Genomes and Genes
National Institute for Medical Research
Organization: National Institute for Medical Research
- Inhibition of vascular endothelial growth factor during the postovulatory period prevents pregnancy in the marmosetHamish M Fraser
Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, EH16 4TJ Edinburgh, UK
Contraception 82:572-8. 2010..This study investigated the effects of inhibition of vascular endothelial growth factor (VEGF) during the first postpartum cycle in marmosets housed with a fertile male where a 90% fertility rate is normal...
- PITX2 controls asymmetric gonadal development in both sexes of the chick and can rescue the degeneration of the right ovarySilvana Guioli
Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 134:4199-208. 2007..There is therefore a mechanism in females that actively promotes the underlying L-R asymmetry initiated by Pitx2 and the degeneration of the right gonad, and a mechanism in males that allows it to be ignored or overridden...
- Differentiation and function of Th17 T cellsBrigitta Stockinger
Division of Molecular Immunology, The MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
Curr Opin Immunol 19:281-6. 2007..Furthermore, the role of pathogens and pathogen-derived molecules in influencing effector T-cell polarization needs to be re-evaluated in the light of the differentiation conditions that favor Th17 T-cell responses...
- A randomized controlled trial of genotypic HIV drug resistance testing in HIV-1-infected children: the PERA (PENTA 8) trialHannah Green
MRC Clinical Trials Unit, London, UK
Antivir Ther 11:857-67. 2006..To evaluate the longer-term utility of genotypic resistance testing in HIV-1-infected children with virological failure...
- Some investigations into non-passive listeningA R Palmer
MRC Institute of Hearing Research, University Park, Nottingham, UK
Hear Res 229:148-57. 2007....
- Commentary: The relationship between parity and overweight--a life course perspectiveGita Mishra
MRC National Survey of Health and Development, University College and Royal Free Medical School, 1 19 Torrington Place, London WC1E 6BT, UK
Int J Epidemiol 36:102-3. 2007
- Chromosome organization: new facts, new modelsMiguel R Branco
MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK
Trends Cell Biol 17:127-34. 2007....
- Longitudinal changes in dietary patterns during adult lifeG D Mishra
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
Br J Nutr 96:735-44. 2006....
- The death of human platelets during incubation in citrated plasma involves shedding of CD42b and aggregation of dead plateletsPaul S Hartley
MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
Thromb Haemost 95:100-6. 2006....
- Amphibian metamorphosis as a model for the developmental actions of thyroid hormoneJamshed R Tata
National Institute for Medical Research, Mill Hill, London NW7 2HA, UK
Mol Cell Endocrinol 246:10-20. 2006..There is evidence that this may also be so for thyroid hormone regulated transcription during amphibian metamorphosis...
- Connexin43 levels are increased in mouse neural crest cells exposed to homocysteineMarit J Boot
Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
Birth Defects Res A Clin Mol Teratol 76:133-7. 2006..Elevated homocysteine levels during embryonic development can result in neural tube and cardiovascular defects. The mechanisms that underlie the toxic effect of homocysteine are largely unknown...
- Sumoylation: a new wrestler in the DNA repair ringLuis Aragon
Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
Proc Natl Acad Sci U S A 102:4661-2. 2005
- Neuroimaging in Parkinson's diseaseDavid J Brooks
Medical Research Council Clinical Sciences Center and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, United Kingdom
NeuroRx 1:243-54. 2004..It is concluded that in the future functional imaging will provide a valuable adjunct to clinical assessment when judging the efficacy of putative neuroprotective approaches to PD...
- Centromeric repositioning of coreceptor loci predicts their stable silencing and the CD4/CD8 lineage choiceMatthias Merkenschlager
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
J Exp Med 200:1437-44. 2004..These data provide evidence that lineage-specific developmental programs are established early during the transition from the DP to the single positive stage...
