D E J Linden
- How psychotherapy changes the brain--the contribution of functional neuroimagingD E J Linden
School of Psychology, University of Wales Bangor, Bangor, UK
Mol Psychiatry 11:528-38. 2006....
- Neuroimaging in psychiatry: from bench to bedsideDavid E J Linden
Bangor Imaging Unit, Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University Bangor, UK
Front Hum Neurosci 3:49. 2009..We expect that neuroimaging will play an increasing role in the future refinement of the diagnostic process and aid in the development of new therapies in the field of psychiatry...
- Brain imaging and psychotherapy: methodological considerations and practical implicationsDavid E J Linden
School of Psychology and North Wales Clinical School, Bangor University, Brigantia Building, Bangor, Wales, UK
Eur Arch Psychiatry Clin Neurosci 258:71-5. 2008..I will discuss their initial application in depression and OCD, and suggest potential alternative options based on recent developments in neurofeedback technology...
- The p300: where in the brain is it produced and what does it tell us?David E J Linden
School of Psychology, Brigantia Building, University of Wales, Bangor LL57 2AS, UK
Neuroscientist 11:563-76. 2005..Knowledge about the generators of the P300 will be crucial for a better understanding of its cognitive significance and its continuing clinical application...
- The brain's voices: comparing nonclinical auditory hallucinations and imageryDavid E J Linden
Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, UK
Cereb Cortex 21:330-7. 2011..Our results reveal mechanisms of the generation of sensory experience in the absence of external stimulation and suggest new approaches to the investigation of the neurobiology of psychopathology...
- The working memory networks of the human brainDavid E J Linden
Wolfson Centre of Clinical and Cognitive Neuroscience, School of Psychology, University of Wales Bangor, North Wales Clinical School, Bangor, Wales
Neuroscientist 13:257-67. 2007..Finally, the author highlights open questions for cognitive neuroscience research of working memory, such as that of the mechanisms for integrating different types of content (binding) or those providing the link to long-term memory...
- What, when, where in the brain? Exploring mental chronometry with brain imaging and electrophysiologyDavid E J Linden
School of Psychology, University of Wales Bangor, Bangor, Wales, UK
Rev Neurosci 18:159-71. 2007..It will be argued that similar design principles as established for behavioural studies of mental chronometry should apply to neurophysiological investigations as well...
- [Auditory hallucinations and functional imaging]D E J Linden
School of Psychology and North Wales Clinical School, University of Wales, Bangor, Wales, UK
Fortschr Neurol Psychiatr 76:S33-9. 2008..Future research with functional and structural imaging should go beyond correlating brain activity and symptoms and also address the functional and structural connectivity patterns in the brain that enable hallucinations...
- Dysbindin-1 genotype effects on emotional working memoryC Wolf
Wolfson Centre for Cognitive and Clinical Neuroscience, School of Psychology, Bangor University, Bangor, UK
Mol Psychiatry 16:145-55. 2011..The combination of imaging and genetics thus allows us to bridge the gap between the cellular/molecular and systems/behavioral level and extend the cognitive neuroscience approach to a comprehensive biology of cognition...
- Emotional faces and the default mode networkS Sreenivas
North Wales Organisation for Randomised Trials in Health and Social Care, Bangor University, Bangor, UK
Neurosci Lett 506:229-34. 2012..The emotion-specific differential pattern of DMN deactivation may be explored further in patients with mood disorder, where the quest for biological markers of emotional biases is still ongoing...
- Neural signatures of stimulus features in visual working memory--a spatiotemporal approachHelen M Morgan
Wolfson Centre for Clinical and Cognitive Neuroscience and Wales Institute of Cognitive Neuroscience, School of Psychology, Bangor University, Penrallt Road, Gwynedd, UK
Cereb Cortex 20:187-97. 2010....
- Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophreniaCorinna Haenschel
Department of Psychiatry, Johann Wolfgang Goethe University, Frankfurt, Germany
J Neurosci 29:9481-9. 2009..Inability to maintain oscillatory activity in specific frequency bands could thus result in the information overload that may underlie both cognitive deficits and psychopathological symptoms of schizophrenia...
