Keith George

Summary

Affiliation: Liverpool John Moores University
Country: UK

Publications

  1. doi request reprint The endurance athletes heart: acute stress and chronic adaptation
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Br J Sports Med 46:i29-36. 2012
  2. pmc Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study
    Rory O'Hanlon
    Department of Cardiovascular Magnetic Resonance, Royal Brompton and Harefield NHS Foundation Trust, London, UK
    J Cardiovasc Magn Reson 12:38. 2010
  3. doi request reprint Exercise and the heart: can you have too much of a good thing?
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    Med Sci Sports Exerc 40:1390-2. 2008
  4. doi request reprint Diastolic function in healthy humans: non-invasive assessment and the impact of acute and chronic exercise
    Keith P George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Eur J Appl Physiol 108:1-14. 2010
  5. doi request reprint Cardiac adaptation to acute and chronic participation in endurance sports
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Liverpool, UK
    Heart 97:1999-2004. 2011
  6. pmc Mitral annular myocardial velocity assessment of segmental left ventricular diastolic function after prolonged exercise in humans
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK
    J Physiol 569:305-13. 2005
  7. doi request reprint Anabolic steroid use and longitudinal, radial, and circumferential cardiac motion
    Peter J Angell
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    Med Sci Sports Exerc 44:583-90. 2012
  8. doi request reprint Left ventricular wall segment motion after ultra-endurance exercise in humans assessed by myocardial speckle tracking
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 15 21 Webster Street, Liverpool L3 2ET, UK
    Eur J Echocardiogr 10:238-43. 2009
  9. doi request reprint Systematic review and meta-analysis of training mode, imaging modality and body size influences on the morphology and function of the male athlete's heart
    Victor Utomi
    Cardiorespiratory Research Group, Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Heart 99:1727-33. 2013
  10. doi request reprint Why isn't flow-mediated dilation enhanced in athletes?
    Daniel J Green
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    Med Sci Sports Exerc 45:75-82. 2013

