Alasdair J Nisbet

Summary

Affiliation: Moredun Research Institute
Country: UK

Publications

  1. ncbi request reprint Genomic organization and expression analysis for hcstk, a serine/threonine protein kinase gene of Haemonchus contortus, and comparison with Caenorhabditis elegans par-1
    Sia Nikolaou
    Primary Industries Research Victoria Animal Genetics and Genomics, 475 Mickleham Road, Attwood, Victoria 3049, Australia
    Gene 343:313-22. 2004
  2. doi request reprint Genomics of reproduction in nematodes: prospects for parasite intervention?
    Alasdair J Nisbet
    Parasitology Division, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, Scotland, UK
    Trends Parasitol 24:89-95. 2008
  3. doi request reprint Protection of ewes against Teladorsagia circumcincta infection in the periparturient period by vaccination with recombinant antigens
    Alasdair J Nisbet
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, United Kingdom Electronic address
    Vet Parasitol 228:130-136. 2016
  4. pmc Global characterization of microRNAs in Trichomonas gallinae
    Min Jun Xu
    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China
    Parasit Vectors 7:99. 2014
  5. doi request reprint Successful immunization against a parasitic nematode by vaccination with recombinant proteins
    Alasdair J Nisbet
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 0PZ, United Kingdom
    Vaccine 31:4017-23. 2013
  6. pmc Identification and characterization of microRNAs in Clonorchis sinensis of human health significance
    Min Jun Xu
    Department of Parasitology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong Province 510642, PR China
    BMC Genomics 11:521. 2010
  7. pmc In silico analysis of expressed sequence tags from Trichostrongylus vitrinus (Nematoda): comparison of the automated ESTExplorer workflow platform with conventional database searches
    Shivashankar H Nagaraj
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia
    BMC Bioinformatics 9:S10. 2008
  8. ncbi request reprint Stage-specific gene expression in Teladorsagia circumcincta (Nematoda: Strongylida) infective larvae and early parasitic stages
    Alasdair J Nisbet
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, UK
    Int J Parasitol 38:829-38. 2008
  9. doi request reprint A macrophage migration inhibitory factor-like tautomerase from Teladorsagia circumcincta (Nematoda: Strongylida)
    A J Nisbet
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Scotland, UK
    Parasite Immunol 32:503-11. 2010
  10. doi request reprint A calcium-activated apyrase from Teladorsagia circumcincta: an excretory/secretory antigen capable of modulating host immune responses?
    A J Nisbet
    Parasitology Division, Moredun Research Institute, Penicuik, Scotland, UK
    Parasite Immunol 33:236-43. 2011

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Genomic organization and expression analysis for hcstk, a serine/threonine protein kinase gene of Haemonchus contortus, and comparison with Caenorhabditis elegans par-1
    Sia Nikolaou
    Primary Industries Research Victoria Animal Genetics and Genomics, 475 Mickleham Road, Attwood, Victoria 3049, Australia
    Gene 343:313-22. 2004
    ..elegans. In spite of a substantial amino acid sequence identity in the functional domains between the predicted proteins HcSTK and PAR-1, overall, the findings suggest a unique functional role for each molecule...
  2. doi request reprint Genomics of reproduction in nematodes: prospects for parasite intervention?
    Alasdair J Nisbet
    Parasitology Division, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, Scotland, UK
    Trends Parasitol 24:89-95. 2008
    ..Here, we review recent developments, focusing on technological aspects and on molecules associated with sex-specific differences in adult nematodes...
  3. doi request reprint Protection of ewes against Teladorsagia circumcincta infection in the periparturient period by vaccination with recombinant antigens
    Alasdair J Nisbet
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, United Kingdom Electronic address
    Vet Parasitol 228:130-136. 2016
    ..Antigen-specific IgG and IgA levels in blood collected within 48h of birth from lambs largely reflected those in the colostrum of their ewes...
