John Newsom-Davis

Summary

Country: UK

Publications

  1. ncbi request reprint Neuromyotonia
    J Newsom-Davis
    Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Rev Neurol (Paris) 160:S85-9. 2004
  2. ncbi request reprint Lambert-Eaton myasthenic syndrome
    J Newsom-Davis
    Department of Clinical Neurology, University of Oxford, Grande Bretagne
    Rev Neurol (Paris) 160:177-80. 2004
  3. ncbi request reprint Neuromyotonia: a diverse disorder
    John Newsom-Davis
    University of Oxford, Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
    Neurol India 54:350. 2006
  4. ncbi request reprint Neuromuscular junction channelopathies: a brief overview
    John Newsom-Davis
    University of Oxford, Department of Clinical Neurology, Oxford, UK
    Acta Neurol Belg 105:181-6. 2005
  5. ncbi request reprint Dok-7 mutations underlie a neuromuscular junction synaptopathy
    David Beeson
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Science 313:1975-8. 2006
  6. ncbi request reprint Quantitative EMG of facial muscles in myasthenia patients with MuSK antibodies
    Maria E Farrugia
    Department of Clinical Neurophysiology, The Radcliffe Infirmary, Oxford OX2 6HE, UK
    Clin Neurophysiol 118:269-77. 2007
  7. ncbi request reprint Clinical features of the DOK7 neuromuscular junction synaptopathy
    Jacqueline Palace
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, UK
    Brain 130:1507-15. 2007
  8. ncbi request reprint MRI and clinical studies of facial and bulbar muscle involvement in MuSK antibody-associated myasthenia gravis
    Maria Elena Farrugia
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    Brain 129:1481-92. 2006
  9. ncbi request reprint Myasthenia gravis seronegative for acetylcholine receptor antibodies
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine and Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom
    Ann N Y Acad Sci 1132:84-92. 2008
  10. ncbi request reprint Single-fiber electromyography in limb and facial muscles in muscle-specific kinase antibody and acetylcholine receptor antibody myasthenia gravis
    Maria Elena Farrugia
    Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Muscle Nerve 33:568-70. 2006

