Abraham Acevedo-Arozena

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint ENU mutagenesis, a way forward to understand gene function
    Abraham Acevedo-Arozena
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom
    Annu Rev Genomics Hum Genet 9:49-69. 2008
  2. pmc Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration
    Peter I Joyce
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 25:291-307. 2016
  3. pmc Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease
    Hilda Tateossian
    MRC Mammalian Genetics Unit, Harwell, UK
    Hum Mol Genet 22:2553-65. 2013
  4. pmc A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity
    Peter I Joyce
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 24:1883-97. 2015
  5. pmc Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice
    Silvia Corrochano
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, United Kingdom
    PLoS ONE 9:e105595. 2014

Collaborators

  • Vincent Plagnol
  • Arimantas Lionikas
  • Edward Ryder
  • Gillian P Bates
  • David C Rubinsztein
  • Roger D Cox
  • Steve Dm Brown
  • Peter I Joyce
  • Silvia Corrochano
  • Michelle Stewart
  • Sarah Carter
  • Philip McGoldrick
  • Pietro Fratta
  • Linda Greensmith
  • Elizabeth M C Fisher
  • Sebastian Brandner
  • Hilda Tateossian
  • Jeanne Estabel
  • Christopher Esapa
  • Allison S Landman
  • Jorge Galino
  • Jacqueline K White
  • Henning Wackerhage
  • Gemma Codner
  • Lydia Teboul
  • Andrey Y Abramov
  • Helen Hilton
  • Jennifer Tucker
  • Olga A Beskina
  • Ramiro Ramirez-Solis
  • Michael Groves
  • Bharani Shiva Busam
  • David L H Bennet
  • Vinaya Phatak
  • Tu Vinh Luong
  • David L H Bennett
  • Saumya Kumar
  • Patrick M Nolan
  • Macdonnell J Stanford
  • Michelle Simon
  • P Hande Ozdinler
  • James Dick
  • William Weber
  • Timothy Meyer
  • Virginie Bros-Facer
  • Steven J West
  • Rachele A Saccon
  • Ines Heise
  • Ning Zhu
  • Joel May
  • Georgina Osborne
  • Maurizio Renna
  • Sara Wells
  • Susan Morse
  • Philomena Mburu
  • Nick Warr
  • Andrew Parker
  • Michael Cheeseman

Detail Information

Publications5

  1. ncbi request reprint ENU mutagenesis, a way forward to understand gene function
    Abraham Acevedo-Arozena
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom
    Annu Rev Genomics Hum Genet 9:49-69. 2008
    ..N-ethyl-N-nitrosourea (ENU) mutagenesis has been widely used for both approaches to generate mouse mutants. Here we review progress in ENU mutagenesis screening, with an emphasis on creating mouse models for human disorders...
  2. pmc Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration
    Peter I Joyce
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 25:291-307. 2016
    ..Our results highlight a vital role for ZFP106 in sensory and motor neuron maintenance and reveal a novel player in mitochondrial dysfunction and neurodegeneration. ..
  3. pmc Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease
    Hilda Tateossian
    MRC Mammalian Genetics Unit, Harwell, UK
    Hum Mol Genet 22:2553-65. 2013
    ..The identification and characterization of the Tgif mutant supports the role of TGFβ signalling in the development of chronic OM and provides an important candidate gene for genetic studies in the human population...
  4. pmc A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity
    Peter I Joyce
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 24:1883-97. 2015
    ..These unique mice allow us to further our understanding of ALS by separating the central motor neuron body degeneration and the peripheral effects from a fALS mutation expressed at endogenous levels. ..
  5. pmc Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice
    Silvia Corrochano
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, United Kingdom
    PLoS ONE 9:e105595. 2014
    ..Interestingly, Igf-1r deficiency had no discernible effects on downstream mTOR signalling in HD mice. These results do not support a broad beneficial effect of diminishing the IIS pathway in HD pathology in a mammalian system. ..