Alexander Hammers

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint Flumazenil positron emission tomography and other ligands for functional imaging
    Alexander Hammers
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, 33 Queen Square, London WC1N 3BG, UK
    Neuroimaging Clin N Am 14:537-51. 2004
  2. ncbi request reprint Statistical neuroanatomy of the human inferior frontal gyrus and probabilistic atlas in a standard stereotaxic space
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Hum Brain Mapp 28:34-48. 2007
  3. ncbi request reprint Automatic detection and quantification of hippocampal atrophy on MRI in temporal lobe epilepsy: a proof-of-principle study
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, Hammersmith Hospital, DuCane Road, London, UK
    Neuroimage 36:38-47. 2007
  4. ncbi request reprint Balancing bias, reliability, noise properties and the need for parametric maps in quantitative ligand PET: [(11)C]diprenorphine test-retest data
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, DuCane Road, London, UK
    Neuroimage 38:82-94. 2007
  5. ncbi request reprint A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195
    Alexander N Anderson
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, UK
    Neuroimage 36:28-37. 2007
  6. doi request reprint Improving intersubject image registration using tissue-class information benefits robustness and accuracy of multi-atlas based anatomical segmentation
    Rolf A Heckemann
    Division of Neuroscience and Mental Health, Faculty of Medicine, Department of Computing, Imperial College, London, UK
    Neuroimage 51:221-7. 2010
  7. doi request reprint Measurement of hippocampal atrophy using 4D graph-cut segmentation: application to ADNI
    Robin Wolz
    Department of Computing, Imperial College London, London, UK
    Neuroimage 52:109-18. 2010
  8. ncbi request reprint Upregulation of opioid receptor binding following spontaneous epileptic seizures
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Brain 130:1009-16. 2007
  9. ncbi request reprint Multiclassifier fusion in human brain MR segmentation: modelling convergence
    Rolf A Heckemann
    Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College at Hammersmith Hospital Campus, London, UK
    Med Image Comput Comput Assist Interv 9:815-22. 2006
  10. ncbi request reprint [11C]Flumazenil PET in temporal lobe epilepsy: do we need an arterial input function or kinetic modeling?
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 28:207-16. 2008

Detail Information

Publications56

  1. ncbi request reprint Flumazenil positron emission tomography and other ligands for functional imaging
    Alexander Hammers
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, 33 Queen Square, London WC1N 3BG, UK
    Neuroimaging Clin N Am 14:537-51. 2004
    ..Future studies aiming to elucidate the pathophysiology of IGEs may benefit from the use of subtype-specific opioid ligands, available now, and GABAB ligands, if and when they become available...
  2. ncbi request reprint Statistical neuroanatomy of the human inferior frontal gyrus and probabilistic atlas in a standard stereotaxic space
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Hum Brain Mapp 28:34-48. 2007
    ..Applications include probabilistic determination of location in group studies, automatic labeling of new scans, and detection of anatomical abnormalities in patients...
  3. ncbi request reprint Automatic detection and quantification of hippocampal atrophy on MRI in temporal lobe epilepsy: a proof-of-principle study
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, Hammersmith Hospital, DuCane Road, London, UK
    Neuroimage 36:38-47. 2007
    ..The method has the potential to automatically detect unilateral HA, but further work is needed to determine its performance in detecting clinically important bilateral disease...
  4. ncbi request reprint Balancing bias, reliability, noise properties and the need for parametric maps in quantitative ligand PET: [(11)C]diprenorphine test-retest data
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, DuCane Road, London, UK
    Neuroimage 38:82-94. 2007
    ..86) but unacceptably low for VOI-derived VD estimates at the low doses of injected radioactivity (0.24/0.04). Our data can inform the choice of methodology for a given biological problem...
  5. ncbi request reprint A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195
    Alexander N Anderson
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, UK
    Neuroimage 36:28-37. 2007
    ..The reference-to-target ratio and the Logan graphical approach were significantly less reliable and less sensitive...
  6. doi request reprint Improving intersubject image registration using tissue-class information benefits robustness and accuracy of multi-atlas based anatomical segmentation
    Rolf A Heckemann
    Division of Neuroscience and Mental Health, Faculty of Medicine, Department of Computing, Imperial College, London, UK
    Neuroimage 51:221-7. 2010
    ....
  7. doi request reprint Measurement of hippocampal atrophy using 4D graph-cut segmentation: application to ADNI
    Robin Wolz
    Department of Computing, Imperial College London, London, UK
    Neuroimage 52:109-18. 2010
    ..Power analysis shows that 67 and 206 subjects are needed for the AD and MCI groups respectively to detect a 25% change in volume loss with 80% power and 5% significance...