  4. pmc Global characterization of microRNAs in Trichomonas gallinae
    Min Jun Xu
    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China
    Parasit Vectors 7:99. 2014
    ..microRNAs (miRNAs) are a class of small non-coding RNAs that play key roles in gene regulation. However, no miRNAs have been characterized from T. gallinae...
  5. doi request reprint Successful immunization against a parasitic nematode by vaccination with recombinant proteins
    Alasdair J Nisbet
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 0PZ, United Kingdom
    Vaccine 31:4017-23. 2013
    ....
  6. pmc Identification and characterization of microRNAs in Clonorchis sinensis of human health significance
    Min Jun Xu
    Department of Parasitology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong Province 510642, PR China
    BMC Genomics 11:521. 2010
    ..sinensis residing chronically in the biliary tract, we developed an integrative approach combining deep sequencing and bioinformatic predictions with stem-loop real-time PCR analysis...
  7. pmc In silico analysis of expressed sequence tags from Trichostrongylus vitrinus (Nematoda): comparison of the automated ESTExplorer workflow platform with conventional database searches
    Shivashankar H Nagaraj
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia
    BMC Bioinformatics 9:S10. 2008
    ..In this study, we evaluated EST data analysis for the parasitic nematode Trichostrongylus vitrinus (order Strongylida) using ESTExplorer, compared with database matching alone...
  8. ncbi request reprint Stage-specific gene expression in Teladorsagia circumcincta (Nematoda: Strongylida) infective larvae and early parasitic stages
    Alasdair J Nisbet
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, UK
    Int J Parasitol 38:829-38. 2008
    ..Nucleotide sequence data reported in this paper are available in the EMBL, GenBank and DDJB databases under accession numbers AM 743198-AM 744942...
  9. doi request reprint A macrophage migration inhibitory factor-like tautomerase from Teladorsagia circumcincta (Nematoda: Strongylida)
    A J Nisbet
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Scotland, UK
    Parasite Immunol 32:503-11. 2010
    ..Neither native, purified Tci-MIF nor recombinant Tci-MIF-1 dramatically influenced the in vitro migration of sheep monocytes...
  10. doi request reprint A calcium-activated apyrase from Teladorsagia circumcincta: an excretory/secretory antigen capable of modulating host immune responses?
    A J Nisbet
    Parasitology Division, Moredun Research Institute, Penicuik, Scotland, UK
    Parasite Immunol 33:236-43. 2011
    ..The potential immunomodulatory roles of this Tci-APY-1 are discussed in relation to purinergic signalling...
  11. doi request reprint Immune recognition of the surface associated antigen, Tc-SAA-1, from infective larvae of Teladorsagia circumcincta
    A J Nisbet
    Moredun Research Institute, Scotland, UK
    Parasite Immunol 31:32-40. 2009
    ..IgA in abomasal mucus derived from sheep that had received a trickle infection of T. circumcincta bound recombinant Tc-SAA-1...
  12. doi request reprint Psoroptes ovis: identification of vaccine candidates by immunoscreening
    Alasdair J Nisbet
    Moredun Research Institute, Parasitology Division, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, Scotland, UK
    Exp Parasitol 120:194-9. 2008
    ....
  13. ncbi request reprint Eukaryotic expression of recombinant Pso o 1, an allergen from Psoroptes ovis, and its localization in the mite
    A J Nisbet
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, Scotland
    Parasitology 134:83-9. 2007
    ..Serum raised against recombinant Pso o 1 cross-reacted with mature Der p 1 and allowed Pso o 1 to be immunolocalized to the gut of P. ovis...
  14. ncbi request reprint A house dust mite allergen homologue from poultry red mite Dermanyssus gallinae (De Geer)
    A J Nisbet
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, Scotland, UK
    Parasite Immunol 28:401-5. 2006
    ..Immunolocalization of tropomyosin in mites indicated a ubiquitous distribution of the molecule in mite tissues. Immunolocalization and Western blotting also indicated that poultry red mites ingest host IgY...
