R Glynne-Jones

Summary

Affiliation: Mount Vernon Cancer Centre
Country: UK

Publications

  1. ncbi request reprint Improving chemoradiotherapy in rectal cancer
    R Glynne-Jones
    Mount Vernon Hospital, London, UK
    Oncologist 6:29-34. 2001
  2. ncbi request reprint Chemoradiation schedules--what radiotherapy?
    R Glynne-Jones
    Mount Vernon Cancer Centre, Northwood, Middlesex HA6 2RN, UK
    Eur J Cancer 38:258-69. 2002
  3. ncbi request reprint The reliability of lymph-node staging in rectal cancer after preoperative chemoradiotherapy
    M Beresford
    Mount Vernon Cancer Centre, Northwood, Middlesex, UK
    Clin Oncol (R Coll Radiol) 17:448-55. 2005
  4. ncbi request reprint A phase I dose escalation study of continuous oral capecitabine in combination with oxaliplatin and pelvic radiation (XELOX-RT) in patients with locally advanced rectal cancer
    R Glynne-Jones
    Mount Vernon Cancer Centre, Northwood, London, UK
    Ann Oncol 17:50-6. 2006
  5. doi request reprint Challenges in the neoadjuvant treatment of rectal cancer: balancing the risk of recurrence and quality of life
    R Glynne-Jones
    Radiotherapy Department, Mount Vernon Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, United Kingdom Electronic address
    Cancer Radiother 17:675-85. 2013
  6. ncbi request reprint The integration of oral capecitabine into chemoradiation regimens for locally advanced rectal cancer: how successful have we been?
    R Glynne-Jones
    Mount Vernon Cancer Centre, Northwood, London, UK
    Ann Oncol 17:361-71. 2006
  7. pmc The impact of surgically induced ischaemia on protein levels in patients undergoing rectal cancer surgery
    G K Atkin
    Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, UK, and Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201 2013, USA
    Br J Cancer 95:928-33. 2006
  8. ncbi request reprint Short course continuous, hyperfractionated, accelerated radiation therapy (CHART) as preoperative treatment for rectal cancer
    S Brooks
    Mount Vernon Cancer Center, Northwood, Middlesex, HA6 2RN, London, United Kingdom
    Acta Oncol 45:1079-85. 2006
  9. ncbi request reprint A randomized trial of chemoradiation using mitomycin or cisplatin, with or without maintenance cisplatin/5FU in squamous cell carcinoma of the anus (ACT II)
    R James
    Maidstone General Hospital, Maidstone, United Kingdom Cancer Research UK and UCL Cancer Trials Centre, London, United Kingdom Mount Vernon Hospital, Northwood, United Kingdom St James s University Hospital, Leeds, United Kingdom St Mark s Hospital, London, United Kingdom The Royal Marsden Hospital, London, United Kingdom
    J Clin Oncol 27:LBA4009. 2009
  10. ncbi request reprint A phase I/II study of CHARTWEL with concurrent chemotherapy in locally advanced, inoperable carcinoma of the oesophagus
    J Harney
    Marie Curie Research Wing, Mount Vernon Hospital, Northwood, Middlesex, UK
    Clin Oncol (R Coll Radiol) 15:109-14. 2003

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Improving chemoradiotherapy in rectal cancer
    R Glynne-Jones
    Mount Vernon Hospital, London, UK
    Oncologist 6:29-34. 2001
    ..Oral chemotherapy has the additional advantage of simplifying chemoradiation and providing a treatment that is more appealing to patients...
  2. ncbi request reprint Chemoradiation schedules--what radiotherapy?
    R Glynne-Jones
    Mount Vernon Cancer Centre, Northwood, Middlesex HA6 2RN, UK
    Eur J Cancer 38:258-69. 2002
    ..We explore the evidence for total dose; fractionation; fraction size; the effects of a gap in treatment; and scheduling of radiation in SCRT...
  3. ncbi request reprint The reliability of lymph-node staging in rectal cancer after preoperative chemoradiotherapy
    M Beresford
    Mount Vernon Cancer Centre, Northwood, Middlesex, UK
    Clin Oncol (R Coll Radiol) 17:448-55. 2005
    ..To determine the prognostic significance of the nodal stage and number of nodes recovered in the surgical specimen after preoperative synchronous chemoradiation (SCRT) and surgery for locally advanced or unresectable rectal cancer...