- Brain cell membrane motion-restricted phospholipids in patients with schizophrenia who have seriously and dangerously violently offendedBasant K Puri
MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England, W12 0HS, UK
Prog Neuropsychopharmacol Biol Psychiatry 32:751-4. 2008..These results suggest that patients with schizophrenia who have predominantly positive symptoms may not show neuroimaging-based signs compatible with the membrane phospholipid hypothesis of schizophrenia...
- The structure of protein evolution and the evolution of protein structureRichard A Goldstein
Division of Mathematical Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Curr Opin Struct Biol 18:170-7. 2008..Increasingly, these elements are being combined...
- From microcirculation to cardiac event: protection with PreteraxPaolo G Camici
Medical Research Council Clinical Sciences Centre and National Heart and Lung Institute, Imperial College, London, UK
J Hypertens 26:S8-S10. 2008..This suggests that coronary microvascular dysfunction can be reversed by treatment with these drugs and might contribute to the prevention of ischaemic heart disease in these patients...
- A coarse-grained molecular model for actin-myosin simulationWilliam R Taylor
Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
J Mol Graph Model 29:266-79. 2010..The effects of the myosin twofold symmetry and the restriction of an attached cargo were also tested. These results provide the basis for the development of a dynamic model of processive motion...
- Trauma, attempted suicide, and morning cortisol in a community sample of adolescentsRobert Young
MRC Social and Public Health Sciences Unit, Glasgow, UK
J Trauma Stress 23:288-91. 2010....
- Forming and interpreting gradients in the early Xenopus embryoJames C Smith
National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
Cold Spring Harb Perspect Biol 1:a002477. 2009....
- A system to simulate and reproduce audio-visual environments for spatial hearing researchBernhard U Seeber
Auditory Perception Lab, Department of Psychology, University of California at Berkeley, Berkeley, CA 94530 1650, USA
Hear Res 260:1-10. 2010....
- The use of ultrasound in the assessment and treatment of Achilles tendinosisA W M Mitchell
Chelsea and Westminster Hospital, London, England, UK
J Bone Joint Surg Br 91:1405-9. 2009..Some of the pathological processes which occur in Achilles tendinopathy can be identified by ultrasound, which may also be used to direct local treatment...
- Fifth Warren K. Sinclair Keynote Address: Issues in quantifying the effects of low-level radiationDudley T Goodhead
Medical Research Council, Harwell, Didcot OX11 0RD, UK
Health Phys 97:394-406. 2009..Finally, some comments are offered on aspects that lie outside the current paradigm...
- A boosting approach to structure learning of graphs with and without prior knowledgeShahzia Anjum
Medical Research Council, Harwell, UK
Bioinformatics 25:2929-36. 2009....
- The clinical value of myocardial blood flow measurementPaolo G Camici
Medical Research Council, Clinical Sciences Centre and National Heart and Lung Institute, Imperial College, London, United Kingdom
J Nucl Med 50:1076-87. 2009....
- Life-course socioeconomic positions and subclinical atherosclerosis in the multi-ethnic study of atherosclerosisEmily T Lemelin
Department of Epidemiology, University of Michigan, 1214 S University, Ann Arbor, MI 48104, United States
Soc Sci Med 68:444-51. 2009..Our results contribute to the growing body of work that shows that SEP at multiple points in the life-course, and at the individual and neighborhood level, contributes to the development of atherosclerosis...
- Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imagingSubrata K Bose
MRC Clinical Sciences Centre, Imperial College London, United Kingdom
Schizophr Res 106:148-55. 2008..Overall, these analyses have shown the potential utility of pattern recognition tools in the classification of psychiatric patients based upon molecular imaging of a single target...
- Reduction in cerebral atrophy associated with ethyl-eicosapentaenoic acid treatment in patients with Huntington's diseaseB K Puri
MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
J Int Med Res 36:896-905. 2008..These findings show that treatment with ethyl-EPA is associated with significant reduction in brain atrophy, particularly in the caudate and thalamus. No other drug tested in Huntington's disease has shown this effect...