  15. ncbi request reprint Molecular characterization, expression and localization of tropomyosin and paramyosin immunodominant allergens from sheep scab mites (Psoroptes ovis)
    A J Nisbet
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, Scotland
    Parasitology 133:515-23. 2006
    ..ovis. Staining was especially prevalent in the anterior sections of the mites, possibly associated with locomotory muscles in this region...
  16. pmc A recombinant subunit vaccine for the control of ovine psoroptic mange (sheep scab)
    Stewart T G Burgess
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian, Scotland, EH26 0PZ, UK
    Vet Res 47:26. 2016
    ..This vaccine represents the greatest reduction in lesion size to date with a sheep scab vaccine, providing encouragement for future production of a commercially-viable means of immunoprophylaxis...
  17. pmc A preliminary proteomic characterisation of extracellular vesicles released by the ovine parasitic nematode, Teladorsagia circumcincta
    Thomas Tzelos
    Moredun Research Institute, Pentlands Science Park, Bush Loan, EH26 0PZ, Edinburgh, UK Electronic address
    Vet Parasitol 221:84-92. 2016
    ..circumcincta infected sheep, and could potentially represent useful targets for future vaccine intervention studies. ..
  18. pmc The use of a Psoroptes ovis serodiagnostic test for the analysis of a natural outbreak of sheep scab
    Stewart T G Burgess
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian, EH26 0PZ, Scotland, UK
    Parasit Vectors 5:7. 2012
    ..The development of a diagnostic assay would enable farmers and veterinarians to detect disease at an early stage, reducing the risk of developing clinical disease and limiting spread...
  19. pmc Transcriptomic analysis of circulating leukocytes reveals novel aspects of the host systemic inflammatory response to sheep scab mites
    Stewart T G Burgess
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian, Scotland, United Kingdom
    PLoS ONE 7:e42778. 2012
    ....
  20. pmc Development of a cDNA microarray for the measurement of gene expression in the sheep scab mite Psoroptes ovis
    Stewart T G Burgess
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, UK
    Parasit Vectors 5:30. 2012
    ..In order to identify alternative means of disease control, a deeper understanding of both the parasite and its interaction with the host are required...
  21. doi request reprint Assessment of cathepsin D and L-like proteinases of poultry red mite, Dermanyssus gallinae (De Geer), as potential vaccine antigens
    Kathryn Bartley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, Scotland, UK
    Parasitology 139:755-65. 2012
    ..Dg-CatD-1 and L-1 both have potential as vaccine antigens as part of a multi-component vaccine and have the potential to be improved as vaccine antigens using alternative expression systems...
  22. pmc The effect of Psoroptes ovis infestation on ovine epidermal barrier function
    Miriam R Stoeckli
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian, Scotland, EH26 0PZ, United Kingdom
    Vet Res 44:11. 2013
    ..Many of these features have also been documented in human and canine atopic dermatitis suggesting that sheep scab may provide a model for the elucidation of events occurring in the early phases of atopic sensitisation...
  23. doi request reprint Gene expression changes in a P-glycoprotein (Tci-pgp-9) putatively associated with ivermectin resistance in Teladorsagia circumcincta
    Alison J Dicker
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, Scotland, United Kingdom
    Int J Parasitol 41:935-42. 2011
    ..These changes could form the basis of an IVM resistance marker to monitor the spread of resistance and to evaluate management practices aimed at delaying its spread...
  24. pmc Two major ruminant acute phase proteins, haptoglobin and serum amyloid A, as serum biomarkers during active sheep scab infestation
    Beth Wells
    Moredun Research Institute, Pentlands Science Park, Midlothian EH26 0PZ, UK
    Vet Res 44:103. 2013
    ....
  25. pmc Suppression of ovine lymphocyte activation by Teladorsagia circumcincta larval excretory-secretory products
    Tom N McNeilly
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, UK
    Vet Res 44:70. 2013
    ..However, the impact of Tci-L4-ES-mediated lymphocyte suppression during T. circumcincta infection remains to be determined...