Collaborators

Detail Information

Publications40

  1. doi request reprint The endurance athletes heart: acute stress and chronic adaptation
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Br J Sports Med 46:i29-36. 2012
    ..The combination of acute endurance exercise stress on the heart and prolonged periods of training are considered together in the final section...
  2. pmc Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study
    Rory O'Hanlon
    Department of Cardiovascular Magnetic Resonance, Royal Brompton and Harefield NHS Foundation Trust, London, UK
    J Cardiovasc Magn Reson 12:38. 2010
    ..We sought to correlate the relationship between acute bouts of ultra endurance exercise leading to cardiac biomarkers elevation and the presence of myocardial inflammation and fibrosis using CMR...
  3. doi request reprint Exercise and the heart: can you have too much of a good thing?
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    Med Sci Sports Exerc 40:1390-2. 2008
    ..This initial introduction sets out the background to the main articles that will document our current understanding of these problems as well as suggest important avenues for further research...
  4. doi request reprint Diastolic function in healthy humans: non-invasive assessment and the impact of acute and chronic exercise
    Keith P George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Eur J Appl Physiol 108:1-14. 2010
    ....
  5. doi request reprint Cardiac adaptation to acute and chronic participation in endurance sports
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Liverpool, UK
    Heart 97:1999-2004. 2011
    ..Recent commentaries, case reports and case series data have posed the question whether you can 'overdose on exercise', and that is the focus of this brief review...
  6. pmc Mitral annular myocardial velocity assessment of segmental left ventricular diastolic function after prolonged exercise in humans
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK
    J Physiol 569:305-13. 2005
    ..4 +/- 0.8 and 3.3 +/- 0.7, respectively) suggests that the depression in diastolic function is likely to be due to altered relaxation of the left ventricle; however, the exact aetiology of this change remains to be determined...
  7. doi request reprint Anabolic steroid use and longitudinal, radial, and circumferential cardiac motion
    Peter J Angell
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    Med Sci Sports Exerc 44:583-90. 2012
    ..The purpose of this study was to investigate the effect of anabolic steroid (AS) use on cardiac structure and function and cardiovascular risk factors...
  8. doi request reprint Left ventricular wall segment motion after ultra-endurance exercise in humans assessed by myocardial speckle tracking
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, 15 21 Webster Street, Liverpool L3 2ET, UK
    Eur J Echocardiogr 10:238-43. 2009
    ..Recently developed strain and strain rate imaging provide the unique opportunity to assess tissue deformation in all planes of motion...
  9. doi request reprint Systematic review and meta-analysis of training mode, imaging modality and body size influences on the morphology and function of the male athlete's heart
    Victor Utomi
    Cardiorespiratory Research Group, Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Heart 99:1727-33. 2013
    ..Controversy related to training-specific cardiac adaptation in male athletes, and continuing developments in imaging technology and scaling prompted this systematic review and meta-analysis...
  10. doi request reprint Why isn't flow-mediated dilation enhanced in athletes?
    Daniel J Green
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    Med Sci Sports Exerc 45:75-82. 2013
    ..Studies performed in animals and humans strongly suggest that exercise training and physical activity enhance arterial endothelial function. Studies of athletes have, however, been less definitive...
  11. doi request reprint Effects of time of day on post-exercise blood pressure: circadian or sleep-related influences?
    Helen Jones
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Chronobiol Int 25:987-98. 2008
    ..This phenomenon cannot be attributed simply to the residual effects of sleep, as it was not observed when participants exercised after a period of daytime sleep...
  12. doi request reprint The impact of chronic endurance and resistance training upon the right ventricular phenotype in male athletes
    Victor Utomi
    Research Institute for Sport and Exercise Sciences, Liverpool John Moore s University, Tom Reilly Building, Byrom Street, Liverpool, L3 3AF, UK
    Eur J Appl Physiol 115:1673-82. 2015
    ..resistance-trained male athletes. Secondary aims included comparison of RV function in all groups using myocardial speckle tracking, and the impact of allometric scaling on RV data interpretation...
  13. doi request reprint Left ventricular myocardial strain and strain rates in sub-endocardial and sub-epicardial layers before and after a marathon
    Fang Chan-Dewar
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street Campus, Liverpool, L3 3AF, UK
    Eur J Appl Physiol 109:1191-6. 2010
    ..There are differences in deformation characteristics between the sub-endocardium and sub-epicardium at baseline, and the limited changes observed post-race were not specific to any region or depth of the LV wall...
  14. doi request reprint Evidence of increased electro-mechanical delay in the left and right ventricle after prolonged exercise
    Fang Chan-Dewar
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Eur J Appl Physiol 108:581-7. 2010
