Genomes and Genes
Affiliation: National Blood Service
- Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxiaEnca Martin-Rendon
Stem Cell Research Laboratory, National Blood Service, Oxford Centre, The John Radcliffe Hospital, Headington, OX3 9BQ, United Kingdom
Stem Cells 25:1003-12. 2007..These results, therefore, provide a global view of the signaling and regulatory network that controls oxygen sensing in human adult stem/progenitor cells derived from hematopoietic tissues...
- Patenting human genes and stem cellsEnca Martin-Rendon
Stem Cell Research Laboratory, NHS Blood and Transplant, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
Recent Pat DNA Gene Seq 1:25-34. 2007..This review summarizes some of the recent published patents on pluripotency genes, gene transfer into stem cells and genetic reprogramming and takes the hematopoietic and embryonic stem cell as model systems...
- Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic reviewEnca Martin-Rendon
Stem Cell Research Laboratory, NHS Blood and Transplant, John Radcliffe Hospital, Headington, Oxford OX3 9BQ, UK
Eur Heart J 29:1807-18. 2008..To provide systematic assessment of the safety and efficacy of autologous bone marrow-derived stem cell (BMSC) transplantation in acute myocardial infarction (AMI) based on clinical evidence...
- Long-term effects of autologous bone marrow stem cell treatment in acute myocardial infarction: factors that may influence outcomesDavid M Clifford
Stem Cell Research Laboratory, NHS Blood and Transplant, John Radcliffe Hospital, Oxford, United Kingdom
PLoS ONE 7:e37373. 2012....
- Stem cell treatment for acute myocardial infarctionDavid M Clifford
StemCell Research Lab, NuffieldDepartment of ClinicalLaboratory Sciences, University of Oxford, Oxford, UK
Cochrane Database Syst Rev 2:CD006536. 2012..Stem cell therapy offers a promising approach to the regeneration of damaged vascular and cardiac tissue after acute myocardial infarction (AMI). This has resulted in multiple randomised controlled trials (RCTs) worldwide...
- Intermediate filaments and the function of the dystrophin-protein complexDerek J Blake
Department of Phrmacology, University of Oxford, Oxford, United Kingdom
Trends Cardiovasc Med 12:224-8. 2002..The interaction between the DPC and the IF network may be disrupted in patients with Duchenne muscular dystrophy and in mice lacking alpha-dystrobrevin...
- Stem cell therapy for chronic ischaemic heart disease and congestive heart failureSheila A Fisher
Systematic Review Initiative, NHS Blood and Transplant, Level 2, John Radcliffe Hospital, Headington, Oxford, Oxon, UK, OX3 9BQ
Cochrane Database Syst Rev 4:CD007888. 2014..The last decade has seen a plethora of randomised controlled trials (RCTs) developed worldwide which have generated conflicting results...
- Human cardiosphere-derived cells from patients with chronic ischaemic heart disease can be routinely expanded from atrial but not epicardial ventricular biopsiesHelen H L Chan
Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, UK
J Cardiovasc Transl Res 5:678-87. 2012..6-fold more CD90+ cells than those from non-diabetic patients (n = 18). No effect of age or other co-morbidities was detected. Thus, CDCs from atrial biopsies may vary in their therapeutic potential...
- Route of delivery and baseline left ventricular ejection fraction, key factors of bone-marrow-derived cell therapy for ischaemic heart diseaseSusan J Brunskill
Systematic Reviews Initiative, Clinical Research Group, NHSBT Oxford, John Radcliffe Hospital, Oxford, UK
Eur J Heart Fail 11:887-96. 2009..This study aimed to assess whether route of delivery and baseline left ventricular ejection fraction (LVEF) of the participants may also affect the outcome of BMSC treatment in patients with AMI and ischaemic heart disease (IHD)...
- Meta-analysis of cell therapy trials for patients with heart failureSheila A Fisher
From the Systematic Review Group, R and D Department, NHS Blood and Transplant, Oxford, UK S A F, C D Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK S A F, C D, E M R Department of Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK A M and Stem Cell Research Laboratory, R and D Department, NHS Blood and Transplant, Oxford, UK E M R
Circ Res 116:1361-77. 2015..Cell-based therapies are a promising intervention for the treatment of heart failure (HF) secondary to ischemic and nonischemic cardiomyopathy. However, the clinical efficacy of such new treatment requires further evaluation...
- Current evidence of the efficacy of cell-based therapies in heart failureEmma Harvey
Stem Cell Research Laboratory, NHS Blood and Transplant
Circ J 79:229-36. 2015....
- Iron particles for noninvasive monitoring of bone marrow stromal cell engraftment into, and isolation of viable engrafted donor cells from, the heartDaniel J Stuckey
Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, UK, OX1 3PT
Stem Cells 24:1968-75. 2006..The magnetic properties of the iron-labeled donor cells can be used for their isolation from host tissue to enable further characterization...
- Functional requirements for fukutin-related protein in the Golgi apparatusChris T Esapa
Department of Pharmacology, University of Oxford, Oxford, UK
Hum Mol Genet 11:3319-31. 2002..Aberrant processing of dystroglycan caused by a mislocalized FKRP mutant could be a novel mechanism that causes congenital muscular dystrophy...
- CXCR2 modulates bone marrow vascular repair and haematopoietic recovery post-transplantSarah J M Hale
Stem Cell Research Laboratory, NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK Nuffield Division of Clinical and Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Br J Haematol 169:552-64. 2015..Taken together, our data demonstrate that CXCR2 regulates bone marrow blood vessel repair/regeneration and haematopoietic recovery, and clinically may be a therapeutic target for improving bone marrow transplantation. ..
- Stem cell plasticityEnca Martin-Rendon
Stem Cell Laboratory, National Blood Service, Oxford Centre, Oxford, UK
Br J Haematol 122:877-91. 2003
- New methods to titrate EIAV-based lentiviral vectorsEnca Martin-Rendon
Oxford BioMedica, Medawar Centre, Oxford Science Park, Robert Robinson Avenue, Oxford, OX4 4GA, UK
Mol Ther 5:566-70. 2002..They also allow us to determine the integration efficiency of different vector genomes. This technology has proved very useful, especially in the absence of marker genes and where vectors express multiple genes...
- The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formationMaria G Roubelakis
Stem Cell Research Laboratory, National Blood Service, NHS Blood and Transplant Authority, Oxford OX3 5BG, UK
J Cell Biochem 102:955-69. 2007..These studies thus provide the basis for defining the function of the mPZR isoforms in vivo, particularly with respect to their roles in regulating SHP-2-dependent cell migration during development...
- Glycosylation defects and muscular dystrophyDerek J Blake
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
Adv Exp Med Biol 564:97-8. 2005
- Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI studyCarolyn A Carr
Cardiac Metabolism Research Group, Dept of Physiology, Anatomy and Genetics, Sherrington Bldg, Univ of Oxford, Parks Road Oxford, United Kingdom OX1 3PT
Am J Physiol Heart Circ Physiol 295:H533-42. 2008..However, no significant improvement in any measure of cardiac function was observed at any time. We conclude that cultured BMSCs are not the optimal cell population to treat the infarcted heart...