Gerald A Lincoln
Affiliation: National Institute for Medical Research
- Prolactin actions in the sheep testis: a test of the priming hypothesisG A Lincoln
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, United Kingdom
Biol Reprod 65:936-43. 2001..Testis diameter and inhibin A were marginally increased in group B + PRL. Overall, this thorough experiment provides minimal support for the priming hypothesis...
- Characterizing a mammalian circannual pacemakerGerald A Lincoln
Centre for Reproductive Biology, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Scotland
Science 314:1941-4. 2006..These new insights open the way for a molecular analysis of long-term timing mechanisms...
- Melatonin entrainment of circannual rhythmsGerald A Lincoln
MRC Biological Timing Group, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, UK
Chronobiol Int 23:301-6. 2006..This paper focuses on the pars tuberalis (PT) of the mammalian pituitary gland as a model melatonin-responsive tissue to investigate the molecular basis of these two basic long-term timing processes...
- Decoding the nightly melatonin signal through circadian clockworkGerald A Lincoln
MRC Biological Timing Group, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Mol Cell Endocrinol 252:69-73. 2006..The melatonin signal is thus decoded through circadian clock genes...
- Photorefractoriness in mammals: dissociating a seasonal timer from the circadian-based photoperiod responseGerald A Lincoln
The Queen s Medical Research Instiute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
Endocrinology 146:3782-90. 2005..Under constant photoperiod the two timers can dissociate, leading to the apparent refractory state...
- Clock genes in calendar cells as the basis of annual timekeeping in mammals--a unifying hypothesisG A Lincoln
Medical Research Council, Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
J Endocrinol 179:1-13. 2003....
- Prolactin cycles in sheep under constant photoperiod: evidence that photorefractoriness develops within the pituitary gland independently of the prolactin output signalG A Lincoln
Medical Research Council, Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
Biol Reprod 69:1416-23. 2003..The results support the conclusion that photorefractoriness is regulated at the level of the pituitary gland independently of the PRL output signal...
- Neuroendocrine regulation of seasonal gonadotrophin and prolactin rhythms: lessons from the Soay ram modelG A Lincoln
MRC Human Reproductive Sciences Unit Centre for Reproductive Biology, 37 Chalmers Street Edinburgh EH3 9ET, UK
Reprod Suppl 59:131-47. 2002....
- The irritable male syndromeG A Lincoln
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, UK
Reprod Fertil Dev 13:567-76. 2001..The working hypothesis is that IMS is a transition state associated with low hypothalamic amine levels triggered, in part, by the withdrawal of opioid peptides...
- Clock genes and the long-term regulation of prolactin secretion: evidence for a photoperiod/circannual timer in the pars tuberalisG A Lincoln
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK
J Neuroendocrinol 15:390-7. 2003..A speculative, but testable, extension of this hypothesis is that intrinsically regulated changes in the phase of Per/Cry rhythms, regulates both photorefractoriness and the generation of circannual rhythms in prolactin secretion...
- Noradrenaline and dopamine regulation of prolactin secretion in sheep: role in prolactin homeostasis but not photoperiodismG A Lincoln
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, UK
J Neuroendocrinol 14:36-44. 2002..In contrast, the lack of responses to the antagonists in the HPD rams, support the view that neither DA, nor NA, mediate the photoperiodic control of PRL secretion...
- Temporal expression of seven clock genes in the suprachiasmatic nucleus and the pars tuberalis of the sheep: evidence for an internal coincidence timerGerald Lincoln
Medical Research Council, Human Reproductive Sciences Unit, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK
Proc Natl Acad Sci U S A 99:13890-5. 2002....
- Multiple effects of melatonin on rhythmic clock gene expression in the mammalian pars tuberalisJonathan D Johnston
School of Biological Sciences, University of Aberdeen, Scotland, UK
Endocrinology 147:959-65. 2006..Our results provide the first example of acute sensitivity of multiple clock genes to one endocrine stimulus and suggest that rising melatonin levels may reset circadian rhythms in the PT, independently of previous phase...
- Hypothesis: cyclical histogenesis is the basis of circannual timingDavid G Hazlerigg
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, UK
J Biol Rhythms 26:471-85. 2011..In this review, the authors discuss how testing this hypothesis will depend on the use of cellular/molecular tools and animal models borrowed from developmental biology and neural stem cell research...
- Sheep exhibit novel variations in the organization of the mammalian type II gonadotropin-releasing hormone receptor genePaula M Gault
Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh Academic Centre, Edinburgh EH16 4SB, United Kingdom
Endocrinology 145:2362-74. 2004..Testis and pituitary sections were negative with exon 1 riboprobes and exon 1 or 2-3 oligonucleotide probes in in situ hybridization. A hepta-helical type II GnRH receptor is therefore not expressed from this sheep gene...
- An investigation of the effectiveness of testosterone implants in combination with the prolactin inhibitor quinagolide in the suppression of spermatogenesis in menW Morton Hair
MRC Human Reproductive Sciences Unit, The University of Edinburgh, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
Hum Reprod 18:749-55. 2003....
- A physiological model of a circannual oscillatorDuncan J Macgregor
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
J Biol Rhythms 23:252-64. 2008..The circannual oscillation requires a delayed negative feedback mechanism. The authors highlight specific features of the pituitary dynamics as a guide to future research on circannual rhythms...
- Long-day suppressed expression of type 2 deiodinase gene in the mediobasal hypothalamus of the Saanen goat, a short-day breeder: implication for seasonal window of thyroid hormone action on reproductive neuroendocrine axisShinobu Yasuo
Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
Endocrinology 147:432-40. 2006..This long-day suppression of Dio2 may provide a mechanism that accounts for the lack of responsiveness to thyroxine during the mid to late anestrus...
- Photoperiod effects on gene expression for hypothalamic appetite-regulating peptides and food intake in the ramIain J Clarke
Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
Am J Physiol Regul Integr Comp Physiol 284:R101-15. 2003..We conclude that photoperiod-induced increase in VFI correlates with expression of NPY, but not with expression of genes for other putative orexigenic peptides. Ob-Rb gene expression is regulated by photoperiod...
- Influence of photoperiod and gonadal status on food intake, adiposity, and gene expression of hypothalamic appetite regulators in a seasonal mammalChantacha Anukulkitch
Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
Am J Physiol Regul Integr Comp Physiol 292:R242-52. 2007....
- Redefining the limits of day length responsiveness in a seasonal mammalGabriela C Wagner
School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, United Kingdom
Endocrinology 149:32-9. 2008..This adaptive mechanism may be related to the latitude of origin and the timing of the seasonal transitions...
- Ancestral TSH mechanism signals summer in a photoperiodic mammalElodie A Hanon
School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland
Curr Biol 18:1147-52. 2008..In mammals this provides the missing link between the pineal melatonin signal and thyroid-dependent seasonal biology...