  8. ncbi request reprint Upregulation of opioid receptor binding following spontaneous epileptic seizures
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Brain 130:1009-16. 2007
    ..This study provides direct human in vivo evidence for changes in opioid receptor availability over a time course of hours following spontaneous seizures, emphasizing an important role of the opioid system in seizure control...
  9. ncbi request reprint Multiclassifier fusion in human brain MR segmentation: modelling convergence
    Rolf A Heckemann
    Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College at Hammersmith Hospital Campus, London, UK
    Med Image Comput Comput Assist Interv 9:815-22. 2006
    ..Fit parameters of this model are potential indicators of the quality of a given label propagation method or the consistency of the input segmentations used...
  10. ncbi request reprint [11C]Flumazenil PET in temporal lobe epilepsy: do we need an arterial input function or kinetic modeling?
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 28:207-16. 2008
    ..Full quantification with an image-independent input should ideally be used in the evaluation of FMZ PET; at least in TLE, intrasubject correlations do not predict equivalent clinical usefulness...
  11. ncbi request reprint Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Hum Brain Mapp 19:224-47. 2003
    ..Its potential applications range from the automatic labeling of new scans to the detection of anatomical abnormalities in patients. Further data can be extracted from the atlas for the detailed analysis of individual structures...
  12. ncbi request reprint Reference and target region modeling of [11C]-(R)-PK11195 brain studies
    Federico E Turkheimer
    Division of Neuroscience, Department of Clinical Neuroscience, Imperial College London, London, United Kingdom
    J Nucl Med 48:158-67. 2007
    ....
  13. doi request reprint Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effect
    Colm J McGinnity
    Centre for Neuroscience, Department of Medicine, Imperial College London, London W12 0NN, UK
    Neuroimage 79:72-80. 2013
    ..Denoising, resolution recovery and precise anatomical segmentation can extract valuable information from PET studies that would be missed with conventional post-processing procedures...
  14. ncbi request reprint Fully automatic segmentation of the hippocampus and the amygdala from MRI using hybrid prior knowledge
    Marie Chupin
    Department of Clinical and Experimental Epilepsy, ION, UCL, London, UK
    Med Image Comput Comput Assist Interv 10:875-82. 2007
    ..001) for Hc and from 81% to 84% (p < 0.002) for Am, with equivalent improvements in volume error...
  15. pmc Automatic volumetry on MR brain images can support diagnostic decision making
    Rolf A Heckemann
    Division of Neurosciences and Mental Health, Imperial College London, Hammersmith Campus, Du Cane Road, London, UK
    BMC Med Imaging 8:9. 2008
    ....
  16. doi request reprint Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    Paul Edison
    MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 32:412-9. 2008
    ..MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage...
  17. pmc Classification and lateralization of temporal lobe epilepsies with and without hippocampal atrophy based on whole-brain automatic MRI segmentation
    Shiva Keihaninejad
    Division of Experimental Medicine, Centre for Neuroscience, Faculty of Medicine, Imperial College London, United Kingdom
    PLoS ONE 7:e33096. 2012
    ..Such morphometric image features may serve as classification and lateralization criteria. The technique also detects unsuspected distinguishing features like the substantia nigra, warranting further study...
  18. doi request reprint Identifying population differences in whole-brain structural networks: a machine learning approach
    Emma C Robinson
    Department of Computing, Imperial College London, London, UK
    Neuroimage 50:910-9. 2010
    ..We show that subjects can be classified successfully (with 87.46% accuracy) and that the features extracted from the discriminant analysis agree with current consensus on the neurological impact of ageing...
  19. ncbi request reprint Grey and white matter flumazenil binding in neocortical epilepsy with normal MRI. A PET study of 44 patients
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Brain 126:1300-18. 2003
    ..FMZ binding increases, particularly periventricular increases, were a prominent feature of MRI-negative focal epilepsies and may represent neuronal migration disturbances...
  20. ncbi request reprint Volumes, spatial extents and a probabilistic atlas of the human basal ganglia and thalamus
    R Laila Ahsan
    Division of Neuroscience, Faculty of Medicine, Imperial College, and MRC Clinical Sciences Centre, Hammersmith Hospital, DuCane Road, London, UK
    Neuroimage 38:261-70. 2007
    ..We present a comprehensive assessment of thalamic and basal ganglia volumetric and geometric data in both native and stereotaxic spaces. Probabilistic maps in MNI/ICBM152 space will allow accurate localization in group analyses...
