Genomes and Genes
Affiliation: King's College London
- Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeatsSelina Wray
MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, UK
J Neurochem 105:2343-52. 2008..Our findings suggest the aggregatory characteristics of PSP-tau differ from those of insoluble tau in Alzheimer's disease brain and this might be related to the presence of a C-terminal cleavage product of tau...
- Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinasesC Hugh Reynolds
The MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, UK
J Biol Chem 283:18177-86. 2008....
- Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesisDiane P Hanger
MRC Centre for Neurodegeneration Research, Department of Neuroscience, King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
J Biol Chem 282:23645-54. 2007....
- Tau cleavage and tau aggregation in neurodegenerative diseaseDiane P Hanger
Department of Neuroscience, King s College London, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, De Crespigny Park, London SE5 8AF, UK
Biochem Soc Trans 38:1016-20. 2010..We also discuss the evidence for the involvement of proteases in the generation of tau pathology in neurodegenerative disease, since these enzymes warrant further investigation as potential therapeutic targets in the tauopathies...
- Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's diseaseJoe Atherton
Institute of Psychiatry, Department of Neuroscience, King s College London, London, SE5 8AF, UK
Aging Cell 13:49-59. 2014....
- The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagyVictoria S Burchell
Department of Molecular Neuroscience, University College London Institute of Neurology, London, UK
Nat Neurosci 16:1257-65. 2013..Parkinson's disease-causing mutations in Fbxo7 interfered with this process, emphasizing the importance of mitochondrial dysfunction in Parkinson's disease pathogenesis. ..
- Using human induced pluripotent stem cells to model cerebellar disease: Hope and hypeSarah Wiethoff
a National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, London, UK
J Neurogenet 29:95-102. 2015..This in turn will permit a greater understanding of cerebellar pathophysiology to inform mechanistically rationalised therapies, which are desperately needed in this field. ..
- Comprehensive analysis of the TRPV4 gene in a large series of inherited neuropathies and controlsKatherine A Fawcett
MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
J Neurol Neurosurg Psychiatry 83:1204-9. 2012..TRPV4 mutations have been identified in Charcot-Marie-Tooth type 2 (CMT2), scapuloperoneal spinal muscular atrophy and distal hereditary motor neuropathy (dHMN)...