- Emotion-cognition interactions in schizophrenia: Implicit and explicit effects of facial expressionStefanie C Linden
Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, United Kingdom
Neuropsychologia 48:997-1002. 2010....
- Enhanced visual short-term memory for angry facesMargaret C Jackson
School of Psychology, Bangor University, Bangor, United Kingdom
J Exp Psychol Hum Percept Perform 35:363-74. 2009..Perhaps processes activated by the presence of specifically angry expressions enhance VSTM because memory for the identities of angry people has particular behavioral relevance...
- Working memory load for faces modulates P300, N170, and N250rHelen M Morgan
Bangor University, Bangor, UK
J Cogn Neurosci 20:989-1002. 2008..Furthermore, we show, for the first time, that WM load affects the N250r and the early visual N170 component. This suggests that higher visual areas play an important role in WM for faces...
- Goal-oriented cognitive rehabilitation for an individual with Mild Cognitive Impairment: behavioural and neuroimaging outcomesLinda Clare
School of Psychology, Bangor University, Bangor, Gwynedd LL57 2AS, UK
Neurocase 15:318-31. 2009..Both client-centred measures and fMRI may assist in detecting clinically-meaningful changes resulting from cognitive rehabilitation interventions...
- Neural correlates of enhanced visual short-term memory for angry faces: an FMRI studyMargaret C Jackson
School of Psychology, Bangor University, Bangor, Gwynedd, United Kingdom
PLoS ONE 3:e3536. 2008..This appears to be of particular evolutionary importance when confronted with potentially threatening displays of emotion - previous research has shown better VSTM for angry versus happy or neutral face identities...
- Random subspace ensembles for FMRI classificationLudmila I Kuncheva
School of Computer Science, Bangor University, LL57 1UT Bangor, U K
IEEE Trans Med Imaging 29:531-42. 2010..The closest rivals were the single SVM and bagging of SVM classifiers. We use kappa-error diagrams to understand the success of RS...
- Improving visual short-term memory by sequencing the stimulus arrayNiklas Ihssen
Wales Institute of Cognitive Neuroscience Wolfson Centre for Clinical and Cognitive Neuroscience, Bangor University, Bangor, Wales
Psychon Bull Rev 17:680-6. 2010..In contrast, temporal segregation of the stimulus input may help participants maximize their performance and utilize their full VSTM capacity...
- Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacyLinda Clare
Bangor University, United Kingdom
Am J Geriatr Psychiatry 18:928-39. 2010..To provide evidence regarding the clinical efficacy of cognitive rehabilitation (CR) in early-stage Alzheimer disease (AD)...
- A Hedonism Hub in the Human BrainG Zacharopoulos
CUBRIC, School of Psychology, Cardiff University, Cardiff, Wales, UK
Cereb Cortex 26:3921-7. 2016..This is the first study to elucidate the relationship between the importance people attach to the human value of hedonism and structural variation in reward-related subcortical brain regions. ..
- Neurofeedback: A promising tool for the self-regulation of emotion networksS J Johnston
Bangor Imaging Unit, Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Bangor, UK
Neuroimage 49:1066-72. 2010..These findings demonstrate the feasibility of fMRI-based neurofeedback of emotion networks and suggest a possible development into a therapeutic tool...
- CACNA1C risk variant is associated with increased amygdala volumeT M Lancaster
Neuroscience and Mental Health Research Institute, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, Wales, UK
Eur Arch Psychiatry Clin Neurosci 266:269-75. 2016..Further study of CACNA1C using intermediate phenotypes for psychosis will determine the mechanisms by which variation in this gene confers risk. ..
- fMRI neurofeedback of higher visual areas and perceptual biasesI Habes
Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF10 3AT, UK
Neuropsychologia 85:208-15. 2016..This study sets the basis for future investigations of perceptual and behavioural consequences of localised self-regulation of neural activity. ..