  21. ncbi request reprint Multivariate statistical analysis of whole brain structural networks obtained using probabilistic tractography
    Emma C Robinson
    Department of Computing, Imperial College, London SW7 2BZ, UK
    Med Image Comput Comput Assist Interv 11:486-93. 2008
    ..Classification performance was tested using a leave-one-out approach and the mean accuracy obtained was 85.4%...
  22. ncbi request reprint The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study
    Sarah von Spiczak
    Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
    Brain 128:906-17. 2005
    ..We therefore discuss a possible role for opioids in the pathophysiology of RLS with respect to sensory and motor symptoms...
  23. pmc A robust method to estimate the intracranial volume across MRI field strengths (1.5T and 3T)
    Shiva Keihaninejad
    Division of Neuroscience and Mental Health, MRC Clinical Sciences Centre, Imperial College London, London, UK
    Neuroimage 50:1427-37. 2010
    ..RBM achieved the best combination of precision and reliability in a group of healthy subjects, a group of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) and can be used as a common normalization framework...
  24. ncbi request reprint Automatic anatomical brain MRI segmentation combining label propagation and decision fusion
    Rolf A Heckemann
    Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College at Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK
    Neuroimage 33:115-26. 2006
    ..We demonstrate a practicable procedure that exceeds the accuracy of previous automatic methods and can compete with manual delineations...
  25. pmc Magnetic resonance imaging of the newborn brain: automatic segmentation of brain images into 50 anatomical regions
    Ioannis S Gousias
    Faculty of Medicine, Imperial College London, and Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, London, United Kingdom
    PLoS ONE 8:e59990. 2013
    ..This registration approach allows the rapid construction of automatically labeled age-specific brain atlases for neonates and the developing brain...
  26. pmc LEAP: learning embeddings for atlas propagation
    Robin Wolz
    Visual Information Processing Group, Department of Computing, Imperial College London, 180 Queen s Gate, London, SW7 2AZ, UK
    Neuroimage 49:1316-25. 2010
    ..with a greater difference between atlas and image. For the segmentation of the hippocampus on 182 images for which a manual segmentation is available, we achieved an average overlap (Dice coefficient) of 0.85 with the manual reference...
  27. ncbi request reprint Diffeomorphic registration using B-splines
    Daniel Rueckert
    Department of Computing, Imperial College London, UK
    Med Image Comput Comput Assist Interv 9:702-9. 2006
    ..The results show that the proposed algorithm generates diffeomorphic transformations while providing similar levels of performance as the existing FFD registration algorithm in terms of registration accuracy...
  28. pmc Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP
    Daniela A Riaño Barros
    Centre for Neuroscience, Department of Medicine, Imperial College London, London, UK MRC Clinical Sciences Centre Hammersmith Hospital, London, UK
    Neuroimage 97:151-62. 2014
    ..The objective of this study was to quantify the test-retest reproducibility of measures of the PET ligand [(11)C]MePPEP in order to assess the stability of CB1-receptor quantification in humans in vivo...
  29. doi request reprint Initial evaluation of 18F-GE-179, a putative PET Tracer for activated N-methyl D-aspartate receptors
    Colm J McGinnity
    Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom
    J Nucl Med 55:423-30. 2014
    ..4 nM. No significant binding was observed with 10 nM GE-179 at 60 other neuroreceptors, channels, or transporters. We describe the kinetic behavior of the radioligand in vivo in humans...
  30. doi request reprint Global-two-stage filtering of clinical PET parametric maps: application to [(11)C]-(R)-PK11195
    Giampaolo Tomasi
    MRC Clinical Sciences Center and Division of Medicine, Imperial College, London, UK
    Neuroimage 55:942-53. 2011
    ..In this work GTS performance is assessed in a clinical context using the neuroinflammation marker [(11)C]-(R)-PK11195 applied to a cohort of Huntington's disease (HD) patients with and without symptoms...
  31. ncbi request reprint Periventricular white matter flumazenil binding and postoperative outcome in hippocampal sclerosis
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Epilepsia 46:944-8. 2005
    ..White matter (WM) [11C]flumazenil volume of distribution (FMZ-Vd) reflects the number of neuronal cell bodies in WM. Our objective was to correlate WM FMZ-Vd in patients with unilateral HS and postsurgical outcome...
  32. pmc Random forest-based similarity measures for multi-modal classification of Alzheimer's disease
    Katherine R Gray
    Biomedical Image Analysis Group, Department of Computing, Imperial College London, UK
    Neuroimage 65:167-75. 2013
    ..Random forest classifiers extend naturally to multi-class problems, and the framework described here could be applied to distinguish between multiple patient groups in the future...