  26. doi request reprint Development of a serodiagnostic test for sheep scab using recombinant protein Pso o 2
    Francesca G Nunn
    Division of Parasitology, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, EH26 0PZ, Scotland, UK
    Mol Cell Probes 25:212-8. 2011
    ..93 and specificity of 0.90. The Pso o 2-based ELISA was able to detect specific antibodies to P. ovis during early experimental infestation prior to disease patency, indicating its utility for detecting sub-clinical infestation...
  27. pmc Transcriptomic analysis of the temporal host response to skin infestation with the ectoparasitic mite Psoroptes ovis
    Stewart T G Burgess
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian, EH26 0PZ, Scotland, UK
    BMC Genomics 11:624. 2010
    ..The main objective of this study was to perform a combined network and pathway analysis of the in vivo skin response to infestation with P. ovis to gain a clearer understanding of the mechanisms and signalling pathways involved...
  28. pmc Host transcription factors in the immediate pro-inflammatory response to the parasitic mite Psoroptes ovis
    Stewart T G Burgess
    Moredun Research Institute, Pentlands Science Park, Edinburgh, Scotland, United Kingdom
    PLoS ONE 6:e24402. 2011
    ..The objective of this study was to gain a clearer understanding of the mechanisms and signaling pathways involved in the instigation of the immediate pro-inflammatory response...
  29. doi request reprint Identification and characterisation of an immunodiagnostic marker for cyathostomin developing stage larvae
    Hamish E G McWilliam
    Division of Parasitology, Moredun Research Institute, Pentlands Science Park, EH26 0PZ, UK
    Int J Parasitol 40:265-75. 2010
    ..A region of the gene encoding orthologous GALA sequences was isolated from 10 separate cyathostomin species, indicating the ubiquity of the protein in this nematode group...
  30. doi request reprint Histamine release factor from Dermanyssus gallinae (De Geer): characterization and in vitro assessment as a protective antigen
    Kathryn Bartley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, Scotland, UK
    Int J Parasitol 39:447-56. 2009
    ..The work presented here demonstrates, to our knowledge for the first time, the feasibility of vaccinating hens with recombinant D. gallinae antigens to control mite infestation and the potential of rDg-HRF-1 as a vaccine antigen...
  31. doi request reprint Teladorsagia circumcincta: activation-associated secreted proteins in excretory/secretory products of fourth stage larvae are targets of early IgA responses in infected sheep
    A J Nisbet
    Parasitology Division, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, UK
    Exp Parasitol 125:329-37. 2010
    ..A recombinant version of Tci-ASP-1 was expressed in Escherichia coli and the purified protein was reactive with IgA present in abomasal mucus derived from immune sheep...
  32. doi request reprint GTP-cyclohydrolase and development in Teladorsagia circumcincta and Dictyocaulus viviparus (Nematoda: Strongylida)
    Rachael H Baker
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 0PZ, UK
    Exp Parasitol 128:309-17. 2011
    ..Alternative roles for GTP-CH in larval development are discussed...
  33. pmc Generation, analysis and functional annotation of expressed sequence tags from the ectoparasitic mite Psoroptes ovis
    Stewart T G Burgess
    Division of Parasitology, Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, UK
    Parasit Vectors 4:145. 2011
    ..To date, no full genomic DNA sequence or large scale transcript datasets are available and prior to this study only 484 P. ovis expressed sequence tags (ESTs) were accessible in public databases...
  34. ncbi request reprint Characterisation of a DM domain-containing transcription factor from Trichostrongylus vitrinus (Nematoda: Strongylida)
    Alasdair J Nisbet
    Parasitology Division, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, EH26 0PZ, Scotland, United Kingdom
    Parasitol Int 55:155-7. 2006
    ..vitrinus. The highest levels of expression in fourth stage larvae coincide with the period in which profound gender-specific alterations in physiology occur in both the parasitic and free-living nematodes...