- Can we change brain functioning with cognition-focused interventions in Alzheimer's disease? The role of functional neuroimagingJorien van Paasschen
School of Psychology, Bangor University, UK
Restor Neurol Neurosci 27:473-91. 2009..Associative memory function is affected in the early stages of AD and also deteriorates disproportionately in comparison to other types of memory in healthy ageing...
- Localizing P300 generators in visual target and distractor processing: a combined event-related potential and functional magnetic resonance imaging studyChristoph Bledowski
Department of Psychiatry, Johann Wolfgang Goethe University, 60590 Frankfurt, Germany
J Neurosci 24:9353-60. 2004..The results point to the involvement of distinct attentional subsystems in target and distractor processing...
- Distributed cortical systems in visual short-term memory revealed by event-related functional magnetic resonance imagingMatthias H J Munk
Max Planck Institut für Hirnforschung, Deutschordenstrasse 46, D 60528 Frankfurt, Germany
Cereb Cortex 12:866-76. 2002..These modulations confirmed a posterior-anterior and right-left dissociation for spatial versus non-spatial memory and revealed that conjunction memory does not rely on a linear addition of the component processes...
- Processing conflicting information: facilitation, interference, and functional connectivityRoi Cohen Kadosh
Institute of Cognitive Neuroscience and Department of Psychology, University College London, London, UK
Neuropsychologia 46:2872-9. 2008..4) These networks were modulated by the two groups that we distinguished based on the ACC activation...
- Tracking the mind's image in the brain I: time-resolved fMRI during visuospatial mental imageryElia Formisano
Department of Cognitive Neuroscience, Faculty of Psychology, Universiteit Maastricht, Postbus 616, The Netherlands
Neuron 35:185-94. 2002..This is confirmed by a trial-by-trial analysis of correlations between reaction time and onset, width, and amplitude of the hemodynamic response. These findings pose neurophysiological constraints on cognitive models of mental imagery...
- Tracking the mind's image in the brain II: transcranial magnetic stimulation reveals parietal asymmetry in visuospatial imageryAlexander T Sack
Department of Psychiatry, Laboratory for Neurophysiology and Neuroimaging, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, DE 60590 Frankfurt, Germany
Neuron 35:195-204. 2002..This is compatible with current theories of spatial hemineglect and constitutes a constraint for models of distributed information processing in the parietal lobes...
- Cortical capacity constraints for visual working memory: dissociation of fMRI load effects in a fronto-parietal networkDavid E J Linden
Max Planck Institut für Himforschung, Deutschordenstrasse 46, D 60528 Frankfurt, Germany
Neuroimage 20:1518-30. 2003..These results indicate that at least two distinct cortical subsystems are recruited for visual WM, and that their interplay changes when the capacity limit is reached...
- Attentional systems in target and distractor processing: a combined ERP and fMRI studyChristoph Bledowski
Department of Psychiatry, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
Neuroimage 22:530-40. 2004..Our results thus demonstrate that distractor and target processing engage a common neuronal system for the detection of rare events, but also task-specific subsystems related to attention and memory processes...
- Decomposition of working memory-related scalp ERPs: crossvalidation of fMRI-constrained source analysis and ICAMichael Wibral
MEG Unit, Brain Imaging Center, Johann Wolfgang Goethe University, Haus 93B, Heinrich Hoffmann Strasse 10, 60528 Frankfurt am Main, Germany
Int J Psychophysiol 67:200-11. 2008..We conclude that testing at the single-subject level is preferable for crossvalidation purposes if the signal-to-noise ratio of the data allows for this approach...
- Separation of the systems for color and spatial manipulation in working memory revealed by a dual-task procedureHarald M Mohr
Johann Wolfgang Goethe Universitat, Germany
J Cogn Neurosci 17:355-66. 2005..We speculate that the ventral-dorsal dissociation of visual processing is conserved for manipulation processes and that manipulation differs from maintenance in the extent to which is relies on central executive resources...
- The brain locus of interaction between number and size: a combined functional magnetic resonance imaging and event-related potential studyRoi Cohen Kadosh
Ben Gurion University of the Negev, Beer Sheva, Israel
J Cogn Neurosci 19:957-70. 2007..We concluded that the processing of magnitude can be subserved by shared or distinct neural substrates, depending on task requirements...