  4. ncbi request reprint A phase I dose escalation study of continuous oral capecitabine in combination with oxaliplatin and pelvic radiation (XELOX-RT) in patients with locally advanced rectal cancer
    R Glynne-Jones
    Mount Vernon Cancer Centre, Northwood, London, UK
    Ann Oncol 17:50-6. 2006
    ..To determine the maximum tolerated dose (MTD) of continuous oral capecitabine plus oxaliplatin and pre-operative pelvic radiotherapy (XELOX-RT)...
  5. doi request reprint Challenges in the neoadjuvant treatment of rectal cancer: balancing the risk of recurrence and quality of life
    R Glynne-Jones
    Radiotherapy Department, Mount Vernon Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, United Kingdom Electronic address
    Cancer Radiother 17:675-85. 2013
    ..This paper explores the background to common variations in practice, and the current and future challenges in the neoadjuvant treatment of rectal cancer. ..
  6. ncbi request reprint The integration of oral capecitabine into chemoradiation regimens for locally advanced rectal cancer: how successful have we been?
    R Glynne-Jones
    Mount Vernon Cancer Centre, Northwood, London, UK
    Ann Oncol 17:361-71. 2006
    ..Data from phase I/II single-agent and combination capecitabine chemoradiation studies provide a clear rationale for replacing infusional 5-FU with oral capecitabine as part of chemoradiation for patients with LARC...
  7. pmc The impact of surgically induced ischaemia on protein levels in patients undergoing rectal cancer surgery
    G K Atkin
    Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, UK, and Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201 2013, USA
    Br J Cancer 95:928-33. 2006
    ..Although rectal cancer was the studied model, the results may be applicable to any solid tumour undergoing extirpation in which molecular markers have been proposed to guide patient therapy...
  8. ncbi request reprint Short course continuous, hyperfractionated, accelerated radiation therapy (CHART) as preoperative treatment for rectal cancer
    S Brooks
    Mount Vernon Cancer Center, Northwood, Middlesex, HA6 2RN, London, United Kingdom
    Acta Oncol 45:1079-85. 2006
    ..This small study suggests preoperative short course CHART for clinically resectable rectal carcinoma is feasible with acceptable compliance and tolerable side effects...
  9. ncbi request reprint A randomized trial of chemoradiation using mitomycin or cisplatin, with or without maintenance cisplatin/5FU in squamous cell carcinoma of the anus (ACT II)
    R James
    Maidstone General Hospital, Maidstone, United Kingdom Cancer Research UK and UCL Cancer Trials Centre, London, United Kingdom Mount Vernon Hospital, Northwood, United Kingdom St James s University Hospital, Leeds, United Kingdom St Mark s Hospital, London, United Kingdom The Royal Marsden Hospital, London, United Kingdom
    J Clin Oncol 27:LBA4009. 2009
    ..This trial addresses two questions: whether (i) replacing MMC with cisplatin (CDDP) improves the complete response (CR) rate, and (ii) two cycles of maintenance chemotherapy after CRT reduces recurrence...
  10. ncbi request reprint A phase I/II study of CHARTWEL with concurrent chemotherapy in locally advanced, inoperable carcinoma of the oesophagus
    J Harney
    Marie Curie Research Wing, Mount Vernon Hospital, Northwood, Middlesex, UK
    Clin Oncol (R Coll Radiol) 15:109-14. 2003
    ..To evaluate the feasibility, efficacy and toxicity of concurrent chemotherapy and continuous, hyperfractionated, accelerated radiotherapy weekend less (CHARTWEL) in the treatment of locally advanced, inoperable oesophageal cancer...
  11. ncbi request reprint The clinical significance of the circumferential resection margin following preoperative pelvic chemo-radiotherapy in rectal cancer: why we need a common language
    R Glynne-Jones
    Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, Middlesex, UK
    Colorectal Dis 8:800-7. 2006
    ....
