H N Jabbour

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint Cloning, sequencing and functional analysis of a truncated cDNA encoding red deer prolactin receptor: an alternative tyrosine residue mediates beta-casein promoter activation
    H N Jabbour
    Institute of Zoology, London, UK
    Mol Cell Endocrinol 123:17-26. 1996
  2. ncbi request reprint Pattern and localisation of expression of vascular endothelial growth factor and its receptor flt-1 in the ovine pituitary gland: expression is independent of hypothalamic control
    H N Jabbour
    MRC Reproductive Biology Unit, Edinburgh, UK
    Mol Cell Endocrinol 134:91-100. 1997
  3. ncbi request reprint Expression of functional prolactin receptors in nonpregnant human endometrium: janus kinase-2, signal transducer and activator of transcription-1 (STAT1), and STAT5 proteins are phosphorylated after stimulation with prolactin
    H N Jabbour
    Medical Research Council Reproductive Biology Unit, Center for Reproductive Biology, Edinburgh, United Kingdom
    J Clin Endocrinol Metab 83:2545-53. 1998
  4. ncbi request reprint Prolactin receptor expression in the testis of the ram: localisation, functional activation and the influence of gonadotrophins
    H N Jabbour
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, UK
    Mol Cell Endocrinol 148:151-61. 1999
  5. ncbi request reprint Localization of interferon regulatory factor-1 (IRF-1) in nonpregnant human endometrium: expression of IRF-1 is up-regulated by prolactin during the secretory phase of the menstrual cycle
    H N Jabbour
    Medical Research Council Reproductive Biology Unit, University of Edinburgh Center for Reproductive Biology, United Kingdom
    J Clin Endocrinol Metab 84:4260-5. 1999
  6. ncbi request reprint Expression, localization, and signaling of PGE(2) and EP2/EP4 receptors in human nonpregnant endometrium across the menstrual cycle
    S A Milne
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, United Kingdom EH3 9ET
    J Clin Endocrinol Metab 86:4453-9. 2001
  7. ncbi request reprint Expression of COX-2 and PGE synthase and synthesis of PGE(2)in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors
    H N Jabbour
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh, EH3 9ET, United Kingdom
    Br J Cancer 85:1023-31. 2001
  8. ncbi request reprint Prostaglandin E2 induces proliferation of glandular epithelial cells of the human endometrium via extracellular regulated kinase 1/2-mediated pathway
    H N Jabbour
    Medical Research Council Human Reproductive Sciences Unit, The University of Edinburgh Academic Centre, Edinburgh, Scotland EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 88:4481-7. 2003
  9. pmc F-prostanoid receptor alters adhesion, morphology and migration of endometrial adenocarcinoma cells
    K J Sales
    MRC Human Reproductive Sciences Unit, Medical Research Council, The Queen s Medical Research Institute, Edinburgh, UK
    Oncogene 27:2466-77. 2008
  10. ncbi request reprint Prolactin actions in the sheep testis: a test of the priming hypothesis
    G A Lincoln
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, United Kingdom
    Biol Reprod 65:936-43. 2001

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Cloning, sequencing and functional analysis of a truncated cDNA encoding red deer prolactin receptor: an alternative tyrosine residue mediates beta-casein promoter activation
    H N Jabbour
    Institute of Zoology, London, UK
    Mol Cell Endocrinol 123:17-26. 1996
    ..Northern blot analysis of red deer testis suggests that this species expresses a second form of the receptor, encoded by a transcript of 1.7 kb, which may correspond to a smaller receptor form or a binding protein...
  2. ncbi request reprint Pattern and localisation of expression of vascular endothelial growth factor and its receptor flt-1 in the ovine pituitary gland: expression is independent of hypothalamic control
    H N Jabbour
    MRC Reproductive Biology Unit, Edinburgh, UK
    Mol Cell Endocrinol 134:91-100. 1997
    ....