- Are numbers special? The comparison systems of the human brain investigated by fMRIRoi Cohen Kadosh
Department of Behavioral Sciences and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
Neuropsychologia 43:1238-48. 2005....
- Common neural substrates for visual working memory and attentionJutta S Mayer
Department of Psychiatry, Johann Wolfgang Goethe University, Heinrich Hoffmann Str 10, 60528 Frankfurt, Germany
Neuroimage 36:441-53. 2007..We propose that competition for resources shared by visual attention and WM encoding can limit processing capabilities in distributed posterior brain regions...
- Imaging the brain activity changes underlying impaired visuospatial judgments: simultaneous FMRI, TMS, and behavioral studiesAlexander T Sack
Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University, 6200 MD Maastricht, The Netherlands
Cereb Cortex 17:2841-52. 2007....
- The spatiotemporal pattern of auditory cortical responses during verbal hallucinationsVincent G van de Ven
Department of Cognitive Neuroscience, Faculty of Psychology, University Maastricht, The Netherlands
Neuroimage 27:644-55. 2005..We suggest that detection of this activity may be facilitated by examining hallucination epochs of sufficient length, in combination with a data-driven approach...
- Dysfunctional long-range coordination of neural activity during Gestalt perception in schizophreniaPeter J Uhlhaas
Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt am Main, 60528, Germany
J Neurosci 26:8168-75. 2006....
- When blue is larger than red: colors influence numerical cognition in synesthesiaRoi Cohen Kadosh
Ben Gurion University of the Negev, Israel
J Cogn Neurosci 17:1766-73. 2005..It is proposed that bidirectional coactivation of brain areas is responsible for the links between color and magnitude processing in color-grapheme synesthesia and that unidirectional models of synesthesia might have to be revised...
- Mental chronometry of working memory retrieval: a combined functional magnetic resonance imaging and event-related potentials approachChristoph Bledowski
Department of Psychiatry, Johann Wolfgang Goethe University, 60590 Frankfurt, Germany
J Neurosci 26:821-9. 2006..This is also supported by their differential temporal contribution to specific subcomponents of the P300 cognitive potential...
- The independent components of auditory P300 and CNV evoked potentials derived from single-trial recordingsBarrie Jervis
SoCCE, University of Plymouth, Plymouth PL4 8AA, UK
Physiol Meas 28:745-71. 2007..For the CNV, BICs corresponding to both the orienting and the expectancy components were found...
- Acquisition of affective dispositions in dementia patientsAndreas Blessing
Department of Psychology, University of Konstanz, D 78457 Konstanz, Germany
Neuropsychologia 44:2366-73. 2006..The results suggest that acquisition and maintenance of implicit affective dispositions are preserved in dementia even when explicit memory is impaired...
- Coordinate and categorical judgements in spatial imagery. An fMRI studyLuigi Trojano
Salvatore Maugeri Foundation, IRCCS, Institute of Telese, Loc S Stefano in Lanterria, Telese Terme, BN, Italy
Neuropsychologia 40:1666-74. 2002....
- Combining transcranial magnetic stimulation and functional imaging in cognitive brain research: possibilities and limitationsAlexander T Sack
Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe Universitat, Heinrich Hoffmann Str 10, 60528, Frankfurt am Main, Germany
Brain Res Brain Res Rev 43:41-56. 2003..We argue that while some of the methodological limitations of TMS applied alone can be overcome by combination with functional neuroimaging, others will persist until its physical and physiological effects can be controlled...
- Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during restVincent G van de Ven
Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe University, Frankfurt, Germany
Hum Brain Mapp 22:165-78. 2004..These results are discussed in the context of the recent debate on the functional relevance of fluctuations of neural activity in the resting state...
- Enhanced vividness of mental imagery as a trait marker of schizophrenia?Alexander T Sack
Department of Cognitive Neuroscience, Faculty of Psychology, University of Maastricht, The Netherlands
Schizophr Bull 31:97-104. 2005..g., frequency of hallucinations). Vividness of mental imagery might thus prove to be an independent trait marker of schizophrenia...
