital, Norwich, UK
Clin Radiol 62:213-20. 2007..To examine the effect of applying increasing amounts of direct current (DC) before and during alternating current radiofrequency ablation of porcine liver...
- Primary central nervous system lymphoma: a single-centre experience of 55 unselected casesD J Hodson
Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
Clin Oncol (R Coll Radiol) 17:185-91. 2005..Many published studies describing this approach include a highly selected group of patients. We report a single-centre experience of unselected cases of PCNSL...
- Fluctuating intraocular pressureDavid Broadway
Norfolk and Norwich University Hospital, Norwich, United Kingdom
J Glaucoma 14:249-51. 2005
- Teaching students to use medical notesM Wilkinson
Department of Histopathology, Norfolk and Norwich University Hospital, Norwich, UK
Med Educ 39:516-7. 2005
- Tight discolouration of the feet and anklesK S Leslie
Norfolk and Norwich University Hospital, Colney Lane, Norwich, Norfolk NR4 7UZ, UK
Clin Exp Dermatol 30:311-2. 2005
- UK audit of left ventricular ejection fraction estimation from equilibrium ECG gated blood pool imagesJohn V Skrypniuk
IPEM Nuclear Medicine Software Working Party, York, UK
Nucl Med Commun 26:205-15. 2005..To examine the variability of results obtained from computer analysis of left ventricular gated blood pool (LVGBP) images by nuclear medicine centres in the UK...
- A mobile screening programme for the cardiovascular and microvascular complications of Type 2 diabetes in primary careM J Sampson
Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital, Norwich, UK
Diabet Med 22:256-7. 2005....
- Chronic periaortitisR N Jois
Department of Rheumatology, Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK
Rheumatology (Oxford) 43:1441-6. 2004..Early diagnosis is important in order to reduce morbidity from complications such as renal failure and mortality from aortic rupture...
- Dermatologists, beacons of epidemics; past, present and future!Kieron S Leslie
Department of Dermatology, Norfolk and Norwich University Hospital, Norwich, Norfolk NR4 7UZ, UK
Int J Dermatol 43:468-70. 2004
- Autoimmune urticariaClive E H Grattan
Dermatology Centre, Norfolk and Norwich University Hospital, Colney, Norwich NR4 7UY, UK
Immunol Allergy Clin North Am 24:163-81, v. 2004....
- T cell recognition of a highly conserved epitope in heat shock protein 60: self-tolerance maintained by TCR distinguishing between asparagine and aspartic acidMark S Lillicrap
Department of Medicine, University of Cambridge, Cambridge CB2 2QQ, UK
Int Immunol 16:405-14. 2004....
- The myelodysplastic syndromes: a matter of life or deathJane E Parker
Department of Haematological Medicine, Norfolk and Norwich University Hospital, Norwich, UK
Acta Haematol 111:78-99. 2004..This paper outlines the apoptotic process in normal hematopoietic cells and summarizes current data regarding the role, potential causes and clinical implications of altered apoptosis in MDS...
- Musculoskeletal assessment of general medical in-patients--joints still crying out for attentionM S Lillicrap
Department of Rheumatology, Addenbrookes Hospital, Cambridge, UK
Rheumatology (Oxford) 42:951-4. 2003..The aim of this study was to assess the extent of musculoskeletal assessment (history and examination) amongst medical in-patients and to determine the effects that GALS (gait, arms, legs, spine) teaching has had on this...
- Aspirin sensitivity and urticariaC E H Grattan
Dermatology Centre, Norfolk and Norwich University Hospital, Norwich, UK
Clin Exp Dermatol 28:123-7. 2003..Cross-reactivity amongst all nonsteroidal drugs is common in aspirin-aggravated chronic urticaria but appears not to occur with selective cyclo-oxygenase 2 inhibitors...
- Hepatocellular carcinoma and the penetrance of HFE C282Y mutations: a cross sectional studyGavin Willis
Department of Molecular Genetics, Norfolk and Norwich University Hospital, Norwich, NR47UY, UK
BMC Gastroenterol 5:17. 2005....
- Monocyte matrix and ADAM metalloproteinase expression in type 2 diabetes after aspirin therapyMike Sampson
Bertram Diabetes Research Unit, Norfolk and Norwich University Hospital NHS Trust, Norwich NR4 7UY, UK
Diabetes Res Clin Pract 71:45-51. 2006..Monocyte ADAM mRNA levels do not differ between group and oral aspirin has no significant effect on these variables...
- Difficult asthma in adults: recognition and approaches to managementB D W Harrison
Department of Respiratory Medicine, Norfolk and Norwich University Hospital, Norwich, UK
Intern Med J 35:543-7. 2005..There is a need for further research using agreed definitions, structured approaches and a full range of investigations in patients with difficult asthma...
- Isolated patellofemoral osteoarthritisSimon T Donell
Institute of Orthopaedics, Norfolk and Norwich University Hospital, Norwich, NR4 7UY UK
Knee 14:169-76. 2007..Fortunately the majority of patients with isolated patellofemoral degenerative changes do not need surgical treatment. Those who are symptomatic can usually be successfully treated with weight loss and quadriceps strengthening exercises...