  33. pmc Multi-region analysis of longitudinal FDG-PET for the classification of Alzheimer's disease
    Katherine R Gray
    Biomedical Image Analysis Group, Department of Computing, Imperial College London, UK
    Neuroimage 60:221-9. 2012
    ..This finding may be usefully applied in the diagnosis of Alzheimer's disease, predicting disease course in individuals with mild cognitive impairment, and in the selection of participants for clinical trials...
  34. doi request reprint Glutamate NMDA receptor dysregulation in Parkinson's disease with dyskinesias
    Imtiaz Ahmed
    Centre for Neuroscience, Imperial College, London, UK
    Brain 134:979-86. 2011
    ..They support the hypothesis that blockade of glutamate transmission may have a place in the management of disabling dyskinesias in Parkinson's disease...
  35. doi request reprint Evaluation of atlas-based segmentation of hippocampi in healthy humans
    Roman Rodionov
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Magn Reson Imaging 27:1104-9. 2009
    ..Our study aims at evaluating the spatial correspondence of hippocampal ROIs obtained using three brain atlases with hippocampal ROI obtained using an automatic segmentation algorithm dedicated to the hippocampus...
  36. pmc Brain Extraction Using Label Propagation and Group Agreement: Pincram
    Rolf A Heckemann
    MedTech West at Sahlgrenska University Hospital, Gothenburg, Sweden Institute of Neuroscience and Physiology, Gothenburg University, Gothenburg, Sweden Centre for Brain Sciences, Imperial College, London, United Kingdom The Neurodis Foundation, Lyon, France
    PLoS ONE 10:e0129211. 2015
    ..Via a novel self-monitoring feature, the program generates the "success index," a scalar metadatum indicative of the accuracy of the output label. Pincram is available as open source software. ..
  37. ncbi request reprint Automatic segmentation of the brain and intracranial cerebrospinal fluid in T1-weighted volume MRI scans of the head, and its application to serial cerebral and intracranial volumetry
    Louis Lemieux
    Epilepsy Research Group, Department of Clinical Neurology, Institute of Neurology, London, UK
    Magn Reson Med 49:872-84. 2003
    ..0 cm(3) for the intracranial volume (ICV). Scan-matching reduced CR to 25.2 cm(3) and 17.1 cm(3) for the TBV and ICV, respectively. For the patients, similar CR values were obtained for the ICV...
  38. doi request reprint Magnetic resonance imaging of the newborn brain: manual segmentation of labelled atlases in term-born and preterm infants
    Ioannis S Gousias
    Centre for the Developing Brain, Imperial College London, and MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Neuroimage 62:1499-509. 2012
    ..Detailed illustrated protocols are made available in the Appendix...
  39. doi request reprint Automatic segmentation of brain MRIs of 2-year-olds into 83 regions of interest
    Ioannis S Gousias
    Imaging Sciences Department, MRC Clinical Sciences Centre and Department of Pediatrics, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Neuroimage 40:672-84. 2008
    ..90+/-0.01, 0.90+/-0.01 and 0.88+/-0.03 respectively. This registration approach allows the rapid construction of automatically labelled age-specific brain atlases for children at the age of 2 years...
  40. ncbi request reprint In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
    Alexander Gerhard
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Neurobiol Dis 21:404-12. 2006
    ..The absence of significant longitudinal changes suggests that microglia are activated early in the disease process, and levels then remain relatively static, possibly driving the disease via cytokine release...
  41. doi request reprint Tailored excitation in 3D with spiral nonselective (SPINS) RF pulses
    Shaihan J Malik
    Robert Steiner MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, UK
    Magn Reson Med 67:1303-15. 2012
    ..Greatest performance enhancement was achieved using parallel transmission, but single channel transmission offers significant improvement over standard excitation pulses...
  42. ncbi request reprint Opioid imaging
    Alexander Hammers
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Neuroimaging Clin N Am 16:529-52, vii. 2006
    ..In the coming decade, we hope to see a more widespread application of the techniques developed in healthy volunteers to patients and more clinical impact of opioid imaging...
  43. ncbi request reprint Progressive neocortical damage in epilepsy
    Rebecca S N Liu
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 53:312-24. 2003
    ..Our results show that ongoing cerebral atrophy may be widespread and remote from the putative epileptic focus, possibly reflecting extensive networks and interconnections between cortical regions...