  12. pmc A phase I/II study of irinotecan when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group Study
    R Glynne-Jones
    Mount Vernon Cancer Centre, Mount Vernon Hospital, Rickmansworth Road, Northwood, Middlesex HA6 2RN, UK
    Br J Cancer 96:551-8. 2007
    ..The tumour downstaging and complete resection rates (negative CRM) are encouragingly high for this very locally advanced group...
  13. ncbi request reprint Can pathological complete response in the primary tumour following pre-operative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for sterilisation of pelvic lymph nodes, a low risk of local recurrence and the appropriateness of local excision?
    R Hughes
    Mount Vernon Cancer Centre, Northwood, Middlesex, UK, HA6 2RN
    Int J Colorectal Dis 21:11-7. 2006
    ..This retrospective study aimed to determine the incidence of involved lymph nodes following pCR (ypT0) after preoperative CRT and total mesorectal excision...
  14. ncbi request reprint Neoadjuvant chemotherapy in MRI-staged high-risk rectal cancer in addition to or as an alternative to preoperative chemoradiation?
    R Glynne-Jones
    Mount Vernon Cancer Centre, Mount Vernon Hospital, Northwood, UK
    Ann Oncol 23:2517-26. 2012
    ..Compliance to postoperative adjuvant chemotherapy is poor. Neoadjuvant chemotherapy (NACT) offers an alternative strategy...
  15. pmc Neoadjuvant chemotherapy prior to preoperative chemoradiation or radiation in rectal cancer: should we be more cautious?
    R Glynne-Jones
    Mount Vernon Cancer Centre, Northwood, Middlesex, HA6 2RN, UK
    Br J Cancer 94:363-71. 2006
    ..The evidence base suggests that concurrent CRT with early positioning of radiotherapy appears the best option for patients with locally advanced rectal cancer and in all disease sites where radiation is the primary local therapy...
  16. ncbi request reprint Complete clinical response after preoperative chemoradiation in rectal cancer: is a "wait and see" policy justified?
    R Glynne-Jones
    Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom
    Dis Colon Rectum 51:10-9; discussion 19-20. 2008
    ....
  17. ncbi request reprint Can I look at my list? An evaluation of a 'prompt sheet' within an oncology outpatient clinic
    R Glynne-Jones
    Barnet and Chase Farm NHS Trust, London, UK
    Clin Oncol (R Coll Radiol) 18:395-400. 2006
    ....
  18. ncbi request reprint Alternative clinical end points in rectal cancer--are we getting closer?
    R Glynne-Jones
    Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, Middlesex, UK
    Ann Oncol 17:1239-48. 2006
    ..We will propose measurement and analytical techniques for minimising bias and intra- and inter-observer variability of the non-validated end points in the hope of basing these judgements on as firm a ground as possible...
  19. ncbi request reprint A single-center study of the utility of squamous cell carcinoma antigen (SCCAg) levels in epidermoid carcinoma of the anal canal and margin (ECACM) treated with chemoradiation (CRT)
    A Swampillai
    Mount Vernon Cancer Centre, Northwood, United Kingdom
    J Clin Oncol 27:4117. 2009
    ..4117 Background: SCCAg is a tumour marker expressed by ECACM, measured by microparticle enzyme immunoassay; normal range 0-150ng/dl...
  20. doi request reprint To PET or not to PET? That is the question. Staging in anal cancer
    N J Bhuva
    Department of Radiotherapy, Oncology Division, Mount Vernon Cancer Centre, Middlesex, UK
    Ann Oncol 23:2078-82. 2012
    ..The role of PET as a definitive modality is still emerging and there are relatively few adequate studies in the literature...
  21. pmc Comparison of conventional and three-dimensional conformal CT planning techniques for preoperative chemoradiotherapy for locally advanced rectal cancer
    C Corner
    Mount Vernon Cancer Centre, Northwood, Middlesex, UK
    Br J Radiol 84:173-8. 2011
    ....
  22. doi request reprint Delaying surgery after neoadjuvant chemoradiotherapy for rectal cancer may reduce postoperative morbidity without compromising prognosis
    S F Kerr
    Centre for Cancer Treatment, Mount Vernon Hospital, Northwood HA62RN, UK
    Br J Surg 95:1534-40. 2008
    ..This retrospective study investigated whether the interval between neoadjuvant chemoradiotherapy and surgery for rectal cancer influences postoperative morbidity or prognosis...