  35. doi request reprint Teladorsagia circumcincta: the transcriptomic response of a multi-drug-resistant isolate to ivermectin exposure in vitro
    Alison J Dicker
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, Scotland, UK
    Exp Parasitol 127:351-6. 2011
    ..Four clusters were identified as vitellogenin; three of these clusters had a statistically significant decrease in number of exposed ESTs compared to unexposed ESTs...
  36. doi request reprint Proteomic analysis of excretory/secretory products released by Teladorsagia circumcincta larvae early post-infection
    S K Smith
    Moredun Research Institute, Midlothian, UK
    Parasite Immunol 31:10-9. 2009
    ..ELISA was performed to assess antigen-specific mucus IgA levels in individual sheep. These experiments provided preliminary evidence that the proteins identified in the larval secretome were subject to these antibody responses...
  37. doi request reprint Development of a recombinant protein-based ELISA for diagnosis of larval cyathostomin infection
    Mairi C Mitchell
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 0PZ, Scotland, UK
    Parasitology 143:1055-66. 2016
    ..Each protein was assessed by enzyme linked immuno sorbent assay (ELISA) for its ability for informing on the presence of encysted larval infection and the level of burden. ..
  38. pmc Identification and evaluation of vaccine candidate antigens from the poultry red mite (Dermanyssus gallinae)
    Kathryn Bartley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, United Kingdom Electronic address
    Int J Parasitol 45:819-30. 2015
    ..7-2.8times higher than in mites fed blood from control hens immunised with adjuvant only, P<0.001). The potential for using these antigens in a recombinant vaccine is discussed...
  39. doi request reprint Characterization of the ovine complement 4 binding protein-beta (C4BPB) chain as a serum biomarker for enhanced diagnosis of sheep scab
    Beth Wells
    Moredun Research Institute, Pentlands Science Park, Midlothian EH26 0PZ, United Kingdom
    Mol Cell Probes 27:158-63. 2013
    ....
  40. pmc Feeding-associated gene expression in sheep scab mites (Psoroptes ovis)
    Carol M McNair
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, nr Edinburgh EH26 0PZ, United Kingdom
    Vet Res 41:16. 2010
    ..An olfactory receptor-like protein was identified in the starved mite population which may help the mite to identify a host...
  41. ncbi request reprint Progress and opportunities in the development of vaccines against mites, fleas and myiasis-causing flies of veterinary importance
    A J Nisbet
    Moredun Research Institute, Edinburgh, UK
    Parasite Immunol 28:165-72. 2006
    ....
  42. doi request reprint Melanisation of Teladorsagia circumcincta larvae exposed to sunlight: a role for GTP-cyclohydrolase in nematode survival
    Rachael H Baker
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, UK
    Int J Parasitol 42:887-91. 2012
    ..031) compared with unexposed larvae. These data suggest that one explanation for the high level of GTP-CH present in pre-parasitic stages of trichostrongylid nematodes is to facilitate melanisation in response to UV exposure...
  43. doi request reprint Molecular characterization, expression and localization of a peroxiredoxin from the sheep scab mite, Psoroptes ovis
    C M McNair
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, Scotland
    Parasitology 136:453-60. 2009
    ..The recombinant protein was recognized by sera from sheep infested with the mite suggesting that it may be secreted or excreted by the mite and interact with the host immune response...
  44. ncbi request reprint Identification of tropomyosin, paramyosin and apolipophorin/vitellogenin as three major allergens of the sheep scab mite, Psoroptes ovis
    J F Huntley
    Moredun Research Institute, Pentland Science Park, Bush Loan, Penicuik, EH26 0PZ, Scotland, UK
    Parasite Immunol 26:335-42. 2004
    ..These studies show for the first time that homologues of the house dust mite 10, 11 and 14 group allergens are represented as immunodominant allergens of the sheep scab mite, and may represent important vaccine candidates...
  45. doi request reprint Recent developments in the diagnosis of ectoparasite infections and disease through a better understanding of parasite biology and host responses
    Beth Wells
    Moredun Research Institute, Pentlands Science Park, Midlothian EH26 0PZ, United Kingdom
    Mol Cell Probes 26:47-53. 2012
    ....