  44. ncbi request reprint Opioid binding in DYT1 primary torsion dystonia: an 11C-diprenorphine PET study
    Alan L Whone
    Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Mov Disord 19:1498-503. 2004
    ..We conclude that aberrant opioid transmission is unlikely to be present in DYT1-PTD and altered opioid transmission is not a common mechanism underlying all disorders of involuntary movement...
  45. ncbi request reprint Implementation and application of a brain template for multiple volumes of interest
    Alexander Hammers
    Neuroscience Group of the Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, United Kingdom
    Hum Brain Mapp 15:165-74. 2002
    ..It can be used for different imaging modalities and in different orientations. It is necessary that imaging data for groups compared are acquired in the same orientation...
  46. pmc Using [(11)C]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism
    Anne Lingford-Hughes
    Centre for Neuropsychopharmacology, Imperial College London, Du Cane Rd, London W12 0NN, United Kingdom Psychopharmacology Unit, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom Hammersmith Imanet Ltd, Hammersmith Hospital, Du Cane Rd, London W12 0NN, United Kingdom Electronic address
    Neuroimage 132:1-7. 2016
    ..We suggest that reduced α5 levels in the nucleus accumbens are associated with addiction since we have now shown this in dependence to two pharmacologically different substances, alcohol and opiates. ..
  47. doi request reprint Opioid Imaging
    Alexander Hammers
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK Epilepsy Group, MRC Clinical Sciences Centre, Room 243, Cyclotron Building, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK Electronic address
    PET Clin 2:67-89. 2007
    ..In the coming decade, there should be a more widespread application of the available techniques to patients and an impact in clinical medicine. ..
  48. pmc Neurological features of epilepsy, ataxia, sensorineural deafness, tubulopathy syndrome
    J Helen Cross
    Neurosciences Unit, Great Ormond Street Hospital for Children NHS Trust and UCL Institute of Child Health, London, UK
    Dev Med Child Neurol 55:846-56. 2013
    ..Here, we provide a detailed characterization of the clinical features of the syndrome to aid patient management with respect to diagnosis, prognostic counselling, and identification of best treatment modalities...
  49. ncbi request reprint Similarity metrics for groupwise non-rigid registration
    Kanwal K Bhatia
    Visual Information Processing, Department of Computing, Imperial College London
    Med Image Comput Comput Assist Interv 10:544-52. 2007
    ..The described groupwise metrics are quantitatively evaluated on simulated and 3D MR datasets, and their performance compared to equivalent pairwise registration...
  50. ncbi request reprint Positron emission tomography partial volume correction: estimation and algorithms
    John A D Aston
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada
    J Cereb Blood Flow Metab 22:1019-34. 2002
    ..The suitability of their application to dynamic and static images is discussed...
  51. ncbi request reprint Brain opioid receptor binding in early abstinence from opioid dependence: positron emission tomography study
    Tim M Williams
    Psychopharmacology Unit, University of Bristol, and Bristol Specialist Drug Service, Blackberry Hill Hospital, UK
    Br J Psychiatry 191:63-9. 2007
    ..Although opioid receptor function in humans is clearly reduced during opioid dependence, what happens to the receptor in early abstinence is not understood...
  52. ncbi request reprint Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil
    Oliver Langer
    Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Medical University of Vienna, Vienna, Austria
    Epilepsia 48:1774-84. 2007
    ..We compared R-[(11)C]verapamil kinetics in homologous brain volumes of interest (VOIs) located ipsilateral and contralateral to the seizure focus...
  53. ncbi request reprint Construction and validation of mean shape atlas templates for atlas-based brain image segmentation
    Qian Wang
    Katholieke Universiteit Leuven, Faculties of Medicine and Engineering, Medical Image Computing ESAT PSI, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Inf Process Med Imaging 19:689-700. 2005
    ....
  54. doi request reprint Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study
    Paul Wicks
    MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, Department of Psychology, London
    Amyotroph Lateral Scler 9:43-9. 2008
    ..This study indicates that [11C]-flumazenil PET can be used to help localize cortical regions associated with cognitive deficits in ALS...
  55. ncbi request reprint Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis
    Martin R Turner
    Department of Neurology, John Radcliffe Hospital, Oxford, UK
    Amyotroph Lateral Scler 8:343-7. 2007
    ..This study provides further evidence for a different pattern of cortical neuronal vulnerability in homD90A versus SALS patients that may provide insight as to their slower rate of disease progression...
  56. ncbi request reprint Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET
    Martin R Turner
    Department of Neurology, The Radcliffe Infirmary, Oxford, UK
    J Neurol 254:1033-6. 2007
    ....