  23. ncbi request reprint Preoperative (neoadjuvant) chemoradiotherapy in oesophageal cancer
    J I Geh
    Queen Elizabeth Hospital, Birmingham, Cookridge Hospital, Leeds and Mount Vernon Hospital, Northwood, UK
    Br J Surg 88:338-56. 2001
    ..New imaging modalities may help to select which patients require surgery. Larger randomized trials of preoperative CRT or chemotherapy are needed to define optimal regimens and produce higher pCR rates with acceptable toxicity...
  24. ncbi request reprint Dynamic contrast-enhanced magnetic resonance imaging is a poor measure of rectal cancer angiogenesis
    G Atkin
    Gray Cancer Institute, Mount Vernon Hospital, Northwood, UK
    Br J Surg 93:992-1000. 2006
    ..The aim of this study was to investigate the use of magnetic resonance imaging (MRI) for non-invasive measurement of rectal cancer angiogenesis and hypoxia...
  25. doi request reprint Critical appraisal of the 'wait and see' approach in rectal cancer for clinical complete responders after chemoradiation
    R Glynne-Jones
    Centre for Cancer Treatment, Mount Vernon Hospital, Northwood HA6 2RN, UK
    Br J Surg 99:897-909. 2012
    ..The aim of this review was to evaluate non-operative treatment of rectal cancer after CRT, and the outcome of patients observed without radical surgery...
  26. ncbi request reprint Locally advanced pancreatic cancer treated with radiation and 5-fluorouracil
    S Mawdsley
    Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex, UK
    Clin Oncol (R Coll Radiol) 14:308-12. 2002
    ..Further studies are needed to determine the most effective combination of chemotherapy agents, combined with radiotherapy in the management of this disease...
  27. pmc The effect of surgically induced ischaemia on gene expression in a colorectal cancer xenograft model
    G Atkin
    Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, UK
    Br J Cancer 94:121-7. 2006
    ....
  28. ncbi request reprint A randomized trial of chemoradiation using mitomycin or cisplatin, with or without maintenance cisplatin/5FU in squamous cell carcinoma of the anus (ACT II)
    R James
    Maidstone General Hospital, Maidstone, United Kingdom Cancer Research UK and UCL Cancer Trials Centre, London, United Kingdom Mount Vernon Hospital, Northwood, United Kingdom St James s University Hospital, Leeds, United Kingdom St Mark s Hospital, London, United Kingdom The Royal Marsden Hospital, London, United Kingdom
    J Clin Oncol 27:LBA4009. 2009
    ..Table: see text]...
  29. pmc Bevacizumab and Combination Chemotherapy in rectal cancer Until Surgery (BACCHUS): a phase II, multicentre, open-label, randomised study of neoadjuvant chemotherapy alone in patients with high-risk cancer of the rectum
    R Glynne-Jones
    Radiotherapy Department, Mount Vernon Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, UK
    BMC Cancer 15:764. 2015
    ..Investigation of intensified NACT is warranted to improve outcomes for patients with LARC. The objective is to evaluate feasibility and efficacy of a four-drug regimen containing bevacizumab prior to surgical resection...
  30. doi request reprint Combination external beam radiotherapy and intraluminal brachytherapy for non-radical treatment of oesophageal carcinoma in patients not suitable for surgery or chemoradiation
    A Aggarwal
    Mount Vernon Cancer Centre, Northwood, Middlesex, UK
    Clin Oncol (R Coll Radiol) 27:56-64. 2015
    ..This single-centre retrospective study evaluated combination external beam radiotherapy and high dose rate brachytherapy for patients in whom radical treatment was appropriate but comorbidity or frailty excluded this as an option...
  31. pmc Perfusion CT imaging of colorectal cancer
    V Goh
    Division of Imaging Sciences and Biomedical Engineering, King s College London, London, UK
    Br J Radiol 87:20130811. 2014
    ..In colorectal cancer, this may be relevant for clinical practice in terms of tumour phenotyping, prognostication, selection of individualized treatment and therapy response assessment. ..