    ..05). Further, post-race peak tissue velocities in basal LV and RV wall segments were reduced (P < 0.05). Recovery from prolonged running was associated with an increased "EMD", and reduced peak tissue velocities, in both ventricles...
  15. doi request reprint Post-exercise blood pressure reduction is greater following intermittent than continuous exercise and is influenced less by diurnal variation
    Helen Jones
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Chronobiol Int 26:293-306. 2009
    ..Therefore, a bout of afternoon exercise that is occasionally interrupted with short rest periods is recommended for lowering BP acutely...
  16. ncbi request reprint Longitudinal and radial systolic myocardial tissue velocities after prolonged exercise
    Keith George
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Appl Physiol Nutr Metab 31:256-60. 2006
    ..10, p > 0.05), age (r = -0.25, p > 0.05), or finishing time (r = -0.13, p > 0.05). Our data suggest that marathon running does not induce any segmental or global depression in LV systolic function...
  17. doi request reprint Anabolic steroids and cardiovascular risk
    Peter Angell
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Sports Med 42:119-34. 2012
    ..Continued efforts to fully document the cardiovascular health consequences of AS use is important to provide a clear, accurate, public health message to the many groups now using AS for performance and image enhancement...
  18. doi request reprint Intermittent exercise abolishes the diurnal variation in endothelial-dependent flow-mediated dilation in humans
    Helen Jones
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores Univ, Henry Cotton Campus, Webster St, Liverpool L3 2ET, UK
    Am J Physiol Regul Integr Comp Physiol 298:R427-32. 2010
    ..This infers a reduced function of the intrinsic endothelial NO-vasodilator system in the morning. We also report, for the first time, that a bout of intermittent exercise abolishes this diurnal variation in endothelium-dependent FMD...
  19. ncbi request reprint Is the magnitude of acute post-exercise hypotension mediated by exercise intensity or total work done?
    Helen Jones
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Eur J Appl Physiol 102:33-40. 2007
    ..0005). The acute post-exercise reduction in BP was clinically similar following high intensity short duration exercise and moderate intensity longer duration exercise that was matched for total work done...
  20. doi request reprint The right ventricle following ultra-endurance exercise: insights from novel echocardiography and 12-lead electrocardiography
    Rachel Lord
    Research Institute for Sport and Exercise Sciences, Tom Reilly Building, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK
    Eur J Appl Physiol 115:71-80. 2015
    ....
  21. doi request reprint Peripheral vascular structure and function in hypertrophic cardiomyopathy
    Nicola Jayne Rowley
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK
    Br J Sports Med 46:i98-103. 2012
    ..We hypothesised that, while HCM patients and athletes would exhibit similar cardiac characteristics, differences would be apparent in their brachial and carotid arteries...
  22. doi request reprint Performance enhancing drug abuse and cardiovascular risk in athletes: implications for the clinician
    Peter J Angell
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Br J Sports Med 46:i78-84. 2012
    ..Specifically we prompt the need for awareness of clinical staff when assessing the potential CV consequences of drug use in athletes...
  23. ncbi request reprint Effect of weightlifting upon left ventricular function and markers of cardiomyocyte damage
    Claire Stephenson
    Research Institute for Sport and Exercise Sciences, Henry Cotton Campus, Liverpool John Moores University, Liverpool L3 2ET, UK
    Ergonomics 48:1585-93. 2005
    ..The small reduction in diastolic filling could not be explained by changes in haemodynamic loading or the post-exercise elevation in heart rate...
  24. doi request reprint Diastolic Doppler flow and tissue Doppler velocities during, and in recovery from, low-intensity supine exercise
    Christoforos D Giannaki
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, L32ET, UK
    Appl Physiol Nutr Metab 33:896-902. 2008
    ..The interpretation of diastolic functional indices measured after physical exertion should be made in light of the present data...
  25. doi request reprint The acute post-exercise response of blood pressure varies with time of day
    Helen Jones
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, Webster Street, Liverpool L3 2ET, UK
    Eur J Appl Physiol 104:481-9. 2008
    ..We conclude that the acutely hypotensive effects following 30 min of steady state exercise are less marked in the morning, probably because the exercise-mediated decrease in peripheral resistance is not as apparent at this time of day...
  26. doi request reprint Chronic adaptation of atrial structure and function in elite male athletes
    Gavin McClean
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, UK
    Eur Heart J Cardiovasc Imaging 16:417-22. 2015
    ....
  27. doi request reprint Exercise and arterial adaptation in humans: uncoupling localized and systemic effects
    Nicola J Rowley
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    J Appl Physiol (1985) 110:1190-5. 2011
    ..These data suggest that localized effects of exercise are evident in the remodeling of arterial size, whereas arterial wall thickness appears to be affected by systemic factors...
  28. ncbi request reprint Cardiac and vascular adaptations to exercise
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Building, 15 21 Webster Street, Liverpool, UK
    Curr Opin Clin Nutr Metab Care 9:677-84. 2006
