Genomes and Genes
S F Parsons
Affiliation: National Blood Service
- Erythroid cell adhesion molecules Lutheran and LW in health and diseaseS F Parsons
Bristol Institute for Transfusion Sciences, UK
Baillieres Best Pract Res Clin Haematol 12:729-45. 1999..These data suggest that the Lu and LW molecules may contribute to the vaso-occlusive events associated with episodes of acute pain in sickle cell disease...
- Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphismsS F Parsons
International Blood Group Reference Laboratory, Bristol Institute for Transfusion Sciences, UK
Blood 89:4219-25. 1997..The Au(a)/Au(b) polymorphism is an A1637 to G substitution in exon 12 encoding a Thr539 (Au(a)) to Ala (Au(b)) change on the G strand of domain 5...
- The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissuesF A Spring
Bristol Institute for Transfusion Sciences, GB
Eur J Immunol 27:891-7. 1997..Transfection of mouse NS-0 cells with normal or Ok(a-) cDNA confirmed the identity of the protein and only the Ok(a-) transfectants failed to react with monoclonal anti-Ok(a) Ab...
- Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinityS F Parsons
Bristol Institute for Transfusion Sciences, Bristol, United Kingdom
Blood 97:312-20. 2001..These results further support a role for Lu gps in sickle cell disease and indicate the utility of mouse models to explore the function of Lu gp-laminin 10/11 interaction in normal erythropoiesis and in sickle cell disease...
- Intercellular adhesion molecule-4 binds alpha(4)beta(1) and alpha(V)-family integrins through novel integrin-binding mechanismsF A Spring
Bristol Institute for Transfusion Sciences, United Kingdom
Blood 98:458-66. 2001..These findings suggest a role for ICAM-4 in normal erythropoiesis and may also be relevant to the adhesive interactions of sickle cells...
- The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu) geneF A Spring
South Western Regional Blood Transfusion Centre, Southmead, Bristol, U K
Immunology 64:37-43. 1988..Evidence is presented here that the Inb antigen is expressed on normal granulocytes and lymphocytes and on the haemopoietic cell lines HEL, K562 and HL-60, a lymphoblastoid cell line and lymphocytes from two patients with B-CLL...