  32. doi request reprint Influence of body composition profile on outcomes following colorectal cancer surgery
    G Malietzis
    Department of Surgery, St Mark s Hospital, Harrow, London, UK
    Br J Surg 103:572-80. 2016
    ..This study examined the role of particular body composition profiles as prognostic markers for patients with colorectal cancer undergoing curative resection...
  33. doi request reprint Complete Response after Chemoradiotherapy in Rectal Cancer (Watch-and-Wait): Have we Cracked the Code?
    R Glynne-Jones
    Mount Vernon Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, UK Electronic address
    Clin Oncol (R Coll Radiol) 28:152-60. 2016
    ....
  34. doi request reprint Decision-making in Colorectal Cancer Tumor Board meetings: results of a prospective observational assessment
    S Shah
    Department of Surgery and Cancer, Imperial College London, St Mary s Hospital, London, W2 1PG, UK
    Surg Endosc 28:2783-8. 2014
    ..Despite this, there are no uniform measures to evaluate them. The aim of this study was to evaluate the performance of colorectal cancer tumor boards, via real-time prospective observation...
  35. doi request reprint Anal cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up
    R Glynne-Jones
    Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom
    Eur J Surg Oncol 40:1165-76. 2014
    ..Here we aim to provide guidelines which can assist medical, radiation and surgical oncologists in the practical management of this unusual cancer. ..
  36. ncbi request reprint Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour
    M G Tytherleigh
    Department of Surgery, Wexham Park Hospital, Slough, Berkshire, SL2 4HL, UK
    Surgeon 4:378-83. 2006
    ..Chemoradiation remains the mainstay of treatment for anal cancers but has not been routinely employed in the management of the BLT without squamous cell carcinoma transformation...
  37. pmc A phase II study to determine the ability of gefitinib to reverse fluoropyrimidine resistance in metastatic colorectal cancer (the INFORM study)
    J Stebbing
    Imperial College, Imperial Healthcare, NHS Trust, Fulham Palace Road, London W6 8RF, UK
    Br J Cancer 98:716-9. 2008
    ..Gefitinib does not sensitise patients with fluoropyrimidine refractory metastatic colorectal cancer to 5-FU chemotherapy...
  38. pmc A phase I/II study of oxaliplatin when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group (CCOG) study
    D Sebag-Montefiore
    Cookridge Hospital, Hospital Lane, Cookridge, West Yorkshire LS16 6QB, UK
    Br J Cancer 93:993-8. 2005
    ..The acceptable toxicity and compliance at 130 mg m(-2) recommend testing this dose in future phase II studies. The tumour downstaging and complete resection rates are encouragingly high for this very locally advanced group...
  39. doi request reprint The diagnosis and management of rectal cancer: expert discussion and recommendations derived from the 9th World Congress on Gastrointestinal Cancer, Barcelona, 2007
    E Van Cutsem
    University Hospital Gasthuisberg, Leuven, Belgium
    Ann Oncol 19:vi1-8. 2008
    ..Health care workers involved in the care of rectal cancer patients should be encouraged to adopt quality control processes leading to increased expertise...
  40. pmc A prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial)
    Graham M Mead
    Southampton University Hospitals Trust, Southampton, United Kingdom
    Blood 112:2248-60. 2008
    ..Compared with the previous trial LY06 with full-dose methotrexate (6.7 g/m(2)), there was a reduction in toxicity with comparable outcomes. This study was registered at www.clinicaltrials.gov as NCT00040690...
  41. ncbi request reprint Chemotherapy or no chemotherapy in clear margins after neoadjuvant chemoradiation in locally advanced rectal cancer: CHRONICLE. A randomised phase III trial of control vs. capecitabine plus oxaliplatin
    R Glynne-Jones
    Clin Oncol (R Coll Radiol) 19:327-9. 2007
  42. ncbi request reprint Saving the sphincter in rectal cancer: are we prepared to change practice?
    M H Wallace
    Department of Surgery, West Herts NHS Trust, Watford General Hospital, Watford, UK
    Colorectal Dis 9:302-8; discussion 308-9. 2007
    ..This article examines the effect such treatment has on the rate of sphincter preservation in patients with rectal cancers close to the anal sphincter mechanism and looks at the evidence for changing clinical practice...