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Neuromyotonia
    J Newsom-Davis
    Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Rev Neurol (Paris) 160:S85-9. 2004
    ..These discoveries should aid diagnosis and offer new approaches to treatment...
  2. ncbi request reprint Lambert-Eaton myasthenic syndrome
    J Newsom-Davis
    Department of Clinical Neurology, University of Oxford, Grande Bretagne
    Rev Neurol (Paris) 160:177-80. 2004
    ..In those with severe weakness, IVIg or plasmapheresis confers short-term benefits. Prednisone alone or combined with azathioprine or cyclosporin can achieve long-term control of the disorder...
  3. ncbi request reprint Neuromyotonia: a diverse disorder
    John Newsom-Davis
    University of Oxford, Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
    Neurol India 54:350. 2006
  4. ncbi request reprint Neuromuscular junction channelopathies: a brief overview
    John Newsom-Davis
    University of Oxford, Department of Clinical Neurology, Oxford, UK
    Acta Neurol Belg 105:181-6. 2005
    ..The Congenital Myasthenic Syndromes are a group of genetically determined heterogeneous disorders, usually recessively inherited. The commonest mutation sites appear to be the acetylcholine receptor epsilon-subunit and rapsyn...
  5. ncbi request reprint Dok-7 mutations underlie a neuromuscular junction synaptopathy
    David Beeson
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Science 313:1975-8. 2006
    ..We showed that recessive inheritance of mutations in Dok-7, which result in a defective structure of the neuromuscular junction, is a cause of CMS with proximal muscle weakness...
  6. ncbi request reprint Quantitative EMG of facial muscles in myasthenia patients with MuSK antibodies
    Maria E Farrugia
    Department of Clinical Neurophysiology, The Radcliffe Infirmary, Oxford OX2 6HE, UK
    Clin Neurophysiol 118:269-77. 2007
    ....
  7. ncbi request reprint Clinical features of the DOK7 neuromuscular junction synaptopathy
    Jacqueline Palace
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, UK
    Brain 130:1507-15. 2007
    ..CMS due to DOK7 mutations are common within our UK cohort and is likely to be under-diagnosed; recognition of the phenotype will help clinical diagnosis, targeted genetic screening and appropriate management...
  8. ncbi request reprint MRI and clinical studies of facial and bulbar muscle involvement in MuSK antibody-associated myasthenia gravis
    Maria Elena Farrugia
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    Brain 129:1481-92. 2006
    ....
  9. ncbi request reprint Myasthenia gravis seronegative for acetylcholine receptor antibodies
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine and Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom
    Ann N Y Acad Sci 1132:84-92. 2008
    ..Overall, these results suggest that complement-activation may be an important pathogenic mechanism even in patients without conventional AChR antibodies...
  10. ncbi request reprint Single-fiber electromyography in limb and facial muscles in muscle-specific kinase antibody and acetylcholine receptor antibody myasthenia gravis
    Maria Elena Farrugia
    Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Muscle Nerve 33:568-70. 2006
    ..These findings demonstrate clear differences between the neurophysiology of MuSK-MG and AChR-MG...
  11. ncbi request reprint Autoimmune disorders of neuronal potassium channels
    John Newsom-Davis
    Weatherall Institute of Molecular Medicine and Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Ann N Y Acad Sci 998:202-10. 2003
    ....
  12. ncbi request reprint Antibodies in myasthenia gravis and related disorders
    Angela Vincent
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Ann N Y Acad Sci 998:324-35. 2003
    ..These antibodies are not found in AChR antibody-positive MG and are predominantly IgG4. MuSK antibody positivity appears to be associated with more severe bulbar disease that can be difficult to treat effectively...
  13. ncbi request reprint Pathogenic autoantibodies in the lambert-eaton myasthenic syndrome
    Bethan Lang
    Neurosciences Group and Department of Clinical Neurology, Oxford University, Oxford, United Kingdom
    Ann N Y Acad Sci 998:187-95. 2003
    ..These results demonstrate an unexpected plasticity in the expression of VGCCs in mammalian neurons and may represent a mechanism by which the pathogenic effects of LEMS IgG are reduced...
  14. ncbi request reprint Seronegative myasthenia gravis
    Angela Vincent
    Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Semin Neurol 24:125-33. 2004
    ..MuSK antibody-positive patients may also differ in the distribution of their electrophysiological abnormalities and their responses to treatments...
  15. doi request reprint Preferential expression of AChR epsilon-subunit in thymomas from patients with myasthenia gravis
    Calman A MacLennan
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
    J Neuroimmunol 201:28-32. 2008
    ..The greater abundance of mRNA for AChR epsilon-subunit than for other subunits suggests that the AChR epsilon-subunit may play a distinctive role in autosensitization in MG-associated thymomas, particularly those of type A or AB...
  16. ncbi request reprint Clinical electrophysiological characterization of the acquired neuromyotonia phenotype of autoimmune peripheral nerve hyperexcitability
    Paul Maddison
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Muscle Nerve 33:801-8. 2006
    ..The pathogenic region of abnormality in peripheral nerve hyperexcitability disorders therefore seems to lie within the terminal branches of peripheral motor nerves...
  17. doi request reprint Prospective study into the incidence of Lambert Eaton myasthenic syndrome in small cell lung cancer
    Miranda Payne
    Department of Medical Oncology, University of Oxford Medical Oncology Unit, Oxford, United Kingdom
