Ross A Breckenridge
Affiliation: National Institute for Medical Research
- Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in miceRoss A Breckenridge
MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
J Mol Cell Cardiol 47:133-41. 2009..We propose that cardiac overexpression of Hand1 offers a useful mouse model of arrhythmogenesis and elevated HAND1 may provide one of the molecular links between the failing heart and arrhythmia...
- Heart failure and mouse modelsRoss Breckenridge
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
Dis Model Mech 3:138-43. 2010..This review outlines the mouse models of heart failure in common usage today, and discusses how adaptations in these models may allow easier translation of animal experimentation into the clinical arena...
- A mouse model to study the link between hypoxia, long QT interval and sudden infant death syndromeMarianne T Neary
Developmental Biology, MRC National Institute for Medical Research, London, NW7 1AA, UK
Dis Model Mech 6:503-7. 2013..This is consistent with known risk factors of SIDS and provides a link between neonatal hypoxia, ECG abnormalities and sudden death...
- Abundance, distribution, mobility and oligomeric state of M₂ muscarinic acetylcholine receptors in live cardiac muscleTatiana A Nenasheva
Division of Physical Biochemistry, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
J Mol Cell Cardiol 57:129-36. 2013..Our estimated encounter rate of 5-10 collisions per second, may explain the latency between acetylcholine application and GIRK channel opening...
- Isolated left ventricular non-compaction: the case for abnormal myocardial developmentRoss A Breckenridge
Department of Clinical Pharmacology, BHF Laboratories, University College, London
Cardiol Young 17:124-9. 2007..Experimental work in animal models provides several candidate transcription factors and signalling molecules that could, in theory, cause ventricular non-compaction if disrupted...
- A role for Dimethylarginine Dimethylaminohydrolase 1 (DDAH1) in mammalian developmentRoss A Breckenridge
Centre for Clinical Pharmacology, University College London, BHF Laboratories, London, UK
Int J Dev Biol 54:215-20. 2010..These expression patterns implicate DDAH1 and DDAH2 in embryonic development, possibly through specific effects on nitric oxide pathways...
- Hypoxia at the heart of sudden infant death syndrome?Marianne T Neary
MRC National Institute for Medical Research, Mill Hill, London, UK
Pediatr Res 74:375-9. 2013..Our model may integrate several epidemiological findings related to risks factors for SIDS, and agrees with previous work suggesting a common final pathological pathway in SIDS. ..
- Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and functionMarianne T Neary
MRC National Institute for Medical Research, Mill Hill, London NW7 1AA
J Mol Cell Cardiol 74:340-52. 2014..We therefore propose that the increase in ambient oxygen encountered by the neonate at birth acts as a key physiological stimulus to cardiac mitochondrial adaptation. ..
- Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolismRoss A Breckenridge
Developmental Biology, MRC National Institute for Medical Research, London, United Kingdom Division of Medicine, University College London, London, United Kingdom
PLoS Biol 11:e1001666. 2013..Understanding hypoxia adaptation in the fetal heart may allow development of strategies to protect cardiomyocytes vulnerable to ischaemia, for example during cardiac ischaemia or surgery. ..