Phillip J Monaghan

Summary

Country: UK

Publications

  1. doi request reprint Comparison of serum cortisol measurement by immunoassay and liquid chromatography-tandem mass spectrometry in patients receiving the 11β-hydroxylase inhibitor metyrapone
    Phillip J Monaghan
    Biochemistry Department, the Christie NHS Foundation Trust, Withington, Manchester M20 4BX, UK
    Ann Clin Biochem 48:441-6. 2011
  2. doi request reprint Proopiomelanocortin interference in the measurement of adrenocorticotrophic hormone: a United Kingdom National External Quality Assessment Service study
    P J Monaghan
    The Christie Pathology Partnership, the Christie NHS Foundation Trust, Manchester, UK
    Clin Endocrinol (Oxf) 85:569-74. 2016
  3. doi request reprint Biomarker development targeting unmet clinical needs
    Phillip J Monaghan
    Department of Clinical Biochemistry, The Christie Pathology Partnership, the Christie NHS Foundation Trust, Manchester, UK Electronic address
    Clin Chim Acta 460:211-9. 2016
  4. doi request reprint Measurement of serotonin in platelet depleted plasma by liquid chromatography tandem mass spectrometry
    Phillip J Monaghan
    Department of Clinical Biochemistry, South Manchester University Hospital Trust, Manchester, M23 9LT, United Kingdom
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2163-7. 2009
  5. doi request reprint The use of mass spectrometry to improve the diagnosis and the management of the HPA axis
    Phillip J Monaghan
    Department of Clinical Biochemistry, the Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
    Rev Endocr Metab Disord 14:143-57. 2013
  6. doi request reprint Serum and plasma 5-hydroxyindoleacetic acid as an alternative to 24-h urine 5-hydroxyindoleacetic acid measurement
    Joanne E Adaway
    Department of Clinical Biochemistry, University Hospital South Manchester NHS Foundation Trust, Manchester, UK The University of Manchester, Manchester Academic Health Science Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, UK
    Ann Clin Biochem 53:554-60. 2016
  7. doi request reprint Serum Cortisol: An Up-To-Date Assessment of Routine Assay Performance
    James M Hawley
    University Hospital South Manchester, Manchester, UK
    Clin Chem 62:1220-9. 2016
  8. doi request reprint Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin
    Chander Shekhar
    Neurogastroenterology Unit, University of Manchester, Manchester, UK
    Gastroenterology 145:749-57; quiz e13-4. 2013

Collaborators

  • Brian G Keevil
  • Lesley A Houghton
  • A White
  • Peter J Whorwell
  • Joanne E Adaway
  • James M Hawley
  • Chander Shekhar
  • Annie Armston
  • Stephen J Lockhart
  • Carrie A Chadwick
  • Laura J Owen
  • Peter J Trainer
  • Jennifer Walsh
  • Juan W Valle
  • Heather Wilshaw
  • Rebecca Dobson
  • Daniel J Cuthbertson
  • Leslie Perry
  • Maisa Freire
  • Julie Morris
  • Basma Issa

Detail Information

Publications8

  1. doi request reprint Comparison of serum cortisol measurement by immunoassay and liquid chromatography-tandem mass spectrometry in patients receiving the 11β-hydroxylase inhibitor metyrapone
    Phillip J Monaghan
    Biochemistry Department, the Christie NHS Foundation Trust, Withington, Manchester M20 4BX, UK
    Ann Clin Biochem 48:441-6. 2011
    ..To investigate the effect of the 11β-hydroxylase inhibitor metyrapone on serum cortisol assay, a comparison of measurement by immunoassay versus liquid chromatography-tandem mass spectrometry (LC-MS/MS) was conducted...
  2. doi request reprint Proopiomelanocortin interference in the measurement of adrenocorticotrophic hormone: a United Kingdom National External Quality Assessment Service study
    P J Monaghan
    The Christie Pathology Partnership, the Christie NHS Foundation Trust, Manchester, UK
    Clin Endocrinol (Oxf) 85:569-74. 2016
    ..The aim of this study was to assess the cross-reactivity of POMC in the main commercial immunoassays for ACTH and to survey the awareness of laboratory professionals to this potential interference...
  3. doi request reprint Biomarker development targeting unmet clinical needs
    Phillip J Monaghan
    Department of Clinical Biochemistry, The Christie Pathology Partnership, the Christie NHS Foundation Trust, Manchester, UK Electronic address
    Clin Chim Acta 460:211-9. 2016
    ..The introduction of new biomarkers can lead to inappropriate utilization of tests if they do not fill in existing gaps in clinical care. We aimed to define a strategy and checklist for identifying unmet needs for biomarkers...
  4. doi request reprint Measurement of serotonin in platelet depleted plasma by liquid chromatography tandem mass spectrometry
    Phillip J Monaghan
    Department of Clinical Biochemistry, South Manchester University Hospital Trust, Manchester, M23 9LT, United Kingdom
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2163-7. 2009
    ..91 (HPLC)-0.83, r(2)=0.97, n=80. Bland Altman analysis showed general agreement, with a mean bias of 3.3 nmol/L. We have developed a simple and robust assay for PDP 5-HT that will increase throughput for clinical trials...
  5. doi request reprint The use of mass spectrometry to improve the diagnosis and the management of the HPA axis
    Phillip J Monaghan
    Department of Clinical Biochemistry, the Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
    Rev Endocr Metab Disord 14:143-57. 2013
    ....
  6. doi request reprint Serum and plasma 5-hydroxyindoleacetic acid as an alternative to 24-h urine 5-hydroxyindoleacetic acid measurement
    Joanne E Adaway
    Department of Clinical Biochemistry, University Hospital South Manchester NHS Foundation Trust, Manchester, UK The University of Manchester, Manchester Academic Health Science Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, UK
    Ann Clin Biochem 53:554-60. 2016
    ..However, 5-hydroxyindoleacetic acid can also be quantified in plasma and serum...
  7. doi request reprint Serum Cortisol: An Up-To-Date Assessment of Routine Assay Performance
    James M Hawley
    University Hospital South Manchester, Manchester, UK
    Clin Chem 62:1220-9. 2016
    ..Here, we investigate the effects of sex, matrix, and antibody specificity on serum cortisol quantification in 6 routine assays...
  8. doi request reprint Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin
    Chander Shekhar
    Neurogastroenterology Unit, University of Manchester, Manchester, UK
    Gastroenterology 145:749-57; quiz e13-4. 2013
    ..We investigated relationships between platelet-depleted plasma concentrations of serotonin, gastrointestinal symptoms, and motor-sensory function in patients with FC or IBS-C compared with healthy volunteers (controls)...