    ..To briefly review some recent studies of cardiac and vascular adaptation to acute exercise and exercise training...
  29. ncbi request reprint Acute changes in cardiovascular function during the onset period of daytime sleep: comparison to lying awake and standing
    Mohammad Zaregarizi
    Research Institute for Sport and Exercise Sciences, Henry Cotton Campus, Liverpool John Moores Univ, Liverpool L3 2ET, UK
    J Appl Physiol 103:1332-8. 2007
    ..05). Our findings suggest that the period between lights out and sleep onset is associated with the largest acute reduction in blood pressure during one afternoon siesta...
  30. doi request reprint Sonographic evaluation of the axillary artery during simulated overhead throwing arm positions
    Claire Stapleton
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Phys Ther Sport 9:126-35. 2008
    ..The aim of this study was to determine changes in axillary artery diameter and peak systolic velocity in asymptomatic individuals during upper limb positioning commonly used to assess vascular pathology in athletes...
  31. doi request reprint Predominance of normal left ventricular geometry in the male 'athlete's heart'
    Victor Utomi
    Research Institute for Sport and Exercise Sciences, Liverpool John Moore s University, Liverpool, UK
    Heart 100:1264-71. 2014
    ..This study evaluated (a) global LV adaption to endurance versus resistance training in male athletes, (b) LV assessment using by modern imaging technologies and (c) the impact of scaling for body size on LV structural data...
  32. ncbi request reprint Postexercise left ventricular function and cTnT in recreational marathon runners
    Keith George
    Research Institute for Sport and Exercise Science, Henry Cotton Campus, Liverpool John Moores University, Liverpool, United Kingdom
    Med Sci Sports Exerc 36:1709-15. 2004
    ..To assess the impact of prolonged exercise on left ventricular (LV) function and the appearance of cardiac troponin T (cTnT) in older and recreational athletes...
  33. ncbi request reprint Chronobiological considerations for exercise and heart disease
    Greg Atkinson
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, UK
    Sports Med 36:487-500. 2006
    ..Nevertheless, it is unclear whether time of day alters the risk of a cardiac event occurring during spontaneous physical activity performed by individuals with established risk factors for heart disease...
  34. ncbi request reprint Sonographic evaluation of the subclavian artery during thoracic outlet syndrome shoulder manoeuvres
    Claire Stapleton
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Man Ther 14:19-27. 2009
    ..Further research is required to determine the cause of heterogenous responses in asymptomatics and discover means to improve test specificity...
  35. doi request reprint Ventricular structure, function, and focal fibrosis in anabolic steroid users: a CMR study
    Peter J Angell
    Health Sciences Department, Liverpool Hope University, Hope Park, Liverpool, L16 9JD, UK
    Eur J Appl Physiol 114:921-8. 2014
    ..Our aim was to document the impact of AS use on cardiac structure, function and the presence of focal fibrosis using the gold standard cardiovascular magnetic resonance imaging (CMR)...
  36. ncbi request reprint Reactivity of ambulatory blood pressure to physical activity varies with time of day
    Helen Jones
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 2ET, United Kingdom
    Hypertension 47:778-84. 2006
    ..485), medication use, age, and sex (P>0.350). In conclusion, under conditions of normal living, the reactivity of BP and HR to a given unit change in activity is highest in the morning and shows a secondary rise in the afternoon...
  37. ncbi request reprint Physical activity before and after diagnosis of colorectal cancer: disease risk, clinical outcomes, response pathways and biomarkers
    David J Harriss
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, Liverpool, UK
    Sports Med 37:947-60. 2007
    ..Research evidence is, however, limited as to whether these markers are beneficially affected by physical activity, either before or after diagnosis of colorectal cancer...
  38. pmc The association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study
    Rebecca Dobson
    Neuroendocrine Tumour Group, University Hospital Aintree, Liverpool, Merseyside, United Kingdom Department of Obesity and Endocrinology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool Merseyside, United Kingdom
    PLoS ONE 8:e73679. 2013
    ..We sought to evaluate the discriminatory utility of diagnostic biomarkers in determining the presence and severity of carcinoid heart disease in patients with metastatic neuroendocrine tumors...
  39. doi request reprint Intraobserver reliability of two-dimensional ultrasound derived strain imaging in the assessment of the left ventricle, right ventricle, and left atrium of healthy human hearts
    David Oxborough
    Faculty of Medicine and Health, University of Leeds, Leeds, UK
    Echocardiography 29:793-802. 2012
    ..To determine the intraobserver reproducibility of peak and temporal values for myocardial strain (ɛ) and strain rate (SR) using a speckle tracking technique in the left ventricle (LV), right ventricle (RV), and left atrium (LA)...
  40. ncbi request reprint Anterior translation at the glenohumeral joint: a cause of axillary artery compression?
    Claire H Stapleton
    Research Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom
    Am J Sports Med 36:539-44. 2008
    ..Lesions to the axillary artery are reported in overhead athletes. One speculated cause is repeated transient compression by the humeral head due to excessive laxity at the glenohumeral joint...