    J Thorac Oncol 5:34-8. 2010
    ..VGCC can also be found in patients with SCLC and cerebellar ataxia. This was a prospective study to assess the incidence of clinical and subclinical LEMS or other neurologic disease in patients with SCLC...
  18. ncbi request reprint Seronegative generalised myasthenia gravis: clinical features, antibodies, and their targets
    Angela Vincent
    Department of Clinical Neurology, University of Oxford, UK
    Lancet Neurol 2:99-106. 2003
    ..Moreover, muscle wasting may be present, which prevents complete response to these therapies...
  19. ncbi request reprint Congenital myasthenic syndromes and the formation of the neuromuscular junction
    David Beeson
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Ann N Y Acad Sci 1132:99-103. 2008
    ....
  20. ncbi request reprint Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG
    Maria Isabel Leite
    Neurosciences Group, Department of Clinical Neurology, University of Oxford, Oxford OX3 9DU, United Kingdom
    Ann Neurol 57:444-8. 2005
    ..However, approximately 75% MuSK- samples showed lymph node-type infiltrates similar to those in AChR+ patients, but with fewer germinal centers. These variations may explain some apparent differences in responses to thymectomy in SNMG...
  21. ncbi request reprint Status of the thymectomy trial for nonthymomatous myasthenia gravis patients receiving prednisone
    John Newsom-Davis
    University of Oxford, Oxford, UK
    Ann N Y Acad Sci 1132:344-7. 2008
    ....
  22. ncbi request reprint Therapy in myasthenia gravis and Lambert-Eaton myasthenic syndrome
    John Newsom-Davis
    Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, United Kingdom
    Semin Neurol 23:191-8. 2003
    ..In both forms, prednisone alone is an option or combined with azathioprine in NP-LEMS. In both MG and LEMS, where weakness is severe, plasma exchange or intravenous immunoglobulin treatment may provide short-term benefit...
  23. ncbi request reprint Detection and characterization of MuSK antibodies in seronegative myasthenia gravis
    John McConville
    Weatherall Institute of Molecular Medicine and Department of Clinical Neurology, Oxford, UK
    Ann Neurol 55:580-4. 2004
    ..They bind to the extracellular Ig-like domains of soluble or native MuSK. Surprisingly they are predominantly in the IgG4 subclass. MuSK-antibody associated MG may be different in etiological and pathological mechanisms...
  24. ncbi request reprint Phenotypic variants of autoimmune peripheral nerve hyperexcitability
    Ian K Hart
    Neuroimmunology Group, University Department of Neurological Science, Walton Centre, Liverpool, UK
    Brain 125:1887-95. 2002
    ....
  25. ncbi request reprint Acetylcholine receptor antibody in Thai generalized myasthenia gravis patients
    Suthipun Jitpimolmard
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    J Med Assoc Thai 89:68-71. 2006
    ..3%. There was no correlation between AChR Ab titer and clinical features. This test is a very valuable test in case of uncertainly in the diagnosis of myasthenia gravis...
  26. ncbi request reprint Is "seronegative" MG explained by autoantibodies to MuSK?
    Angela C Vincent
    Neurology 64:399; author reply 399. 2005
  27. ncbi request reprint Development of a thymectomy trial in nonthymomatous myasthenia gravis patients receiving immunosuppressive therapy
    Gil I Wolfe
    Department of Neurology, University of Texas Southwestern Medical School, Dallas, Texas 75390 8897, USA
    Ann N Y Acad Sci 998:473-80. 2003
    ....
  28. ncbi request reprint HLA-B8 in patients with the Lambert-Eaton myasthenic syndrome reduces likelihood of associated small cell lung carcinoma
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Ann N Y Acad Sci 998:200-1. 2003
  29. ncbi request reprint Structural abnormalities of the AChR caused by mutations underlying congenital myasthenic syndromes
    David Beeson
    Neurosciences Group, Weatherall Institute of Molecular Medicine, The John Radcliffe, Headington, Oxford OX3 9DS, United Kingdom
    Ann N Y Acad Sci 998:114-24. 2003
    ..It was found that mutations within muscle AChRs are the most common cause of CMS. The majority are located within the epsilon-subunit gene and result in AChR deficiency...
  30. ncbi request reprint Myasthenia gravis in a woman with congenital AChR deficiency due to epsilon-subunit mutations
    Rebecca Croxen
    Neurosciences Group, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford, United Kingdom
    Neurology 58:1563-5. 2002
    ..The younger sister developed MG at 34 years. This unusual case raises the possibility that genetic defects of the AChR might be a factor in the etiology of autoimmune MG...
  31. ncbi request reprint The action of Lambert-Eaton myasthenic syndrome immunoglobulin G on cloned human voltage-gated calcium channels
    Ashwin Pinto
    Neurosciences Group, Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Muscle Nerve 25:715-24. 2002
    ..Although several LEMS IgGs can be shown to bind to the alpha(1B) (C2D7) cell line, no functional effects were seen on this channel...
  32. ncbi request reprint Thymic myoid cells and germinal center formation in myasthenia gravis; possible roles in pathogenesis
    Ioannis Roxanis
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    J Neuroimmunol 125:185-97. 2002
    ..As autoantibodies became detectable, myoid cell involvement apparently progressed. Our unifying hypothesis--that an early autoantibody attack on myoid cells provokes local GC formation--helps to resolve many puzzles...

Research Grants1

  1. Thymectomy in Non-Thymomatous MG Patients on Prednisone
    Camilla Buckley; Fiscal Year: 2007
    ..Subgroup analysis may show whether benefits are confined to those who are prednisone naive at entry or in a particular age group. Thus the results will impact on current clinical practice. ..