- Design issues in pivotal drug trials for drug sensitive tuberculosis (TB)Andrew J Nunn
Medical Research Council Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK
Tuberculosis (Edinb) 88:S85-92. 2008..Non-inferiority pivotal trials require that, as far as practicable, the same techniques are used as were employed when the trials assessing the standard regimen were conducted...
- Germ cell differentiation in the marmoset (Callithrix jacchus) during fetal and neonatal life closely parallels that in the humanR T Mitchell
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, Scotland, UK
Hum Reprod 23:2755-65. 2008..We evaluated the marmoset (Callithrix jacchus) as a model by comparing perinatal germ cell differentiation with that in humans...
- Relative sensitivities of repair-deficient mammalian cells for clonogenic survival after alpha-particle irradiationMark A Hill
MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, United Kingdom
Radiat Res 162:667-76. 2004....
- Flumazenil positron emission tomography and other ligands for functional imagingAlexander Hammers
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, 33 Queen Square, London WC1N 3BG, UK
Neuroimaging Clin N Am 14:537-51. 2004..Future studies aiming to elucidate the pathophysiology of IGEs may benefit from the use of subtype-specific opioid ligands, available now, and GABAB ligands, if and when they become available...
- Neurotropins and their receptors are expressed in the human fetal ovaryRichard A Anderson
Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, University of Edinburgh, Edinburgh, United Kingdom EH3 9ET
J Clin Endocrinol Metab 87:890-7. 2002....
- The contraceptive potential of ZP3 and ZP3 peptides in a primate modelMargaret Paterson
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37, Chalmers Street, Edinburgh, EH3 9ET, UK
J Reprod Immunol 53:99-107. 2002..Thus considerable research is still required to identify a combination of ZP epitopes that will induce reversible infertility in the absence of any ovarian dysfunction...
- Neuroendocrine changes and fertility in breast-feeding womenA S McNeilly
MRC Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
Prog Brain Res 133:207-14. 2001....
- Agonist binding and function at the human alpha(2A)-adrenoceptor: allosteric modulation by amiloridesR A Leppik
National Institute for Medical Research, London, United Kingdom
Mol Pharmacol 58:1091-9. 2000....
- Cell memory and cancer--the story of the trithorax and Polycomb group genesC Caldas
University Department of Oncology, CIMR Wellcome MRC Building, Cambridge, UK
Cancer Metastasis Rev 18:313-29. 1999..In this review we outline what is known about the Polycomb and trithorax group of proteins as candidate genes for the memory process, both in terms of basic functions and the roles of abnormalities in these genes resulting in cancer...
- A common disease haplotype segregating in spinocerebellar ataxia 2 (SCA2) pedigrees of diverse ethnic originJ Pang
Division of Biomedical Sciences, Imperial College of Science, Technology and Medicine, London, UK
Eur J Hum Genet 7:841-5. 1999..Interpretation of this data is suggestive that for these pedigrees at least, the mutation has arisen on a single ancestral or predisposing chromosome...
- Elimination of contaminant Escherichia coli chromosomal DNA from preparations of P1 artificial chromosome recombinants facilitates directed subcloningH Davidson
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
Electrophoresis 20:1469-75. 1999..By inference it is applicable to the purification of large inserts from other single-copy plasmid vectors such as bacterial artificial chromosomes (BACs)...
- Laminar boundaries persist in the hippocampal dentate molecular layer of the mutant Shaking Rat Kawasaki despite aberrant granule cell migrationP L Woodhams
Division of Neurobiology, National Institute for Medical Research, London, United Kingdom
J Comp Neurol 409:57-70. 1999..The SRK malformations were very like but not identical to those seen in the mouse reeler mutant, suggesting similar underlying developmental mechanisms...
- Novel and recurrent mutations in keratin 10 causing bullous congenital ichthyosiform erythrodermaW H McLean
Department of Anatomy and Physiology, Medical Sciences Institute, University of Dundee, UK
Exp Dermatol 8:120-3. 1999..Despite the unusual nature of two of these mutations, in particular the double missense mutation, the phenotypes of the affected individuals in these 4 families were entirely typical of BCIE...
- Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 familyM Maconochie
Laboratory of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 126:1483-94. 1999..Our findings have identified the cis-components that allow Hoxa2 to be regulated independently in rhombomeres and cranial neural crest cells...
- A mutation (IVS8+0.6kbdelTC) creating a new donor splice site activates a cryptic exon in an Alu-element in intron 8 of the human beta-glucuronidase geneR Vervoort
Department of Medical Genetics, University Hospital, Vrije Universiteit Brussel, Brussels, Belgium
Hum Genet 103:686-93. 1998..This is the third report of a human disease mutation that creates a splice site and activates an antisense Alu-cassette; the question rises as to how these apparently strong cryptic exons are generally excluded from coding sequences...
- The effect of luteal "rescue" on the expression and localization of matrix metalloproteinases and their tissue inhibitors in the human corpus luteumW C Duncan
Medical Research Council Reproductive Biology Unit, Center for Reproductive Biology, Edinburgh, United Kingdom
J Clin Endocrinol Metab 83:2470-8. 1998..MMPs can function in an environment containing large amounts of TIMP-1, as they have a different cellular localization...
- Modelling cystic fibrosis in the mouseP Dickinson
Molecular Genetics Section, Western General Hospital, Edinburgh, UK
Mol Med Today 1:140-8. 1995..The example of cystic fibrosis illustrates this potential very well, demonstrating the usefulness of mouse models for gaining an improved understanding of the disease in humans and for the testing of new treatments...
- Somatotopic organization of the facial nucleus is disrupted after lesioning and regeneration of the facial nerve: the histological representation of synkinesisDavid Choi
Division of Neurobiology, National Institute for Medical Research, London, England
Neurosurgery 50:355-62; discussion 362-3. 2002..We describe an animal model of facial nerve lesion, repair, and regeneration that demonstrates abnormal organization of the facial nucleus; this model may be used to study synkinesis...
- Minor H antigens: genes and peptidesE Simpson
MRC Clinical Sciences Centre, Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Eur J Immunogenet 28:505-13. 2001....
- An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disordersDawn L Thiselton
Department of Molecular Genetics, Institute of Ophthalmology, University College, London, EC1V 9EL, UK
Genomics 79:560-72. 2002..3-Xp11.23 interval and provides a powerful integrated resource for functional characterization of this clonally unstable, yet gene-rich and clinically significant region of proximal Xp...
- A technique for standardized central analysis of 6-(18)F-fluoro-L-DOPA PET data from a multicenter studyAlan L Whone
Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
J Nucl Med 45:1135-45. 2004..To our knowledge, this is the first time such a centralized approach has been employed with (18)F-DOPA PET and this descriptive basic science article outlines the methods used...
- Plenty more fish in the sea: comparative and functional genomics using teleost modelsGreg Elgar
MRC Rosalind Franklin Centre for Genomics Research, Genome Campus, Hinxton Hinxton, Cambridge, CB10 1SB, UK
Brief Funct Genomic Proteomic 3:15-25. 2004..In this review, the relationship between fish species is examined along with the role of different fish models in a wide range of biological disciplines...
- Quality of lifeRichard Stephens
Cancer Division, Medical Research Council Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
Hematol Oncol Clin North Am 18:483-97. 2004
- The AMP-activated protein kinase cascade--a unifying system for energy controlDavid Carling
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
Trends Biochem Sci 29:18-24. 2004..AMPK could provide a link in human diseases of which the underlying cause is due to defects in energy metabolism...
- Adjunctive high-dose intravenous immunoglobulin treatment for resistant atopic dermatitis: efficacy and effects on intracellular cytokine levels and CD4 countsStephen Jolles
National Institute for Medical Research, Division of Infection and Immunity, The Ridgeway, Mill Hill, London, UK
Acta Derm Venereol 83:433-7. 2003..Adjunctive high-dose intravenous immunoglobulin may be a useful therapeutic approach in adults with severe treatment-resistant atopic dermatitis, but it will require further assessment in randomized controlled trials to establish this...