- The temporal characteristics of motion processing in hMT/V5+: combining fMRI and neuronavigated TMSAlexander T Sack
Department of Neurocognition, Faculty of Psychology, Maastricht University, PO Box 616, Postbus 616, 6200 MD Maastricht, The Netherlands
Neuroimage 29:1326-35. 2006....
- Treating auditory hallucinations by transcranial magnetic stimulation: a randomized controlled cross-over trialMartin Jandl
Department of Psychiatry I, University of Ulm, Ulm, Germany
Neuropsychobiology 53:63-9. 2006..In a previous functional magnetic resonance imaging study, the authors succeeded in demonstrating the activation of Heschl's gyrus during auditory hallucinations (AH)...
- Content- and task-specific dissociations of frontal activity during maintenance and manipulation in visual working memoryHarald M Mohr
Department of Psychiatry, Johann Wolfgang Goethe Universitat, D 60590 Frankfurt am Main, Germany
J Neurosci 26:4465-71. 2006..We suggest that the enhanced demand on cognitive resources in manipulation compared with maintenance was met by interplay of content- and task-specific modules in a frontoparietal network...
- Neuronal correlates of colour-graphemic synaesthesia: a fMRI studyJulia M Sperling
Department of Psychiatry, Johann Wolfgang Goethe University, Frankfurt Main, Germany
Cortex 42:295-303. 2006..These findings support the hypothesis that the grapheme-induced colour perception in synaesthesia is caused by an activation of the colour areas of the human visual cortex...
- Visual perceptual organization deficits in Alzheimer's dementiaPeter J Uhlhaas
Department of Neurophysiology, Max Planck Institute for Brain Research, Department of Psychiatry, Frankfurt am Main, Germany
Dement Geriatr Cogn Disord 25:465-75. 2008..In the current study, we examined the hypothesis that perceptual organization is specifically impaired in AD compared to other dementias...
- Pain response in depersonalization: a functional imaging study using hypnosis in healthy subjectsChristian H Röder
Department of Psychosomatic Medicine and Psychotherapy, Johann Wolfgang Goethe University, Frankfurt, Germany
Psychother Psychosom 76:115-21. 2007..In this study we used hypnosis to induce DP in healthy subjects and to examine neural patterns of pain perception in the state of DP by means of functional magnetic resonance imaging (fMRI)...
- Five hundred years of brain imagesDavid E J Linden
Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe Universitat, Heinrich Hoffmann Str 10, D 60528 Frankfurt am Main, Germany
Arch Neurol 59:308-13. 2002
- Visual hallucinations in schizophrenia investigated with functional magnetic resonance imagingViola Oertel
Neurophysiology and Neuroimaging Laboratory, Deparment of Psychiatry, Goethe University, Frankfurt Main, Germany
Psychiatry Res 156:269-73. 2007..We assume that the hippocampal activity is related to the retrieval of visual images from memory and that sensory cortex activity is related to the vividness of the perceptual experience...
- Contribution of impaired early-stage visual processing to working memory dysfunction in adolescents with schizophrenia: a study with event-related potentials and functional magnetic resonance imagingCorinna Haenschel
Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe University, and Max Planck Institute for Brain Research, Frankfurt, Germany
Arch Gen Psychiatry 64:1229-40. 2007....
- Combining electrophysiology and functional imaging - different methods for different questionsChristoph Bledowski
Trends Cogn Sci 11:500-2. 2007
- Object- and direction-specific interference between manual and mental rotationAlexander T Sack
Faculty of Psychology, Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands
Percept Psychophys 69:1435-49. 2007..This object- and direction-specific interference between manual and mental rotation proved to be independent of task difficulty. We furthermore found an angular distance effect across different stimulus types...
- The corpus callosum in schizophrenia-volume and connectivity changes affect specific regionsAnna Rotarska-Jagiela
Department of Psychiatry, Neurophysiology and Neuroimaging Lab, Johann Wolfgang Goethe University, Frankfurt Main, Germany
Neuroimage 39:1522-32. 2008....