  3. ncbi request reprint Expression of functional prolactin receptors in nonpregnant human endometrium: janus kinase-2, signal transducer and activator of transcription-1 (STAT1), and STAT5 proteins are phosphorylated after stimulation with prolactin
    H N Jabbour
    Medical Research Council Reproductive Biology Unit, Center for Reproductive Biology, Edinburgh, United Kingdom
    J Clin Endocrinol Metab 83:2545-53. 1998
    ..The target genes activated by PRL in the glandular epithelium of the nonpregnant human endometrium remain to be elucidated...
  4. ncbi request reprint Prolactin receptor expression in the testis of the ram: localisation, functional activation and the influence of gonadotrophins
    H N Jabbour
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, UK
    Mol Cell Endocrinol 148:151-61. 1999
    ..The site and pattern of expression of the receptor gene suggest a role for prolactin in the regulation of steroidogenesis and spermatogenesis...
  5. ncbi request reprint Localization of interferon regulatory factor-1 (IRF-1) in nonpregnant human endometrium: expression of IRF-1 is up-regulated by prolactin during the secretory phase of the menstrual cycle
    H N Jabbour
    Medical Research Council Reproductive Biology Unit, University of Edinburgh Center for Reproductive Biology, United Kingdom
    J Clin Endocrinol Metab 84:4260-5. 1999
    ....
  6. ncbi request reprint Expression, localization, and signaling of PGE(2) and EP2/EP4 receptors in human nonpregnant endometrium across the menstrual cycle
    S A Milne
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, United Kingdom EH3 9ET
    J Clin Endocrinol Metab 86:4453-9. 2001
    ....
  7. ncbi request reprint Expression of COX-2 and PGE synthase and synthesis of PGE(2)in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors
    H N Jabbour
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh, EH3 9ET, United Kingdom
    Br J Cancer 85:1023-31. 2001
    ..42 +/- 0.46 vs 1.15 +/- 0.05 respectively; P< 0.001). In conclusion, these data suggest that PGE(2)may regulate neoplastic cell function in an autocrine/paracrine manner via the EP2/EP4 receptors...
  8. ncbi request reprint Prostaglandin E2 induces proliferation of glandular epithelial cells of the human endometrium via extracellular regulated kinase 1/2-mediated pathway
    H N Jabbour
    Medical Research Council Human Reproductive Sciences Unit, The University of Edinburgh Academic Centre, Edinburgh, Scotland EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 88:4481-7. 2003
    ....
  9. pmc F-prostanoid receptor alters adhesion, morphology and migration of endometrial adenocarcinoma cells
    K J Sales
    MRC Human Reproductive Sciences Unit, Medical Research Council, The Queen s Medical Research Institute, Edinburgh, UK
    Oncogene 27:2466-77. 2008
    ..These results reveal a mechanism by which prostanoids regulate cell movement, which may be relevant to pathologies of the endometrium...
  10. ncbi request reprint Prolactin actions in the sheep testis: a test of the priming hypothesis
    G A Lincoln
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, United Kingdom
    Biol Reprod 65:936-43. 2001
    ..Testis diameter and inhibin A were marginally increased in group B + PRL. Overall, this thorough experiment provides minimal support for the priming hypothesis...
  11. ncbi request reprint Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle
    S Battersby
    Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 89:2463-9. 2004
    ..91 +/- 0.75-fold elevation in PK1 expression, compared with controls (P < 0.05). These data identify a paracrine role for the PKs and their receptors in endometrial vascular function...
  12. ncbi request reprint Prolactin receptor expression in human testis and accessory tissues: localization and function
    W M Hair
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9EW, UK
    Mol Hum Reprod 8:606-11. 2002
    ..The demonstration of function and localization of PRL-R presented here suggests multiple roles for PRL in the human male reproductive tract...
  13. pmc Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulate
    S Battersby
    Medical Research Council Human Reproductive Science Unit, The Queen s Medical Research Institute, Edinburgh, UK
    Hum Reprod 22:36-44. 2007
    ..Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma...
  14. pmc Cyclooxygenase enzyme expression and E series prostaglandin receptor signalling are enhanced in heavy menstruation
    O P Milling Smith
    Department of Reproductive and Developmental Sciences, The University of Edinburgh, Edinburgh, UK
    Hum Reprod 22:1450-6. 2007
    ..This study was initiated to elucidate a pattern of expression of the various components of the cyclooxygenase (COX)-prostaglandin signalling pathways present in the endometrium of women with normal and heavy MBLs...