- Angiogenesis in the corpus luteumHamish M Fraser
Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
Reprod Biol Endocrinol 1:88. 2003..By targeting its action at specific stages of the luteal phase in vivo by antagonists, profound inhibitory effects on luteal angiogenesis and function are observed...
- Maintaining transcriptional states through DNA replicationVeronique Azuara
Lymphocyte Development Group, Medical Research Council, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN UK
Cell Cycle 2:521-4. 2003..Our findings may provide novel insights into the mechanisms that allow inactive chromatin structure to be propagated through DNA replication...
- Regulation of peripheral T-cell homeostasis by receptor signallingBenedict Seddon
Department of Molecular Immunology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Curr Opin Immunol 15:321-4. 2003..Recent advances have identified that both signalling through the T-cell receptor and a variety of cytokines are essential for the regulation of these responses...
- Comparative analysis of vertebrate Shh genes identifies novel conserved non-coding sequenceDebbie K Goode
Comparative Genomics Group, HGMP Resource Centre, Hinxton, Cambridge, CB10 1SB, UK
Mamm Genome 14:192-201. 2003..This work demonstrates the value of using Fugu in comparative genomics, which has allowed identification of new putative regulatory elements, as well as corroborating enhancers identified by the more traditional deletion mapping method...
- Relationships between human auditory cortical structure and functionDeborah A Hall
MRC Institute of Hearing Research, University Park, Nottingham, UK
Audiol Neurootol 8:1-18. 2003..Ways in which current knowledge of auditory cortical organisation and different data analysis approaches may benefit future functional neuroimaging studies which seek to link auditory cortical structure and function are discussed...
- Molecular genetics of rhegmatogenous retinal detachmentA J Richards
Department of Pathology University of Cambridge Cambridge, UK
Eye (Lond) 16:388-92. 2002..Here in particular we review Stickler syndrome, and discuss the differential diagnosis of Stickler, Wagner and Marshall syndromes. Other rare inherited disorders associated with RRD are also briefly reviewed...
- The curious history of yeast mitochondrial DNADon Williamson
Parasitology Division, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Nat Rev Genet 3:475-81. 2002..This concept persisted for 30 years and has distorted our understanding of the true nature of the molecule...
- Analyses of the extent of shared synteny and conserved gene orders between the genome of Fugu rubripes and human 20qSarah F Smith
Fugu Genomics, United Kingdom Human Genome Mapping Project Resource Centre, Wellcome Genome Campus, Hinxton Hall, Hinxton, Cambridgeshire, CB10 1SB, United Kingdom
Genome Res 12:776-84. 2002....
- Locus control regions: overcoming heterochromatin-induced gene inactivation in mammalsD Kioussis
National Institute for Medical Research, Division of Molecular Immunology, London, UK
Curr Opin Genet Dev 7:614-9. 1997..This finding implies that all subregions within an LCR are necessary to ensure the establishment of an open chromatin configuration of a gene even when the latter is located in a highly heterochromatic region...
- Conference on Dedritic Cells..Innate & Adaptive ImmunityANNE O GARRA; Fiscal Year: 2004....
- Conference--Host Resistance/Susceptability/ImmunopatholoANNE O GARRA; Fiscal Year: 2005..abstract_text> ..
- COMPUTATIONAL APPROACHES TO PROTEIN SEQUENCE ANALYSISRichard Goldstein; Fiscal Year: 2001..These models will be used to explore which protein properties are likely to be inherent, and to understand how much information can be derived for proteins based on information about known homologs. ..
- 3D atlas & database of murine urogenital developmentDuncan Davidson; Fiscal Year: 2007..This work will thus provide an integrated molecular and morphological description of GU development as a platform for modeling the processes of development, disease, and therapy. ..
- 3D atlas & database of murine urogenital developmentDuncan Davidson; Fiscal Year: 2007..This work will thus 3rovide an integrated molecular and morphological description of GU development as a platform for "nodelling the processes of development, disease, and therapy. ..