  46. doi request reprint The testing of antibodies raised against poultry red mite antigens in an in vitro feeding assay; preliminary screen for vaccine candidates
    Harry W Wright
    Parasitology Division, Moredun Research Institute, Midlothian, EH26 0PZ, Scotland, UK
    Exp Appl Acarol 48:81-91. 2009
    ..8% 14 days after feeding compared with 27.3% for the control group (P = 0.043)...
  47. ncbi request reprint Ability of a proteinase inhibitor mixture to kill poultry red mite, Dermanyssus gallinae in an in vitro feeding system
    R McDevitt
    Avian Science Research Centre, SAC, West Mains Road, Scotland, Edinburgh EH9 3JG, UK
    Vet Parasitol 141:380-5. 2006
    ..A reliable in vitro method for feeding D. gallinae which has the potential to be used to rapidly screen blood-borne products for their efficacy in reducing mite numbers has been developed...
  48. ncbi request reprint Molecular characterization of a family of metalloendopeptidases from the intestinal brush border of Haemonchus contortus
    G F J Newlands
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 OPZ, Scotland
    Parasitology 133:357-68. 2006
    ..MEP-like activity was detected in the H-gal-GP complex over a broad pH range (5-9). Since all 4 MEPs must share a similar microenvironment in the complex, this suggests that each might have a different substrate specificity...
  49. pmc Characterisation of tropomyosin and paramyosin as vaccine candidate molecules for the poultry red mite, Dermanyssus gallinae
    Harry W Wright
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian, EH26 0PZ, Scotland, UK
    Parasit Vectors 9:544. 2016
    ..In this study, recombinant forms of D. gallinae tropomyosin (Der g 10) and paramyosin (Der g 11) were produced, characterised and tested as vaccine candidate molecules...
  50. pmc Characterisation of Dermanyssus gallinae glutathione S-transferases and their potential as acaricide detoxification proteins
    Kathryn Bartley
    Moredun Research Institute, International Research Centre, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, EH26 0PZ, UK
    Parasit Vectors 8:350. 2015
    ..Acaricide resistance and the need for novel control methods are both pressing needs for Dermanyssus gallinae, a highly economically important haematophagous ectoparasite of poultry...
  51. doi request reprint Ovine IgA-reactive proteins from Teladorsagia circumcincta infective larvae
    Samantha Ellis
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK Royal Dick School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK
    Int J Parasitol 44:743-50. 2014
    ..These results indicate that the purified antigens contain components that could be strongly considered as vaccine candidates. ..
  52. doi request reprint IgA and IgG antibody responses following systemic immunization of cattle with native H7 flagellin differ in epitope recognition and capacity to neutralise TLR5 signalling
    Tom N McNeilly
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, UK
    Vaccine 28:1412-21. 2010
    ..coli O157:H7 via neutralisation of TLR5 activation and subsequently reduce vaccine efficacy...
  53. ncbi request reprint Immunological control of scab mites: digestive enzymes as candidate compounds
    A J Nisbet
    Department of Zoology, University of Aberdeen, Scotland, UK
    Vet Parasitol 83:231-9. 1999
    ....
  54. doi request reprint Gene silencing by RNA interference in the house dust mite, Dermatophagoides pteronyssinus
    Edward J Marr
    Division of Vaccines and Diagnostics, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh, Scotland, United Kingdom Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian, Scotland, United Kingdom
    Mol Cell Probes 29:522-6. 2015
    ..pteronyssinus target genes in selected domestic situations of high human-mite interface. ..
  55. pmc Immune modulation by helminth parasites of ruminants: implications for vaccine development and host immune competence
    Tom N McNeilly
    Disease Control, Moredun Research Institute, Pentlands Science Park, EH26 OPZ, UK
    Parasite 21:51. 2014
    ....