  15. ncbi request reprint Potential roles of decidual prolactin in early pregnancy
    H N Jabbour
    MRC Human Reproductive Sciences Unit and Obstetrics and Gynaecology, Department of Reproductive and Development Sciences, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Reproduction 121:197-205. 2001
    ..Localization of the sites of expression of the prolactin receptor indicates that the cytokine may regulate an array of functions in the pregnant uterus that are crucial in im-plantation and early pregnancy...
  16. ncbi request reprint Source and site of action of anti-luteolytic interferon in red deer (Cervus elaphus): possible involvement of extra-ovarian oxytocin secretion in maternal recognition of pregnancy
    D R Bainbridge
    Zoological Society of London, Institute of Zoology, UK
    J Reprod Fertil 116:305-13. 1999
    ....
  17. pmc Temporal expression and signalling of prostacyclin receptor in the human endometrium across the menstrual cycle
    S Battersby
    MRC Human Reproductive Sciences Unit and Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh Chancellor s Building, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Reproduction 127:79-86. 2004
    ..This may underscore a pivotal role for PGI(2) receptor signalling in normal and dysfunctional menstruation...
  18. ncbi request reprint Prolactin induces ERK phosphorylation in epithelial and CD56(+) natural killer cells of the human endometrium
    O Gubbay
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Centre for Reproductive Biology, Edinburgh EH3 9ET, United Kingdom
    J Clin Endocrinol Metab 87:2329-35. 2002
    ..Our data demonstrate that PRL stimulates the ERK pathway in multiple cellular compartments of the human endometrium and identify uterine CD56(+) NK cells as novel PRL target cells...
  19. doi request reprint Placental structure and inflammation in pregnancies associated with obesity
    K A Roberts
    University of Edinburgh, Queens Medical Research Institute, Little France Crescent, Edinburgh, UK
    Placenta 32:247-54. 2011
    ..The aim of this study was to characterise the maternal and placental inflammatory status and investigate associated changes in placental structure in obese women...
  20. ncbi request reprint Sequence and functional characterisation of the marmoset monkey (Callithrix jacchus) prolactin receptor: comparative homology with the human long-form prolactin receptor
    A Dalrymple
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, EH3 9ET, Edinburgh, UK
    Mol Cell Endocrinol 167:89-97. 2000
    ..The marmoset monkey may provide a useful tool to investigate the role of prolactin in primate reproduction...
  21. ncbi request reprint Prostaglandin receptor signalling and function in human endometrial pathology
    H N Jabbour
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Academic Centre, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK
    Trends Endocrinol Metab 15:398-404. 2004
    ..The potential role of prostaglandin receptors in pathological changes of the endometrium has significance for the future development of therapeutic interventions...
  22. ncbi request reprint Cyclooxygenase enzymes and prostaglandins in reproductive tract physiology and pathology
    K J Sales
    MRC Human Reproductive Sciences Unit, Center for Reproductive Biology, The University of Edinburgh Academic Center, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Prostaglandins Other Lipid Mediat 71:97-117. 2003
    ....
  23. ncbi request reprint Autocrine/paracrine regulation of apoptosis in epithelial cells by prostaglandin E2
    H N Jabbour
    Human Reproductive Sciences, Centre for Reproductive Biology, The University of Edinburg Academic Centre, 49 Little France Crescent, UK
    Prostaglandins Leukot Essent Fatty Acids 67:357-63. 2002
    ..These data demonstrate that PGE(2) inhibits apoptosis of epithelial cells possibly via cAMP-dependent pathway...
  24. doi request reprint Endocrine immune interactions in human parturition
    E Golightly
    University of Edinburgh, Division of Reproductive and Developmental Sciences, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Mol Cell Endocrinol 335:52-9. 2011
    ..We propose that amongst these complex interactions it is the immune system that is the driving force behind human parturition...
  25. pmc Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors
    K J Sales
    Department of Medical Biochemistry, University of Cape Town Medical School, Observatory, Cape Town 7925, South Africa
    J Clin Endocrinol Metab 86:2243-9. 2001
    ....