- Hyponatraemia and hypokalaemia during intravenous fluid administrationK Armon
Norfolk and Norwich University Hospital NHS Trust, Colney Lane, Norwich, Norfolk NR4 7UY, UK
Arch Dis Child 93:285-7. 2008..Hospital-acquired hyponatraemia is associated with excessive volumes of hypotonic intravenous fluids and can cause death or permanent neurological deficit...
- Vitamin K prophylaxis for preterm infants: a randomized, controlled trial of 3 regimensPaul Clarke
Neonatal Unit, Hope Hospital, Salford, United Kingdom
Pediatrics 118:e1657-66. 2006..Preterm infants may be at particular risk from either inadequate or excessive vitamin K prophylaxis. Our goal was to assess vitamin K status and metabolism in preterm infants after 3 regimens of prophylaxis...
- Glycaemic control throughout pregnancy and risk of pre-eclampsia in women with type I diabetesR C Temple
Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK
BJOG 113:1329-32. 2006..65 for each 1% increase in HbA1c; P= 0.01). In contrast, there was no relationship between pre-pregnancy care or HbA1c level at booking and risk of pre-eclampsia...
- Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptorsG W M Millington
Department of Dermatology, Norfolk and Norwich University Hospital, Colney Lane, Norwich, UK
Clin Exp Dermatol 31:407-12. 2006..However, they do not necessarily affect skin colour or function in humans, and further studies are needed to clarify these observations...
- Modified Dejour trochleoplasty for severe dysplasia: operative technique and early clinical resultsSimon T Donell
Department of Trauma and Orthopaedics, Norfolk and Norwich University Hospital, Norwich, UK
Knee 13:266-73. 2006..Trochleoplasty for severe dysplasia of the femoral sulcus is a developing procedure. It requires careful attention to detail. For a rare condition the early results have been satisfactory with an acceptable level of complications...
- Monocyte telomere shortening and oxidative DNA damage in type 2 diabetesMike J Sampson
Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital National Health Service Trust, Norwich NR4 7UA, UK
Diabetes Care 29:283-9. 2006..Once shortened to a critical length, cells are triggered into replicative senescence. Type 2 diabetes is associated with oxidative DNA damage, and we hypothesized that telomere shortening would characterize type 2 diabetes...
- Vitamin K status of preterm infants with a prolonged prothrombin timePaul Clarke
Neonatal Unit, Hope Hospital, Salford, UK
Acta Paediatr 94:1822-4. 2005..To investigate the vitamin K status of preterm infants who have a prolonged prothrombin time (PT) in the first month of life...
- How we do it: The role of trans-nasal flexible laryngo-oesophagoscopy (TNFLO) in ENT: one year's experience in a head and neck orientated practice in the UKT Price
Norfolk and Norwich University Hospital, Norwich, Norfolk, UK
Clin Otolaryngol 30:551-6. 2005..Therapeutic procedures such as vocal cord medialization, endolaryngeal laser surgery, insertion of speech prostheses and foreign body removal may be performed without general anaesthesia...
- Direct digital lateral cephalometry: the effects of JPEG compression on image qualityN A Wenger
Department of Oral Health, West Block, Norfolk and Norwich University Hospital, Colney Lane, Norwich, UK
Med Eng Phys 28:560-7. 2006..This study used an aluminium test object to assess the effect of the Joint Photographics Expert Group (JPEG) compression algorithm, on direct digital cephalometric image quality...
- Human cytomegalovirus, endothelial function and atherosclerosisCairistine Grahame-Clarke
Department of Cardiology, Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UZ, UK
Herpes 12:42-5. 2005..However, whether HCMV is a clinically significant cause of atherosclerosis in the general, immunocompetent population remains to be seen...
- Immobilisation following traumatic anterior glenohumeral joint dislocation: a literature reviewToby O Smith
Physiotherapy Department Out Patients East, Norfolk and Norwich University Hospital, Colney Lane, Norwich, Norfolk, NR4 7UY, UK
Injury 37:228-37. 2006..g. small sample sizes, no control groups, not evaluating findings against statistical tests). Recommendations are made to develop the evidence base...
- Syncope associated with pain as the presenting feature of neck malignancy: failure of cardiac pacemaker to prevent attacks in two casesP F Worth
Consultant Neurologist, Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK
J Neurol Neurosurg Psychiatry 76:1301-3. 2005..Two patients are described in whom syncope was the presenting clinical feature of an undiagnosed neck malignancy. Both patients also had attacks associated with paroxysms of severe neck pain. Neither patient responded to cardiac pacing...
- Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activityC E H Grattan
Department of Dermatology, Norfolk and Norwich University Hospital NHS Trust, Colney, Norfolk NR4 7UZ, UK
Clin Exp Allergy 33:337-41. 2003..A secondary aim was to compare a standard manual counting method with automated basophil counts and to look at numbers of other circulating leucocytes that might be relevant to urticaria pathogenesis...