  56. ncbi request reprint A physiological and biochemical model for digestion in the ectoparasitic mite, Psoroptes ovis (Acari: Psoroptidae)
    K A Hamilton
    Department of Zoology, University of Aberdeen, Tillydrone Ave, Aberdeen AB24 2TZ, Scotland, UK
    Int J Parasitol 33:773-85. 2003
    ..The interaction of bacteria and digestive enzymes on the skin surface of the sheep may be responsible for the excessive pathological reactions evident in clinical sheep scab...
  57. ncbi request reprint Trichostrongylus vitrinus (Nematoda: Strongylida): molecular characterization and transcriptional analysis of Tv-stp-1, a serine/threonine phosphatase gene
    Min Hu
    Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
    Exp Parasitol 117:22-34. 2007
    ..vitrinus, O. dentatum and C. elegans, which should have implications for exploring molecular reproductive and developmental processes in strongylid nematodes of socio-economic importance...
  58. ncbi request reprint Ubiquitin-conjugating enzyme genes in Oesophagostomum dentatum
    Pauline A Cottee
    Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
    Parasitol Res 99:119-25. 2006
    ..While the function of a representative ubc-2 gene from O. dentatum could not be established in C. elegans, it is likely to play a key role in the catabolism of proteins and in the development of O. dentatum...
  59. ncbi request reprint Profiling of gender-specific gene expression for Trichostrongylus vitrinus (Nematoda: Strongylida) by microarray analysis of expressed sequence tag libraries constructed by suppressive-subtractive hybridisation
    Alasdair J Nisbet
    Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
    Int J Parasitol 34:633-43. 2004
    ..The potential roles of these genes in gametogenesis, embryogenesis and reproduction in the parasitic nematode are discussed in relation to the known roles of their homologues in C. elegans...
  60. ncbi request reprint Molecular biology of reproduction and development in parasitic nematodes: progress and opportunities
    Alasdair J Nisbet
    Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
    Int J Parasitol 34:125-38. 2004
    ..It also describes the implications of such work for understanding reproduction, tissue migration, hypobiosis, signal transduction and host-parasite interactions at the molecular level, and for seeking new means of parasite intervention...
  61. ncbi request reprint Genomics of reproduction in parasitic nematodes-fundamental and biotechnological implications
    Peter R Boag
    Victorian Institute of Animal Science, Attwood, Australia
    Biotechnol Adv 21:103-8. 2003
    ..This article describes recent progress on the characterisation of sex-specific genes from a parasitic nematode of veterinary importance, and discusses the fundamental scientific and applied implications of this work...
  62. ncbi request reprint Identification of a putative azadirachtin-binding complex from Drosophila Kc167 cells
    Susan L Robertson
    School of Biological Sciences, Department of Zoology, University of Aberdeen, Aberdeen, United Kingdom
    Arch Insect Biochem Physiol 64:200-8. 2007
    ..Identification of the members of this complex by Peptide Mass Fingerprinting (PMF) and N-terminal sequencing identified heat shock protein 60 (hsp60) as one of its components...
  63. ncbi request reprint Oesophagostomum dentatum: potential as a model for genomic studies of strongylid nematodes, with biotechnological prospects
    Robin B Gasser
    Department of Veterinary Science, The University of Melbourne, Werribee, Victoria, Australia
    Biotechnol Adv 25:281-93. 2007
    ..dentatum - pig system provides an attractive model for exploring molecular developmental and reproductive processes in strongylid nematodes, leading toward new intervention methods and biotechnological outcomes...
  64. ncbi request reprint Haemonchus contortus: prokaryotic expression and enzyme activity of recombinant HcSTK, a serine/threonine protein kinase
    Sia Nikolaou
    Primary Industries Research Victoria Animal Genetics and Genomics, 475 Mickleham Road, Attwood, VIC 3049, Australia
    Exp Parasitol 113:207-14. 2006
    ..The findings show that recombinant HcSTK is a functional protein kinase, with activity directed to KXGS motifs, consistent with other members of the PAR-1/MARK STK subfamily...